In vivo gene modification elucidates subtype-specific functions of α2- adrenergic receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 1, 2000, Pages 1-7

  Kable, Joseph W ^a,b   Murrin, L Charles ^a   Bylund, David B ^a,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c 986260 Nebraska Medical Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; RECEPTOR SUBTYPE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; GENE DELETION; GENETIC ENGINEERING; IN VIVO STUDY; KNOCKOUT GENE; MOUSE; NONHUMAN; NORADRENALIN RELEASE; POINT MUTATION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RECEPTOR GENE; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STARTLE REFLEX; STRAIN DIFFERENCE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; HUMANS; MICE; MICE, TRANSGENIC; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0034087475     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. 2A-adrenergic receptor knockout mice. Mol Pharmacol 56:154-161.
2. 2C-adrenoceptor-overexpressing mice are impaired in executing nonspatial and spatial escape strategies. Mol Pharmacol 54:569-576.
3. Björklund M, Sirviö J, Riekkinen PJ, Sallinen J, Scheinin M and Riekkinen P Jr (2000) Overexpression of alpha2C-adrenoceptors impairs water maze navigation. Neuroscience 96:481-487.
4. BjörMund M, Sirviö J, Sallinen J, Scheinin M, Kobilka BK and Riekkinen P Jr (1999) Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns. Neuroscience 88:1187-1198.
5. 2-adrenoceptors: Pharmacological and molecular biological evidence converge. Trends Pharmacol Sci 9:356-361.
6. Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR and Trendelenburg AU (1994) IV. International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 46:121-136.
7. Crabbe JC, Wahlsten D and Dudek BC (1999) Genetics of mouse behavior: Interactions with laboratory environment. Science (Wash DC) 284:1670-1672.
8. 2-adrenergic agonists for regional anesthesia - A clinical review of clonidine (1984-1995). Anesthesiology 85:655-674.
9. 2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice. J Pharmacol Exp Ther 290:403-412.
10. 2C adrenoceptor subtypes in mice. Anesthesiology 90:470-476.
11. Guyenet PG (1997) Is the hypotensive effect of clonidine and related drugs due to imidazoline binding sites? Am J Physiol Regal Integr Comp Physiol 273:R1580-H1584.
12. 2-adrenergic receptors regulate sympathetic neurotransmission. Nature (Lond) 402:181-184.
13. Hein L and Kobilka BK (1995) Adrenergic receptor signal transduction and regulation. Neuropharmacology 34:357-366.
14. 2-adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice. Br J Pharmacol 122:1339-1344.
15. Janumpalli S, Butler LS, Macmillan LB, Limbird LE and McNamara JO (1998) A point mutation (D79N) of the α2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. J Neurosci 18:2004-2008.
16. 2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 94:9950-9955.
17. 2-adrenergic receptor subtypes b and c. Science (Wash DC) 273:803-805.
18. 2C-adrenoceptor homolog. Mol Pharmacol 48:48-55.
19. Lomasney JW, Cotecchia S, Lefkowitz RJ and Caron MG (1991) Molecular biology of alpha-adrenergic receptors: Implications for receptor classification and for structure-function relationships. Biochim Biophys Acta 1095:127-139.
20. 2-adrenoceptor-subtype function. Trends Pharmacol Sci 18:211-219.
21. 2a-adrenergic receptor subtype. Science (Wash DC) 273:801-803.
22. 2B-adrenergic receptor in the development of salt-induced hypertension. Hypertension 33:14-17.
23. Makaritsis KP, Johns C, Gavras I, Altman JD, Handy DE, Bresnahan MR and Gavras H (1999b) Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtype. Hypertension 34:403-407.
24. Maze M and Tranquilli W (1991) Alpha-2 adrenoceptor agonists: Defining the role in clinical anesthesia. Anesthesiology 74:581-605.
25. 2-adrenergic agonist dexmedetomidine in the locus coeruleus of the rat. Anesthesiology 81:1527-1534.
26. Nicholas AP, Hökfelt T and Pieribone VA (1996) The distribution and significance of CNS adrenoceptors examined with in situ hybridization. Trends Pharmacol Sci 17:245-255.
27. Nicholas AP, Pieribone V and Hokfelt T (1993) Distributions of mRNAs for alpha-2 adrenergic receptor subtypes in rat brain: An in situ hybridization study. J Comp Neurol 328:575-594.
28. Rohrer DK and Kobilka BK (1998) Insights from in vivo modification of adrenergic receptor gene expression. Annu Rev Pharmacol Toxicol 38:351-373.
29. Rosin DL, Zeng D, Stornetta RL, Norton FR, Riley T, Okusa MD, Guyenet PG and Lynch KR (1993) Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience 56:139-155.
30. Sallinen J, Haapalinna A, MacDonald E, Viitamaa T, Lähdesmaki J, Rybnikova E, Pelto-Huikko M, Kobilka BK and Scheinin M (1999) Genetic alteration of the alpha-2 adrenoceptor subtype C in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels. Mol Psychiatry 4:443-452.
31. 2C-adrenergic receptor subtype. Neuroscience 86:959-965.
32. 2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. J Neurosci 18:3035-3042.
33. 2-adrenoceptor agonist. Mol Pharmacol 51:36-46.
34. Scheinin M, Lomasney JW, Hayden-Hixson DM, Sehambra UB, Caron MG, Lefkowitz RJ and Fremeau RT Jr (1994) Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. Brain Res Mol Brain Res 21:133-149.
35. 2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 17:7157-7165.
36. Surprenant A, Horstman DA, Akbarali H and Limbird LE (1992) A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science Wash DC) 257:977-980.
37. 2C-adrenoceptor gene. Eur J Neurosci 11:599-603.
38. 2A/D-adrenoceptor-deficient mice. Naunyn-Schmiedeberg's Arch Pharmacol 360:540-551.
39. 2AAR-receptor gene in transgenic animals. Neuroscience 74:199-218.
40. Wang R-F, Lee P-Y, Taniguchi T, Becker B, Podos SM, Serle JB and Mittag TW (1993) Effect of oxymetazoline on aqueous humor dynamics and ocular blood flow in monkeys and rabbits. Arch Ophthalmol 111:535-538.
41. Wei LN (1997) Transgenic animals as new approaches in pharmacological studies. Anna Rev Pharmacol Toxicol 37:119-141.
42. 2A messenger RNA expression. Neuroscience 76:241-260.
43. Yanez RJ and Porter AC (1998) Therapeutic gene targeting. Gene Ther 5:149-159.
44. 2A-adrenoceptor transgenic mice. Br J Pharmacol 126:1522-1530.