The α(2a) adrenergic receptor subtype mediates spinal analgesia evoked by α2 agonists and is necessary for spinal adrenergic-opioid synergy

Journal of Neuroscience

Volumn 17, Issue 18, 1997, Pages 7157-7165

  Stone, Laura S ^a   MacMillan, Leigh B ^b   Kitto, Kelley F ^a   Limbird, Lee E ^b   Wilcox, George L ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antinociception; Gene targeting; Intrathecal; Isobologram; Mice; Morphine; Opioid; Substance P; Synergy; (2a)AR; 2 adrenergic receptor

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; BRIMONIDINE; CLONIDINE; DELTA OPIATE RECEPTOR AGONIST; DELTORPHIN; DEXMEDETOMIDINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; IDAZOXAN; MORPHINE; MU OPIATE RECEPTOR AGONIST; OPIATE AGONIST; PRAZOSIN; RECEPTOR SUBTYPE; SUBSTANCE P; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; DELTA OPIATE RECEPTOR; ENKEPHALIN; MU OPIATE RECEPTOR; QUINOXALINE DERIVATIVE; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A;

ADRENERGIC SYSTEM; ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG TARGETING; INTRATHECAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SPINAL ANESTHESIA; TAIL FLICK TEST; ANIMAL; C57BL MOUSE; DRUG EFFECT; HEAT; NOCICEPTIVE RECEPTOR; PAIN ASSESSMENT; PHYSIOLOGY;

ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANESTHESIA, SPINAL; ANIMALS; BEHAVIOR, ANIMAL; DRUG SYNERGISM; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; HEAT; MICE; MICE, INBRED C57BL; MORPHINE; NOCICEPTORS; PAIN MEASUREMENT; QUINOXALINES; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SUBSTANCE P;

EID: 0030611098     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-18-07157.1997     Document Type: Article

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