Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis

Pharmacology and Therapeutics

Volumn 123, Issue 2, 2009, Pages 224-238

  Fairbanks, Carolyn A ^a,c   Stone, Laura S ^b   Wilcox, George L ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Alpha 2 adrenergic receptor; Analgesia; Antinociception; Interactions; Opioid receptor; Receptor subtype

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 (2,6 DIETHYLANILINO) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTISENSE OLIGONUCLEOTIDE; BRIMONIDINE; CANNABINOID RECEPTOR AGONIST; CLONIDINE; CPP 55940; DELTORPHIN; DEXMEDETOMIDINE; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; FENTANYL; G PROTEIN COUPLED RECEPTOR AGONIST; KETOPROFEN; MORPHINE; MOXONIDINE; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NORADRENALIN; OPIATE; OPIATE AGONIST; OPIATE RECEPTOR; PETHIDINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINOCICEPTION; CENTRAL NERVOUS SYSTEM; CLINICAL TRIAL; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HYPERTENSION; NERVE ENDING; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; NORADRENERGIC NERVE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TRANSGENIC MOUSE;

ADRENERGIC ALPHA-AGONISTS; ALGORITHMS; ANALGESICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; INJECTIONS, SPINAL; MICE; MICE, MUTANT STRAINS; PAIN; PAIN THRESHOLD; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, OPIOID; SPINAL CORD;

EID: 67449095826     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2009.04.001     Document Type: Review

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