Genetic manipulation of kinetoplastida

Parasitology Today

Volumn 15, Issue 9, 1999, Pages 372-378

  Clayton, C E ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOSOME RNA; TETRACYCLINE;

CRITHIDIA; FLAGELLATE; GENE EXPRESSION; GENETIC MANIPULATION; GENETIC TRANSFECTION; GENETIC TRANSFORMATION; LEISHMANIA; NONHUMAN; PHENOTYPE; REPORTER GENE; REVIEW; RNA PROCESSING; TRYPANOSOMA;

ANIMALS; CHROMOSOMES, ARTIFICIAL, YEAST; CRITHIDIA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC MARKERS; KINETOPLASTIDA; LEISHMANIA; PLASMIDS; TRANSFECTION; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

KINETOPLASTIDA;

EID: 0033198238     PISSN: 01694758     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-4758(99)01498-2     Document Type: Review

References (58)

1. Bellofatto V., Cross G.A.M. Expression of a bacterial gene in a trypanosomatid protozoan. Science. 244:;1167-1169.
2. de Lafaille M.A.C., Laban A., Wirth D.F. Gene expression in Leishmania: analysis of essential 5′ DNA sequences. Proc. Natl. Acad. Sci. U. S. A. 89:1992;2703-2707.
3. Hotz H-R.et al. Mechanisms of developmental regulation in Trypanosoma brucei: a polypyrimidine tract in the 3′-untranslated region of a trypanosome surface protein mRNA affects RNA abundance and translation. Nucleic Acids Res. 25:1997;3017-3025.
4. Ghedin E.et al. Inducible expression of suicide genes in Leishmania donovani amastigotes. J. Biol. Chem. 273:1998;22997-23003.
5. Uliana S.R.et al. Structural and functional characterization of the Leishmania amazonensis ribosomal RNA promoter. Mol. Biochem. Parasitol. 76:1996;245-255.
6. Tyler-Cross R.et al. Transient expression mediated by the Trypanosoma cruzi rRNA promoter. Mol. Biochem. Parasitol. 72:1995;23-31.
7. Wirtz L.E., Hartmann C., Clayton C.E. Gene expression mediated by bacteriophage T3 and T7 RNA polymerases in transgenic trypanosomes. Nucleic Acids Res. 22:1994;3887-3894.
8. Kelly J.M.et al. A shuttle vector which facilitates the expression of transfected genes in Trypanosoma cruzi and Leishmania. Nucleic Acids Res. 20:1992;3963-3969.
9. Biebinger S., Clayton C.E. A plasmid shuttle vector bearing an rRNA promoter is extrachromosomally maintained in Crithidia fasciculata. Exp. Parasitol. 83:1996;252-258.
10. Kelly J.M.et al. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase: sensitivity towards agents that are thought to induce oxidative stress. Eur. J. Biochem. 218:1993;29-37.
11. Wong A.K., Curotto de Lafaille C., Wirth D.F. Identification of a cis-acting gene regulatory element from the lemdr locus of Leishmania enriettii. Proc. Natl. Acad. Sci. U. S. A. 269:1994;26497-26502.
12. Martinez-Calvillo S., Lopez I., Hernandez R. pRIBOTEX expression vector: a pTEX derivative for a rapid selection of Trypanosoma cruzi transfectants. Gene. 199:1997;71-76.
13. ten Asbroek A.L.M.A.et al. Stable transformation of Trypanosoma brucei. Mol. Biochem. Parasitol. 59:1993;133-142.
14. Biebinger S.et al. The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context. Nucleic Acids Res. 24:1996;1202-1211.
15. Patnaik P.K. Studies with artificial extrachromosomal elements in trypanosomatids: could specificity in the initiation of DNA replication be linked to that in transcription? Parasitol. Today. 13:1997;468-471.
16. Kelly J.M. Trypanosomatid shuttle vectors: new tools for the functional dissection of parasite genomes. Parasitol. Today. 11:1995;447-451.
17. Eid J.E., Sollner-Webb B. Homologous recombination in the tandem calmodulin genes of Trypanosoma brucei yields multiple products: compensation for deleterious deletions by gene amplification. Genes. Dev. 5:1991;2024-2032.
18. Blundell P.A., Rudenko G., Borst P. Targeting of exogenous DNA into Trypanosoma brucei requires a high degree of homology between donor and target DNA. Mol. Biochem. Parasitol. 76:1996;215-230.
19. McAndrew M.et al. Testing promoter activity in the trypanosome genome: isolation of a metacyclic-type VSG promoter, and unexpected insights into RNA polymerase II transcription. Exp. Parasitol. 90:1998;65-76.
20. Wirtz E., Hoek M., Cross G.A.M. Regulated processive transcription of chromatin by T7 RNA polymerase in Trypanosoma brucei. Nucleic Acids Res. 26:1998;4626-4634.
21. Lee M.G., Axelrod Y.E.N. Construction of trypanosome artificial mini-chromosomes. Nucleic Acids Res. 23:1995;4893-4899.
22. Patnaik P.K.et al. Artificial linear mini-chromosomes for Trypanosoma brucei. Nucleic Acids Res. 24:1996;668-675.
23. Ray D.S., Hines C. Disruption of the Crithidia fasciculata RNH1 gene results in the loss of two active forms of ribonuclease H. Nucleic Acids Res. 23:1995;2526-2530.
24. Gueiros-Filho F.J., Beverley S.M. Selection against the dihydrofolate reductase-thymidylate synthase (DHFR-TS) locus as a probe of genetic alterations in Leishmania major. Mol. Cell. Biol. 16:1996;5655-5663.
25. Lorenz P.et al. Elongation and clustering of glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p. EMBO J. 17:1998;3542-3555.
26. Mottram J.C.et al. Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana. Mol. Microbiol. 22:1996;573-582.
27. Ajioka J., Swindle J. The calmodulin-ubiquitin genes of Trypanosoma cruzi are essential for parasite viability. Mol. Biochem. Parasitol. 78:1996;217-225.
28. Wiese M. A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host. EMBO J. 17:1998;2619-2628.
29. Dumas C.et al. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. EMBO J. 16:1997;2590-2598.
30. Wirtz L.E., Clayton C.E. Inducible gene expression in trypanosomes mediated by a procaryotic repressor. Science. 268:1995;1179-1183.
31. Biebinger S., Wirtz L.E., Clayton C.E. Vectors for inducible over-expression of potentially toxic gene products in bloodstream and procyclic Trypanosoma brucei. Mol. Biochem. Parasitol. 85:1997;99-112.
32. Valdes J.et al. The viral thymidine kinase gene as a tool for the study of mutagenesis in Trypanosoma brucei. Nucleic Acids Res. 24:1996;1809-1815.
33. Blattner J.et al. Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism. Proc. Natl. Acad. Sci. U. S. A. 95:1998;11596-11600.
34. Wirtz E.et al. A tightly regulated inducible expression system for gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol. 99:1999;89-102.
35. Dale E.C., Ow D.W. Gene transfer with subsequent removal of the selection gene from the host genome. Proc. Natl. Acad. Sci. U. S. A. 88:1991;10558-10562.
36. Tovar J.et al. Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival. Proc. Natl. Acad. Sci. U. S. A. 95:1998;5311-5316.
37. Tovar J., Fairlamb A.H. Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi. Nucleic Acids Res. 24:1996;2942-2949.
38. Zhang W.W., Matlashewski G. Loss of virulence in Leishmania donovani deficient in an amastigote-specific protein, A2. Proc. Natl. Acad. Sci. U. S. A. 94:1997;8807-8811.
39. Bastin P., Sherwin T., Gull K. Paraflagellar rod is vital for trypanosome motility. Nature. 391:1998;548.
40. Fire A.et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 391:1998;806-811.
41. Ngo H.et al. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A. 95:1998;14687-14692.
42. Ryan K.A.et al. Isolation of virulence genes directing surface glycosyl-phosphatidylinositol synthesis by functional complementation of Leishmania. Proc. Natl. Acad. Sci. U. S. A. 90:1993;8609-8613.
43. Sommer J.M.et al. Cloning by functional complementation in Trypanosoma brucei. Mol. Biochem. Parasitol. 76:1996;83-90.
44. Kelly J.M., Das P., Tomas A.M. An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector. Mol. Biochem. Parasitol. 65:1994;51-62.
45. Gueiros-Filho F.J., Beverley S.M. Trans-kingdom transposition of the Drosophila element mariner within the protozoon Leishmania. Science. 276:1997;1716-1719.
46. Laban A.et al. Stable expression of the bacterial neor gene in Leishmania enriettii. Nature. 343:1990;572-574.
47. ten Asbroek A.L.M.A., Ouellette M., Borst P. Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. Nature. 348:1990;174-175.
48. Coburn C.M.et al. Stable DNA transfection of a wide range of trypanosomatids. Mol. Biochem. Parasitol. 46:1991;169-180.
49. Cruz A.K., Titus R., Beverley S.M. Plasticity in chromosome number and testing of essential genes in Leishmania by targeting. Proc. Natl. Acad. Sci. U. S. A. 90:1993;1599-1603.
50. Lee M.G-S., Van der Ploeg L.H.T. The hygromycin B-resistance gene as a selectable marker for stable transformation of Trypanosoma brucei. Gene. 105:1991;255-257.
51. Freedman D.J., Beverley S.M. Two more independent selectable markers for stable transfection of Leishmania. Mol. Biochem. Parasitol. 62:1993;37-44.
52. Jefferies D.et al. The ble resistance gene as a new selectable marker for Trypanosoma brucei: fly transmission of stable procyclic transformants to produce antibiotic resistant bloodstream forms. Nucleic Acids Res. 21:1993;191-195.
53. Ruepp S.et al. Survival of Trypanosoma brucei in the tsetse fly is enhanced by the expression of specific forms of procyclin. J. Cell Biol. 137:1997;1369-1379.
54. Joshi P.B.et al. The gene encoding streptothricin acetyltransferase (sat) as a selectable marker for Leishmania expression vectors. Gene. 156:1995;145-149.
55. Hehl A.et al. Expression of GARP, a major surface glycoprotein of Trypanosoma congolense, on the surface of Trypanosoma brucei: characterization and use as a selectable marker. Mol. Biochem. Parasitol. 70:1995;45-58.
56. Ha D.S.et al. Use of the green fluorescent protein as a marker in transfected Leishmania. Mol. Biochem. Parasitol. 77:1996;57-64.
57. LeBowitz J.H., Cruz A., Beverley S.M. Thymidine kinase as a negative selectable marker in Leishmania major. Mol. Biochem. Parasitol. 51:1992;321-326.
58. Buckner F.S., Wilson A.J., Van Voorhis W.C. Trypanosoma cruzi: use of herpes simplex virus-thymidine kinase as a negative selectable marker. Exp. Parasitol. 86:1997;171-180.