Serum concentrations of the interferon-γ-inducible chemokine IP-10/CXCL10 are augmented in both newly diagnosed type I diabetes mellitus patients and subjects at risk of developing the disease

Diabetologia

Volumn 45, Issue 8, 2002, Pages 1107-1110

  Nicoletti, F ^a   Conget, I ^a,b   Di Mauro, M ^a   Di Marco, R ^a   Mazzarino, M ^a   Bendtzen, K ^a,c   Messina, A ^a   Gomis, R ^a,b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF BARCELONA   (Spain)

^c International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

Author keywords

Autoimmunity; Chemokines; Cytokines; Interferon gamma; IP 10 CXCL10

Indexed keywords

ALPHA CHEMOKINE; AUTOANTIBODY; GAMMA INTERFERON INDUCIBLE PROTEIN 10;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH RISK POPULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELATIVE; SOLID PHASE EXTRACTION;

ADULT; ANTIBODIES; AUTOANTIBODIES; CHEMOKINES, CXC; DIABETES MELLITUS, TYPE 1; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; INTERFERON TYPE II; MALE; MIDDLE AGED; OSMOLAR CONCENTRATION; REFERENCE VALUES; RISK FACTORS;

EID: 0036372419     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-002-0879-5     Document Type: Article

References (10)

1. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus
2. Chemokines in autoimmune diseases
3. Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes
4. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating lesions
5. CXCL10 (IFN-γ-Inducible Protein-10) control of the encephalitogenic CD4+T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis
6. Over-expression of interferon gamma-inducible protein 10 in the liver of patients with type I autoimmune hepatitis identified by suppression subtractive hybridization
7. Thyrocytes from autoimmune thyroid disorder produce the chemokine IP-10 and Mig and attract CXCR3+ lymphocytes
8. Serum levels of the interferon-γ-inducing cytokine interleukin-18 are increased inindividuals at high risk of developing Type I diabetes
9. Elevated serum IP-10 levels observed in type 1 diabetes
10. Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM