The genome of the African trypanosome Trypanosoma brucei

Science

Volumn 309, Issue 5733, 2005, Pages 416-422

  Berriman, Matthew ^a   Ghedin, Elodie ^b,c   Hertz Fowler, Christiane ^a   Blandin, Gaëlle ^b   Renauld, Hubert ^a   Bartholomeu, Daniella C ^b   Lennard, Nicola J ^a   Caler, Elisabet ^b   Hamlin, Nancy E ^a   Haas, Brian ^b   Böhme, Ulrike ^a   Hannick, Linda ^b   Aslett, Martin A ^a   Shallom, Joshua ^b   Marcello, Lucio ^d   Hou, Lihua ^b   Wickstead, Bill ^e   Alsmark, U Cecilia M ^f   Arrowsmith, Claire ^a   Atkin, Rebecca J ^a   Barron, Andrew J ^a   Bringaud, Frederic ^g   Brooks, Karen ^a   Carrington, Mark ^h   Cherevach, Inna ^a   Chillingworth, Tracey Jane ^a   Churcher, Carol ^a   Clark, Louise N ^a   Corton, Craig H ^a   Cronin, Ann ^a   Davies, Rob M ^a   Doggett, Jonathon ^a   Djikeng, Appolinaire ^b   Feldblyum, Tamara ^b   Field, Mark C ^h   Fraser, Audrey ^a   Goodhead, Ian ^a   Hance, Zahra ^a   Harper, David ^a   Harris, Barbara R ^a   Hauser, Heidi ^a   Hostetler, Jessica ^b   Ivens, Al ^a   Jagels, Kay ^a   Johnson, David ^a   Johnson, Justin ^b   Jones, Kristine ^b   Kerhornou, Arnaud X ^a   Koo, Hean ^b   Larke, Natasha ^a   Landfear, Scott ⁱ   Larkin, Christopher ^b   Leech, Vanessa ^h   Line, Alexandra ^a   Lord, Angela ^a   MacLeod, Annette ^d   Mooney, Paul J ^a   Moule, Sharon ^a   Martin, David M A ^j   Morgan, Gareth W ^k   Mungall, Karen ^a   Norbertczak, Halina ^a   Ormond, Doug ^a   Pai, Grace ^b   Peacock, Chris S ^a   Peterson, Jeremy ^b   Quail, Michael A ^a   Rabbinowitsch, Ester ^a   Rajandream, Marie Adele ^a   Reitter, Chris ^h   Salzberg, Steven L ^b   Sanders, Mandy ^a   Schobel, Seth ^b   Sharp, Sarah ^a   Simmonds, Mark ^a   Simpson, Anjana J ^b   Tallon, Luke ^b   Turner, C Michael R ^l   Tait, Andrew ^d   Tivey, Adrian R ^a   Van Aken, Susan ^b   Walker, Danielle ^a   Wanless, David ^b   Wang, Shiliang ^b   White, Brian ^a   White, Owen ^b   Whitehead, Sally ^a   Woodward, John ^a   Wortman, Jennifer ^b   Adams, Mark D ^m   Embley, T Martin ^f   Gull, Keith ^e   Ullu, Elisabetta ⁿ   Barry, J David ^d   Fairlamb, Alan H ^j   Opperdoes, Fred ^o   Barrell, Barclay G ^a   Donelson, John E ^p   Hall, Neil ^a,b   Fraser, Claire M ^b   Melville, Sara E ^h   El Sayed, Najib M ^b,c   more..

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b J CRAIG VENTER INSTITUTE   (United States)

^c GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NEWCASTLE UNIVERSITY   (United Kingdom)

^g UNIVERSITÉ DE BORDEAUX   (France)

^h UNIVERSITY OF CAMBRIDGE   (United Kingdom)

ⁱ OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^j UNIVERSITY OF DUNDEE   (United Kingdom)

^k IMPERIAL COLLEGE LONDON   (United Kingdom)

^l UNIVERSITY OF GLASGOW   (United Kingdom)

^m CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^o DE DUVE INSTITUTE   (Belgium)

^p UNIVERSITY OF IOWA   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; DISEASES; DRUG PRODUCTS; METABOLISM; PROTEINS;

EUKARYOTIC ORGANISMS; TRYPANOSOMA BRUCEI; VARIANT SURFACE GLYCOPROTEINS (VSG);

GENES;

GLYCOPROTEIN;

GENOME;

AFRICA; AFRICAN TRYPANOSOMIASIS; ARTICLE; CHROMOSOME ANALYSIS; COMPARATIVE STUDY; CYTOSKELETON; ENDOCYTOSIS; EUKARYOTE; GENE EXPRESSION; GENE SEQUENCE; GENETIC RECOMBINATION; GENOME ANALYSIS; IMMUNE SYSTEM; LEISHMANIA MAJOR; LIVESTOCK; MAMMAL; METABOLISM; MOSAICISM; NONHUMAN; PRIORITY JOURNAL; PSEUDOGENE; TELOMERE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

EUKARYOTA; LEISHMANIA MAJOR; MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 22244441812     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112642     Document Type: Article

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57. We thank our colleagues at the Wellcome Trust Sanger Institute and the Institute for Genomic Research, colleagues in the T. brucei and Tritryp genome networks, and the Trypanosomatid research community for their support. We also thank K. Stuart, P. Myler, E. Worthey [Seattle Biomedical Research Institute (SBRI)], and B. Andersson (Karolinska Institutet) for helpful discussions of the manuscript and P. Myler and G. Aggarwal (SBRI) for preparation of Plate 3. Funding for this work was provided by the Wellcome Trust and a grant from the National Institute for Allergy and Infectious Diseases (NIAID) to N.M.E.-S. (AI43062). Funding for provision of DNA resources was provided by Wellcome Trust grants to S.E.M. (062513) and C.M.R.T. (062513). Funding for several T. brucei genome network and Tritryp genome meetings over the past decade was provided by the Burroughs Wellcome Fund, NIAID, the Wellcome Trust, and the World Health Organisation Special Programme for Research and Training in Tropical Diseases. Correspondence and requests for sequence data should be addressed to M.B. (mb4@sanger.acuk) or N.M.E.-S. (nelsayed@tigr.org). Requests for DNA resources should be addressed to S.E.M. (sm160@cam.ac.uk), and requests for updates or amendments to genome annotation should be directed to C.H.-F. (chf@sanger.acuk). All data sets and the genome sequence and annotation are available through GeneDB at www.genedb.org. Sequence data have been deposited at DNA Data Bank of Japan/European Molecular Biology Laboratory/ GenBank with consecutive accession numbers CP000066 to CP000071 for chromosomes 3 to 8 and project accession numbers AAGZ00000000, AAHA00000000, and AAHB0000000 for the whole-chromosome shotgun projects of chromosomes 9 to 11. The versions of chromosomes 9 to 11 described in this paper are the first versions, AAGZ01000000, AAHA01000000, and AAHB01000000, and unassembled contigs (overlapping contiguous sequences) have accession number CR940345.