Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

Endocrinology

Volumn 141, Issue 6, 2000, Pages 1930-1935

  Egawa, Katsuya ^a,d   Nakashima, Naoki ^a   Sharma, Prem M ^a   Maegawa, Hiroshi ^d   Nagai, Yoshio ^d   Kashiwagi, Atsunori ^d   Kikkawa, Ryuichi ^d   Olefsky, Jerrold M ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; S6 KINASE; WORTMANNIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

EID: 0034455290     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.6.7516     Document Type: Article

References (21)

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