Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence

Journal of Biological Chemistry

Volumn 281, Issue 50, 2006, Pages 38150-38158

  Vickers, Tim J ^a   Orsomando, Giuseppe ^b   De La Garza, Rocío Díaz ^b   Scott, David A ^a   Kang, Song O ^a   Hanson, Andrew D ^b   Beverley, Stephen M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; GENES; GENETIC ENGINEERING; METABOLISM; SYNTHESIS (CHEMICAL);

GENES ENCODING; MUTANTS; REGULATORY DOMAIN; VACUOLES;

ENZYMES;

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); PTERIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; S ADENOSYLMETHIONINE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GROWTH; CHEMICAL ANALYSIS; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DELETION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; IN VITRO STUDY; LEISHMANIA; NONHUMAN; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA PRIMERS; GENES, PROTOZOAN; LEISHMANIA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MOLECULAR SEQUENCE DATA; MUTATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; VIRULENCE;

ESCHERICHIA COLI; EUKARYOTA; LEISHMANIA MAJOR; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 33845988740     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M608387200     Document Type: Article

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