Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages

EMBO Journal

Volumn 16, Issue 10, 1997, Pages 2590-2598

  Dumas, Carole ^a   Ouellette, Marc ^a   Tovar, Jorge ^a   Cunningham, Mark L ^a   Fairlamb, Alan H ^a   Tamar, Samira ^a   Olivier, Martin ^a   Papadopoulou, Barbara ^a  

^a NONE

Author keywords

Gene targeting; Intracellular survival; Leishmania; Oxidative stress; Trypanothione reductase

Indexed keywords

MESSENGER RNA; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; TRYPANOTHIONE;

ARTICLE; GENE DISRUPTION; GENE TRANSLOCATION; LEISHMANIA; MACROPHAGE; MARKER GENE; NONHUMAN; OXIDATIVE STRESS; PHYSIOLOGY; PRIORITY JOURNAL;

ANIMALS; GENES, PROTOZOAN; GENETIC ENGINEERING; GENETIC MARKERS; HUMANS; KANAMYCIN KINASE; LEISHMANIA; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; MACROPHAGES; MICE; MUTAGENESIS; NADH, NADPH OXIDOREDUCTASES; OXIDATIVE STRESS; PHENOTYPE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SELECTION (GENETICS); SUPEROXIDES;

KINETOPLASTIDA; LEISHMANIA DONOVANI; LEISHMANIA MAJOR; PROTOZOA; TRYPANOSOMATIDAE;

EID: 0030926411     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.10.2590     Document Type: Article

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