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Volumn 200, Issue 2, 2009, Pages 177-187

Implication of nitric oxide in the increased islet-cells vulnerability of adult progeny from protein-restricted mothers and its prevention by taurine

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAMMA INTERFERON RECEPTOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PEROXIREDOXIN; PEROXIREDOXIN 3; PEROXIREDOXIN 5; PROTEIN SERCA2B; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TAURINE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 67449168618     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0234     Document Type: Article
Times cited : (11)

References (70)
  • 1
    • 0033621893 scopus 로고    scopus 로고
    • IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(C) T lymphocytes
    • Amrani A, Verdaguer J, Thiessen S, Bou S & Santamaria P 2000 IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(C) T lymphocytes. Journal of Clinical Investigation 105 459-468.
    • (2000) Journal of Clinical Investigation , vol.105 , pp. 459-468
    • Amrani, A.1    Verdaguer, J.2    Thiessen, S.3    Bou, S.4    Santamaria, P.5
  • 2
    • 0037288692 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and diabetes mellitus
    • Araki E, Oyadomari S & Mori M 2003 Endoplasmic reticulum stress and diabetes mellitus. Internal Medicine 42 7-14.
    • (2003) Internal Medicine , vol.42 , pp. 7-14
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 3
    • 0036828855 scopus 로고    scopus 로고
    • SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarco-endoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells
    • Arredouani A, Guiot Y, Jonas JC, Liu LH, Nenquin M, Pertusa JA, Rahier J, Rolland JF, Shull GE, Stevens M et al. 2002 SERCA3 ablation does not impair insulin secretion but suggests distinct roles of different sarco-endoplasmic reticulum Ca(2+) pumps for Ca(2+) homeostasis in pancreatic beta-cells. Diabetes 51 3245-3253.
    • (2002) Diabetes , vol.51 , pp. 3245-3253
    • Arredouani, A.1    Guiot, Y.2    Jonas, J.C.3    Liu, L.H.4    Nenquin, M.5    Pertusa, J.A.6    Rahier, J.7    Rolland, J.F.8    Shull, G.E.9    Stevens, M.10
  • 6
    • 1242272070 scopus 로고    scopus 로고
    • Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation
    • Averous J, Bruhat A, Jousse C, Carraro V, Thiel G & Fafournoux P 2004 Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. Journal of Biological Chemistry 279 5288-5297.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 5288-5297
    • Averous, J.1    Bruhat, A.2    Jousse, C.3    Carraro, V.4    Thiel, G.5    Fafournoux, P.6
  • 7
    • 0037354853 scopus 로고    scopus 로고
    • Proinflammatory cytokines induce NF-kappaB-dependent/NO-independent chemokine gene expression in MIN6 beta cells
    • Baker MS, Chen X, Rotramel A, Nelson J & Kaufman DB 2003 Proinflammatory cytokines induce NF-kappaB-dependent/NO-independent chemokine gene expression in MIN6 beta cells. Journal of Surgical Research 110 295-303.
    • (2003) Journal of Surgical Research , vol.110 , pp. 295-303
    • Baker, M.S.1    Chen, X.2    Rotramel, A.3    Nelson, J.4    Kaufman, D.B.5
  • 11
    • 0036596396 scopus 로고    scopus 로고
    • Taurine supplementation to a low-protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets
    • Boujendar S, Reusens B, Merezak S, Ahn MT, Arany E, Hill D & Remacle C 2002 Taurine supplementation to a low-protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia 45 856-866.
    • (2002) Diabetologia , vol.45 , pp. 856-866
    • Boujendar, S.1    Reusens, B.2    Merezak, S.3    Ahn, M.T.4    Arany, E.5    Hill, D.6    Remacle, C.7
  • 12
    • 0030814110 scopus 로고    scopus 로고
    • Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels
    • Bruhat A, Jousse C, Wang XZ, Ron D, Ferrara M & Fafournoux P 1997 Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. Journal of Biological Chemistry 272 17588-17593.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 17588-17593
    • Bruhat, A.1    Jousse, C.2    Wang, X.Z.3    Ron, D.4    Ferrara, M.5    Fafournoux, P.6
  • 13
    • 0035029867 scopus 로고    scopus 로고
    • Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays
    • Cardozo AK, Kruhoffer M, Leeman R, Orntoft T & Eizirik DL 2001a Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes 50 909-920.
    • (2001) Diabetes , vol.50 , pp. 909-920
    • Cardozo, A.K.1    Kruhoffer, M.2    Leeman, R.3    Orntoft, T.4    Eizirik, D.L.5
  • 16
    • 0031773879 scopus 로고    scopus 로고
    • Effect of taurine on the insulin secretion of rat fetal islets from dams fed a low protein diet
    • Cherif H, Reusens B, Ahn MT, Hoet JJ & Remacle C 1998 Effect of taurine on the insulin secretion of rat fetal islets from dams fed a low protein diet. Journal of Endocrinology 159 341-348.
    • (1998) Journal of Endocrinology , vol.159 , pp. 341-348
    • Cherif, H.1    Reusens, B.2    Ahn, M.T.3    Hoet, J.J.4    Remacle, C.5
  • 17
    • 21344458137 scopus 로고    scopus 로고
    • Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: Effect of improved metabolic control
    • Cipollone F, Chiarelli F, Davi G, Ferri C, Desideri G, Fazia M, Iezzi A, Santilli F, Pini B, Cuccurullo C et al. 2005 Enhanced soluble CD40 ligand contributes to endothelial cell dysfunction in vitro and monocyte activation in patients with diabetes mellitus: effect of improved metabolic control. Diabetologia 48 1216-1224.
    • (2005) Diabetologia , vol.48 , pp. 1216-1224
    • Cipollone, F.1    Chiarelli, F.2    Davi, G.3    Ferri, C.4    Desideri, G.5    Fazia, M.6    Iezzi, A.7    Santilli, F.8    Pini, B.9    Cuccurullo, C.10
  • 18
    • 0026316923 scopus 로고
    • Islet function in offspring of mothers on low-protein diet during gestation
    • Dahri S, Snoeck A, Reusens-Billen B, Remacle C & Hoet JJ 1991 Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40 115-120.
    • (1991) Diabetes , vol.40 , pp. 115-120
    • Dahri, S.1    Snoeck, A.2    Reusens-Billen, B.3    Remacle, C.4    Hoet, J.J.5
  • 19
    • 0035432603 scopus 로고    scopus 로고
    • Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP
    • Darville MI & Eizirik DL 2001 Cytokine induction of Fas gene expression in insulin-producing cells requires the transcription factors NF-kappaB and C/EBP. Diabetes 50 1741-1748.
    • (2001) Diabetes , vol.50 , pp. 1741-1748
    • Darville, M.I.1    Eizirik, D.L.2
  • 21
    • 0842328798 scopus 로고    scopus 로고
    • Roles of mitochondria in health and disease
    • Duchen MR 2004 Roles of mitochondria in health and disease. Diabetes 53 S96-S102.
    • (2004) Diabetes , vol.53
    • Duchen, M.R.1
  • 22
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
    • Eizirik DL & Mandrup-Poulsen T 2001 A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44 2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 23
    • 0031426764 scopus 로고    scopus 로고
    • Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM?
    • Eizirik DL & Pavlovic D 1997 Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM? Diabetes/Metabolism Reviews 13 293-307.
    • (1997) Diabetes/Metabolism Reviews , vol.13 , pp. 293-307
    • Eizirik, D.L.1    Pavlovic, D.2
  • 24
    • 33847653346 scopus 로고    scopus 로고
    • CHOP(C) /EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations
    • Fujita Y, Ito M, Nozawa Y, Yoneda M, Oshida Y & Tanaka M 2007 CHOP(C) /EBP homologous protein) and ASNS (asparagine synthetase) induction in cybrid cells harboring MELAS and NARP mitochondrial DNA mutations. Mitochondrion 7 80-88.
    • (2007) Mitochondrion , vol.7 , pp. 80-88
    • Fujita, Y.1    Ito, M.2    Nozawa, Y.3    Yoneda, M.4    Oshida, Y.5    Tanaka, M.6
  • 25
    • 0033615544 scopus 로고    scopus 로고
    • Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation
    • Ghafourifar P, Schenk U, Klein SD & Richter C 1999 Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. Journal of Biological Chemistry 274 31185-31188.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 31185-31188
    • Ghafourifar, P.1    Schenk, U.2    Klein, S.D.3    Richter, C.4
  • 27
    • 0036895383 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the development of diabetes: A review
    • Harding HP & Ron D 2002 Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 51 S455-S461.
    • (2002) Diabetes , vol.51
    • Harding, H.P.1    Ron, D.2
  • 29
    • 0026595620 scopus 로고
    • Physiological actions of taurine
    • Huxtable RJ 1992 Physiological actions of taurine. Physiological Reviews 72 101-163.
    • (1992) Physiological Reviews , vol.72 , pp. 101-163
    • Huxtable, R.J.1
  • 30
    • 39049130650 scopus 로고    scopus 로고
    • Taurine increases mitochondrial buffering of calcium: Role in neuroprotection
    • El Idrissi A 2006 Taurine increases mitochondrial buffering of calcium: role in neuroprotection. Amino Acids 34 321-328.
    • (2006) Amino Acids , vol.34 , pp. 321-328
    • El Idrissi, A.1
  • 32
    • 0023852783 scopus 로고
    • The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins
    • Kozutsumi Y, Segal M, Normington K, Gething MJ & Sambrook J 1988 The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332 462-464.
    • (1988) Nature , vol.332 , pp. 462-464
    • Kozutsumi, Y.1    Segal, M.2    Normington, K.3    Gething, M.J.4    Sambrook, J.5
  • 33
    • 0242363618 scopus 로고    scopus 로고
    • Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells
    • Kutlu B, Cardozo AK, Darville MI, Kruhoffer M, Magnusson N, Orntoft T & Eizirik DL 2003 Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 52 2701-2719.
    • (2003) Diabetes , vol.52 , pp. 2701-2719
    • Kutlu, B.1    Cardozo, A.K.2    Darville, M.I.3    Kruhoffer, M.4    Magnusson, N.5    Orntoft, T.6    Eizirik, D.L.7
  • 37
    • 0033949313 scopus 로고    scopus 로고
    • Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOSK-/-)
    • Liu D, Pavlovic D, Chen MC, Flodström M, Sandler S & Eizirik DL 2000 Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOSK-/-). Diabetes 49 1116-1122.
    • (2000) Diabetes , vol.49 , pp. 1116-1122
    • Liu, D.1    Pavlovic, D.2    Chen, M.C.3    Flodström, M.4    Sandler, S.5    Eizirik, D.L.6
  • 38
    • 0031897507 scopus 로고    scopus 로고
    • Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation
    • Loweth AC, Williams GT, James RF, Scarpello JH & Morgan NG 1998 Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes 47 727-732.
    • (1998) Diabetes , vol.47 , pp. 727-732
    • Loweth, A.C.1    Williams, G.T.2    James, R.F.3    Scarpello, J.H.4    Morgan, N.G.5
  • 40
    • 0035144493 scopus 로고    scopus 로고
    • Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
    • McCullough KD, Martindale JL, Klotz LO, Aw TY & Holbrook NJ 2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Molecular and Cellular Biology 21 1249-1259.
    • (2001) Molecular and Cellular Biology , vol.21 , pp. 1249-1259
    • McCullough, K.D.1    Martindale, J.L.2    Klotz, L.O.3    Aw, T.Y.4    Holbrook, N.J.5
  • 41
    • 0035156716 scopus 로고    scopus 로고
    • Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: The protective role of taurine
    • Merezak S, Hardikar AA, Yajnik CS, Remacle C & Reusens B 2001 Intrauterine low protein diet increases fetal beta-cell sensitivity to NO and IL-1 beta: the protective role of taurine. Journal of Endocrinology 171 299-308.
    • (2001) Journal of Endocrinology , vol.171 , pp. 299-308
    • Merezak, S.1    Hardikar, A.A.2    Yajnik, C.S.3    Remacle, C.4    Reusens, B.5
  • 45
    • 0036372419 scopus 로고    scopus 로고
    • Serum concentrations of the interferongamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed type I diabetes mellitus patients and subjects at risk of developing the disease
    • Nicoletti F, Conget I, Di Mauro M, Di Marco R, Mazzarino MC, Bendtzen K, Messina A & Gomis R 2002 Serum concentrations of the interferongamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed type I diabetes mellitus patients and subjects at risk of developing the disease. Diabetologia 45 1107-1110.
    • (2002) Diabetologia , vol.45 , pp. 1107-1110
    • Nicoletti, F.1    Conget, I.2    Di Mauro, M.3    Di Marco, R.4    Mazzarino, M.C.5    Bendtzen, K.6    Messina, A.7    Gomis, R.8
  • 46
    • 0035863111 scopus 로고    scopus 로고
    • Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells
    • Oh-Hashi K, Maruyama W & Isobe K 2001 Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells. Free Radical Biology and Medicine 30 213-221.
    • (2001) Free Radical Biology and Medicine , vol.30 , pp. 213-221
    • Oh-Hashi, K.1    Maruyama, W.2    Isobe, K.3
  • 47
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S & Mori M 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death and Differentiation 11 381-389.
    • (2004) Cell Death and Differentiation , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 48
    • 0035845568 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
    • Oyadomari S, Takeda K, Takiguchi M, Gotoh T, Matsumoto M, Wada I, Akira S, Araki E & Mori M 2001 Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. PNAS 98 10845-10850.
    • (2001) PNAS , vol.98 , pp. 10845-10850
    • Oyadomari, S.1    Takeda, K.2    Takiguchi, M.3    Gotoh, T.4    Matsumoto, M.5    Wada, I.6    Akira, S.7    Araki, E.8    Mori, M.9
  • 52
    • 41849120416 scopus 로고    scopus 로고
    • The intrauterine metabolic environment modulates the gene expression pattern in foetal rat islets: Prevention by maternal taurine supplementation
    • Reusens B, Sparre T, Kalbe L, Bouckenooghe T, Theys N, Kruhoffer M, Orntoft T, Nerup J & Remacle C 2008 The intrauterine metabolic environment modulates the gene expression pattern in foetal rat islets: prevention by maternal taurine supplementation. Diabetologia 51 836-845.
    • (2008) Diabetologia , vol.51 , pp. 836-845
    • Reusens, B.1    Sparre, T.2    Kalbe, L.3    Bouckenooghe, T.4    Theys, N.5    Kruhoffer, M.6    Orntoft, T.7    Nerup, J.8    Remacle, C.9
  • 54
    • 33745410626 scopus 로고    scopus 로고
    • Mitochondrial disease
    • Schapira AH 2006 Mitochondrial disease. Lancet 368 70-82.
    • (2006) Lancet , vol.368 , pp. 70-82
    • Schapira, A.H.1
  • 55
    • 0001015125 scopus 로고    scopus 로고
    • Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate
    • Seo MS, Kang SW, Kim K, Baines IC, Lee TH & Rhee SG 2000 Identification of a new type of mammalian peroxiredoxin that forms an intramolecular disulfide as a reaction intermediate. Journal of Biological Chemistry 275 20346-20354.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 20346-20354
    • Seo, M.S.1    Kang, S.W.2    Kim, K.3    Baines, I.C.4    Lee, T.H.5    Rhee, S.G.6
  • 56
    • 23344432499 scopus 로고    scopus 로고
    • Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure
    • Simmons RA, Suponitsky-Kroyter I & Selak MA 2005 Progressive accumulation of mitochondrial DNA mutations and decline in mitochondrial function lead to beta-cell failure. Journal of Biological Chemistry 280 28785-28791.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 28785-28791
    • Simmons, R.A.1    Suponitsky-Kroyter, I.2    Selak, M.A.3
  • 57
    • 0025124447 scopus 로고
    • Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas
    • Snoeck A, Remacle C, Reusens B & Hoet JJ 1990 Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biology of the Neonate 57 107-118.
    • (1990) Biology of the Neonate , vol.57 , pp. 107-118
    • Snoeck, A.1    Remacle, C.2    Reusens, B.3    Hoet, J.J.4
  • 60
    • 67449139436 scopus 로고    scopus 로고
    • Early programming of islet antioxidant activities and mitochondrial function by maternal low protein diet
    • Theys N, Reusens B & Remacle C 2008 Early programming of islet antioxidant activities and mitochondrial function by maternal low protein diet. Diabetologia 51 S114.
    • (2008) Diabetologia , vol.51
    • Theys, N.1    Reusens, B.2    Remacle, C.3
  • 61
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
    • Tiedge M, Lortz S, Drinkgern J & Lenzen S 1997 Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 46 1733-1742.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 62
    • 18744433759 scopus 로고    scopus 로고
    • Relation between obesity from childhood to adulthood and the metabolic syndrome: Population based study
    • Vanhala M, Vanhala P, Kumpusalo E, Halonen P & Takala J 1998 Relation between obesity from childhood to adulthood and the metabolic syndrome: population based study. BMJ 317 319.
    • (1998) BMJ , vol.317 , pp. 319
    • Vanhala, M.1    Vanhala, P.2    Kumpusalo, E.3    Halonen, P.4    Takala, J.5
  • 63
    • 0033592423 scopus 로고    scopus 로고
    • Peroxynitrite modification of protein thiols: Oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase
    • Viner RI, Williams TD & Schoneich C 1999 Peroxynitrite modification of protein thiols: oxidation, nitrosylation, and S-glutathiolation of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase. Biochemistry 38 12408-12415.
    • (1999) Biochemistry , vol.38 , pp. 12408-12415
    • Viner, R.I.1    Williams, T.D.2    Schoneich, C.3
  • 64
    • 0028574053 scopus 로고
    • Mitochondrial DNA sequence variation in human evolution and disease
    • Wallace DC 1994 Mitochondrial DNA sequence variation in human evolution and disease. PNAS 91 8739-8746.
    • (1994) PNAS , vol.91 , pp. 8739-8746
    • Wallace, D.C.1
  • 65
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
    • Wang XZ & Ron D 1996 Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 272 1347-1349.
    • (1996) Science , vol.272 , pp. 1347-1349
    • Wang, X.Z.1    Ron, D.2
  • 66
    • 0030839198 scopus 로고    scopus 로고
    • Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide
    • Wilson GL, Patton NJ & LeDoux SP 1997 Mitochondrial DNA in beta-cells is a sensitive target for damage by nitric oxide. Diabetes 46 1291-1295.
    • (1997) Diabetes , vol.46 , pp. 1291-1295
    • Wilson, G.L.1    Patton, N.J.2    LeDoux, S.P.3
  • 68
    • 0036403330 scopus 로고    scopus 로고
    • Regulation of nitric oxide synthesis by dietary factors
    • Wu G & Meininger CJ 2002 Regulation of nitric oxide synthesis by dietary factors. Annual Review of Nutrition 22 61-86.
    • (2002) Annual Review of Nutrition , vol.22 , pp. 61-86
    • Wu, G.1    Meininger, C.J.2
  • 69
    • 8744246392 scopus 로고    scopus 로고
    • Hypermethylation of the inducible nitric-oxide synthase gene promoter inhibits its transcription
    • Yu Z & Kone BC 2004 Hypermethylation of the inducible nitric-oxide synthase gene promoter inhibits its transcription. Journal of Biological Chemistry 279 46954-46961.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 46954-46961
    • Yu, Z.1    Kone, B.C.2
  • 70
    • 0033960945 scopus 로고    scopus 로고
    • Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage
    • Zumsteg U, Frigerio S & Hollander GA 2000 Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. Diabetes 49 39-47.
    • (2000) Diabetes , vol.49 , pp. 39-47
    • Zumsteg, U.1    Frigerio, S.2    Hollander, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.