Regulation of neutrophil apoptosis by modulation of PKB/Akt activation

Frontiers in Bioscience

Volumn 14, Issue 7, 2009, Pages 2400-2412

  Rane, Madhavi J ^a,b   Klein, Jon B ^a,b,c  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Apoptosis; HSP27; Inflammation; MK2; Neutrophils; p38 MAPK; PDK1; PDK2; Pi 3k; PKB AKT; Review

Indexed keywords

PROTEIN KINASE B;

APOPTOSIS; CYTOLOGY; ENZYME ACTIVATION; HUMAN; METABOLISM; NEUTROPHIL; PHYSIOLOGY; REVIEW;

APOPTOSIS; ENZYME ACTIVATION; HUMANS; NEUTROPHILS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 63849157597     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3386     Document Type: Article

References (114)

1. Keatings, V., P. Collins, D. Scott and P. Barnes: Differences in interleukin-8 and tumor necrosis factoralpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. American journal of respiratory and critical care medicine 153 (2), 530-4. (1996).
2. Keatings, V.M. and P.J. Barnes: Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects. Am. J. Respir. Crit. Care Med., 155 (2), 449-453 (1997). (Pubitemid 27085784)
3. Hill, A., D. Bayley and R. Stockley: The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. American journal of respiratory and critical care medicine, 160 (3), 893-8. (1999). (Pubitemid 29442027)
4. Beeh, K.M., J. Beier, O. Kornmann and R. Buhl: Sputum matrix metalloproteinase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects. Respiratory Medicine, 97 (6), 634-639 (2003). (Pubitemid 36675664)
5. Corradi, M., P. Montuschi, L.E. Donnelly, A. Pesci, S.A. Kharitonov and P.J. Barnes: Increased nitrosothiols in exhaled breath condensate in inflammatory airwaydiseases. Am. J. Respir. Crit. Care Med., 163 (4), 854-858 (2001). (Pubitemid 32275854)
6. Morrison D, Rahman I, Lannan S, MacNee W.: Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. American journal of respiratory and critical care medicine, 159 (2), 473-9. ( 1999). (Pubitemid 29084868)
7. Akira, S. and K. Takeda: Toll-like receptor signalling. Nat Rev Immunol, 4 (7), 499-511 (2004). (Pubitemid 38931765)
8. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM, Haslett C.: Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83 (3), 865-75. (1989). (Pubitemid 19080618)
9. Klein, J.B., A. Buridi, P.Y. Coxon, M.J. Rane, T. Manning, R. Kettritz and K.R. McLeish: Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis. Cellular Signalling, 13 (5), 335-343 (2001). (Pubitemid 32448951)
10. Klein, J.B., M.J. Rane, J.A. Scherzer, P.Y. Coxon, R. Kettritz, J.M. Mathiesen, A. Buridi and K.R. McLeish: Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways. J Immunol, 164 (8), 4286-4291 (2000). (Pubitemid 30215090)
11. Arruda, M.A., A.G. Rossi, M.S. de Freitas, C. Barja-Fidalgo and A.V. Graca-Souza: Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3- kinase, MAPK, and NF-KB. J Immunol, 173 (3), 2023- 2030 (2004). (Pubitemid 38971639)
12. Jozsef, L., T. Khreiss and J.G. Filep: CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes. FASEB J., 04-2048fje (2004).
13. Perianayagam, M.C., V.S. Balakrishnan, A.J. King, B.J.G. Pereira and B.L. Jaber: C5a delays apoptosis of human neutrophils by a phosphatidylinositol 3-kinasesignaling pathway. Kidney Int, 61 (2), 456-463 (2002). (Pubitemid 34102585)
14. Selva, E., P. Brest, A. Loubat, S. Lassalle, P. Auberger and P. Hofman: Inhibition of apoptosis induced by heat shock preconditioning is associated with decreased phagocytosis in human polymorphonuclear leukocytes through inhibition of Rac and Cdc42. Immunol Cell Biol, 85 (3), 257-264 (2007). (Pubitemid 46701427)
15. van Zandbergen, G., J. Gieffers, H. Kothe, J. Rupp, A. Bollinger, E. Aga, M. Klinger, H. Brade, K. Dalhoff, M. Maass, W. Solbach and T. Laskay: Chlamydia pneumoniae multiply in neutrophil granulocytes and delay their spontaneous apoptosis. J Immunol, 172 (3), 1768-1776 (2004). (Pubitemid 38116825)
16. Chan, T.O. and P.N. Tsichlis: PDK2: A Complex Tail in One Akt. Sci. STKE, 2001 (66), pe1- (2001) '.
17. Franke, T.F., S.-I. Yang, T.O. Chan, K. Datta, A. Kazlauskas, D.K. Morrison, D.R. Kaplan and P.N. Tsichlis: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell, 81 (5), 727-736 (1995).
18. Alessi, D.R., S.R. James, C.P. Downes, A.B. Holmes, P.R.J. Gaffney, C.B. Reese and P. Cohen: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Current Biology, 7 (4), 261-269 (1997). (Pubitemid 27176852)
19. Rane, M.J., P.Y. Coxon, D.W. Powell, R. Webster, J.B. Klein, W. Pierce, P. Ping and K.R. McLeish: p38 Kinase-dependent MAPKAPK-2 Activation Functions as 3- Phosphoinositide-dependent Kinase-2 for Akt in Human Neutrophils. J. Biol. Chem., 276 (5), 3517-3523 (2001).
20. Burelout, C., P.H. Naccache and S.G. Bourgoin: Dissociation between the translocation and the activation of Akt in fMLP-stimulated human neutrophils-effect of prostaglandin E2. J Leukoc Biol, 81 (6), 1523-1534 (2007) doi:10.1189/jlb.0406256. (Pubitemid 46827975)
21. Filippa, N., C.L. Sable, C. Filloux, B. Hemmings and E. Van Obberghen: Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol. Cell. Biol., 19 (7), 4989-5000 (1999). (Pubitemid 29289538)
22. Konishi, H., H. Matsuzaki, M. Tanaka, Y. Takemura, S.i. Kuroda, Y. Ono and U. Kikkawa: Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Letters, 410 (2-3), 493-498 (1997). (Pubitemid 27304124)
23. Moule, S.K., G.I. Welsh, N.J. Edgell, E.J. Foulstone, C.G. Proud and R.M. Denton: Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta - adrenergic agonists in rat epididymal fat cells. Activation of protein kinase b by wortmannin-sensitive and - insensitive mechanisms. J. Biol. Chem., 272 (12), 7713- 7719 (1997). (Pubitemid 27137323)
24. Sable, C.L., N. Filippa, B. Hemmings and E. Van Obberghen: cAMP stimulates protein kinase B in a wortmannin-insensitive manner. FEBS Letters, 409 (2), 253-257 (1997). (Pubitemid 27273887)
25. Yano, S., H. Tokumitsu and T.R. Soderling: Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature, 396 (6711), 584-587 (1998). (Pubitemid 28563720)
26. Sasaki, K., M. Sato and Y. Umezawa: Fluorescent indicators for Akt/Protein Kinase B and dynamics of Akt activity visualized in living cells. J. Biol. Chem., 278 (33), 30945-30951 (2003). (Pubitemid 36994606)
27. Brunet, A., A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis and M.E. Greenberg: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell, 96 (6), 857-868 (1999). (Pubitemid 29165088)
28. Cardone, M.H., N. Roy, H.R. Stennicke, G.S. Salvesen, T.F. Franke, E. Stanbridge, S. Frisch and J.C. Reed: Regulation of cell death protease caspase-9 by phosphorylation. Science, 282 (5392), 1318-1321 (1998). (Pubitemid 28524494)
29. Cross, D.A.E., D.R. Alessi, P. Cohen, M. Andjelkovich and B.A. Hemmings: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature, 378 (6559), 785-789 (1995). (Pubitemid 26004411)
30. Crossley, L.J.: Neutrophil activation by fMLP regulates FOXO (forkhead) transcription factors by multiple pathways, one of which includes the binding of FOXO to the survival factor Mcl-1. J Leukoc Biol, 74 (4), 583-592 (2003) ]. (Pubitemid 38040386)
31. Datta, S.R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh and M.E. Greenberg: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91 (2), 231-241 (1997). (Pubitemid 27456390)
32. De Mesquita, D.D., Q. Zhan, L. Crossley and J.A. Badwey: p90-RSK and Akt may promote rapid phosphorylation/inactivation of glycogen synthase kinase 3 in chemoattractant-stimulated neutrophils. FEBS Letters, 502 (3), 84-88 (2001). (Pubitemid 32728265)
33. Du, K. and M. Montminy: CREB is a regulatory target for the protein kinase Akt/PKB. J. Biol. Chem., 273 (49), 32377-32379 (1998). (Pubitemid 28557606)
34. Gardai, S.J., D.A. Hildeman, S.K. Frankel, B.B. Whitlock, S.C. Frasch, N. Borregaard, P. Marrack, D.L. Bratton and P.M. Henson: Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J. Biol. Chem., 279 (20), 21085-21095 (2004). (Pubitemid 38656511)
35. Kim, A.H., G. Khursigara, X. Sun, T.F. Franke and M.V. Chao: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol. Cell. Biol., 21 (3), 893-901 (2001). (Pubitemid 32104737)
36. Nidai Ozes, O., L.D. Mayo, J.A. Gustin, S.R. Pfeffer, L.M. Pfeffer and D.B. Donner: NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401 (6748), 82-85 (1999).
37. Kim, A.H., T. Sasaki and M.V. Chao: JNK-interacting protein 1 promotes Akt1 activation. J. Biol. Chem., 278 (32), 29830-29836 (2003). (Pubitemid 36962371)
38. Kim, A.H., H. Yano, H. Cho, D. Meyer, B. Monks, B. Margolis, M.J. Birnbaum and M.V. Chao: Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron, 35 (4), 697-709 (2002). (Pubitemid 35223029)
39. Song, J.J. and Y.J. Lee: Dissociation of Akt1 from its negative regulator JIP1 is mediated through the ASK1- MEK-JNK signal transduction pathway during metabolic oxidative stress: a negative feedback loop. J. Cell Biol., 170 (1), 61-72 (2005). (Pubitemid 40994096)
40. Song, J.J. and Y.J. Lee: Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. J. Biol. Chem., 280 (29), 26845-26855 (2005). (Pubitemid 41040718)
41. Maurer, U., C. Charvet, A.S. Wagman, E. Dejardin and D.R. Green: Glycogen Synthase Kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell, 21 (6), 749-760 (2006). (Pubitemid 43376126)
42. Akgul, C., D.A. Moulding, M.R.H. White and S.W. Edwards: In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins. FEBS Letters, 478 (1-2), 72-76 (2000). (Pubitemid 30462261)
43. Kozopas, K.M., T. Yang, H.L. Buchan, P. Zhou and R.W. Craig: MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc Nat Acad of Sci 90 (8), 3516-3520 (1993). (Pubitemid 23111397)
44. Nechushtan A, Smith CL, Hsu YT, Youle RJ. : Conformation of the Bax C-terminus regulates subcellular location and cell death. EMBO J 9 (18), 2330-41 (1999). (Pubitemid 29213267)
45. Yamaguchi H, Baldridge, WH: The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change. Oncogene, 53 (20), 7779-86 (2001). (Pubitemid 33121951)
46. Datta, S.R., A. Katsov, L. Hu, A. Petros, S.W. Fesik, M.B. Yaffe and M.E. Greenberg: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell, 6 (1), 41-51 (2000).
47. Robey RB, Hay N: Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene, 34 (25), 4683-96 (2006). (Pubitemid 44187618)
48. Li, P., D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri and X. Wang: Cytochrome c and dATP-dependent formation of Apaf-1/Caspase-9 complex initiates an apoptotic protease cascade. Cell, 91 (4), 479- 489 (1997). (Pubitemid 27508237)
49. Jahani-Asl, A., A. Basak and B.K. Tsang: Caspase-3- mediated cleavage of Akt: Involvement of non-consensus sites and influence of phosphorylation. FEBS Letters, 581 (16), 2883-2888 (2007). (Pubitemid 46899030)
50. Xu, J., D. Liu and Z. Songyang: The role of Asp-462 in regulating Akt activity. J. Biol. Chem., 277 (38), 35561- 35566 (2002).
51. Perianayagam, M.C., N.E. Madias, B.J.G. Pereira and B.L. Jaber: CREB transcription factor modulates Bcl2 transcription in response to C5a in HL-60-derived neutrophils. Eur J Clin Inv, 36 (5), 353-361 (2006).
52. Modur, V., R. Nagarajan, B.M. Evers and J. Milbrandt: FOXO proteins regulate Tumor Necrosis Factor-related-apoptosis inducing ligand Expression. Implications for PTEN mutation in prostate cancer. J. Biol. Chem., 277 (49), 47928-47937 (2002). (Pubitemid 36159321)
53. Burgering, B.M.T. and G.J.P.L. Kops: Cell cycle and death control: long live Forkheads. Trends Biochem Sci 27 (7), 352-360 (2002). (Pubitemid 34756518)
54. Lehtinen, M.K., Z. Yuan, P.R. Boag, Y. Yang, J. Villen, E.B.E. Becker, S. DiBacco, N. de la Iglesia, S. Gygi, T.K. Blackwell and A. Bonni: A Conserved MSTFOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell, 125 (5), 987-1001 (2006). (Pubitemid 43795191)
55. Jang, S.-W., S.-J. Yang, S. Srinivasan and K. Ye: Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J. Biol. Chem., 282 (42), 30836-30844 (2007). (Pubitemid 350035233)
56. Abraham, E.: Alterations in cell signaling in sepsis. Clin Infect Dis, 41 (s7), S459-S464 (2005). (Pubitemid 41598306)
57. Mermel, C.H., M.L. McLemore, F. Liu, S. Pereira, J. Woloszynek, C.A. Lowell and D.C. Link: Src family kinases are important negative regulators of G-CSFdependent granulopoiesis. Blood, 108 (8), 2562-2568 (2006).
58. Al-Shami, A. and P.H. Naccache: Granulocytemacrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase. J. Biol. Chem., 274 (9), 5333-5338 (1999). (Pubitemid 29109175)
59. Gardai, S., B.B. Whitlock, C. Helgason, D. Ambruso, V. Fadok, D. Bratton and P.M. Henson: Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J. Biol. Chem., 277 (7), 5236-5246 (2002). (Pubitemid 34968567)
60. Chen, R., O. Kim, J. Yang, K. Sato, K.M. Eisenmann, J. McCarthy, H. Chen and Y. Qiu: Regulation of Akt/PKB activation by tyrosine phosphorylation. J. Biol. Chem., 276 (34), 31858-31862 (2001).
61. Conus, N.M., K.M. Hannan, B.E. Cristiano, B.A. Hemmings and R.B. Pearson: Direct Identification of Tyrosine 474 as a Regulatory Phosphorylation Site for the Akt Protein Kinase. J. Biol. Chem., 277 (41), 38021-38028 (2002). (Pubitemid 35154653)
62. Jiang, T. and Y. Qiu: Interaction between Src and a Cterminal proline-rich motif of Akt is required for Akt activation. J. Biol. Chem., 278 (18), 15789-15793 (2003). (Pubitemid 36799692)
63. Balendran, A., A. Casamayor, M. Deak, A. Paterson, P. Gaffney, R. Currie, C.P. Downes and D.R. Alessi: PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol, 9 (8), 393-404 (1999). (Pubitemid 29205782)
64. Toker, A. and A.C. Newton: Akt/Protein Kinase B is regulated by autophosphorylation at the hypothetical PDK- 2 Site. J. Biol. Chem., 275 (12), 8271-8274 (2000). (Pubitemid 30180163)
65. Delcommenne, M., C. Tan, V. Gray, L. Rue, J. Woodgett and S. Dedhar: Phosphoinositide-3-OH kinasedependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Nat Acad Sci, 95 (19), 11211-11216 (1998). (Pubitemid 28450107)
66. Troussard, A.A., N.M. Mawji, C. Ong, A. Mui, R. St.-Arnaud and S. Dedhar: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J. Biol. Chem., 278 (25), 22374- 22378 (2003). (Pubitemid 36830287)
67. Feng, J., J. Park, P. Cron, D. Hess and B.A. Hemmings: Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J. Biol. Chem., 279 (39), 41189-41196 (2004). (Pubitemid 39287721)
68. Hill, M.M., M. Andjelkovic, D.P. Brazil, S. Ferrari, D. Fabbro and B.A. Hemmings: Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase. J. Biol. Chem., 276 (28), 25643-25646 (2001).
69. Viniegra, J.G., N. Martinez, P. Modirassari, J.H. Losa, C.P. Cobo, V.J.S.-A. Lobo, C.I.A. Luquero, L. Alvarez-Vallina, S. Ramon y Cajal, J.M. Rojas and R. Sanchez-Prieto: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J. Biol. Chem., 280 (6), 4029-4036 (2005). (Pubitemid 40288566)
70. Hresko, R.C. and M. Mueckler: mTOR{middle dot}RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes. J. Biol. Chem., 280 (49), 40406- 40416 (2005). (Pubitemid 41780527)
71. Rane, M.J., Y. Pan, S. Singh, D.W. Powell, R. Wu, T. Cummins, Q. Chen, K.R. McLeish and J.B. Klein: Heat Shock Protein 27 controls apoptosis by regulating Akt activation. J. Biol. Chem., 278 (30), 27828-27835 (2003). (Pubitemid 36899975)
72. Nomura, M., A. Kaji, Z. He, W.-Y. Ma, K.-i. Miyamoto, C.S. Yang and Z. Dong: Inhibitory mechanisms of tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem., 276 (49), 46624-46631 (2001).
73. Nomura, M., A. Kaji, W.-Y. Ma, S. Zhong, G. Liu, G.T. Bowden, K.-i. Miyamoto and Z. Dong: Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J. Biol. Chem., 276 (27), 25558-25567 (2001).
74. Wang, Y., M.M. Zeigler, G.K. Lam, M.G. Hunter, T.D. Eubank, V.V. Khramtsov, S. Tridandapani, C.K. Sen and C.B. Marsh: The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am. J. Respir. Cell Mol. Biol., 36 (1), 68-77 (2007). (Pubitemid 46067709)
75. Xu, L., P.S. Pathak and D. Fukumura: Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin Cancer Res, 10 (2), 701-707 (2004). (Pubitemid 38174009)
76. Zhang QS, Maddock DA, Chen JP, Heo S, Chiu C, Lai D, Souza K, Mehta S, Wan YS Cytokine-induced p38 activation feedback regulates the prolonged activation of AKT cell survival pathway initiated by reactive oxygen species in response to UV irradiation in human keratinocytes. Int J Oncol, 5 (19), 1057-61 (2001).
77. Baudhuin, L.M., K.L. Cristina, J. Lu and Y. Xu: Akt Activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is eell-line specific. Mol Pharmacol, 62 (3), 660-671 (2002). (Pubitemid 36329385)
78. Bae, Y.-S., Y. Kim, J.C. Park, P.-G. Suh and S.H. Ryu: The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKCdependent Akt activation. J Leukoc Biol, 71 (2), 329-338 (2002).
79. Kotone-Miyahara, Y., K. Yamashita, K.-K. Lee, S. Yonehara, T. Uchiyama, M. Sasada and A. Takahashi: Short-term delay of Fas-stimulated apoptosis by GM-CSF as a result of temporary suppression of FADD recruitment in neutrophils: evidence implicating phosphatidylinositol 3- kinase and MEK1-ERK1/2 pathways downstream of classical protein kinase C. J Leukoc Biol, 76 (5), 1047-1056 (2004). (Pubitemid 39458716)
80. Das S, Bhattacharyya S, Ghosh S, Majumdar S:. TNF-alpha induced altered signaling mechanism in human neutrophil. Mol Cell Bioch, 1-2 (197), 97-108 (1999). (Pubitemid 29408082)
81. Pongracz, J., P. Webb, K. Wang, E. Deacon, O.J. Lunn and J.M. Lord: Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-delta. J. Biol. Chem., 274 (52), 37329-37334 (1999).
82. Ruvolo, P.P.: Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharm Res, 47 (5), 383-392 (2003). (Pubitemid 36379200)
83. Powell, D.J., E. Hajduch, G. Kular and H.S. Hundal: Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKC{zeta}-dependent mechanism. Mol. Cell. Biol., 23 (21), 7794-7808 (2003). (Pubitemid 37271476)
84. Hodgkinson CP, Sale EM, Sale GJ: Characterization of PDK2 activity against protein kinase B gamma. Biochemistry, 32 (41), 10351-9 (2002). (Pubitemid 34856461)
85. Zhu, D., H. Hattori, H. Jo, Y. Jia, K.K. Subramanian, F. Loison, J. You, Y. Le, M. Honczarenko, L. Silberstein and H.R. Luo: Deactivation of phosphatidylinositol 3, 4, 5- trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Nat Acad Sci, 103 (40), 14836- 14841 (2006). (Pubitemid 44527815)
86. Chen, Q., D.W. Powell, M.J. Rane, S. Singh, W. Butt, J.B. Klein and K.R. McLeish: Akt phosphorylates p47phox and mediates respiratory burst activity in human neutrophils. J Immunol, 170 (10), 5302-5308 (2003). (Pubitemid 36554765)
87. Kettritz, R., M. Choi, W. Butt, M. Rane, S. Rolle, F.C. Luft and J.B. Klein: Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils. J Am Soc Nephrol, 13 (7), 1740-1749 (2002). (Pubitemid 34700598)
88. Rane, M.J., D. Gozal, W. Butt, E. Gozal, W.M. Pierce, Jr., S.Z. Guo, R. Wu, A.D. Goldbart, V. Thongboonkerd, K.R. McLeish and J.B. Klein: {gamma}-Amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion. J Immunol, 174 (11), 7242- 7249 (2005). (Pubitemid 40705693)
89. Subramanian, K.K., Y. Jia, D. Zhu, B.T. Simms, H. Jo, H. Hattori, J. You, J.P. Mizgerd and H.R. Luo: Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood, 109 (9), 4028-4037 (2007). (Pubitemid 46641758)
90. Strassheim, D., J.-Y. Kim, J.-S. Park, S. Mitra and E. Abraham: Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol, 174 (12), 8064-8071 (2005). (Pubitemid 40806317)
91. Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v- Akt at the plasma membrane. Science, 5541 (294), 374- 80 (2001). (Pubitemid 32963405)
92. Chae, K.-S., M. Martin-Caraballo, M. Anderson and S.E. Dryer: Akt activation is necessary for growth factor-induced trafficking of functional KCa channels in developing parasympathetic neurons. J Neurophysiol, 93 (3), 1174-1182 (2005) doi:10.1152/jn.00796.2004. (Pubitemid 40283709)
93. Knobbe, C.B., J. Reifenberger, B. Blaschke and G. Reifenberger: Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. J. Natl. Cancer Inst., 96 (6), 483-486 (2004). (Pubitemid 38443652)
94. Ono, H., H. Sakoda, M. Fujishiro, M. Anai, A. Kushiyama, Y. Fukushima, H. Katagiri, T. Ogihara, Y. Oka, H. Kamata, N. Horike, Y. Uchijima, H. Kurihara and T. Asano: Carboxyterminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. Am J Physiol Cell Physiol, 293 (5), C1576-1585 (2007). (Pubitemid 350085642)
95. Charette, S.J., J.N. Lavoie, H. Lambert and J. Landry: Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol. Cell. Biol., 20 (20), 7602-7612 (2000).
96. Lambert, H., S.J. Charette, A.F. Bernier, A. Guimond and J. Landry: HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus. J. Biol. Chem., 274 (14), 9378-9385 (1999).
97. Bruey JM, Paul C, Fromentin A, Hilpert S, Arrigo AP, Solary E, Garrido C: Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene, 42 (19), 4855-63 (2000).
98. Garrido, C., A. Fromentin, B. Bonnotte, N. Favre, M. Moutet, A.-P. Arrigo, P. Mehlen and E. Solary: Heat Shock Protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res, 58 (23), 5495- 5499 (1998). (Pubitemid 28551136)
99. Garrido, C., P. Mehlen, A. Fromentin, A. Hammann, M. Assem, A.-P. Arrigo and B. Chauffert: Inconstant association between 27-kDa Heat-Shock Protein (Hsp27) content and doxorubicin resistance in human colon cancer cells. The doxorubicin-protecting effect of Hsp27. Eur J Bioch, 237 (3), 653-659 (1996).
100. Garrido, C., P. Ottavi, A. Fromentin, A. Hammann, A.-P. Arrigo, B. Chauffert and P. Mehlen: HSP27 as a mediator of confluence-dependent resistance to cell death induced by anticancer drugs. Cancer Res, 57 (13), 2661- 2667 (1997). (Pubitemid 27283777)
101. Mehlen, P., K. Schulze-Osthoff and A.-P. Arrigo: Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks fas/apo-1- and staurosporine-induced cell death. J. Biol. Chem., 271 (28), 16510-16514 (1996). (Pubitemid 26239003)
102. Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz-Latoud C, Gurbuxani S, Arrigo AP, Kroemer G, Solary E, Garrido C: Hsp27 negatively regulates cell death by interacting with cytochrome c. Nature Cell Biol, 9 (2), 645-52 (2000).
103. Garrido, C., J.-M. Bruey, A. Fromentin, A. Hammann, A.P. Arrigo and E. Solary: HSP27 inhibits cytochrome cdependent activation of procaspase-9. FASEB J., 13 (14), 2061-2070 (1999). (Pubitemid 29517636)
104. Pandey P, Farber R, Nakazawa A, Kumar S, Bharti A, Nalin C, Weichselbaum R, Kufe D, Kharbanda S: Hsp27 functions as a negative regulator of cytochrome cdependent activation of procaspase-3. Oncogene, 16 (19), 1975-81 (2000). (Pubitemid 30229410)
105. Voss, O.H., S. Batra, S.J. Kolattukudy, M.E. Gonzalez-Mejia, J.B. Smith and A.I. Doseff: Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J. Biol. Chem., 282 (34), 25088-25099 (2007). (Pubitemid 47347561)
106. Paul, C., F. Manero, S. Gonin, C. Kretz-Remy, S. Virot and A.-P. Arrigo: Hsp27 as a negative regulator of cytochrome c release. Mol. Cell. Biol., 22 (3), 816-834 (2002). (Pubitemid 34053061)
107. Gabai, V.L., K. Mabuchi, D.D. Mosser and M.Y. Sherman: Hsp72 and stress kinase c-jun N-terminal kinase regulate the Bid-dependent pathway in Tumor Necrosis Factor-induced apoptosis. Mol. Cell. Biol., 22 (10), 3415- 3424 (2002). (Pubitemid 34453981)
108. Parcellier, A., E. Schmitt, S. Gurbuxani, D. Seigneurin-Berny, A. Pance, A. Chantome, S. Plenchette, S. Khochbin, E. Solary and C. Garrido: HSP27 Is a ubiquitin-binding protein involved in IκB alpha proteasomal degradation. Mol. Cell. Biol., 23 (16), 5790- 5802 (2003). (Pubitemid 36951341)
109. Breitschopf, K., A.M. Zeiher and S. Dimmeler: Ubiquitin-mediated degradation of the proapoptotic active form of Bid. A functional consequence on apoptosis induction. J. Biol. Chem., 275 (28), 21648-21652 (2000). (Pubitemid 30481872)
110. Dimmeler, S., K. Breitschopf, J. Haendeler and A.M. Zeiher: Dephosphorylation targets Bcl-2 for ubiquitindependent degradation: A link between the apoptosome and the proteasome Pathway. J. Exp. Med., 189 (11), 1815- 1822 (1999). (Pubitemid 29272698)
111. Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S: Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J 24 (22), 6653-64 (2003). (Pubitemid 38009611)
112. Ley, R., K. Balmanno, K. Hadfield, C. Weston and S.J. Cook: Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem., 278 (21), 18811-18816 (2003). (Pubitemid 36799262)
113. Wu, R., H. Kausar, P. Johnson, D.E. Montoya-Durango, M. Merchant and M.J. Rane: Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J. Biol. Chem., 282 (30), 21598-21608 (2007). (Pubitemid 47195774)
114. Scheid, M.P. and J.R. Woodgett: PKB/AKT: functional insights from genetic models. Nat Rev Mol Cell Biol, 2 (10), 760-768 (2001). (Pubitemid 33679838)