Chronic endothelln-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

Journal of Clinical Investigation

Volumn 107, Issue 9, 2001, Pages 1193-1202

  Ishibashi, Ken Ichi ^a   Imamura, Takeshi ^a   Sharma, Prem M ^a   Huang, Jie ^a   Ugi, Satoshi ^a   Olefsky, Jerrold M ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BQ 610; DEOXYGLUCOSE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; S6 KINASE; CBL PROTEIN; CBL PROTEIN, HUMAN; CBL PROTEIN, MOUSE; ENDOTHELIN A RECEPTOR; ENDOTHELIN RECEPTOR; GAB1 PROTEIN, MOUSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; GNAI2 PROTEIN, MOUSE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUSCLE PROTEIN; MUTASE; OLIGOPEPTIDE; ONCOPROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; SLC2A4 PROTEIN, MOUSE; SQUALENE HOPENE CYCLASE; SQUALENE-HOPENE CYCLASE; TYROSINE; UBIQUITIN PROTEIN LIGASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE TRANSLOCATION; GLUCOSE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; METABOLISM; MOUSE; PHOSPHORYLATION; TRANSPORT AT THE CELLULAR LEVEL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; DEOXYGLUCOSE; DRUG INTERACTIONS; ENDOTHELIN-1; GLUCOSE TRANSPORTER TYPE 4; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HETEROTRIMERIC GTP-BINDING PROTEINS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; INTRAMOLECULAR TRANSFERASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; OLIGOPEPTIDES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SIGNAL TRANSDUCTION; TYROSINE; UBIQUITIN-PROTEIN LIGASES;

EID: 0034744273     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11753     Document Type: Article

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