메뉴 건너뛰기




Volumn 11, Issue 2, 2009, Pages 75-81

Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy

Author keywords

Microenvironment; Radiotherapy; Reactive stroma; Treatment resistance

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BETA1 INTEGRIN; CTCE 9908; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCLEROPROTEIN; UNCLASSIFIED DRUG;

EID: 67449087327     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-009-0317-y     Document Type: Article
Times cited : (21)

References (101)
  • 1
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown JM, Attardi LD (2005) The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 5:231-237
    • (2005) Nat Rev Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 2
    • 0942300643 scopus 로고    scopus 로고
    • Apoptosis-modulating agents in combination with radiotherapy-current status and outlook
    • Belka C, Jendrossek V, Pruschy M et al (2004) Apoptosis-modulating agents in combination with radiotherapy-current status and outlook. Int J Radiat Oncol Biol Phys 58:542-554
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 542-554
    • Belka, C.1    Jendrossek, V.2    Pruschy, M.3
  • 3
    • 28544443984 scopus 로고    scopus 로고
    • Promoting apoptosis as a strategy for cancer drug discovery
    • Fesik SW (2005) Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5:876-885
    • (2005) Nat Rev Cancer , vol.5 , pp. 876-885
    • Fesik, S.W.1
  • 4
    • 13144280868 scopus 로고    scopus 로고
    • Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis
    • Marini P, Schmid A, Jendrossek V et al (2005) Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis. BMC Cancer 5:5
    • (2005) BMC Cancer , vol.5 , pp. 5
    • Marini, P.1    Schmid, A.2    Jendrossek, V.3
  • 5
    • 33747829837 scopus 로고    scopus 로고
    • Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo
    • Marini P, Denzinger S, Schiller D et al (2006) Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: Enhanced effects in vitro and dose-dependent growth delay in vivo. Oncogene 25:5145-5154
    • (2006) Oncogene , vol.25 , pp. 5145-5154
    • Marini, P.1    Denzinger, S.2    Schiller, D.3
  • 6
    • 67650348505 scopus 로고    scopus 로고
    • Efficacy of a triple treatment with irradiation, agonistic TRAIL receoptor antibodies and EGFR blockade
    • Niyazi M, Marini P, Daniel PT et al (2009) Efficacy of a triple treatment with irradiation, agonistic TRAIL receoptor antibodies and EGFR blockade. Strahlenther Onkol 185:8-18
    • (2009) Strahlenther Onkol , vol.185 , pp. 8-18
    • Niyazi, M.1    Marini, P.2    Daniel, P.T.3
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 9
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342-348
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 10
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe SW, Cepero E, Evan G (2004) Intrinsic tumour suppression. Nature 432:307-315
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 11
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M et al (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633-637
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3
  • 12
    • 0026504147 scopus 로고
    • Social controls on cell survival and cell death
    • Raff MC (1992) Social controls on cell survival and cell death. Nature 356:397-400
    • (1992) Nature , vol.356 , pp. 397-400
    • Raff, M.C.1
  • 13
    • 20644445860 scopus 로고    scopus 로고
    • Immunology for the next generation
    • Balkwill F (2005) Immunology for the next generation. Nat Rev Immunol 5:509-512
    • (2005) Nat Rev Immunol , vol.5 , pp. 509-512
    • Balkwill, F.1
  • 15
    • 37549013776 scopus 로고    scopus 로고
    • A microenvironmental model of carcinogenesis
    • Gatenby RA, Gillies RJ (2008) A microenvironmental model of carcinogenesis. Nat Rev Cancer 8:56-61
    • (2008) Nat Rev Cancer , vol.8 , pp. 56-61
    • Gatenby, R.A.1    Gillies, R.J.2
  • 16
    • 33947583623 scopus 로고    scopus 로고
    • Reprogramming metastatic tumour cells with embryonic microenvironments
    • Hendrix MJ, Seftor EA, Seftor RE et al (2007) Reprogramming metastatic tumour cells with embryonic microenvironments. Nat Rev Cancer 7:246-255
    • (2007) Nat Rev Cancer , vol.7 , pp. 246-255
    • Hendrix, M.J.1    Seftor, E.A.2    Seftor, R.E.3
  • 17
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing
    • Dvorak HF (1986) Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650-1659
    • (1986) N Engl J Med , vol.315 , pp. 1650-1659
    • Dvorak, H.F.1
  • 18
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta LA, Kohn EC (2001) The microenvironment of the tumour-host interface. Nature 411:375-379
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 19
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - Bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE (2004) Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4:839-849
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 20
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 22
    • 0036547417 scopus 로고    scopus 로고
    • Death and antideath: Tumour resistance to apoptosis
    • Igney FH, Krammer PH (2002) Death and antideath: Tumour resistance to apoptosis. Nat Rev Cancer 2:277-288
    • (2002) Nat Rev Cancer , vol.2 , pp. 277-288
    • Igney, F.H.1    Krammer, P.H.2
  • 23
    • 0030087944 scopus 로고    scopus 로고
    • Supramolecular assembly of basement membranes
    • Timpl R, Brown JC (1996) Supramolecular assembly of basement membranes. Bioessays 18:123-32
    • (1996) Bioessays , vol.18 , pp. 123-132
    • Timpl, R.1    Brown, J.C.2
  • 24
    • 0031908852 scopus 로고    scopus 로고
    • Structure and biological activity of the extracellular matrix
    • Aumailley M, Gayraud B (1998) Structure and biological activity of the extracellular matrix. J Mol Med 76:253-265
    • (1998) J Mol Med , vol.76 , pp. 253-265
    • Aumailley, M.1    Gayraud, B.2
  • 25
    • 0034757893 scopus 로고    scopus 로고
    • Components of cellmatrix adhesions
    • Zamir E, Geiger B (2001) Components of cellmatrix adhesions. J Cell Sci 114:3577-3579
    • (2001) J Cell Sci , vol.114 , pp. 3577-3579
    • Zamir, E.1    Geiger, B.2
  • 26
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt FM (2002) Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 21:3919-3926
    • (2002) EMBO J , vol.21 , pp. 3919-3926
    • Watt, F.M.1
  • 27
  • 28
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO (2002) Integrins: Bidirectional, allosteric signaling machines. Cell 110:673-687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 29
    • 0037205002 scopus 로고    scopus 로고
    • Integrin connections map: To infinity and beyond
    • Martin KH, Slack JK, Boerner SA et al (2002) Integrin connections map: to infinity and beyond. Science 296:1652-1653
    • (2002) Science , vol.296 , pp. 1652-1653
    • Martin, K.H.1    Slack, J.K.2    Boerner, S.A.3
  • 30
    • 0036229695 scopus 로고    scopus 로고
    • Integrin regulation of growth factor receptors
    • Yamada KM, Even-Ram S (2002) Integrin regulation of growth factor receptors. Nat Cell Biol 4:E75-76
    • (2002) Nat Cell Biol , vol.4
    • Yamada, K.M.1    Even-Ram, S.2
  • 31
    • 0025084503 scopus 로고
    • Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines
    • Fridman R, Giaccone G, Kanemoto T et al (1990) Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines. Proc Natl Acad Sci U S A 87:6698-6702
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 6698-6702
    • Fridman, R.1    Giaccone, G.2    Kanemoto, T.3
  • 32
    • 0033032317 scopus 로고    scopus 로고
    • Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
    • Sethi T, Rintoul RC, Moore SM et al (1999) Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med 5:662-668
    • (1999) Nat Med , vol.5 , pp. 662-668
    • Sethi, T.1    Rintoul, R.C.2    Moore, S.M.3
  • 33
    • 3142554541 scopus 로고    scopus 로고
    • Fibronectin alters cell survival and intracellular signaling of confluent A549 cultures after irradiation
    • Cordes N, Beinke C (2004) Fibronectin alters cell survival and intracellular signaling of confluent A549 cultures after irradiation. Cancer Biol Ther 3:47-53
    • (2004) Cancer Biol Ther , vol.3 , pp. 47-53
    • Cordes, N.1    Beinke, C.2
  • 34
    • 0036990102 scopus 로고    scopus 로고
    • Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells
    • Mueller MM, Fusenig NE (2002) Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells. Differentiation 70:486-497
    • (2002) Differentiation , vol.70 , pp. 486-497
    • Mueller, M.M.1    Fusenig, N.E.2
  • 36
    • 0035823238 scopus 로고    scopus 로고
    • Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
    • Puthalakath H, Villunger A, O'Reilly LA et al (2001) Bmf: A proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science 293:1829-1832
    • (2001) Science , vol.293 , pp. 1829-1832
    • Puthalakath, H.1    Villunger, A.2    O'Reilly, L.A.3
  • 37
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja A, Rodriguez-Viciana P, Wennstrom S et al (1997) Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16:2783-2793
    • (1997) EMBO J , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3
  • 38
    • 27644439209 scopus 로고    scopus 로고
    • Anoikis
    • Gilmore AP (2005) Anoikis. Cell Death Differ 12[Suppl 2]:1473-1477
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1473-1477
    • Gilmore, A.P.1
  • 39
    • 0037133640 scopus 로고    scopus 로고
    • Integrins regulate the apoptotic response to DNA damage through modulation of p53
    • Lewis JM, Truong TN, Schwartz MA (2002) Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc Natl Acad Sci U S A 99:3627-3632
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3627-3632
    • Lewis, J.M.1    Truong, T.N.2    Schwartz, M.A.3
  • 40
    • 0344825374 scopus 로고    scopus 로고
    • Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death
    • Hazlehurst LA, Landowski TH, Dalton WS (2003) Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death. Oncogene 22:7396-7402
    • (2003) Oncogene , vol.22 , pp. 7396-7402
    • Hazlehurst, L.A.1    Landowski, T.H.2    Dalton, W.S.3
  • 41
    • 0346157370 scopus 로고    scopus 로고
    • Tumor-stroma interaction of human pancreatic cancer: Acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins
    • Miyamoto H, Murakami T, Tsuchida K et al (2004) Tumor-stroma interaction of human pancreatic cancer: Acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas 28:38-44
    • (2004) Pancreas , vol.28 , pp. 38-44
    • Miyamoto, H.1    Murakami, T.2    Tsuchida, K.3
  • 42
    • 0033021996 scopus 로고    scopus 로고
    • Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death
    • Uhm JH, Dooley NP, Kyritsis AP et al (1999) Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death. Clin Cancer Res 5:1587-1594
    • (1999) Clin Cancer Res , vol.5 , pp. 1587-1594
    • Uhm, J.H.1    Dooley, N.P.2    Kyritsis, A.P.3
  • 43
    • 0034893416 scopus 로고    scopus 로고
    • Cell adhesion-mediated drug resistance (CAMDR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation
    • Damiano JS, Hazlehurst LA, Dalton WS (2001) Cell adhesion-mediated drug resistance (CAMDR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia 15:1232-1239
    • (2001) Leukemia , vol.15 , pp. 1232-1239
    • Damiano, J.S.1    Hazlehurst, L.A.2    Dalton, W.S.3
  • 44
    • 4844231863 scopus 로고    scopus 로고
    • XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
    • Cao C, Mu Y, Hallahan DE, Lu B (2004) XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. Oncogene 23:7047-7052
    • (2004) Oncogene , vol.23 , pp. 7047-7052
    • Cao, C.1    Mu, Y.2    Hallahan, D.E.3    Lu, B.4
  • 45
    • 33644778551 scopus 로고    scopus 로고
    • Beta 1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury
    • Cordes N, Seidler J, Durzok R et al (2006) Beta 1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. Oncogene 25:1378-1390
    • (2006) Oncogene , vol.25 , pp. 1378-1390
    • Cordes, N.1    Seidler, J.2    Durzok, R.3
  • 46
    • 48149105146 scopus 로고    scopus 로고
    • Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells
    • Serebriiskii I, Castello-Cros R, Lamb A et al (2008) Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol 27:573-585
    • (2008) Matrix Biol , vol.27 , pp. 573-585
    • Serebriiskii, I.1    Castello-Cros, R.2    Lamb, A.3
  • 47
    • 0346118914 scopus 로고    scopus 로고
    • Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway
    • Fornaro M, Plescia J, Chheang S et al (2003) Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway. J Biol Chem 278:50402-50411
    • (2003) J Biol Chem , vol.278 , pp. 50402-50411
    • Fornaro, M.1    Plescia, J.2    Chheang, S.3
  • 48
    • 0035958902 scopus 로고    scopus 로고
    • A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
    • Matter ML, Ruoslahti E (2001) A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription. J Biol Chem 276:27757-27763
    • (2001) J Biol Chem , vol.276 , pp. 27757-27763
    • Matter, M.L.1    Ruoslahti, E.2
  • 49
    • 0030961084 scopus 로고    scopus 로고
    • CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
    • Inohara N, Koseki T, Hu Y et al (1997) CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc Natl Acad Sci U S A 94:10717-10722
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10717-10722
    • Inohara, N.1    Koseki, T.2    Hu, Y.3
  • 50
    • 31544464931 scopus 로고    scopus 로고
    • Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways
    • Han S, Khuri FR, Roman J (2006) Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 66:315-323
    • (2006) Cancer Res , vol.66 , pp. 315-323
    • Han, S.1    Khuri, F.R.2    Roman, J.3
  • 51
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick NA, Neilson EG, Moses HL (2004) Stromal fibroblasts in cancer initiation and progression. Nature 432:332-337
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 52
    • 5444261094 scopus 로고    scopus 로고
    • The stroma reaction myofibroblast: A key player in the control of tumor cell behavior
    • Desmouliere A, Guyot C, Gabbiani G (2004) The stroma reaction myofibroblast: A key player in the control of tumor cell behavior. Int J Dev Biol 48:509-517
    • (2004) Int J Dev Biol , vol.48 , pp. 509-517
    • Desmouliere, A.1    Guyot, C.2    Gabbiani, G.3
  • 53
    • 34447309766 scopus 로고    scopus 로고
    • The myofibroblast: One function, multiple origins
    • Hinz B, Phan SH, Thannickal VJ et al (2007) The myofibroblast: One function, multiple origins. Am J Pathol 170:1807-1816
    • (2007) Am J Pathol , vol.170 , pp. 1807-1816
    • Hinz, B.1    Phan, S.H.2    Thannickal, V.J.3
  • 54
    • 0036605996 scopus 로고    scopus 로고
    • Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model
    • Tuxhorn JA, McAlhany SJ, Dang TD et al (2002) Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model. Cancer Res 62:3298-3307
    • (2002) Cancer Res , vol.62 , pp. 3298-3307
    • Tuxhorn, J.A.1    McAlhany, S.J.2    Dang, T.D.3
  • 55
    • 57349113716 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/ FGFR-2 axis
    • Giulianelli S, Cerliani JP, Lamb CA et al (2008) Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. Int J Cancer 123:2518-2531
    • (2008) Int J Cancer , vol.123 , pp. 2518-2531
    • Giulianelli, S.1    Cerliani, J.P.2    Lamb, C.A.3
  • 56
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW et al (1999) Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res 59:5002-5011
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3
  • 57
    • 8444250723 scopus 로고    scopus 로고
    • Tumour-stroma interaction: Cancer-associated fibroblasts as novel targets in anti-cancer therapy?
    • Micke P, Ostman A (2004) Tumour-stroma interaction: Cancer-associated fibroblasts as novel targets in anti-cancer therapy? Lung Cancer 45[Suppl 2]:S163-175
    • (2004) Lung Cancer , vol.45 , Issue.SUPPL. 2
    • Micke, P.1    Ostman, A.2
  • 59
    • 0032544686 scopus 로고    scopus 로고
    • Tumor induction of VEGF promoter activity in stromal cells
    • Fukumura D, Xavier R, Sugiura T et al (1998) Tumor induction of VEGF promoter activity in stromal cells. Cell 94:715-725
    • (1998) Cell , vol.94 , pp. 715-725
    • Fukumura, D.1    Xavier, R.2    Sugiura, T.3
  • 60
    • 0031828004 scopus 로고    scopus 로고
    • The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1
    • Serini G, Bochaton-Piallat ML, Ropraz P et al (1998) The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873-881
    • (1998) J Cell Biol , vol.142 , pp. 873-881
    • Serini, G.1    Bochaton-Piallat, M.L.2    Ropraz, P.3
  • 61
    • 48249118837 scopus 로고    scopus 로고
    • Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression
    • Wang J, Yu W, Cai Y et al (2008) Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. Neoplasia 10:847-856
    • (2008) Neoplasia , vol.10 , pp. 847-856
    • Wang, J.1    Yu, W.2    Cai, Y.3
  • 62
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A, Gupta PB, Sgroi DC et al (2005) Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3
  • 63
    • 44849127372 scopus 로고    scopus 로고
    • The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis
    • Noma K, Smalley KS, Lioni M et al (2008) The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 134:1981-1993
    • (2008) Gastroenterology , vol.134 , pp. 1981-1993
    • Noma, K.1    Smalley, K.S.2    Lioni, M.3
  • 64
    • 33745837774 scopus 로고    scopus 로고
    • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
    • Loeffler M, Kruger JA, Niethammer AG, Reisfeld RA (2006) Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest 116:1955-1962
    • (2006) J Clin Invest , vol.116 , pp. 1955-1962
    • Loeffler, M.1    Kruger, J.A.2    Niethammer, A.G.3    Reisfeld, R.A.4
  • 65
    • 34250876926 scopus 로고    scopus 로고
    • Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity
    • Shekhar MP, Santner S, Carolin KA, Tait L (2007) Direct involvement of breast tumor fibroblasts in the modulation of tamoxifen sensitivity. Am J Pathol 170:1546-1560
    • (2007) Am J Pathol , vol.170 , pp. 1546-1560
    • Shekhar, M.P.1    Santner, S.2    Carolin, K.A.3    Tait, L.4
  • 66
    • 16044364385 scopus 로고    scopus 로고
    • Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiationinduced apoptosis
    • Santana P, Pena LA, Haimovitz-Friedman A et al (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiationinduced apoptosis. Cell 86:189-199
    • (1996) Cell , vol.86 , pp. 189-199
    • Santana, P.1    Pena, L.A.2    Haimovitz-Friedman, A.3
  • 67
    • 23644445797 scopus 로고    scopus 로고
    • Engaging the vascular component of the tumor response
    • Fuks Z, Kolesnick R (2005) Engaging the vascular component of the tumor response. Cancer Cell 8:89-91
    • (2005) Cancer Cell , vol.8 , pp. 89-91
    • Fuks, Z.1    Kolesnick, R.2
  • 68
    • 52649143725 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
    • Bianco R, Rosa R, Damiano V et al (2008) Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells. Clin Cancer Res 14:5069-5080
    • (2008) Clin Cancer Res , vol.14 , pp. 5069-5080
    • Bianco, R.1    Rosa, R.2    Damiano, V.3
  • 69
    • 8544283077 scopus 로고    scopus 로고
    • Host acid sphingomyelinase regulates microvascular function not tumor immunity
    • Garcia-Barros M, Lacorazza D, Petrie H et al (2004) Host acid sphingomyelinase regulates microvascular function not tumor immunity. Cancer Res 64:8285-8291
    • (2004) Cancer Res , vol.64 , pp. 8285-8291
    • Garcia-Barros, M.1    Lacorazza, D.2    Petrie, H.3
  • 70
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • Moeller BJ, Cao Y, Li CY, Dewhirst MW (2004) Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 5:429-441
    • (2004) Cancer Cell , vol.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 71
    • 33745517944 scopus 로고    scopus 로고
    • HIF-1 and tumour radiosensitivity
    • Moeller BJ, Dewhirst MW (2006) HIF-1 and tumour radiosensitivity. Br J Cancer 95:1-5
    • (2006) Br J Cancer , vol.95 , pp. 1-5
    • Moeller, B.J.1    Dewhirst, M.W.2
  • 72
    • 33847793485 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death
    • Bonnaud S, Niaudet C, Pottier G et al (2007) Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. Cancer Res 67:1803-1811
    • (2007) Cancer Res , vol.67 , pp. 1803-1811
    • Bonnaud, S.1    Niaudet, C.2    Pottier, G.3
  • 73
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W, Giancotti FG (2004) Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5:816-826
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 74
    • 36849053853 scopus 로고    scopus 로고
    • Beta1 integrin as a molecular therapeutic target
    • Cordes N, Park CC (2007) Beta1 integrin as a molecular therapeutic target. Int J Radiat Biol 83:753-760
    • (2007) Int J Radiat Biol , vol.83 , pp. 753-760
    • Cordes, N.1    Park, C.C.2
  • 75
    • 33847382879 scopus 로고    scopus 로고
    • Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells
    • Hess F, Estrugo D, Fischer A et al (2007) Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells. Oncogene 26:1372-1384
    • (2007) Oncogene , vol.26 , pp. 1372-1384
    • Hess, F.1    Estrugo, D.2    Fischer, A.3
  • 76
    • 38449113305 scopus 로고    scopus 로고
    • Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance
    • Zutter MM (2007) Integrin-mediated adhesion: Tipping the balance between chemosensitivity and chemoresistance. Adv Exp Med Biol 608:87-100
    • (2007) Adv Exp Med Biol , vol.608 , pp. 87-100
    • Zutter, M.M.1
  • 77
    • 25144501954 scopus 로고    scopus 로고
    • Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model
    • Bisanz K, Yu J, Edlund M et al (2005) Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model. Mol Ther 12:634-643
    • (2005) Mol Ther , vol.12 , pp. 634-643
    • Bisanz, K.1    Yu, J.2    Edlund, M.3
  • 78
    • 32944469169 scopus 로고    scopus 로고
    • Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo
    • Park CC, Zhang H, Pallavicini M et al (2006) Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res 66:1526-1535
    • (2006) Cancer Res , vol.66 , pp. 1526-1535
    • Park, C.C.1    Zhang, H.2    Pallavicini, M.3
  • 79
    • 58149147360 scopus 로고    scopus 로고
    • Integrin agonists as adjuvants in chemotherapy for melanoma
    • Schwartz MA, McRoberts K, Coyner M et al (2008) Integrin agonists as adjuvants in chemotherapy for melanoma. Clin Cancer Res 14:6193-6197
    • (2008) Clin Cancer Res , vol.14 , pp. 6193-6197
    • Schwartz, M.A.1    McRoberts, K.2    Coyner, M.3
  • 80
    • 0037805549 scopus 로고    scopus 로고
    • Basement membranes: Structure, assembly and role in tumour angiogenesis
    • Kalluri R (2003) Basement membranes: Structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 3:422-433
    • (2003) Nat Rev Cancer , vol.3 , pp. 422-433
    • Kalluri, R.1
  • 81
    • 0142151097 scopus 로고    scopus 로고
    • Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    • Baluk P, Morikawa S, Haskell A et al (2003) Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol 163:1801-1815
    • (2003) Am J Pathol , vol.163 , pp. 1801-1815
    • Baluk, P.1    Morikawa, S.2    Haskell, A.3
  • 82
    • 20144385966 scopus 로고    scopus 로고
    • Type VII collagen is required for Ras-driven human epidermal tumorigenesis
    • Ortiz-Urda S, Garcia J, Green CL et al (2005) Type VII collagen is required for Ras-driven human epidermal tumorigenesis. Science 307:1773-1776
    • (2005) Science , vol.307 , pp. 1773-1776
    • Ortiz-Urda, S.1    Garcia, J.2    Green, C.L.3
  • 83
    • 42349086700 scopus 로고    scopus 로고
    • Targeting a tumor-specific laminin domain critical for human carcinogenesis
    • Tran M, Rousselle P, Nokelainen P et al (2008) Targeting a tumor-specific laminin domain critical for human carcinogenesis. Cancer Res 68:2885-2894
    • (2008) Cancer Res , vol.68 , pp. 2885-2894
    • Tran, M.1    Rousselle, P.2    Nokelainen, P.3
  • 84
    • 33746846469 scopus 로고    scopus 로고
    • Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness
    • Topczewska JM, Postovit LM, Margaryan NV et al (2006) Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness. Nat Med 12:925-932
    • (2006) Nat Med , vol.12 , pp. 925-932
    • Topczewska, J.M.1    Postovit, L.M.2    Margaryan, N.V.3
  • 85
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick NA, Chytil A, Plieth D et al (2004) TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303:848-851
    • (2004) Science , vol.303 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3
  • 86
    • 42449111736 scopus 로고    scopus 로고
    • Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    • Kim SY, Lee CH, Midura BV et al (2008) Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin Exp Metastasis 25:201-211
    • (2008) Clin Exp Metastasis , vol.25 , pp. 201-211
    • Kim, S.Y.1    Lee, C.H.2    Midura, B.V.3
  • 87
    • 21344441462 scopus 로고    scopus 로고
    • Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner
    • Guleng B, Tateishi K, Ohta M et al (2005) Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 65:5864-5871
    • (2005) Cancer Res , vol.65 , pp. 5864-5871
    • Guleng, B.1    Tateishi, K.2    Ohta, M.3
  • 88
    • 55749088215 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: Therapeutic implications and synergism with epidermal growth factor receptor inhibition
    • Fischer H, Taylor N, Allerstorfer S et al (2008) Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: Therapeutic implications and synergism with epidermal growth factor receptor inhibition. Mol Cancer Ther 7:3408-3419
    • (2008) Mol Cancer Ther , vol.7 , pp. 3408-3419
    • Fischer, H.1    Taylor, N.2    Allerstorfer, S.3
  • 89
    • 0037989982 scopus 로고    scopus 로고
    • A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
    • Scott AM, Wiseman G, Welt S et al (2003) A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res 9:1639-1647
    • (2003) Clin Cancer Res , vol.9 , pp. 1639-1647
    • Scott, A.M.1    Wiseman, G.2    Welt, S.3
  • 90
    • 2342640981 scopus 로고    scopus 로고
    • Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumorstromal interactions
    • Ohuchida K, Mizumoto K, Murakami M et al (2004) Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumorstromal interactions. Cancer Res 64:3215-3222
    • (2004) Cancer Res , vol.64 , pp. 3215-3222
    • Ohuchida, K.1    Mizumoto, K.2    Murakami, M.3
  • 91
    • 40749125285 scopus 로고    scopus 로고
    • Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation
    • Kadenhe-Chiweshe A, Papa J, McCrudden KW et al (2008) Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation. Mol Cancer Res 6:1-9
    • (2008) Mol Cancer Res , vol.6 , pp. 1-9
    • Kadenhe-Chiweshe, A.1    Papa, J.2    McCrudden, K.W.3
  • 92
    • 57849106330 scopus 로고    scopus 로고
    • PDGFC mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L et al (2009) PDGFC mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 15:21-34
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3
  • 93
    • 44449168998 scopus 로고    scopus 로고
    • Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin
    • Kabakov AE, Makarova YM, Malyutina YV (2008) Radiosensitization of human vascular endothelial cells through Hsp90 inhibition with 17-N-allilamino-17-demethoxygeldanamycin. Int J Radiat Oncol Biol Phys 71:858-865
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 858-865
    • Kabakov, A.E.1    Makarova, Y.M.2    Malyutina, Y.V.3
  • 94
    • 33749349945 scopus 로고    scopus 로고
    • Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent
    • Ramakrishnan V, Bhaskar V, Law DA et al (2006) Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol 5:273-286
    • (2006) J Exp Ther Oncol , vol.5 , pp. 273-286
    • Ramakrishnan, V.1    Bhaskar, V.2    Law, D.A.3
  • 95
    • 33846188062 scopus 로고    scopus 로고
    • Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin
    • Mulgrew K, Kinneer K, Yao XT et al (2006) Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin. Mol Cancer Ther 5:3122-3129
    • (2006) Mol Cancer Ther , vol.5 , pp. 3122-3129
    • Mulgrew, K.1    Kinneer, K.2    Yao, X.T.3
  • 96
    • 34249814899 scopus 로고    scopus 로고
    • Disruption of endothelial cell interactions with the novel HU177 cryptic collagen epitope inhibits angiogenesis
    • Cretu A, Roth JM, Caunt M et al (2007) Disruption of endothelial cell interactions with the novel HU177 cryptic collagen epitope inhibits angiogenesis. Clin Cancer Res 13:3068-3078
    • (2007) Clin Cancer Res , vol.13 , pp. 3068-3078
    • Cretu, A.1    Roth, J.M.2    Caunt, M.3
  • 97
    • 38149098569 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors
    • Delbaldo C, Raymond E, Vera K et al (2008) Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs 26:35-43
    • (2008) Invest New Drugs , vol.26 , pp. 35-43
    • Delbaldo, C.1    Raymond, E.2    Vera, K.3
  • 98
    • 34249087162 scopus 로고    scopus 로고
    • Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
    • Nabors LB, Mikkelsen T, Rosenfeld SS et al (2007) Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J Clin Oncol 25:1651-1657
    • (2007) J Clin Oncol , vol.25 , pp. 1651-1657
    • Nabors, L.B.1    Mikkelsen, T.2    Rosenfeld, S.S.3
  • 99
    • 58149329018 scopus 로고    scopus 로고
    • Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme
    • Veeravagu A, Liu Z, Niu G et al (2008) Integrin alphavbeta3-targeted radioimmunotherapy of glioblastoma multiforme. Clin Cancer Res 14:7330-7339
    • (2008) Clin Cancer Res , vol.14 , pp. 7330-7339
    • Veeravagu, A.1    Liu, Z.2    Niu, G.3
  • 100
    • 39049171151 scopus 로고    scopus 로고
    • A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo
    • Bhaskar V, Zhang D, Fox M et al (2007) A function blocking anti-mouse integrin alpha5beta1 antibody inhibits angiogenesis and impedes tumor growth in vivo. J Transl Med 5:61
    • (2007) J Transl Med , vol.5 , pp. 61
    • Bhaskar, V.1    Zhang, D.2    Fox, M.3
  • 101
    • 55349083640 scopus 로고    scopus 로고
    • Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors
    • He X, Fang L, Wang J et al (2008) Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res 68:8678-8686
    • (2008) Cancer Res , vol.68 , pp. 8678-8686
    • He, X.1    Fang, L.2    Wang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.