Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of α2B adrenoceptors

Journal of Neuroscience

Volumn 20, Issue 24, 2000, Pages 9242-9251

  Sawamura, Shigehito ^a,b   Kingery, Wade S ^a,b   Davies, M Frances ^a,b   Agashe, Geeta S ^a,b   Clark, J David ^a,b   Kobilka, Brian K ^c   Hashimoto, Toshizaku ^d   Maze, Mervyn ^d,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

Author keywords

Analgesia; Anesthesia; Fos immunoreactivity; Locus coeruleus; Nitrous oxide; Noradrenergic

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; DOPAMINE BETA MONOOXYGENASE; NITROUS OXIDE; PROTEIN FOS; SAPORIN;

ANALGESIC ACTIVITY; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN STEM; DRUG EFFECT; DRUG MECHANISM; IMMUNOREACTIVITY; LOCUS CERULEUS; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NORADRENERGIC NERVE; PONS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEDATION;

EID: 0034671195     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-24-09242.2000     Document Type: Article

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