Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production

Regulatory Peptides

Volumn 151, Issue 1-3, 2008, Pages 139-146

  Mosén, Henrik ^a   Östenson, Claes Göran ^b   Lundquist, Ingmar ^c   Alm, Per ^a   Henningsson, Ragnar ^a   Jimenez Feltström, Javier ^a   Guenifi, Amel ^b   Efendic, Suad ^b   Salehi, Albert ^a  

^a LUND UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Goto Kakizaki rat; Insulin secretion; Islet isoforms of nitric oxide synthase; Nitric oxide; Type 2 diabetes

Indexed keywords

ARGININE; FORSKOLIN; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; NEURONAL CONSTITUTIVE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GOTO KAKIZAKI RAT; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ARGININE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; FORSKOLIN; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR;

RATTUS;

EID: 56349139928     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2008.07.002     Document Type: Article

References (53)

1. Ostenson C.G., Khan A., Abdel-Halim S.M., Guenifi A., Suzuki K., Goto Y., and Efendic S. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36 1 (1993) 3-8
2. Giroix M.H., Vesco L., and Portha B. Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes. Endocrinology 132 2 (1993) 815-822
3. Tsuura Y., Ishida H., Okamoto Y., Kato S., Sakamoto K., Horie M., Ikeda H., Okada Y., and Seino Y. Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM. Diabetes 42 10 (1993) 1446-1453
4. Ling Z.C., Efendic S., Wibom R., Abdel-Halim S.M., Ostenson C.G., Landau B.R., and Khan A. Glucose metabolism in Goto-Kakizaki rat islets. Endocrinology 139 6 (1998) 2670-2675
5. Salehi A., Henningsson R., Mosen H., Ostenson C.G., Efendic S., and Lundquist I. Dysfunction of the islet lysosomal system conveys impairment of glucose-induced insulin release in the diabetic GK rat. Endocrinology 140 7 (1999) 3045-3053
6. Ostenson C.G., Sandberg-Nordqvist A.C., Chen J., Hallbrink M., Rotin D., Langel U., and Efendic S. Overexpression of protein-tyrosine phosphatase PTP sigma is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochem Biophys Res Commun 291 4 (2002) 945-950
7. Abdel-Halim S.M., Guenifi A., Khan A., Larsson O., Berggren P.O., Ostenson C.G., and Efendic S. Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP. Diabetes 45 7 (1996) 934-940
8. Panagiotidis G., Alm P., and Lundquist I. Inhibition of islet nitric oxide synthase increases arginine-induced insulin release. Eur J Pharmacol 229 2-3 (1992) 277-278
9. Panagiotidis G., Akesson B., Rydell E.L., and Lundquist I. Influence of nitric oxide synthase inhibition, nitric oxide and hydroperoxide on insulin release induced by various secretagogues. Br J Pharmacol 114 2 (1995) 289-296
10. Akesson B., Mosen H., Panagiotidis G., and Lundquist I. Interaction of the islet nitric oxide system with l-arginine-induced secretion of insulin and glucagon in mice. Br J Pharmacol 119 4 (1996) 758-764
11. Henningsson R., and Lundquist I. Arginine-induced insulin release is decreased and glucagon increased in parallel with islet NO production. Am J Physiol 275 3 Pt 1 (1998) E500-E506
12. Henningsson R., Alm P., Ekstrom P., and Lundquist I. Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study. Diabetes 48 1 (1999) 66-76
13. Alm P., Ekstrom P., Henningsson R., and Lundquist I. Morphological evidence for the existence of nitric oxide and carbon monoxide pathways in the rat islets of Langerhans: an immunocytochemical and confocal microscopical study. Diabetologia 42 8 (1999) 978-986
14. Akesson B., Henningsson R., Salehi A., and Lundquist I. Islet constitutive nitric oxide synthase and glucose regulation of insulin release in mice. J Endocrinol 163 1 (1999) 39-48
15. Akesson B., and Lundquist I. Influence of nitric oxide modulators on cholinergically stimulated hormone release from mouse islets. J Physiol 515 Pt 2 (1999) 463-473
16. Akesson B., and Lundquist I. Nitric oxide and hydroperoxide affect islet hormone release and Ca(2+) efflux. Endocrine 11 1 (1999) 99-107
17. Henningsson R., Alm P., Lindstrom E., and Lundquist I. Chronic blockade of NO synthase paradoxically increases islet NO production and modulates islet hormone release. Am J Physiol Endocrinol Metab 279 1 (2000) E95-E107
18. Henningsson R., Alm P., and Lundquist I. Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia. Am J Physiol Cell Physiol 280 5 (2001) C1242-1254
19. Salehi A., Ekelund M., Henningsson R., and Lundquist I. Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets. Endocrine 16 2 (2001) 97-104
20. Henningsson R., Salehi A., and Lundquist I. Role of nitric oxide synthase isoforms in glucose-stimulated insulin release. Am J Physiol Cell Physiol 283 1 (2002) C296-304
21. Salehi A., Ekelund M., and Lundquist I. Total parenteral nutrition-stimulated activity of inducible nitric oxide synthase in rat pancreatic islets is suppressed by glucagon-like peptide-1. Horm Metab Res 35 1 (2003) 48-54
22. Knowles R.G., and Moncada S. Nitric oxide synthases in mammals. Biochem J 298 Pt 2 (1994) 249-258
23. Corbett J.A., Sweetland M.A., Wang J.L., Lancaster Jr. J.R., and McDaniel M.L. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. Proc Natl Acad Sci U S A 90 5 (1993) 1731-1735
24. Eizirik D.L., and Pavlovic D. Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM?. Diabetes Metab Rev 13 4 (1997) 293-307
25. Schmidt H.H., Warner T.D., Ishii K., Sheng H., and Murad F. Insulin secretion from pancreatic B cells caused by l-arginine-derived nitrogen oxides. Science 255 5045 (1992) 721-723
26. Lajoix A.D., Reggio H., Chardes T., Peraldi-Roux S., Tribillac F., Roye M., Dietz S., Broca C., Manteghetti M., Ribes G., Wollheim C.B., and Gross R. A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Diabetes 50 6 (2001) 1311-1323
27. Heding. A simplified insulin radioimmunoassay method. In: Donato L., Milhaud G., Sirchis J., and Euratom (Eds). Labelled proteins in Tracer Studies 345-350 (1966)
28. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
29. Guenifi A., Abdel-Halim S.M., Hoog A., Falkmer S., and Ostenson C.G. Preserved beta-cell density in the endocrine pancreas of young, spontaneously diabetic Goto-Kakizaki (GK) rats. Pancreas 10 2 (1995) 148-153
30. Jimenez-Feltstrom J., Lundquist I., Obermuller S., and Salehi A. Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase. Regul Pept 122 2 (2004) 109-118
31. Jimenez-Feltstrom J., Lundquist I., and Salehi A. Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway. Cell Tissue Res 319 2 (2005) 221-230
32. Qader S.S., Jimenez-Feltstrom J., Ekelund M., Lundquist I., and Salehi A. Expression of islet inducible nitric oxide synthase and inhibition of glucose-stimulated insulin release after long-term lipid infusion in the rat is counteracted by PACAP27. Am J Physiol Endocrinol Metab 292 5 (2007) E1447-1455
33. Abdel-Halim S.M., Guenifi A., He B., Yang B., Mustafa M., Hojeberg B., Hillert J., Bakhiet M., and Efendic S. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes. Diabetes 47 3 (1998) 498-504
34. Portela-Gomes G.M., Lukinius A., Ljungberg O., Efendic S., Ahren B., and Abdel-Halim S.M. PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets. Regul Pept 113 1-3 (2003) 31-39
35. DiPilato L.M., Cheng X., and Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A 101 47 (2004) 16513-16518
36. Buck J., Sinclair M.L., Schapal L., Cann M.J., and Levin L.R. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci U S A 96 1 (1999) 79-84
37. Tsuura Y., Ishida H., Shinomura T., Nishimura M., and Seino Y. Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets. Biochem Biophys Res Commun 252 1 (1998) 34-38
38. Antoine M.H., Ouedraogo R., Sergooris J., Hermann M., Herchuelz A., and Lebrun P. Hydroxylamine, a nitric oxide donor, inhibits insulin release and activates K+ATP channels. Eur J Pharmacol 313 3 (1996) 229-235
39. Smukler S.R., Tang L., Wheeler M.B., and Salapatek A.M. Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Diabetes 51 12 (2002) 3450-3460
40. Gross R., Roye M., Manteghetti M., Hillaire-Buys D., and Ribes G. Alterations of insulin response to different beta cell secretagogues and pancreatic vascular resistance induced by N omega-nitro-l-arginine methyl ester. Br J Pharmacol 116 3 (1995) 1965-1972
41. Jaffrey S.R., Erdjument-Bromage H., Ferris C.D., Tempst P., and Snyder S.H. Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nat Cell Biol 3 2 (2001) 193-197
42. Brorson J.R., Schumacker P.T., and Zhang H. Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology. J Neurosci 19 1 (1999) 147-158
43. Barg S., Eliasson L., Renstrom E., and Rorsman P. A subset of 50 secretory granules in close contact with l-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells. Diabetes 51 Suppl 1 (2002) S74-S82
44. Rorsman P., and Renstrom E. Insulin granule dynamics in pancreatic beta cells. Diabetologia 46 8 (2003) 1029-1045
45. Jimenez J., Henningsson R., and Lundquist I. Modulation of islet isoforms of nitric oxide synthase by different insulin secretagogues. Diabetologia 44 (2001) Supplement 1:A 129, abstract 491
46. Beffy P., Lajoix A.D., Masiello P., Dietz S., Peraldi-Roux S., Chardes T., Ribes G., and Gross R. A constitutive nitric oxide synthase modulates insulin secretion in the INS-1 cell line. Mol Cell Endocrinol 183 1-2 (2001) 41-48
47. Novelli M., Pocai A., Lajoix A.D., Beffy P., Bezzi D., Marchetti P., Gross R., and Masiello P. Alteration of beta-cell constitutive NO synthase activity is involved in the abnormal insulin response to arginine in a new rat model of type 2 diabetes. Mol Cell Endocrinol 219 1-2 (2004) 77-82
48. Gross R., Roye M., Manteghetti M., Broca C., Hillaire-Buys D., Masiello P., and Ribes G. Mechanisms involved in the effect of nitric oxide synthase inhibition on l-arginine-induced insulin secretion. Br J Pharmacol 120 3 (1997) 495-501
49. Takamura T., Kato I., Kimura N., Nakazawa T., Yonekura H., Takasawa S., and Okamoto H. Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J Biol Chem 273 5 (1998) 2493-2496
50. Lundquist I., Alm P., Salehi A., Henningsson R., Grapengiesser E., and Hellman B. Carbon monoxide stimulates insulin release and propagates Ca2+ signals between pancreatic beta-cells. Am J Physiol Endocrinol Metab 285 5 (2003) E1055-1063
51. Henningsson R., Alm P., and Lundquist I. Occurrence and putative hormone regulatory function of a constitutive heme oxygenase in rat pancreatic islets. Am J Physiol 273 2 Pt 1 (1997) C703-C709
52. Mosen H., Salehi A., Alm P., Henningsson R., Jimenez-Feltstrom J., Ostenson C.G., Efendic S., and Lundquist I. Defective glucose-stimulated insulin release in the diabetic Goto-Kakizaki (GK) rat coincides with reduced activity of the islet carbon monoxide signaling pathway. Endocrinology 146 3 (2005) 1553-1558
53. Hartsfield C.L. Cross talk between carbon monoxide and nitric oxide. Antioxid Redox Signal 4 2 (2002) 301-307