Analysis of genomic rearrangements associated with EGFRvIII expression suggests involvement of Alu repeat elements

Neuro-Oncology

Volumn 2, Issue 3, 2000, Pages 159-163

  Frederick, Lori ^a   Eley, Greg ^a   Wang, Xiao Yang ^a   James, C David ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; RNA;

ARTICLE; BRAIN TUMOR; GENE REARRANGEMENT; GENETICS; GLIOBLASTOMA; HUMAN; METABOLISM; NUCLEOTIDE REPEAT; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BRAIN NEOPLASMS; DNA, NEOPLASM; GENE REARRANGEMENT; GLIOBLASTOMA; HUMANS; POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPETITIVE SEQUENCES, NUCLEIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM;

EID: 0034231944     PISSN: 15228517     EISSN: None     Source Type: Journal    
DOI: 10.1093/neuonc/2.3.159     Document Type: Article

References (23)

1. Bigner, S.H., Humphrey, P.A., Wong, A.J., Vogelstein, B., Mark, J., Friedman, H.S., and Bigner, D.D. (1990) Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res. 50, 8017-8022.
2. Callaghan, T., Antczak, M., Flickinger, T., Raines, M., Myers, M., and Kung, H.J. (1993) A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution. Oncogene 8, 2939-2948.
3. Deininger, P.L., and Batzer, M.A. (1999) Alu repeats and human disease. Mol. Genet. Metab. 67, 183-193.
4. Ekstrand, A.J., Sugawa, N., James, C.D., and Collins, V.P. (1992) Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N-and/or C-terminal tails. Proc. Natl. Acad. Sci. U.S.A. 89, 4309-4313.
5. Feldkamp, M.M., Lau, N., Rak, J., Kerbel, R.S., and Guha, A. (1999) Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int J. Cancer 81, 118-124.
6. Foord, O.S., and Rose, E.A. (1994) Long-distance PCR. PCR Methods Appl. 3, S149-S161.
7. Frederick, L., Wang, X.-Y., Eley, G., and James, C.D. (2000) Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 60, 1383-1387.
8. Goike, H.M., Asplund, A.C., Pettersson, E.H., Liu L., Sanoudou, D., and Collins, V.P. (1999) Acquired rearrangement of an amplified epidermal growth factor receptor (EGFR) gene in a human glioblastoma xenograft. J. Neuropath. Exp. Neurol. 58, 697-701.
9. Haley, J., Whittle, N., Bennet, P., Kinchington, D., Ullrich, A., and Waterfield, M. (1987) The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcription. Oncogene Res. 1, 375-396.
10. Holland, E.C., Hively, W.P., DePinho, R.A., and Varmus, H.E. (1998) A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12, 3675-3685.
11. Humphrey, P.A., Wong, A.J., Vogelstein, B., Friedman, H.S., Werner, M.H., Bigner, D.D., and Bigner, S.H. (1988) Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer Res. 48, 2231-2238.
12. Humphrey, P.A., Wong, A.J., Vogelstein, B., Zalutsky, M.R., Fuller, G.N., Archer, G.E., Friedman, H.S., Kwatra, M.M., Bigner, S.H., and Bigner, D.D. (1990) Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. Proc. Natl. Acad. Sci. U.S.A. 87, 4207-4211.
13. James, C.D., Carlbom, E., Dumanski, J.P., Hansen, M., Nordenskjold, M., Collins V.P., and Cavenee, W.K. (1988) Clonal genomic alterations in glioma malignancy stages. Cancer Res. 48, 5546-5551.
14. Libermann, T.A., Nusbaum, H.R., Razon, N., Kris, R., Lax, I., Soreq, H., Whittle, N., Waterfield, M.D., Ullrich, A., and Schlessinger, J. (1985) Amplification, enhanced expression and possible rearrangement of ECF receptor gene in primary human brain tumours of glial origin. Nature 313, 144-147.
15. Maiden, L.T., Novak, U., Kaye, A.H., and Burgess, A.W. (1988) Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme. Cancer Res. 48, 2711-2714.
16. Moscatello, D.K., Holgado-Madruga, M., Emlet, D.R., Montgomery, R.B., and Wong, A.J. (1998) Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J. Biol. Chem. 273, 200-206.
17. Nagane, M., Levitzki, A., Gazit, A., Cavenee, W.K., and Huang, H.J. (1998) Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc. Natl. Acad. Sci. U.S.A. 95, 5724-5729.
18. Reiter, J.L., Eley G., Cora, E.M., Baron, A.T., James, C.D., and Maihle, N.J. (2000) Complete human EGFR gene structure and a novel 3 kb alternative transcript encoding a truncated 110 kDa form of the receptor. Proc. Am. Assoc Cancer Res. 41, 5006.
19. Strohman, R.C. (1999) Five stages of the Human Genome Project. Nat. Biotechnol. 17, 112.
20. Sugawa, N., Ekstrand, A.J., James, C.D., and Collins, V.P. (1990) Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc. Natl. Acad. Sci. U.S.A. 87, 8602-8606.
21. Wong, A.J., Ruppert, J.M., Bigner, S.H., Grzeschik, C.H., Humphrey, P.A., Bigner, D.S., and Vogelstein, B. (1992) Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl. Acad. Sci. U.S.A. 89, 2965-2969.
22. Yamazaki, H., Fukui, Y., Ueyama, Y., Tamaoki, N., Kawamoto, T., Taniguchi, S., and Shibuya, M. (1988) Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors. Mol. Cell. Biol. 8, 1816-1820.
23. Yamazaki, H., Ohba, Y., Tamaoki N., and Shibuya M. (1990) A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Jpn. J. Cancer Res. 81, 773-779.