메뉴 건너뛰기




Volumn 27, Issue SUPPL. 3, 1996, Pages

Pharmacology of moxonidine, an I1-imidazoline receptor agonist

Author keywords

Hypertension; I1 Receptors; Moxonidine; Review; Rostroventrolateral medulla oblongata; 2 Adrenergic receptors

Indexed keywords

6 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 1H 3 BENZAZEPINE; ANTIHYPERTENSIVE AGENT; CLONIDINE; EFAROXAN; GUANABENZ; IDAZOXAN; IMIDAZOLINE I1 RECEPTOR AGONIST; MOXONIDINE; OUABAIN; RAUWOLSCINE; RILMENIDINE; UNCLASSIFIED DRUG; DRUG RECEPTOR; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTORS;

EID: 0029835162     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199627003-00005     Document Type: Conference Paper
Times cited : (61)

References (52)
  • 1
    • 0027162322 scopus 로고
    • The management of hypertension and associated risk factors for the prevention of long-term cardiac complications
    • Houston MC. The management of hypertension and associated risk factors for the prevention of long-term cardiac complications. J Cardiovasc Pharmacol 1993;21(suppl 2):S2-13.
    • (1993) J Cardiovasc Pharmacol , vol.21 , Issue.2 SUPPL.
    • Houston, M.C.1
  • 2
    • 0025347391 scopus 로고
    • Blood pressure, stroke and coronary heart disease
    • Collins R, Peto R, MacMahon S, et al. Blood pressure, stroke and coronary heart disease. Lancet 1990;335:827-38.
    • (1990) Lancet , vol.335 , pp. 827-838
    • Collins, R.1    Peto, R.2    MacMahon, S.3
  • 3
    • 0026558088 scopus 로고
    • New insights and approaches to reduce endorgan damage in the treatment of hypertension: Subsets of hypertension approach
    • Houston MC. New insights and approaches to reduce endorgan damage in the treatment of hypertension: subsets of hypertension approach. Am Heart J 1992;123:1337-67.
    • (1992) Am Heart J , vol.123 , pp. 1337-1367
    • Houston, M.C.1
  • 4
    • 0023712512 scopus 로고
    • General pharmacology of the novel centrally acting antihypertensive agent moxonidine
    • Armah BI, Hofferber E, Stenzel W. General pharmacology of the novel centrally acting antihypertensive agent moxonidine. Drug Res 1988;38:1426-34.
    • (1988) Drug Res , vol.38 , pp. 1426-1434
    • Armah, B.I.1    Hofferber, E.2    Stenzel, W.3
  • 5
    • 0345551711 scopus 로고
    • Caloric intake and radio tele- Metrically assessed high blood pressure
    • Rupp H, Turcani M, Jacob R. Caloric intake and radio tele- metrically assessed high blood pressure. Pharm Pharmacol Lett 1993;3:103-6.
    • (1993) Pharm Pharmacol Lett , vol.3 , pp. 103-106
    • Rupp, H.1    Turcani, M.2    Jacob, R.3
  • 6
    • 0019831542 scopus 로고
    • Discontinuation syndrome after continuous infusion of clonidine in the spontaneously hypertensive rat
    • Thoolen MJMC, Timmermans PBMWM, van Zwieten PA. Discontinuation syndrome after continuous infusion of clonidine in the spontaneously hypertensive rat. Life Sci 1981;28:2103-9.
    • (1981) Life Sci , vol.28 , pp. 2103-2109
    • Thoolen, M.J.M.C.1    Timmermans, P.B.M.W.M.2    Van Zwieten, P.A.3
  • 7
    • 0020657142 scopus 로고
    • Precipitaion by yohimbine of the withdrawal syndromes of clonidine, guanfacine and methyldopa in the spontaneously hypertensive rat
    • Thoolen MJMC, Hendriks JCA, Timmermans PBMWM, van Zwieten PA. Precipitaion by yohimbine of the withdrawal syndromes of clonidine, guanfacine and methyldopa in the spontaneously hypertensive rat. J Cardiovasc Pharmacol 1983;5:224-8.
    • (1983) J Cardiovasc Pharmacol , vol.5 , pp. 224-228
    • Thoolen, M.J.M.C.1    Hendriks, J.C.A.2    Timmermans, P.B.M.W.M.3    Van Zwieten, P.A.4
  • 8
    • 0019974514 scopus 로고
    • Guanfacine and clonidine: Antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat
    • Thoolen MJMC, Timmermans PBMWM, van Zwieten PA. Guanfacine and clonidine: antihypertensive and withdrawal characteristics after continuous infusion and its interruption in the spontaneously hypertensive and normotensive rat. Naunyn Schmiedebergs Arch Pharmacol 1982;319:82-6.
    • (1982) Naunyn Schmiedebergs Arch Pharmacol , vol.319 , pp. 82-86
    • Thoolen, M.J.M.C.1    Timmermans, P.B.M.W.M.2    Van Zwieten, P.A.3
  • 9
    • 0027970460 scopus 로고
    • Mechanisms of cardiac cell damage due to catecholamines: Significance of drugs regulating central sympathetic outflow
    • Rupp H, Dhalla KS, Dhalla NS. Mechanisms of cardiac cell damage due to catecholamines: significance of drugs regulating central sympathetic outflow. J Cardiovasc Pharmacol 1994;24(suppl 1):S16-24.
    • (1994) J Cardiovasc Pharmacol , vol.24 , Issue.1 SUPPL.
    • Rupp, H.1    Dhalla, K.S.2    Dhalla, N.S.3
  • 10
    • 0029787839 scopus 로고    scopus 로고
    • Rebound and aspects of tolerability of centrally acting antihypertensive drugs
    • this issue
    • Webster J, Koch HF. Rebound and aspects of tolerability of centrally acting antihypertensive drugs. J Cardiovasc Pharmacol 1996;27(suppl 3):S49-54 (this issue).
    • (1996) J Cardiovasc Pharmacol , vol.27 , Issue.3 SUPPL.
    • Webster, J.1    Koch, H.F.2
  • 11
    • 0026297148 scopus 로고
    • Effects of nifedipine and moxonidine on cardiac structure in spontaneously hypertensive rats (SHR) -stereological studies on myocytes, capillaries, arteries and cardiac interstitium
    • Mall G, Greber D, Gharehbaghi H, Wiest G, Amann K, Mattfeldt T. Effects of nifedipine and moxonidine on cardiac structure in spontaneously hypertensive rats (SHR) -stereological studies on myocytes, capillaries, arteries and cardiac interstitium. Bas Res Cardiol 1991;86(suppl 3):33-44.
    • (1991) Bas Res Cardiol , vol.86 , Issue.3 SUPPL. , pp. 33-44
    • Mall, G.1    Greber, D.2    Gharehbaghi, H.3    Wiest, G.4    Amann, K.5    Mattfeldt, T.6
  • 12
    • 0026629011 scopus 로고
    • Beneficial effect of nifedipine and moxonidine on glomerulosclerosis in spontaneously hypertensive rats
    • Irzyniec T, Mall G, Greber D, Ritz E. Beneficial effect of nifedipine and moxonidine on glomerulosclerosis in spontaneously hypertensive rats. Am J Hypertens 1992;5:437-43.
    • (1992) Am J Hypertens , vol.5 , pp. 437-443
    • Irzyniec, T.1    Mall, G.2    Greber, D.3    Ritz, E.4
  • 13
    • 0030013287 scopus 로고    scopus 로고
    • Sympathetic nervous system in salt-sensitive and obese hypertension: Amelioration of multiple abnormalities by a central sympatholytic agent
    • [in press]
    • Ernsberger P, Koletsky RJ, Collins LA, Bedol D. Sympathetic nervous system in salt-sensitive and obese hypertension: amelioration of multiple abnormalities by a central sympatholytic agent. Cardiovasc Drugs Ther [in press].
    • Cardiovasc Drugs Ther
    • Ernsberger, P.1    Koletsky, R.J.2    Collins, L.A.3    Bedol, D.4
  • 14
    • 0016751347 scopus 로고
    • Centrally induced hypotension by 2-(2,6-dichlorphenyl)-5,6-dihydroimidazo (2,1-b)-thiazole (compound 44-549)
    • van Zwieten PA. Centrally induced hypotension by 2-(2,6-dichlorphenyl)-5,6-dihydroimidazo (2,1-b)-thiazole (compound 44-549). Pharmacology 1975;13:352-5.
    • (1975) Pharmacology , vol.13 , pp. 352-355
    • Van Zwieten, P.A.1
  • 19
    • 0021153959 scopus 로고
    • Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines
    • Bousquet P, Feldman J, Schwartz J. Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines. J Pharmacol Exp Ther 1984;230:232-6.
    • (1984) J Pharmacol Exp Ther , vol.230 , pp. 232-236
    • Bousquet, P.1    Feldman, J.2    Schwartz, J.3
  • 21
    • 0023712513 scopus 로고
    • 2-receptor selectivity and specificity of the antihypertensive agent moxonidine
    • 2-receptor selectivity and specificity of the antihypertensive agent moxonidine. Drug Res 1988;38:1435-42.
    • (1988) Drug Res , vol.38 , pp. 1435-1442
    • Armah, B.I.1
  • 25
    • 9444275582 scopus 로고    scopus 로고
    • Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits
    • [submitted]
    • Chan CKS, Sannajust F, Head GA. Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits. J Pharmacol Exp Ther [submitted].
    • J Pharmacol Exp Ther
    • Chan, C.K.S.1    Sannajust, F.2    Head, G.A.3
  • 26
    • 0028871265 scopus 로고
    • Central monoamine systems and new antihypertensive agents
    • Head GA. Central monoamine systems and new antihypertensive agents. Clin Exp Hypertens 1995;17:141-52.
    • (1995) Clin Exp Hypertens , vol.17 , pp. 141-152
    • Head, G.A.1
  • 28
    • 0029642563 scopus 로고
    • Mechanism of sympathoinhibition by imidazolines
    • Szabo B, Urban R, Starke K. Mechanism of sympathoinhibition by imidazolines. Ann NY Acad Sci 1995;763:552-65.
    • (1995) Ann NY Acad Sci , vol.763 , pp. 552-565
    • Szabo, B.1    Urban, R.2    Starke, K.3
  • 29
    • 0028065342 scopus 로고
    • 1-imidazoline receptor agonist, moxonidine
    • 1-imidazoline receptor agonist, moxonidine. Br J Pharmacol 1994;112:1089-94.
    • (1994) Br J Pharmacol , vol.112 , pp. 1089-1094
    • Penner, S.B.1    Smyth, D.D.2
  • 30
    • 0028394706 scopus 로고
    • 1-imidazoline preferring receptors: Two unique sites mediating natriuresis in the rat
    • 1-imidazoline preferring receptors: two unique sites mediating natriuresis in the rat. Cardiovasc Drugs Ther 1994;8:43-8.
    • (1994) Cardiovasc Drugs Ther , vol.8 , pp. 43-48
    • Penner, S.B.1    Smyth, D.D.2
  • 31
    • 0028334230 scopus 로고
    • Attenuated renal response to moxonidine and rilmenidine in one kidney-one clip hypertensive rats
    • Li P, Penner SB, Smyth DD. Attenuated renal response to moxonidine and rilmenidine in one kidney-one clip hypertensive rats. Br J Pharmacol 1994;112:200-6.
    • (1994) Br J Pharmacol , vol.112 , pp. 200-206
    • Li, P.1    Penner, S.B.2    Smyth, D.D.3
  • 32
    • 0027538272 scopus 로고
    • Renal imidazoline preferring sites and solute excretion in the rat
    • Allan DR, Penner SB, Smyth DD. Renal imidazoline preferring sites and solute excretion in the rat. Br J Pharmacol 1993;108:870-5.
    • (1993) Br J Pharmacol , vol.108 , pp. 870-875
    • Allan, D.R.1    Penner, S.B.2    Smyth, D.D.3
  • 33
    • 0027049728 scopus 로고
    • Early association of sympathetic overactivity. hypertension, insulin resistance and coronary risk
    • Julius S, Gudbrandsson T. Early association of sympathetic overactivity. hypertension, insulin resistance and coronary risk. J Cardiovasc Pharmacol 1992;20(suppl 8):S40-8.
    • (1992) J Cardiovasc Pharmacol , vol.20 , Issue.8 SUPPL.
    • Julius, S.1    Gudbrandsson, T.2
  • 34
    • 0026569450 scopus 로고
    • Obesity, the sympathetic nervous system and essential hypertension
    • Tuck ML. Obesity, the sympathetic nervous system and essential hypertension. Hypertension 1992;19(suppl I):I-67-77.
    • (1992) Hypertension , vol.19 , Issue.1 SUPPL.
    • Tuck, M.L.1
  • 35
    • 0027248150 scopus 로고
    • Cicadian variation of ischemic cardiac events
    • Kiowski W, Osswald S. Cicadian variation of ischemic cardiac events. J Cardiovasc Pharmacol 1993;21(suppl 2):S45-8.
    • (1993) J Cardiovasc Pharmacol , vol.21 , Issue.2 SUPPL.
    • Kiowski, W.1    Osswald, S.2
  • 36
    • 0027999544 scopus 로고
    • Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion
    • Lepran I, Papp JG. Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion. J Cardiovasc Pharmacol 1994;24(suppl 1):S9-15.
    • (1994) J Cardiovasc Pharmacol , vol.24 , Issue.1 SUPPL.
    • Lepran, I.1    Papp, J.G.2
  • 39
    • 0021123691 scopus 로고
    • Sleep apnoea in a hypertensive population
    • Kales A, Bixler EO, Cadieux RJ, et al. Sleep apnoea in a hypertensive population. Lancet 1984;2:1005-8.
    • (1984) Lancet , vol.2 , pp. 1005-1008
    • Kales, A.1    Bixler, E.O.2    Cadieux, R.J.3
  • 41
    • 0027049437 scopus 로고
    • The metabolic cardiovascular syndrome: Syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome
    • Hjermann I. The metabolic cardiovascular syndrome: syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol 1992;20(suppl 8):S5-10.
    • (1992) J Cardiovasc Pharmacol , vol.20 , Issue.8 SUPPL.
    • Hjermann, I.1
  • 42
    • 0027076722 scopus 로고
    • The sympathetic nervous system may modulate the metabolic cardiovascular syndrome in essential hypertension
    • Kjeldsen SE, Rostrup M, Moan A, Mundal HH, Gjesdal K, Eide IK. The sympathetic nervous system may modulate the metabolic cardiovascular syndrome in essential hypertension. J Cardiovasc Pharmacol 1992;20(suppl 8):S32-9.
    • (1992) J Cardiovasc Pharmacol , vol.20 , Issue.8 SUPPL.
    • Kjeldsen, S.E.1    Rostrup, M.2    Moan, A.3    Mundal, H.H.4    Gjesdal, K.5    Eide, I.K.6
  • 43
    • 0027062816 scopus 로고
    • Abdominal fat distribution and the metabolic syndrome
    • Björntorp P. Abdominal fat distribution and the metabolic syndrome. J Cardiovasc Pharmacol 1992;20(suppl 8):S26-8.
    • (1992) J Cardiovasc Pharmacol , vol.20 , Issue.8 SUPPL.
    • Björntorp, P.1
  • 44
    • 0027195457 scopus 로고
    • Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia and hyperinsulinemia
    • Lind L, Lithell H. Decreased peripheral blood flow in the pathogenesis of the metabolic syndrome comprising hypertension, hyperlipidemia and hyperinsulinemia. Am Heart J 1993;125:1494-7.
    • (1993) Am Heart J , vol.125 , pp. 1494-1497
    • Lind, L.1    Lithell, H.2
  • 46
    • 0027154112 scopus 로고
    • Diabetes. Obesity and hypertension: Role of insulin and the sympathetic nervous system
    • Landsberg L. Diabetes. Obesity and hypertension: role of insulin and the sympathetic nervous system. Cardiovasc Risk Factors 1993;3:153-8.
    • (1993) Cardiovasc Risk Factors , vol.3 , pp. 153-158
    • Landsberg, L.1
  • 47
    • 0028326072 scopus 로고
    • Pathophysiology of obesity-related hypertension: Role of insulin and the sympathetic nervous system
    • Landsberg L. Pathophysiology of obesity-related hypertension: role of insulin and the sympathetic nervous system. J Cardiovasc Pharmacol 1994;23(suppl 1):S1-8.
    • (1994) J Cardiovasc Pharmacol , vol.23 , Issue.1 SUPPL.
    • Landsberg, L.1
  • 48
    • 0028911164 scopus 로고
    • Excess catecholamines and the metabolic syndrome: Should central imidazoline receptors be a therapeutic target?
    • Rupp H, Jacob R. Excess catecholamines and the metabolic syndrome: should central imidazoline receptors be a therapeutic target? Med Hypothesis 1995;44:217-25.
    • (1995) Med Hypothesis , vol.44 , pp. 217-225
    • Rupp, H.1    Jacob, R.2
  • 49
    • 0000323682 scopus 로고
    • (Koletsky rat): A model for the interactions between hypertension and obesity
    • Koletsky RJ, Ernsberger P. Obese SHR (Koletsky rat): a model for the interactions between hypertension and obesity. Colloq INSERM 1992;218:373-5.
    • (1992) Colloq INSERM , vol.218 , pp. 373-375
    • Koletsky, R.J.1    Ernsberger, P.2    Obese, S.H.R.3
  • 50
    • 0003122203 scopus 로고
    • Effects of agmatine and moxonidine on glucose metabolism: An integrated approach towards pathophysiological mechanisms in cardiovascular metabolic disorders
    • Kaan EC, Brückner R, Frohly P, Tulp M, Schäfer SG, Ziegler D. Effects of agmatine and moxonidine on glucose metabolism: an integrated approach towards pathophysiological mechanisms in cardiovascular metabolic disorders. Cardiovasc Risk Factors 1995;5:19-27.
    • (1995) Cardiovasc Risk Factors , vol.5 , pp. 19-27
    • Kaan, E.C.1    Brückner, R.2    Frohly, P.3    Tulp, M.4    Schäfer, S.G.5    Ziegler, D.6
  • 51
    • 0028986474 scopus 로고
    • 1-imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats
    • 1-imidazoline receptor agonist, moxonidine, on gastric secretion and gastric mucosal injury in rats. Br J Pharmacol 1995;114:751-4.
    • (1995) Br J Pharmacol , vol.114 , pp. 751-754
    • Glavin, G.1    Smyth, D.D.2
  • 52
    • 0028356483 scopus 로고
    • Ocular actions of moxonidine: A possible role for imidazoline receptors
    • Ogidigben M, Chu TH, Potter DE. Ocular actions of moxonidine: a possible role for imidazoline receptors. J Pharmacol Exp Ther 1994;269:897-904.
    • (1994) J Pharmacol Exp Ther , vol.269 , pp. 897-904
    • Ogidigben, M.1    Chu, T.H.2    Potter, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.