Substitution of a mutant α2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 18, 1997, Pages 9950-9955

  Lakhlani, Parul P ^a   Macmillan, Leigh B ^a   Guo, Tian Zhi ^a,b   Mccool, Brian A ^c   Lovinger, David M ^c   Maze, Mervyn ^a,b   Limbird, Lee E ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ANALGESIC AGENT; ANESTHETIC AGENT; ASPARTIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; GENETICS; MOUSE; MUTATION; PHYSIOLOGY; ANALGESIA; ANIMAL CELL; ANTINOCICEPTION; CALCIUM CURRENT; GENE MUTATION; GENE TARGETING; LOCUS CERULEUS; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; SEDATION; STATISTICAL ANALYSIS; TRANQUILIZING ACTIVITY;

ANALGESICS; ANESTHETICS; ANIMALS; ASPARTIC ACID; BEHAVIOR, ANIMAL; MICE; MUTATION; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0030610424     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.18.9950     Document Type: Article

References (46)

1. Ruffolo, R. R., Jr., Nichols, A. J., Stadel, J. M. & Hieble, J. P. (1993) Annu. Rev. Pharmacol. Toxicol. 33, 243-279.
2. Hoffman, B. B. & Lefkowitz, R. J. (1996) in The Pharmacological Basis of Therapeutics, eds. Hardman, J. G. & Limbird, L. E. (McGraw-Hill, New York), pp. 199-248.
3. Bylund, D. B., Eikenburg, D. C., Hieble, J. P., Langer, S. Z., Lefkowitz, R. J., Minneman, K. P., Molinoff, P. B., Ruffolo, R. R., Jr. & Trendelenburg, U. (1994) Pharmacol. Rev. 46, 121-136.
4. Limbird, L. E. (1988) FASEB J. 2, 2686-2695.
5. Hieble, J. P. & Ruffolo, R. R., Jr. (1996) Prog. Drug Res. 47, 81-130.
6. Hasty, P., Ramirez-Solis, R., Krumlanf, R. & Bradley, A. (1991) Nature (London) 350, 243-246.
7. Valancius, V. & Smithies, O. (1991) Mol. Cell. Biol. 11, 1402-1408.
8. MacMillan, L. B., Hein, L., Smith, M. S., Piascik, M. T. & Limbird, L. E. (1996) Science 273, 801-803.
9. Probst, W. C., Snyder, L. A., Schuster, D. I., Brosius, J. & Sealfon, S. C. (1992) DNA Cell Biol. 11, 1-20.
10. Tian, W.-N. & Deth, R. C. (1993) Life Sci. 52, 1899-1907.
11. Horstman, D. A., Brandon, S., Wilson, A. L., Guyer, C. A., Cragoe, E. J., Jr. & Limbird, L. E. (1990) J. Biol. Chem. 265, 21590-21595.
12. Neve, K. A., Cox, B. A., Hinningsen, R. A., Spanoyannis, A. & Neve, R. L. (1993) Mol. Pharmacol. 39, 733-737.
13. Kong, H., Raynor, K., Yasuda, K., Moe, S. T., Portoghese, P. S., Bell, G. & Reisine, T. (1993) J. Biol. Chem. 268, 23055-23058.
14. Ceresa, B. P. & Limbird, L. E. (1994) J. Biol. Chem. 269, 29557-29564.
15. Chung, F. Z., Wang, C. D., Potter, P. C., Venter, J. C. & Fraser, C. M. (1988) J. Biol. Chem. 263, 4052-4055.
16. Surprenant, A., Horstman, D. A., Akbarali, H. & Limbird, L. E. (1992) Science 257, 977-980.
17. Lakhlani, P. P., Lovinger, D. M. & Limbird, L. E. (1996) Mol. Pharmacol. 50, 96-103.
18. Ramirez-Solis, R., Davis, A. C. & Bradley, A. (1993) Methods Enzymol. 225, 855-878.
19. Matsumoto, M., Zornow, M. H., Rabin, B. C. & Maze, M. (1993) Brain Res. 627, 325-329.
20. Masuko, S., Nakajima, Y., Nakajima, S. & Yamaguchi, K. (1986) J. Neurosci. 6, 3229-3241.
21. Choi, S. & Lovinger, D. M. (1996) J. Neurosci. 16, 36-45.
22. Swanson, L. W. (1976) Brain Res. 110, 39-56.
23. Ikeda, S. R., Lovinger, D. M., McCool, B. A. & Lewis, D. L. (1995) Neuron 14, 1029-1038.
24. Segal, I. S., Vickery, R. G., Walton, J. K., Doze, V. A. & Maze, M. (1988) Anesthesiology 69, 818-823.
25. Vickery, R. G., Sheridan, B. C., Segal, I. S. & Maze, M. (1988) Anesth. Analg. 67, 611-615.
26. van Galen, P. J. M., Stiles, G. L., Michaels, G. & Jacobson, K. A. (1992) Med. Res. Rev. 12, 423-471.
27. Segal, I. S., Javis, D. J., Duncan, S. R., White, P. F. & Maze, M. (1991) Anesthesiology 74, 220-225.
28. Hayashi, Y. & Maze, M. (1993) Br. J. Anesthesiol. 71, 108-118.
29. Limberger, N., Trendelenburg, A. U. & Starke, K. (1995) Naunyn-Schmiedebergs Arch. Pharmacol. 352, 43-48.
30. Trendelenburg, A. U., Limberger, N. & Starke, K. (1996) J. Pharmacol. Exp. Ther. 278, 462-467.
31. Wang, R., MacMillan, L. B., Fremeau, R. T., Jr., Magnuson, M. A., Linder, J. & Limbird, L. E. (1996) Neuroscience 74, 199-218.
32. Chabre, O., Conklin, B. R., Brandon, S., Bourne, H. R. & Limbird, L. E. (1994) J. Biol. Chem. 269, 5730-5734.
33. Correa-Sales, C., Rabin, B. C. & Maze, M. (1992) Anesthesiology 76, 948-952.
34. Nacif-Coelho, C., Correa-Sales, C., Chang, L. L. & Maze, M. (1994) Anesthesiology 81, 1527-1534.
35. Margalit, D. & Segal, M. (1979) Psychopharmacology 62, 169-173.
36. Guo, T.-Z., Jiang, J. Y., Buttermann, A. E. & Maze, M. (1996) Anesthesiology 84, 873-881.
37. Aghajanian, G. K. & VanderMaelen, C. P. (1982) Science 215, 1394-1396.
38. Nestler, E. J., Alreja, M. & Aghajanian, G. K. (1994) Brain Res. Bull. 35, 521-528.
39. Williams, J. T., Henderson, G. & North, R. A. (1985) Neuroscience 14, 95-101.
40. Dolin, S. J. & Little, H. J. (1986) Br. J. Pharmacol. 88, 904-914.
41. Maze, M. (1989) Int. Anesthesiol. Clin. 27, 248-258.
42. Mizobe, T., Maghsoudi, K., Sitwala, K., Tianzhi, G., Ou, J. & Maze, M. (1996) J. Clin. Invest. 98, 1076-1080.
43. Millan, M. J., Bervoets, K., Rivet, J.-M., Widdowson, P., Renouard, A., Le Marouille-Girardon & Gobert, A. (1994) J. Pharmacol. Exp. Ther. 270, 958-972.
44. Yaksh, T. L. (1985) Pharmacol. Biochem. Behav. 22, 845-858.
45. Pertovaara, A., Kauppila, T., Jyvasjarvi, E. & Kalso, E. (1991) Neuroscience 44, 705-714.
46. Hayashi, Y., Guo, T.-Z. & Maze, M. (1995) Anesthesiology 82, 954-962.