Fatal attraction: Chemokines and type 1 diabetes

Journal of Clinical Investigation

Volumn 110, Issue 11, 2002, Pages 1611-1613

  Atkinson, Mark A ^a   Brian Wilson, S ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4;

ANGIOGENESIS; CELL MATURATION; CELL POPULATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE; MOLECULAR BIOLOGY; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; TH1 CELL; TH2 CELL;

EID: 0036894536     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0217311     Document Type: Note

References (19)

1. Atkinson, M., and Eisenbarth, G. 2001. Type 1 diabetes: New perspectives on disease pathogenesis and treatment. Lancet. 358:221-229.
2. Kim, S.H., Cleary, M.M., Fox, H.S., Chantry, D., and Sarvetnick, N. 2002. CCR4-bearing T cells participate in autoimmune diabetes. J. Clin. Invest. 110:1675-1686. doi:10.1172/JCI200215715.
3. Baggiolini, M. 2000. Reflecfions on chemokines. Immunol. Rev. 177:1-5.
4. Proudfoot, A.E.I. 2002. Chemokine receptors: Multifaceted therapeutic targets. Nat. Rev. Immunol. 2:106-115.
5. Mellado, M., Rodriguez-Frade, J.M., Manes, S., and Martinez, C. 2001. Chemokine signaling and functional responses: The role of receptor dimerization and TK pathway activation. Annu. Rev. Immunol. 19:397-421.
6. Rossi, D., and Zlotnik, A. 2000. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:216-242.
7. Murphy, P.M., et al. 2000. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52:145-176.
8. Atkinson, M.A., and Leiter, E.H. 1999. The NOD mouse model of type 1 diabetes mellitus: As good as it gets? Nat. Med. 5:601-604.
9. Gill, B.M., Jaramillo, A., Ma, L., Laupland, K.B., and Delovitch, T.L. 1995. Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes. Diabetes. 44:614-619.
10. Grattan, M., Mi, Q.S., Meagher, C., and Delovitch, T.L. 2002. Congenic mapping of the diabetogenic locus Idd4 to a 5.2-cM region of chromosome 11 in NOD mice: Identification of two potential candidate subloci. Diabetes. 51:215-223.
11. Szanya, V., Ermann, J., Taylor, C., Holness, C., and Fathman, C.G. 2002. The subpopulation of CD4(+)CD25(+) splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J. Immunol. 169:2461-2465.
12. Bradley, L.M., et al. 1999. Islet-specific Th1, but not Th2, cells secrete multiple chemokines and promote rapid induction of autoimmune diabetes. J. Immunol. 162:2511-2520.
13. Cameron, M.J., et al. 2000. Differential expression of CC chemokines and the CCRS receptor in the pancreas is associated with progression to type 1 diabetes. J. Immunol. 165:1102-1110.
14. Chen, M.C., Proost, P., Gysemans, C., Mathieu, C., and Eizirik, D.L. 2001. Monocyte chemoattractant protein-1 is expressed in pancreatic islers from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 44:325-332.
15. Shimada, A., et al. 2001. Elevated serum IP-10 levels observed in type 1 diabetes. Diabetes Care. 24:510-515.
16. Nicoletti, F., et al. 2002. Serum concentrations of the interferon-gamma-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed Type 1 diabetes mellitus patients and subjeccs at risk of developing the disease. Dia betologia. 45:1107-1110.
17. Lohmann, T., et al. 2002. Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Diabetes. 51:2474-2480
18. Szalai, C., et al. 1999. Chemokine receptor CCR2 and CCR5 polymorphisms in children with insulin-dependent diabetes mellitus. Pediatr. Res. 46:82-84.
19. Ravinovitch, A., and Suarez-Pinzon, W.L 1998 Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol. 55:1139-1149.