Intravenous Opioids Stimulate Norepinephrine and Acetylcholine Release in Spinal Cord Dorsal Horn: Systematic Studies in Sheep and an Observation in a Human

Anesthesiology

Volumn 84, Issue 1, 1996, Pages 143-154

  Bouaziz, Hervé ^a   Tong, Chuanyao ^a   Yoon, Young ^a   Hood, David D ^a   Eisenach, James C ^a,b  

^a Department of Anesthesia ^*

^b WAKE FOREST BAPTIST HEALTH   (United States)

Author keywords

Analgesics, opioid: Morphine; Cerebrospinal fluid components: Acetylcholine; norepinephrine.; Effect site: Spinal cord

Indexed keywords

ACETYLCHOLINE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; DOPAMINE; FENTANYL; FLUNIXIN; HALOTHANE; IDAZOXAN; KETAMINE; MONOAMINE; MORPHINE; NALOXONE; NEOSTIGMINE; NORADRENALIN; OPIATE; PENICILLIN G; PENTOBARBITAL;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; DRUG MIXTURE; FEMALE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; NORADRENALIN RELEASE; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PRIORITY JOURNAL; SHEEP; SPINAL CORD DORSAL HORN;

ACETYLCHOLINE; ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS, OPIOID; ANIMALS; DIALYSIS; DIOXANES; DOPAMINE; FEMALE; FENTANYL; HUMANS; IDAZOXAN; IMIDAZOLES; INJECTIONS, INTRAVENOUS; MALE; MICROCHEMISTRY; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-2; SHEEP; SPINAL CORD; STIMULATION, CHEMICAL;

EID: 0030029052     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199601000-00017     Document Type: Article

References (38)

1. Joris JL, Dubner R, Hargreaves KM: Opioid analgesia at peripheral sites: A target for opioids released during stress and inflammation. Anesth Analg 1987; 66:1277-81
2. Porreca F, Heyman JS, Mosberg HI, Omnaas JR, Vaught JL: Role of mu and delta receptors in supraspinal and spinal analgesic effects of [D-Pen2, D-Pen5]enkephalin in the mouse. J Pharmacol Exp Ther 1987; 241:393-400
3. Yaksh TL: Spinal opiate analgesia: Characteristics and principles of action. Pain 1981; 11:293-346
4. Randich A, Thurston CL, Ludwig PS, Robertson JD, Rasmussen C: Intravenous morphine-induced activation of vagal afferents: Peripheral, spinal, and CNS substrates mediating inhibition of spinal nociception and cardiovascular responses. J Neurophysiol 1992; 68: 1027-45
5. Roerig SC, Fujimoto JM: Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice. J Pharmacol Exp Ther 1989; 249:762-8
6. Fields HL, Heinricher MM, Mason P: Neurotransmitters in nociceptive modulatory circuits. Ann Rev Neurosci 1991; 14:219-45
7. Kuraishi Y, Hirota N, Sato Y, Kaneko S, Satoh M, Takagi H: Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res 1985; 359: 177-82
8. Headley PM, Duggan AW, Griersmith BT: Selective reduction by noradrenaline and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurones. Brain Res 1978; 145:185-9
9. Basbaum AI, Fields HL: Endogenous pain control mechanisms: Review and hypothesis. Ann Neurol 1978; 4:451-62
10. Tseng LLF, Tang R: Differential actions of the blockade of spinal opioid, adrenergic and serotonergic receptors on the tail-flick inhibition induced by morphine microinjected into dorsal raphe and central gray in rats. Neuroscience 1989; 33:93-100
11. Chiang C-Y, Zhuo M: Evidence for the involvement of a descending cholinergic pathway in systemic morphine analgesia. Brain Res 1989; 478:293-300
12. Dirksen R, Nijhuis GMM: The relevance of cholinergic transmission at the spinal level to opiate effectiveness. Eur J Pharmacol 1983; 91:215-21
13. 2 adrenoceptor-mediated antinociception in sheep. J Pharmacol Exp Ther 1993; 265:536-42
14. Hood DD, Eisenach JC, Tuttle R: Phase I safety assessment of intrathecal neostigmine in humans. ANESTHESIOLOGY 1995; 82:331-43
15. Eisenach JC, Tong C, Limauro D: Intrathecal clonidine and the response to hemorrhage. ANESTHESIOLOGY 1992; 77:522-8
16. Payne R, Madsen J, Harvey RC, Inturrisi CE: A chronic sheep preparation for the study of drug pharmacokinetics in spinal and ventricular csf. J Pharmacol Meth 1986; 16:277-96
17. 2-adrenoceptor agonists in conscious, unrestrained sheep. Neuropharmacology 1988; 27:213-6
18. Shiomi H, Takagi H: Morphine analgesia and the bulbospinal noradrenergic system: Increase in the concentration of normethanephrine in the spinal cord of the rat caused by analgesics. Br J Pharmacol 1974; 52:519-26
19. Kuraishi Y, Harada Y, Satoh M, Takagi H: Antagonism by phenoxybenzamine of the analgesic effect of morphine injected into the nucleus reticularis gigantocellularis of the rat. Neuropharmacology 1979; 18:107-10
20. Stevens CW, Monasky MS, Yaksh TL: Spinal infusion of opiate and α2-agonists in rats: Tolerance and cross tolerance studies. J Pharmacol Exp Ther 1988; 244:63-70
21. Clark FM, Yeomans DC, Proudfit HK: The noradrenergic innervation of the spinal cord: Differences between two substrains of Sprague-Dawley rats determined using retrograde tracers combined with immunocytochemistry. Neurosci Lett 1991; 125:155-8
22. Kwiat GC, Basbaum AI: The origin of brainstem noradrenergic and serotonergic projections to the spinal cord dorsal horn in the rat. Somatosens Mot Res 1992; 9:157-73
23. Yaksh TL, Tyce GM: Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cord. Brain Res 1979; 171:119-28
24. Matos FF, Rollema H, Brown JL, Basbaum AI: Do opioids evoke the release of serotonin in the spinal cord?: An in vivo microdialysis study of the regulation of extracellular serotonin in the rat. Pain 1992; 48:439-47
25. Zhuo M, Gebhart GF: Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res 1990; 535:67-78
26. Barber RP, Phelps PE, Houser CR, Crawford GD, Salvatetra PM: The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: An immunocytochemical study. J Comp Neurol 1984; 229:329-46
27. Jones BE, Pare M, Beaudet A: Retrograde labeling of neurons in the brain stem following injections of [3H]choline into the rat spinal cord. Neuroscience 1986; 18:901-16
28. Gordh T, Jr., Jansson I, Hartvig P, Gillberg PG, Post C: Interactions between noradrenergic and cholinergic mechanisms involved in spinal nociceptive processing. Acta Anaesthesiol Scand 1989; 33: 39-47
29. 2 receptor systems. ANESTHESIOLOGY 1994; 80: 1338-48
30. Taiwo YO, Fabian A, Pazoles CJ, Fields HL: Potentiation of morphine antinociception by monoamine reuptake inhibitors in the rat spinal cord. Pain 1985; 21:329-37
31. Kerrick JM, Fine PG, Lipman AG, Love G: Low-dose amitriptyline as an adjunct to opioids for postoperative orthopedic pain: A placebo-controlled trial. Pain 1993; 52:325-30
32. Gordon NC, Heller PH, Gear RW, Levine JD: Temporal factors in the enhancement of morphine analgesia by desipramine. Pain 1993; 53:273-6
33. Weinstock M, Davidson JT, Rosin AJ, Schnieden H: Effect of physostigmine on morphine-induced postoperative pain and somnolence. Br J Anaesth 1982; 54:429-34
34. Petersson J, Gordh TE, Hartvig P, Wiklund L: A double-blind trial of the analgesic properties of physostigmine in postoperative patients. Acta Anaesthesiol Scand 1986; 30:283-8
35. Rosenblatt WH, Cioffi AM, Sinatra R, Saberski LR, Silverman DG: Metoclopramide: An analgesic adjunct to patient-controlled analgesia. Anesth Analg 1991; 73:553-5
36. Kandler D, Lisander B: Analgesic action of metoclopramide in prosthetic hip surgery. Acta Anaesthesiol Scand 1993; 37:49-53
37. Hood DD, Eisenach JC, Tong C, Tommasi E, Yaksh TL: Cardiorespiratory and spinal cord blood flow effects of intrathecal neostigmine methylsulfate, clonidine, and their combination in sheep. ANESTHESIOLOGY 1995; 82:428-35
38. Yaksh TL, Grafe MR, Malkmus S, Rathbun ML, Eisenach JC: Studies on the safety of chronically administered intrathecal neostigmine methylsulfate in rats and dogs. ANESTHESIOLOGY 1995; 82:412-27