Genetic alteration of α(2C)-adrenoceptor expression in mice: Influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective α2-adrenoceptor agonist

Molecular Pharmacology

Volumn 51, Issue 1, 1997, Pages 36-46

  Sallinen, Jukka ^a   Link, Richard E ^e   Haapalinna, Antti ^b   Viitamaa, Timo ^b   Kulatunga, Maya ^a   Sjöholm, Birgitta ^a   Macdonald, Ewen ^c   Pelto Huikko, Markku ^c,d   Leino, Tiina ^b   Barsh, Gregory S ^e   Kobilka, Brian K ^e   Scheinin, Mika ^a,f  

^a UNIVERSITY OF TURKU   (Finland)

^b ORION CORPORATION   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^e STANFORD UNIVERSITY   (United States)

^f UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2C ADRENERGIC RECEPTOR; ANESTHETIC AGENT; ANTIHYPERTENSIVE AGENT; DEXMEDETOMIDINE; DOPAMINE; HOMOVANILLIC ACID; MESSENGER RNA; MONOAMINE; NORADRENALIN; SEROTONIN; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN; BRAIN METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GENE; GENE ACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTHERMIA; IN SITU HYBRIDIZATION; LOCOMOTION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; TRANSGENIC MOUSE;

EID: 0031015266     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.1.36     Document Type: Article

References (34)

1. 2-adrenoceptor subtypes. Annu. Rev. Pharmacol. Toxicol. 32:243-279 (1993).
2. MacDonald, E., M. Scheinin, H. Scheinin, and R. Virtanen. Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist. J. Pharmacol. Exp. Ther. 259:848-854 (1991).
3. Bylund, D. B., D. C. Eikenberg, J. P. Hieble, S. Z. Langer, R. J. Lefkowitz, K. P. Minneman, P. B. Molinoff, R. R. Ruffolo, and U. Trendelenburg. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol. Rev. 46:121-136 (1994).
4. 2-adrenergic receptor subtypes in rat brain: an in situ hybridization study. J. Comp. Neurol. 328:575-594 (1993).
5. 2-adrenergic receptor subtype gene expression in rat brain. Brain Res. Mol. Brain Res. 21:133-149 (1994).
6. 2A-adrenergic receptor-like immunoreactivity. Brain Res. 650:181-204 (1992).
7. 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience 56:139-155 (1993).
8. Boyd, A. L., and D. Samid. Review: molecular biology of transgenic animals. J. Anim. Sci. 71:1-9 (1993).
9. Soriano, P. Gene targeting in ES cells. Annu. Rev. Neurosci. 18:1-18 (1995).
10. Bond, R. A., P. Leff, D. T. Johnson, C. A. Milano, H. A. Rockman, T. R. McMinn, S. Apparsundaram, M. F. Hyek, T. P. Kenakin, L. F. Allen, and R. J. Lefkowitz. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor. Nature (Lond.) 374:272-276 (1995).
11. Baik, J., R. Picetti, A. Salardi, G. Thiriet, A. Dierich, A. Depaulis, M. Le Meur, and E. Borelli. Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature (Lond.) 377:424-428 (1995).
12. Hein, L., G. S. Barsh, R. E. Pratt, V. J. Dzau, and B. K. Kobilka. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature (Lond.) 377:744-747 (1995).
13. Ichiki, T., P. A. Labosky, C. Shiota, S. Okuyama, Y. Imagawa, A. Fogo, F. Niimura, I. Ichikawa, B. L. M. Hogan, and T. Inagami. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature (Lond.) 377:748-750 (1995).
14. 2A-adrenergic receptor subtype. Science (Washington D. C.) 273:801-803 (1996).
15. 2-adrenergic receptor subtypes b and c. Science (Washington D. C.) 273:803-805 (1996).
16. 2C-adrenoceptor homolog. Mol. Pharmacol. 48:48-55 (1995).
17. Nagy, A., J. Rossant, R. Nagy, W. Abramow-Newerly, and J. Roder C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90:8424-8428 (1993).
18. Palmiter, R. D., and R. L. Brinster. Germ-line transformation of mice. Annu. Rev. Genet. 20:465-499 (1986).
19. Hanahan, D. Transgenic mice as probes into complex systems. Science (Washington D. C.) 246:1265-1275 (1989).
20. 2-C10 homolog responsible for an interspecies variation in antagonist binding. Mol. Pharmacol. 42:16-27 (1992).
21. von Zastrow, M., R. Link, D. Daunt, G. Barsh, and B. Kobilka. Subtype-specific differences in the intracellular sorting of G protein-coupled receptors. J. Biol. Chem. 268:763-766 (1993).
22. Overbeek, P., A, E. Aguilar-Cordova, G. Hanten, D. Schaffner L, P. Patel, R. Lebovitz M, and M. Lieberman W. Coinjection strategy for visual identification of transgenic mice. Transgenic Res. 1:31-37 (1991).
23. Link, R. E. Ph. D. Thesis, Stanford University (1994).
24. Dagerlind, Å., K. Friberg, A. J. Bean, and T. Hökfelt. Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybridization histochemistry. Histochemistry 98:39-49 (1992).
25. 2-adrenoceptors in the rat brain. Mol. Neuropharmacol. 1:219-229 (1992).
26. 3H]idazoxan in rat brain. J. Pharmacol. Exp. Ther. 241:1079-1091 (1987).
27. Sidman, R. L., J. B. Angevine, and E. T. Pierce. Atlas of the Mouse Brain and Spinal Cord. Harvard University Press, Cambridge (1971).
28. Paxinos, G., and C. Watson. The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego (1986).
29. 3H]RX821002 as radioligands. Biochim. Biophys. Acta 1266:207-214 (1995).
30. Mefford, I. Applications of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain. J. Neurosci. Methods 3:207-224 (1981).
31. MacDonald, E., H. Scheinin, and M. Scheinin. Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative. Eur. J. Pharmacol. 158:119-127 (1988).
32. Ojala-Karlsson, P., and M. Scheinin. Improved high performance liquid chromatographic method for the routine determination of unconjugated 3-methoxy-4-hydroxyphenylethyleneglycol in human plasma using solid-phase extraction and electrochemical detection. J. Chromatogr. 565:131-139 (1991).
33. Myers, R., D, and T. F. Lee. Neurochemical aspects of thermoregulation, in Advances in Comparative and Environmental Physiology (L. Wang C, ed.). Springer-Verlag, Berlin/Heidelberg, 162-203 (1989).
34. Gerlai, R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci. 19:177-181 (1996).