Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block

Acta Anaesthesiologica Scandinavica

Volumn 50, Issue 2, 2006, Pages 222-227

  Kanazi, G E ^a   Aouad, M T ^a   Jabbour Khoury, S I ^a   Al Jazzar, M D ^a   Alameddine, M M ^a   Al Yaman, R ^a   Bulbul, M ^a   Baraka, A S ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

2 adrenoreceptor agonist; Dexmedetomidine; Int rathecal adjuvants; Spinal anesthesia

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ANESTHETIC AGENT; ATROPINE; BUPIVACAINE; CLONIDINE; DEXMEDETOMIDINE; DIAZEPAM; EPHEDRINE; KETOPROFEN; PARACETAMOL; RINGER LACTATE SOLUTION;

ADULT; AGED; ARTICLE; BACKACHE; BLADDER TUMOR; BRADYCARDIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEART RATE; HEMODYNAMICS; HUMAN; HYPOTENSION; LEG PAIN; MAJOR CLINICAL STUDY; MEAN ARTERIAL PRESSURE; MOTOR SYSTEM; NAUSEA; NEUROLOGIC DISEASE; PAIN; PARESTHESIA; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSTATE TUMOR; RANDOMIZED CONTROLLED TRIAL; SEDATION; SENSORY SYSTEM; SPINAL ANESTHESIA; TRANSURETHRAL RESECTION; VOMITING;

ADRENERGIC ALPHA-AGONISTS; AGED; ANALYSIS OF VARIANCE; ANESTHESIA, SPINAL; ANESTHETICS, COMBINED; ANESTHETICS, LOCAL; BUPIVACAINE; CLONIDINE; CONSCIOUS SEDATION; DEXMEDETOMIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG SYNERGISM; HEMODYNAMIC PROCESSES; HUMANS; MALE; NERVE BLOCK; PAIN MEASUREMENT; PROSPECTIVE STUDIES; TIME FACTORS; UROGENITAL NEOPLASMS;

EID: 33644778044     PISSN: 00015172     EISSN: 13996576     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2006.00919.x     Document Type: Article

References (37)

1. Strebel S Gurzeler J Schneider M Aeschbach A Kindler C Small-dose intrathecal clonidine and isobaric bupivacaine for orthopedic surgery: a dose-response-study Anesth Analg 2004 99 1231 8
2. Dobrydnjov I Axelsson K Thorn S-E et al. Clonidine combined with small-dose bupivacaine during spinal anesthesia for inguinal herniorrhaphy: a randomized double-blinded study Anesth Analg 2003 96 1496 503
3. Dobrydnjov I Axelsson K Samarutel J Holmstrom B Postoperative pain relief following intrathecal bupivacaine combined with intrathecal or oral clonidine Acta Anaesthesiol Scand 2002 46 806 14
4. De Kock M Gautier P Fanard L Hody J Lavand'homme P Intrathecal ropivacaine and clonidine for ambulatory knee arthroscopy Anesthesiology 2001 94 574 8
5. Gordh T Jr. Post C Olsson Y Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration Anesth Analg 1986 65 12 1303 11
6. Coursin DB Maccioli GA. Dexmedetomidine Curr Opin Crit Care 2001 7 221 6
7. Fragen RJ Fitzgerald PC Effect of dexmedetomidine on the minimum alveolar concentration (MAC) of sevoflurane in adults age 55-70 years J Clin Anesth 1999 11 466 70
8. Martin E Ramsay G Mantz J Sum-Ping ST The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit J Intensive Care Med 2000 18 29 34
9. 2-adrenergic agonist Pharmacol Toxicol 1991 68 140 3
10. Savola M Woodley J Kendig J Maze M Alpha2B adrenoreceptor activation inhibits nociceptor response in the spinal cord of the neonatal rat Eur J Pharmacol 1990 183 740
11. Stevens C Brenner G Spinal administration of adrenergic agents produces analgesia in amphibians Eur J Pharmacol 1996 316 205 10
12. Asano T Dohi S Ohta S Shimonaka H Iida H Antinociception by epidural and systemic alpha 2 adrenoreceptor agonists and their binding affinity in rat spinal cord and brain Anesth Analg 2000 90 400 7
13. Bromage PR A comparison of the hydrochloride and carbon dioxide salts of lidocaine and prilocaine in epidural analgesia Acta Anaesthesiol Scand 1965 16 55 69
14. Aldrete JA The post anesthesia recovery score revisited J Clin Anesth 1995 7 89 91
15. Eisenach J Shafer S Bucklin B Carswell J Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep Anesthesiology 1994 80 1349 59
16. Lo WC Harris J Clarke RW Endogenous opioids support the spinal inhibitory action of an alpha 2-adrenoceptor agonist in the decerebrated spinalised rabbit Neurosci Lett 2003 340 95 8
17. Talke P Xu M Paloheimo M Kalso E Effects of intrathecally administered dexmedetomidine, MPV-2426 and tizanidine on EMG in rats Acta Anaesthesiol Scand 2003 47 347 54
18. Xu M Kontinen VK Kalso E Effects of radolmidine, a novel alpha2-adrenergic agonist compared with dexmedetomidine in different pain models in the rat Anesthesiology 2000 93 473 81
19. Horvath G Joo G Dobos I Klimscha W Toth G Benedek G The synergistic antinociceptive interactions of endomorphin-1 with dexmedetomidine and/or S(+)-ketamine in rats Anesth Analg 2001 93 1018 24
20. Shimode N Fukuoka T Tanimoto M Tashiro C Tokunaga A Noguchi K The effects of dexmedetomidine and halothane on the Fos expression in the spinal dorsal horn using a rat postoperative pain model Neurosci Lett 2003 343 45 8
21. Onttonen T Pertovaara A The mechanical antihyperalgesic effect of intrathecally administered MPV-2426, a novel alpha2-adrenoceptor agonist, in a rat model of postoperative pain Anesthesiology 2000 92 1740 5
22. Takano Y Yaksh TL Characterization of the pharmacology of intrathecally administered alpha 2-agonists and antagonists in rats J Pharmacol Exp Ther 1992 261 764 72
23. Fukushima K Nishimi Y Mori K Takeda J Effect of epidurally administered dexmedetomidine on sympathetic activity and postoperative pain in man Anesth Analg 1996 82 S121
24. Maroof M Khan SA Jain D et al. Evaluation of effect of dexmedetomidine in reducing shivering following epidural anesthesia Anesthesiology 2004 101 A495
25. Bioco O Bonnet F Mazoit JX Effects of epinephrine and clonidine on plasma concentrations of spinal bupivacaine Acta Anaesthesiol Scand 1992 36 684 8
26. 2 adrenergic agonists for regional anesthesia Anesthesiology 1996 85 655 74
27. Lawhead RG Blaxall HS Bylund BD Alpha-2A is the predominant α-2 adrenergic receptor subtype in human spinal cord Anesthesiology 1992 77 983 91
28. Smith MS Schumbra UB Wilson KH et al. Alpha 2 adrenergic receptor in human spinal cord: specific localized expression of mRNA encoding alpha-2 adrenergic receptor subtypes at four distinct levels Brain Res 1995 34 109 17
29. Yaksh TL Jage J Takano Y Pharmacokinetics and pharmacodynamics of medullar agents. The spinal actions of α-2 adrenergic agonists as analgesics. In: Atikenhead AR Benad G Brown BR et al. Baillieres Clinical Anaesthesiology Vol. 7, No. 3. London Bailliere Tindall 1993 597 614
30. Fairbanke CA Wilcox GL Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine J Pharmacol Exp Ther 1999 288 1107 16
31. Yaksh TL Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing Pharmacol Biochem Behav 1985 22 845 58
32. Smith C Birnbaum G Carter JL Greenstein J Lublin FD Tizanidine treatment of spasticity caused by multiple sclerosis Neurology 1994 44 9 34 43
33. Post C Gordh T Minor G Archer T Freedman J Antinociceptive effects and spinal cord tissue concentrations after intrathecal injection of guanfacine or clonidine into rats Anesth Analg 1987 66 317 24
34. Klimscha W Chiari A Kraffn P et al. Hemodynamic and analgesic effects of clonidine added repetitively to continuous epidural and spinal blocks Anesth Analg 1995 80 322 7
35. Niemi L Effects of intrathecal clonidine on duration of bupivacaine spinal anesthesia, hemodynamics and postoperative analgesia in patients undergoing knee arthroscopy Acta Anaesthesiol Scand 1994 38 742 8
36. D'Angelo R Evans R Dean LA et al. Spinal clonidine prolongs labor analgesia from spinal sufentanil and bupivacaine Anesth Analg 1999 88 573 6
37. Filos KS Goudas LC Patroni O Polysou V Hemo-dynamic and analgesic profile after intrathecal clonidine in humans: a dose-response study Anesthesiology 1994 81 591 601