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Volumn 14, Issue 16, 2008, Pages 5069-5080

Vascular endothelial growth factor receptor-1 contributes to resistance to anti - epidermal growth factor receptor drugs in human cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; P70S6 KINASE; PHOSPHOTRANSFERASE; PLACENTAL GROWTH FACTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; ANTINEOPLASTIC AGENT; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 ((1 METHYLPIPERIDIN 4 YL)METHOXY)QUINAZOLIN 4 AMINE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; PIPERIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

EID: 52649143725     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-4905     Document Type: Article
Times cited : (129)

References (52)
  • 1
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: Towards the systems level
    • Citri A, Yarden Y. EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 2006;7:505-16.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 2
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005;5:341 -54.
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 3
    • 33746485766 scopus 로고    scopus 로고
    • Epidermal growth factor receptor targeting in cancer
    • Mendelsohn J, Baselga J. Epidermal growth factor receptor targeting in cancer. Semin Oncol 2006:33:369-85.
    • (2006) Semin Oncol , vol.33 , pp. 369-385
    • Mendelsohn, J.1    Baselga, J.2
  • 4
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005;23:2445-59.
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 5
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008:358:1160-74.
    • (2008) N Engl J Med , vol.358 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 6
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 7
    • 33750842076 scopus 로고    scopus 로고
    • Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogene-sis
    • Shibuya M. Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogene-sis. J Biochem Mol Biol 2006;39:469-78.
    • (2006) J Biochem Mol Biol , vol.39 , pp. 469-478
    • Shibuya, M.1
  • 8
    • 20944441857 scopus 로고    scopus 로고
    • Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
    • Fan F, Wey JS, McCarty MF, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005;24:2647-53.
    • (2005) Oncogene , vol.24 , pp. 2647-2653
    • Fan, F.1    Wey, J.S.2    McCarty, M.F.3
  • 9
    • 0029560298 scopus 로고
    • Melanoma cell lines express VEGF receptor KDR and respond to exogenously added VEGF
    • Liu B, Earl HM, Baban D. Melanoma cell lines express VEGF receptor KDR and respond to exogenously added VEGF, Biochem Biophys Res Commun 1995;217:721-7.
    • (1995) Biochem Biophys Res Commun , vol.217 , pp. 721-727
    • Liu, B.1    Earl, H.M.2    Baban, D.3
  • 10
    • 0035068834 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma
    • Strizzi L, Catalano A, Vianale G. Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma. J Pathol 2001;193:468-75.
    • (2001) J Pathol , vol.193 , pp. 468-475
    • Strizzi, L.1    Catalano, A.2    Vianale, G.3
  • 11
    • 0030969559 scopus 로고    scopus 로고
    • Fontanini G.Vignati S, Boldrini L, et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 1997;3:861-5.
    • Fontanini G.Vignati S, Boldrini L, et al. Vascular endothelial growth factor is associated with neovascularization and influences progression of non-small cell lung carcinoma. Clin Cancer Res 1997;3:861-5.
  • 12
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 13
    • 34547098129 scopus 로고    scopus 로고
    • Targeting hypoxia cell signaling for cancer therapy
    • Melillo G. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev 2007;26:341-52.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 341-352
    • Melillo, G.1
  • 14
    • 0027412319 scopus 로고    scopus 로고
    • Goldman CK, Kim J.Wong WL, King V, Brock T, Gillespie GY. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 1993:4:121-33.
    • Goldman CK, Kim J.Wong WL, King V, Brock T, Gillespie GY. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol Biol Cell 1993:4:121-33.
  • 15
    • 0031039923 scopus 로고    scopus 로고
    • Transforming growth factor α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP2-dependent DNA binding and transacti-vation
    • Gille J, Swerlick RA, Caughman SW. Transforming growth factor α-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP2-dependent DNA binding and transacti-vation. EMBO J 1997;16:750-9.
    • (1997) EMBO J , vol.16 , pp. 750-759
    • Gille, J.1    Swerlick, R.A.2    Caughman, S.W.3
  • 16
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • Perrotte P, Matsumoto T, Inoue K, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res1999;5:257-65.
    • Clin Cancer Res1999;5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 17
    • 0033818695 scopus 로고    scopus 로고
    • Antiangio-genic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor anti-sense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F, Bianco R, Damiano V, et al. Antiangio-genic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor anti-sense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000;6:3739-47.
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 18
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • Bruns CJ, Solorzano CC, Harbison MT et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000;60:2926-35.
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 19
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human Cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, et al. Inhibition of growth factor production and angiogenesis in human Cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 2001;7:1459-65.
    • (2001) Clin Cancer Res , vol.7 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 20
    • 0033636606 scopus 로고    scopus 로고
    • A mechanism for modulation of cellular responses to VEGF:activation of the integrins
    • ByzovaTV, Goldman CK, Pampori N, et al. A mechanism for modulation of cellular responses to VEGF:activation of the integrins. Mol Cell 2000:6:851-60.
    • (2000) Mol Cell , vol.6 , pp. 851-860
    • Byzova, T.V.1    Goldman, C.K.2    Pampori, N.3
  • 21
    • 0036530301 scopus 로고    scopus 로고
    • VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    • Dias S, Shmelkov SV, Lam G, Rafii S. VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 2002;99:2532-40.
    • (2002) Blood , vol.99 , pp. 2532-2540
    • Dias, S.1    Shmelkov, S.V.2    Lam, G.3    Rafii, S.4
  • 22
    • 0035160312 scopus 로고    scopus 로고
    • Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
    • Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Rev 2001;7:1194-201.
    • (2001) Nat Rev , vol.7 , pp. 1194-1201
    • Lyden, D.1    Hattori, K.2    Dias, S.3
  • 23
    • 0035915421 scopus 로고    scopus 로고
    • Insulinlike growth factor-l receptor signaling and resistance to trastuzumab (Herceptin)
    • LuY, Zi X, ZhaoY, Mascarenhas D, Pollak M. Insulinlike growth factor-l receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst (Bethesda) 2001;93:1852-7.
    • (2001) J Natl Cancer Inst (Bethesda) , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 24
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor activity of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
    • Viloria-Petit A, CrombetT Jothy S, et al. Acquired resistance to the antitumor activity of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res 2001;61:5090-101.
    • (2001) Cancer Res , vol.61 , pp. 5090-5101
    • Viloria-Petit, A.1    CrombetT Jothy, S.2
  • 25
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling Cancer Res 2002;62:200-7.
    • (2002) Cancer Res , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 26
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to anti-epidermal growth factor receptor therapy
    • Ciardiello F, Bianco R, Caputo R, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to anti-epidermal growth factor receptor therapy. Clin Cancer Res 2004;10:784-93.
    • (2004) Clin Cancer Res , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3
  • 27
    • 20644447818 scopus 로고    scopus 로고
    • Molecular determinants of cetuximab efficacy
    • Vallbohmer D, Zhang W, Gordon M, et al. Molecular determinants of cetuximab efficacy. J Clin Oncol 2005;23:3536-44.
    • (2005) J Clin Oncol , vol.23 , pp. 3536-3544
    • Vallbohmer, D.1    Zhang, W.2    Gordon, M.3
  • 28
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am 2004;18:1007-21.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 1007-1021
    • Ellis, L.M.1
  • 29
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR. Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 30
    • 0037115405 scopus 로고    scopus 로고
    • Carlomagno F.Vitagliano D, GuidaT, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002;62:7284-90.
    • Carlomagno F.Vitagliano D, GuidaT, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 2002;62:7284-90.
  • 31
    • 33846850223 scopus 로고    scopus 로고
    • Vandetanib (ZD6474): An orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis
    • Herbst RS, Heymach JV, O'Reilly MS, Onn A, Ryan AJ. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin Investig Drugs 2007;16:239-49.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 239-249
    • Herbst, R.S.1    Heymach, J.V.2    O'Reilly, M.S.3    Onn, A.4    Ryan, A.J.5
  • 32
    • 29144521942 scopus 로고    scopus 로고
    • Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer
    • Melisi D, Caputo R, DamianoV, et al. Zoledronic acid cooperates with a cyclooxygenase-2 inhibitor and gefitinib in inhibiting breast and prostate cancer. Endocr Relat Cancer 2005:12:1051-8.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 1051-1058
    • Melisi, D.1    Caputo, R.2    DamianoV3
  • 33
    • 6344278621 scopus 로고    scopus 로고
    • Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor
    • Errico M, Riccioni T, Iyer S, et al. Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor. J Biol Chem 2004;279:43929-39.
    • (2004) J Biol Chem , vol.279 , pp. 43929-43939
    • Errico, M.1    Riccioni, T.2    Iyer, S.3
  • 34
    • 0345304917 scopus 로고    scopus 로고
    • Allele-specific patterns of the mouse parathyroid hormone-related protein: Influences on cell adhesion and migration
    • Benelli R, Peissel B, Manenti G, et al. Allele-specific patterns of the mouse parathyroid hormone-related protein: influences on cell adhesion and migration. Oncogene 2003;22:7711-5.
    • (2003) Oncogene , vol.22 , pp. 7711-7715
    • Benelli, R.1    Peissel, B.2    Manenti, G.3
  • 35
    • 34347234200 scopus 로고    scopus 로고
    • The chemoinvasion assay: A method to assess tumor and endothelial cell invasion and its modulation
    • Albini A, Benelli R. The chemoinvasion assay: a method to assess tumor and endothelial cell invasion and its modulation. Nat Protoc 2007;2:504-11.
    • (2007) Nat Protoc , vol.2 , pp. 504-511
    • Albini, A.1    Benelli, R.2
  • 36
    • 34047250470 scopus 로고    scopus 로고
    • Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10
    • Bennett RD, MauerAS, Strehler EE. Calmodulin-like protein increases filopodia-dependent cell motility via up-regulation of myosin-10. J Biol Chem 2007;282:3205-12.
    • (2007) J Biol Chem , vol.282 , pp. 3205-3212
    • Bennett, R.D.1    Mauer, A.S.2    Strehler, E.E.3
  • 37
    • 0037616593 scopus 로고    scopus 로고
    • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
    • Bianco R, Shin I, Ritter CA, et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 2003;22:2812-22.
    • (2003) Oncogene , vol.22 , pp. 2812-2822
    • Bianco, R.1    Shin, I.2    Ritter, C.A.3
  • 38
    • 0141960451 scopus 로고    scopus 로고
    • Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    • She QB, Solit D, Basso A, Moasser MM. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Clin Cancer Res 2003;9:4340-6.
    • (2003) Clin Cancer Res , vol.9 , pp. 4340-4346
    • She, Q.B.1    Solit, D.2    Basso, A.3    Moasser, M.M.4
  • 39
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-43.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 40
    • 0037137612 scopus 로고    scopus 로고
    • Anthranilic acid amides: A novel class of antiangiogenic VEGF receptor kinase inhibitors
    • Manley PW, Furet P, Bold G. Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem 2002;45:5687-93.
    • (2002) J Med Chem , vol.45 , pp. 5687-5693
    • Manley, P.W.1    Furet, P.2    Bold, G.3
  • 41
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • PaoW, MillerVA, Politi KA, etal. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 42
    • 0032590011 scopus 로고    scopus 로고
    • PIK3CA is implicated as an oncogene in ovarian cancer
    • Shayesteh L, Lu Y, KuoWL, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999;21:99-102.
    • (1999) Nat Genet , vol.21 , pp. 99-102
    • Shayesteh, L.1    Lu, Y.2    KuoWL3
  • 43
    • 18844371753 scopus 로고    scopus 로고
    • PLC and PI3K pathways are important in the inhibition of EGF-in-duced cell migration by gefitinib ('Iressa', ZD1839)
    • ShienT, Doihara H, Hara H, et al. PLC and PI3K pathways are important in the inhibition of EGF-in-duced cell migration by gefitinib ('Iressa', ZD1839). Breast Cancer 2004;11:367-73.
    • (2004) Breast Cancer , vol.11 , pp. 367-373
    • Shien, T.1    Doihara, H.2    Hara, H.3
  • 44
    • 17944377486 scopus 로고    scopus 로고
    • Neshat MS, Mellinghoff IK.Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-9.
    • Neshat MS, Mellinghoff IK.Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A 2001;98:10314-9.
  • 45
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • Morgillo F, KimWY, Kim ES, Ciardiello F, HongWK, Lee HY. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007;13:2795-803.
    • (2007) Clin Cancer Res , vol.13 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.Y.2    Kim, E.S.3    Ciardiello, F.4    Hong, W.K.5    Lee, H.Y.6
  • 46
    • 2542591571 scopus 로고    scopus 로고
    • Regulation of p27Kip1 protein levels contributes to mito-genic effects of the RET/PTC kinase in thyroid carcinoma cells
    • Vitagliano D, Carlomagno F, Motti ML, etal. Regulation of p27Kip1 protein levels contributes to mito-genic effects of the RET/PTC kinase in thyroid carcinoma cells. Cancer Res 2004;64:3823-9.
    • (2004) Cancer Res , vol.64 , pp. 3823-3829
    • Vitagliano, D.1    Carlomagno, F.2    Motti, M.L.3
  • 47
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flfl, two receptors for vascular endothelial growth factor
    • Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Flfl, two receptors for vascular endothelial growth factor. J Biol Chem 1994:269:26988-95.
    • (1994) J Biol Chem , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 48
    • 0035114105 scopus 로고    scopus 로고
    • Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis
    • Hiratsuka S, Maru Y, Okada A, Seiki M, NodaT, Shibuya M. Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res 2001;61:1207-13.
    • (2001) Cancer Res , vol.61 , pp. 1207-1213
    • Hiratsuka, S.1    Maru, Y.2    Okada, A.3    Seiki, M.4    Noda, T.5    Shibuya, M.6
  • 50
    • 0035885932 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors
    • Masood R, Cai J, ZhengT Smith DL, Hinton DR, Gill PS. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood 2001;98:1904-13.
    • (2001) Blood , vol.98 , pp. 1904-1913
    • Masood, R.1    Cai, J.2    ZhengT Smith, D.L.3    Hinton, D.R.4    Gill, P.S.5
  • 51
    • 33745264885 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases
    • Lesslie DP, Summy JM, Parikh NU, et al. Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases. Br J Cancer 2006;94:1710-17.
    • (2006) Br J Cancer , vol.94 , pp. 1710-1717
    • Lesslie, D.P.1    Summy, J.M.2    Parikh, N.U.3
  • 52
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan RN, Ribal RD, Zacharoulis S, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005:438:820-7.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Ribal, R.D.2    Zacharoulis, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.