Granulocyte-macrophage colony-stimulating factor delays neutrophil constitutive apoptosis through phosphoinositide 3-kinase and extracellular signal-regulated kinase pathways

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 4286-4291

  Klein, Jon B ^a,c   Rane, Madhavi J ^a   Scherzer, Janice A ^a   Coxon, Patricia Y ^a   Kettritz, Ralph ^b   Mathiesen, Jeanine M ^a   Buridi, Abdul ^a   McLeish, Kenneth R ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GENISTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; PHOSPHATIDYLINOSITOL 3 KINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034655090     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.4286     Document Type: Article

References (39)

1. 2. J. Leukocyte Biol. 52:269.
2. Savill, J., I. Dransfield, N. Hogg, and C. Haslett. 1990. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343:170.
3. Scheid, M. P., R. W. Lauener, and V. Duronio. 1995. Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem. J. 312:159.
4. Savill, J., and C. Haslett. 1995. Granulocyte clearance by apoptosis in the resolution of inflammation. Semin. Cell Biol. 6:385.
5. Whyte, M. K., J. Savill, L. C. Meagher, A. Lee, and C. Haslett. 1997. Coupling of neutrophil apoptosis to recognition by macrophages: coordinated acceleration by protein synthesis inhibitors. J. Leukocyte Biol. 62:195.
6. Kettritz, R., R. J. Falk, J. C. Jennette, and M. L. Gaido. 1997. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNFα-mediated apoptosis. J. Am. Soc. Nephrol. 8:1091.
7. Cox, G. 1996. IL-10 enhances resolution of pulmonary inflammation in vivo by promoting apoptosis of neutrophils. Am. J. Physiol. 271:L566.
8. Wei, S., J. H. Liu, P. K. Epling-Burnette, A. M. Gamero, D. Ussery, E. W. Pearson, M. E. Elkabani, J. I. Diaz, and J. Y. Djeu. 1996. Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J. Immunol. 157:5155.
9. Hebert, M. J., T. Takano, H. Holthofer, and H. R. Brady. 1996. Sequential morphologic events during apoptosis of human neutrophils: modulation by lipoxygenase-derived eicosanoids. J .Immunol. 157:3105.
10. Kettritz, R., M. L. Gaido, H. Haller, F. C. Luft, C. J. Jennette, and R. J. Falk. 1998. Interleukin-8 delays spontaneous and tumor necrosis factor-α-mediated apoptosis of human neutrophils. Kidney Int. 53:84.
11. Lee, A., M. K. Whyte, and C. Haslett. 1993. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J. Leukocyte Biol. 54:283.
12. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JUK-p38 MAP kinases on apoptosis. Science 270: 1326.
13. Widmann, C. 1998. Caspase-dependent cleavage of signaling proteins during apoptosis: a turn-off mechanism for anti-apoptotic signals. J. Biol. Chem. 273: 7141.
14. Jarpe, M. B., C. Widmann, C. Knall, T. K. Schlesinger, S. Gibson, T. Yujiri, G. R. Fanger, E. W. Gelfand, and G. L. Johnson. 1998. Anti-apoptotic versus pro-apoptotic signal transduction: checkpoints and stop signs along the road to death. Oncogens 17:1475.
15. Frasch, S. C., J. A. Nick, V. A. Fadok, D. L. Bratton, G. S. Worthen, and P. M. Henson. 1998. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J. Biol. Chem. 273:8389.
16. Wang, X., J. L. Martindale, Y. Liu, and N. J. Holbrook. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem. J. 333:291.
17. McLeish, K. R., C. Knall, R. A. Ward, P. Gerwins, P. Y. Coxon, J. B. Klein, and G. L. Johnson. 1998. Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF. J. Leukocyte Biol. 64:537.
18. Tilton, B., M. Andjelkovic, S. A. Didichenko, B. A. Hemmings, and M. Thelen. 1997. G-Protein-coupled receptors and Fcγ-receptors mediate activation of Akt/ protein kinase B in human phagocytes. J. Biol. Chem. 272:28096.
19. Klein, J. B., J. A. Scherzer, G. Harding, A. A. Jacobs, and K. R. McLeish. 1995. TNF-α stimulates increased plasma membrane guanine nucleotide binding protein activity in polymorphonuclear leukocytes [published erratum appears in 1995 J. Leukocyte Biol. 57:803.]. J. Leukocyte Biol. 57:500.
20. Kontos, C. D., T. P. Stauffer, W. P. Yang, J. D. York, L. Huang, M. A. Blanar, T. Meyer, and K. G. Peters. 1998. Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol. Cell. Biol. 18:4131.
21. Bondeva, T., L. Pirola, G. Bulgarelli-Leva, I. Rubio, R. Wetzker, and M. P. Wymann. 1998. Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK. Science 282:293.
22. Wymann, M. P., and L. Pirola. 1998. Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta 1436:127.
23. del Peso, L., M. Gonzalez-Garcia, C. Page, R. Herrera, and G. Nunez. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687.
24. Harada, H., B. Becknell, M. Wilm, M. Mann, L. J. Huang, S. S. Taylor, J. D. Scott, and S. J. Korsmeyer. 1999. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 3:413.
25. Datta, S. R., H. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231.
26. Savill, J. 1997. Apoptosis in resolution of inflammation. J. Leukocyte Biol. 61: 375.
27. Colotta, F., F. Re, N. Polentarutti, S. Sozzani, and A. Mantovani. 1992. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80:2012.
28. Sweeney, J. F., P. K. Nguyen, G. M. Omann, and D. B. Hinshaw. 1998. Lipopolysaccharide protects polymorphonuclear leukocytes from apoptosis via tyrosine phosphorylation-dependent signal transduction pathways. J. Surg. Res. 74:64.
29. Keel, M., U. Ungethum, U. Steckholzer, E. Niederer, T. Hartung, O. Trentz, and W. Ertel. 1997. Interleukin-10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood 90:3356.
30. Dransfield, I., A. M. Buckle, J. S. Savill, A. McDowall, C. Haslett, and N. Hogg. 1994. Neutrophil apoptosis is associated with a reduction in CD16 (FcγRIII) expression. J. Immunol. 153:1254.
31. Yousefi, S., D. R. Green, K. Blaser, and H. U. Simon. 1994. Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91:10868.
32. Berra, E., M. T. Diaz-Meco, and J. Moscat. 1998. The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway [published erratum appears in 1998 J. Biol. Chem. 273:16630.]. J. Biol. Chem. 273:10792.
33. Zundel, W., and A. Giaccia. 1998. Inhibition of the anti-apoptotic PI(3)K/Akt/ Bad pathway by stress. Genes Dev. 12:1941.
34. Yang, E., J. Zha, J. Jockel, L. H. Boise, C. B. Thompson, and S. J. Korsmeyer. 1995. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285.
35. Cardone, M. H., N. Roy, H. R. Stennicke, G. S. Salvesen, T. F. Franke, E. Stanbridge, S. Frisch, and J. C. Reed. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318.
36. Hawes, B. E., L. M. Luttrell, T. van Biesen, and R. J. Lefkowitz. 1996. Phosphatidylinositol 3-kinase is an early intermediate in the G βγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 271:12133.
37. Kilgour, E., I. Gout, and N. G. Anderson. 1996. Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways. Biochem. J. 315:517.
38. Knall, C., G. S. Worthen, and G. L. Johnson. 1997. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc. Natl. Acad. Sci. USA 94:3052.
39. McLeish, K. R., C. Knall, R. A. Ward, P. Gerwins., P. Y. Coxon, J. B. Klein, and G. L. Johnson. 1998. Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF. J. Leukocyte Biol. 64:537.