The antiproliferative and cell cycle effects of 5,6,7,8-tetrahydro- N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 1, 1998, Pages 315-321

  Tonkinson, John L ^a,b   Habeck, Lillian L ^a   Toth, John E ^a   Mendelsohn, Laurane G ^a   Bewley, Jesse ^a   Shackelford, Katherine A ^a   Gates, Susan B ^a   Ray, James ^a   Chen, Victor J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Schleicher and Schuell Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6,7,8 TETRAHYDRO N 5,N 10 CARBONYLFOLIC ACID; HYPOXANTHINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE INHIBITOR; METHYLENETETRAHYDROFOLIC ACID; METHYLENETETRAHYDROFOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LYMPHATIC LEUKEMIA; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PURINE SYNTHESIS; PYRIMIDINE SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; DEOXYADENINE NUCLEOTIDES; DRUG SYNERGISM; ENZYME INHIBITORS; FOLIC ACID; HUMANS; HYPOXANTHINE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); THYMINE NUCLEOTIDES; TUMOR CELLS, CULTURED;

EID: 0032454658     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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