Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 5, 2008, Pages 1448-1453

  Cavazzuti, Antonio ^a   Paglietti, Giuseppe ^b   Hunter, William N ^c   Gamarro, Francisco ^d   Piras, Sandra ^b   Loriga, Mario ^b   Alleca, Sergio ^b   Corona, Paola ^b   McLuskey, Karen ^c   Tulloch, Lindsay ^c   Gibellini, Federica ^a,c   Ferrari, Stefania ^a   Costi, Maria Paola ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF SASSARI   (Italy)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Antifolates; Antitrypanosomatid agents; Drug discovery

Indexed keywords

ANTIPARASITIC AGENT; CELL PROTEIN; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR; FOLIC ACID ANTAGONIST; PROTEIN PTR1; PTERIDINE REDUCTASE INHIBITOR; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; ANTITRYPANOSOMAL AGENT; FOLIC ACID; ISONIPECOTIC ACID; METHYL 1 (4 ((2,4 DIAMINOPTERIDIN 6 YLMETHYL)METHYLAMINO)BENZOYL)PIPERIDINE 4 CARBOXYLATE; METHYL 1 (4 (2,4 DIAMINOPTERIDIN 6 YLMETHYLAMINO)BENZOYL)PIPERIDINE 4 CARBOXYLATE; METHYL 1-(4-((2,4-DIAMINOPTERIDIN-6-YLMETHYL)METHYLAMINO)BENZOYL)PIPERIDINE-4-CARBOXYLATE; METHYL 1-(4-(2,4-DIAMINOPTERIDIN-6-YLMETHYLAMINO)BENZOYL)PIPERIDINE-4-CARBOXYLATE; OXIDOREDUCTASE; PROTOZOAL PROTEIN; PTERIDINE DERIVATIVE; PTERIDINE REDUCTASE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME INHIBITION; ENZYME SUBSTRATE; LEISHMANIA MAJOR; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; SCREENING TEST; TRYPANOSOMA CRUZI; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; DRUG SENSITIVITY; ENZYMOLOGY; X RAY CRYSTALLOGRAPHY;

LEISHMANIA MAJOR; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

ANIMALS; ANTIPROTOZOAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FOLIC ACID; ISONIPECOTIC ACIDS; LEISHMANIA MAJOR; OXIDOREDUCTASES; PARASITIC SENSITIVITY TESTS; PROTOZOAN PROTEINS; PTERIDINES; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 40349108458     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0704384105     Document Type: Article

References (41)