Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major

Molecular Microbiology

Volumn 71, Issue 6, 2009, Pages 1386-1401

  Murta, Silvane M F ^a,b   Vickers, Tim J ^a   Scott, David A ^a,c   Beverley, Stephen M ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 FORMYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID DERIVATIVE; FORMATE TETRAHYDROFOLATE LIGASE; METHYLENETETRAHYDROFOLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ARTICLE; DHCH1 GENE; ENZYME INHIBITION; EPISOME; FTL GENE; GENE; GENE SEGREGATION; GENETIC COMPLEMENTATION; GENETIC TRANSFECTION; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CLONING, MOLECULAR; FOLIC ACID ANTAGONISTS; GENE KNOCKOUT TECHNIQUES; GENES, ESSENTIAL; GENES, PROTOZOAN; LEISHMANIA MAJOR; LEUCOVORIN; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MUTATION; RECOMBINANT PROTEINS;

LEISHMANIA MAJOR; PROTOZOA;

EID: 62449213529     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2009.06610.x     Document Type: Article

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