Blood-brain barrier models

Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport

Volumn , Issue , 2007, Pages 29-55

  Deli, M A ^a  

^a INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

[No Author keywords available]

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EID: 60949097805     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-30380-2_2     Document Type: Chapter

References (174)

1. Abbott NJ. 2000. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol Neurobiol 20:131-147.
2. Abbott NJ. 2002. Astrocyte-endothelial interactions and the blood-brain barrier permeability. J Anat 200:629-638.
3. Abbott NJ. 2005. Dynamics of CNS barriers: Evolution, differentiation and modulation. Cell Mol Neurobiol 25:5-23.
4. Abbott NJ, Hughes C C W, Revest PA, Greenwood J. 1992. Development and characterisation of a rat brain capillary endothelial culture: Towards an in vitro blood-brain barrier. J Cell Sci 103:23-37.
5. Abbott NJ, Rönnbäck L, Hansson E. 2006. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41-53.
6. Abbruscato TJ, Davis TP. 1999. Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity. J Pharmacol Exp Ther 289:668-675.
7. Abulrob A, Sprong H, Van Bergen en Henegouwen P, Stanimirovic D. 2005. The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells. J Neurochem 95:1201-1214.
8. Alt C, Duvefelt K, Franzen B, Yang Y, Engelhardt B. 2005. Gene and protein expression profiling of the microvascular compartment in experimental autoimmune encephalomy-elitis in C57Bl/6 and SJL mice. Brain Pathol 15:1-16.
9. Annunziata P, Cioni C, Santonini R, Paccagnini E. 2002. Substance P antagonist blocks leakage and reduces activation of cytokine-stimulated rat brain endothelium. J Neuroimmunol 131:41-49.
10. Annunziata P, Cioni C, Toneatto S, Paccagnini E. 1998. HIV-1 gp120 increases the permeability of rat brain endothelium cultures by a mechanism involving substance P. AIDS 12:2377-2385.
11. Arthur FE, Shivers RR, Bowman PD. 1987. Astrocyte-mediated induction of tight junctions in brain capillary endothelium: An efficient in vitro model. Brain Res 433:155-159.
12. Badger JL, Stins MF, Kim KS. 1999. Citrobacter freundii invades and replicates in human brain microvascular endo-thelial cells. Infect Immun 67:4208-4215.
13. Banks WA. 1999. Physiology and pathology of the blood-brain barrier: Implications for microbial pathogenesis, drug delivery and neurodegenerative disorders. J Neurovirol 5:538-555.
14. Batrakova EV, Li S, Vinogradov SV, Alakhov VY, Miller DW, et al. 2001a. Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: Contributions of energy depletion and membrane fluidization. J Pharmacol Exp Ther 299:483-493.
15. Batrakova EV, Miller DW, Li S, Alakhov VY, Kabanov AV, et al. 2001b. Pluronic P85 enhances the delivery of digoxin to the brain: In vitro and in vivo studies. J Pharmacol Exp Ther 296:551-557.
16. Bauer HC, Bauer H. 2000. Neural induction of the blood-brain barrier: Still an enigma. Cell Mol Neurobiol 20:13-28.
17. Berezowski V, Landry C, Dehouck M-P, Cecchelli R, Fenart L. 2004. Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier. Brain Res 1018:1-9.
18. Boveri M, Berezowski V, Price A, Slupek S, Lenfant AM, et al. 2005. Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: Comparison between primary glial cells and C6 cell line. Glia 51:187-198.
19. Boveri M, Kinsner A, Berezowski V, Lenfant AM, Draing C, et al. 2006. Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: Role of pro-inflammatory cytokines and nitric oxide. Neuroscience 137:1193-1209.
20. Bowman PD, Betz AL, Wolinsky JS, Penny JB, Shivers RR, et al. 1981. Primary cultures of capillary endothelium from rat brain. In Vitro 17:353-362.
21. Bowman PD, Ennis SR, Rarey KE, Betz AL, Goldstein GW. 1983. Brain microvessel endothelial cells in tissue culture: A model for study of blood-brain barrier permeability. Ann Neurol 14:396-402.
22. Brightman MW, Reese TS. 1969. Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 40:648-677.
23. Brillault J, Berezowski V, Cecchelli R, Dehouck M-P. 2002. Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia. J Neurochem 83:807-817.
24. Brown J, Reading SJ, Jones S, Fitchett CJ, Howl J, et al. 2000. Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: A comparison with the human bladder cancer derived epithelial cell line T24/83. Lab Invest 80:37-45.
25. Brown RC, Mark KS, Egleton RD, Huber JD, Burroughs AR, et al. 2003. Protection against hypoxia-induced increase in blood-brain barrier permeability: Role of tight junction proteins and NFkB. J Cell Sci 116:693-700.
26. Brückener KE, el Bayâ A, Galla H-J, Schmidt MA. 2003. Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP. J Cell Sci 116:1837-1846.
27. Cecchelli R, Dehouck B, Descamps L, Fenart L, Buée-Scherrer V, et al. 1999. In vitro model for evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 36:165-178.
28. Cestelli A, Catania C, D'Agostino S, Di Liegro I, Licata L, et al. 2001. Functional feature of a novel model of blood brain barrier: Studies on permeation of test compounds. J Control Release 76:139-147.
29. Chen L, Kis B, Busija DW, Yamashita H, Ueta Y. 2005. Adre-nomedullin protects rat cerebral endothelial cells from oxi-dant damage in vitro. Regul Pept 130:27-34.
30. Chishty M, Reichel A, Siva J, Abbott NJ, Begley DJ. 2001. Affinity for the P-glycoprotein efflux pump at the blood-brain barrier may explain the lack of CNS side-effects of modern antihistamines. J Drug Target 9:223-228.
31. Chopineau J, Robert S, Fenart L, Cecchelli R, Lagoutte B, et al. 1998. Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood-brain barrier. J Control Release 56:231-237.
32. Coisne C, Dehouck L, Faveeuw C, Delplace Y, Miller F, et al. 2005. Mouse syngenic in vitro blood-brain barrier model: A new tool to examine inflammatory events in cerebral endo-thelium. Lab Invest 85:734-746.
33. Cucullo L, Hallene K, Dini G, Dal Toso R, Janigro D. 2004. Glycerophosphoinositol and dexamethasone improve transendothelial electrical resistance in an in vitro study of the blood-brain barrier. Brain Res 997:147-151.
34. de Boer AG, van der Sandt I C J, Gaillard PJ. 2003. The role of drug transporters at the blood-brain barrier. Annu Rev Pharmacol Toxicol 43:629-656.
35. de Vries HE, Blom-Roosemalen MC, de Boer AG, van Berkel TJ, Breimer DD, et al. 1996a. Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. J Pharmacol Exp Ther 277:1418-1423.
36. de Vries HE, Blom-Roosemalen MC, van Oosten M, de Boer AG, van Berkel TJ, et al. 1996b. The influence of cytokines on the integrity of the blood-brain barrier in vitro. J Neuroimmunol 64:37-43.
37. De Bault LE, Cancilla PA. 1980. Gamma-glutamyl transpepti-dase in isolated brain endothelial cells: Induction by glial cells in vitro. Science 207:653-655.
38. Dehouck M-P, Méresse S, Delorme P, Fruchart JC, Cecchelli R. 1990. An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro. J Neurochem 54:1798-1801.
39. Dehouck M-P, Méresse S, Dehouck B, Fruchart JC, Cecchelli R. 1992. In vitro reconstituted blood-brain barrier. J Control Release 21:81-92.
40. Deli MA. 2005. The role of blood-brain barrier in neurode-generative diseases. Molecular Bases of Neurodegeneration. Di Liegro I, Savettieri G, editors. Kerala, India: Research Signpost; pp. 137-161.
41. Deli MA, Abrahám CS, Kataoka Y, Niwa M. 2005. Permeability studies on in vitro blood-brain barrier models: Physiology, pathology, and pharmacology. Cell Mol Neurobiol 25:59-127.
42. Deli MA, ábrahám CS, Niwa M, Falus A. 2003. N, N-diethyl-2-[4-(phenylmethyl) phenoxy]-ethanamide increases the permeability of primary mouse cerebral endothelial cell monolayers. Inflamm Res 52:S39-S40.
43. Deli MA, Dehouck M-P, Ábrahám CS, Cecchelli R, Joó F. 1995a. Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cells: The early effects of 30, 50-cyclic adenosine monophosphate. Exp Physiol 80:675-678.
44. Deli MA, Dehouck M-P, Cecchelli R, Ábrahám CS, Joó F. 1995b. Histamine induces a selective albumin permeation through the blood-brain barrier in vitro. Inflamm Res 44:S56-S57.
45. Deli MA, Descamps L, Dehouck M-P, Cecchelli R, Joó F, et al. 1995c. Exposure of tumor necrosis factor a to the luminal membrane induces a delayed increase of permeability and formation of cytoplasmic actin stress fibers in brain capillary endothelial cells cocultured with astrocytes. J Neurosci Res 41:717-726.
46. Deli MA, Sakaguchi S, Nakaoke R, Abrahám CS, Takahata H, et al. 2000. PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrP (C). Neuroreport 11:3931-3936.
47. Descamps L, Cecchelli R, Torpier G. 1997. Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers. J Neuroimmunol 74:173-184.
48. Descamps L, Coisne C, Dehouck B, Cecchelli R, Torpier G. 2003. Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury. Glia 42:46-58.
49. Diaz CM, Penfold PL, Provis JM. 1998. Modulation of the resistance of a human endothelial cell line by human retinal glia. Aust N Z J Ophthalmol 26:S62-S64.
50. Dobbie MS, Hurst RD, Klein NJ, Surtees R A H. 1999. Upre-gulation of intracellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor-α in an in vitro model of the blood-brain barrier. Brain Res 830:330-336.
51. Dohgu S, Takata F, Yamauchi A, Nakagawa S, Egawa T, et al. 2005. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res 1038:208-215.
52. Doolittle ND, Abrey LE, Bleyer WA, Brem S, Davis TP, et al. 2005. New frontiers in translational research in neuro-oncology and the blood-brain barrier: Report of the tenth annualBlood- BrainBarrierDisruptionConsortiumMeeting. Clin Cancer Res 11:421-428.
53. Doolittle ND, Miner ME, Hall WA, Siegal T, Jerome E, et al. 2000. Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer 88:637-647.
54. Duport S, Robert F, Muller D, Grau G, Parisi L, et al. 1998. An in vitro blood-brain barrier model: Cocultures between endothelial cells and organotypic brain slice cultures. Proc Natl Acad Sci USA 95:1840-1845.
55. Dömötör E, Sipos I, Kittel A, Abbott NJ, Ádám-Vízi V. 1998. Improved growth of cultured brain microvascular endothelial cells on glass coated with a biological matrix. Neuro-chem Int 33:473-478.
56. Easton AS, Abbott JN. 2002. Bradykinin increases permeability by calcium and 5-lipoxygenase in the ECV304/C6 cell culture model of the blood-brain barrier. Brain Res 953:157-169.
57. El Hafny B, Bourre JM, Roux F. 1996. Synergistic stimulation of gamma-glutamyl transpeptidase and alkaline phospha-tase activities by retinoic acid and astroglial factors in immortalized rat brain microvessel endothelial cells. J Cell Physiol 167:451-460.
58. Enerson BE, Drewes LR. 2006. The rat blood-brain barrier transcriptome. J Cereb Blood Flow Metab 26:959-973.
59. Farkas A, Szatmári E, Orbók A, Wilhelm I, Wejksza K, et al. 2005. Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of beta-catenin in cerebral endothelial cells. J Neurosci Res 80:855-861.
60. Fenart L, Casanova A, Dehouck B, Duhem C, Slupek S, et al. 1999. Evaluation of effect of charge and lipid coatingon ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier. J Pharmacol Exp Ther 291:1017-1022.
61. Fillebeen C, Dehouck B, Benäissa M, Dhennin-Duthille I, Cecchelli R, et al. 1999. Tumor necrosis factor-α increases lactoferrin transcytosis through the blood-brain barrier. J Neurochem 73:2491-2500.
62. Fischer S, Clauss M, Wiesnet M, Renz D, Schaper W, et al. 1999. Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO. Am J Physiol Cell Physiol 276:C812-C820.
63. Fischer S, Renz D, Schaper W, Karliczek GF. 1995. In vitro effects of fentanyl, methohexital, and thiopental brain en-dothelial permeability. Anesthesiology 82:451-458.
64. Fischer S, Renz D, Schaper W, Karliczek GF. 2001. In vitro effects of dexamethasone on hypoxia-induced hyperperme-ability and expression of vascular endothelial growth factor. Eur J Pharmacol 411:231-243.
65. Franke H, Galla H-J, Beuckmann CT. 1999. An improved low-permeability in vitro-model of the blood-brain barrier: Transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol. Brain Res 818:65-71.
66. Franzen B, Duvefelt K, Jonsson C, Engelhardt B, Ottervald J, et al. 2003. Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-alpha. Brain Res Mol Brain Res 115:130-146.
67. Gaillard PJ, de Boer AB, Breimer DD. 2003. Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. Microvasc Res 65:24-31.
68. Gaillard PJ, de Boer AG. 2000. Relationship between permeability status of the blood-brain barrier and in vitro permeability coefficient of a drug. Eur J Pharm Sci 12:95-102.
69. Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, et al. 2005. In vitro models for the blood-brain barrier. Toxicol. In Vitro 19:299-334.
70. Garcia CM, Darland DC, Massingham LJ, D'Amore PA. 2004. Endothelial cell-astrocyte interactions and TGF beta are required for induction of blood-neural barrier properties. Brain Res Dev Brain Res 152:25-38.
71. Ge S, Song L, Pachter JS. 2005. Where is the blood-brain barrier... really? J Neurosci Res 79:421-427.
72. Giese H, Mertsch K, Blasig IE. 1995. Effect of MK-801 and U83836E on a porcine brain capillary endothelial cell barrier during hypoxia. Neurosci Lett 191:169-172.
73. Girod J, Fenart L, Regina A, Dehouck M-P, Hong G, et al. 1999. Transport of cationized anti-tetanus Fab'2 fragments across an in vitro blood-brain barrier model: Involvement of the transcytosis pathway. J Neurochem 73:2002-2008.
74. Gloor SM, Weber A, Adachi N, Frei K. 1997. Interleukin-1 modulates protein tyrosine phosphatase activity and permeability of brain endothelial cells. Biochem Biophys Res Commun 239:804-809.
75. Grabb PA, Gilbert MR. 1995. Neoplastic and pharmacological influence on the permeability of an in vitro blood-brain barrier. J Neurosurg 82:1053-1058.
76. Greenwood J, Pryce G, Devine L, Male DK, dos Santos WL, et al. 1996. SV40 large immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics. J Neuroimmunol 71:51-63.
77. Gumbleton M, Audus KL. 2001. Progress andlimitationsinthe use ofinvitro cell cultures to serve as a permeability screen for the blood-brain barrier. J Pharm Sci 90:1681-1698.
78. Hamm S, Dehouck B, Kraus J, Wolburg-Buchholz K, Wolburg H, et al. 2004. Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res 315:157-166.
79. Hart MN, Van Dyk LF, Moore SA, Shasby DM, Cancilla PA. 1987. Differential opening of the brain endothelial barrier following neutralization of the endothelial luminal anionic charge in vitro. J Neuropathol Exp Neurol 46:141-153.
80. Haseloff RF, Blasig IE, Bauer H-C, Bauer H. 2005. In search of the astrocytic factor (s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro. Cell Mol Neurobiol 25:25-39.
81. Haseloff RF, Krause E, Bigl M, Mikoteit K, Stanimirovic D, et al. 2006. Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reox-ygenation. Proteomics 6:1803-1809.
82. Hayashi K, Nakao S, Nakaoke R, Nakagawa, S., Kitagawa, N., et al. 2004. Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier. Regul Pept 123:77-83.
83. Hoheisel D, Nitz T, Franke H, Wegener J, Hakvoort A, et al. 1998. Hydroocortisone reinforces the blood-brain barrier properties in a serum free cell culture system. Biochem Biophys Res Commun 247:312-315.
84. Hori S, Ohtsuki S, Hosoya K, Nakashima E, Terasaki T. 2004. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endo-thelial cells through Tie-2 activation in vitro. J Neurochem 89:503-513.
85. Hosoya K, Tetsuka K, Nagase K, Tomi M, Saeki S, et al. 2000. Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive simian virus 40 large T-antigen gene. AAPS Pharmsci 2(3):E27, pp. 1-11. [http://www.pharmsci.org]
86. Hudson LC, Bragg DC, Tompkins MB, Meeker RB. 2005. Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells. Brain Res 1058:148-160.
87. Hurst RD, Clark JB. 1997. Nitric oxide-induced blood-brain barrier dysfunction is not mediated by inhibition of mito-chondrial respiratory chain activity and/or energy depletion. Nitric Oxide 1:121-129.
88. Hurst RD, Clark JB. 1998. Alterations in transendothelial electrical resistance by vasoactive agonists and cyclic AMP in a blood-brain barrier model system. Neurochem Res 23:149-154.
89. Hurst RD, Clark JB. 1999. Butyric acid mediated induction of enhanced transendothelial resistance in an in vitro model blood-brain barrier system. Neurochem Int 35:261-267.
90. Hurst RD, Fritz IB. 1996. Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J Cell Physiol 167:81-88.
91. Hurst RD, Heales S J R, Dobbie MS, Barker JE, Clark JB. 1998. Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood-brain barrier model system. Brain Res 802:232-240.
92. Igarashi Y, Utsumi H, Chiba H, Yamada-Sasamori Y, Tobioka H, et al. 1999. Glial cell-line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier. Biochem Biophys Res Commun 261:108-112.
93. Jong AY, Stins MF, Huang S-H, Chen S H M, Kim KS. 2001. Traversal of Candida albicans across human blood-brain barrier in vitro. Infect Immun 69:4536-4544.
94. Joó F. 1985. The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain. Neurochem Int 7:1-25.
95. Joó F. 1992. The cerebral microvessels in culture, an update. J Neurochem 58:1-17.
96. Joó F. 1993. The blood-brain barrier in vitro: The second decade. Neurochem Int 23:499-521.
97. Joó F, Karnushina I. 1973. A procedure for the isolation of capillaries from rat brain. Cytobios 8:41-48.
98. KÁsa P, Pákáski M, Joó F, Lajtha A. 1991. Endothelial cells from human fetal brain microvessels may be cholinocep-tive, but do not synthesize acetylcholine. J Neurochem 56:2143-2146.
99. Kiessling F, Kartenbeck J, Haller C. 1999. Cell-cell contacts in the human cell line ECV304 exhibit both endothelial and epithelial characteristics. Cell Tissue Res 297:131-140.
100. Kim JA, Tran ND, Li Z, Yang F, Zhou W, et al. 2006. Brain endothelial hemostasis regulation by pericytes. J Cereb Blood Flow Metab 26:209-217.
101. Kis B, Deli MA, Kobayashi H, Abrahám CS, Yanagita T, et al. 2001. Adrenomedullin regulates blood-brain barrier functions in vitro. Neuroreport 12:4139-4142.
102. Kondo T, Kinouchi H, Kawase M, Yoshimoto T. 1996. Astro-glial cells inhibit the increasing permeability of brain endo-thelial cell monolayer following hypoxia/reoxygenation. Neurosci Lett 208:101-104.
103. Krizanac-Bengez L, Kapural M, Parkinson F, Cucullo L, Hossain M, et al. 2003. Effects of transient loss of shear stress on blood-brain barrier endothelium: Role of nitric oxide and IL-6. Brain Res 977:239-246.
104. Krizanac-Bengez L, Mayberg MR, Cunningham E, Hossain M, Ponnampalam S, et al. 2006. Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model. J Cell Physiol 206:68-77.
105. Krizbai IA, Deli MA. 2003. Signalling pathways regulating the tight junction permeability in the blood-brain barrier. Cell Mol Biol (Noisy-le-grand) 49:23-31.
106. Kusch-Poddar M, Drewe J, Fux I, Gutmann H. 2005. Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier. Brain Res 1064:21-31.
107. Kusuhara H, Sugiyama Y. 2001a. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1). Drug Discov Today 6:150-156.
108. Kusuhara H, Sugiyama Y. 2001b. Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 2). Drug Discov Today 6:206-212.
109. Kusuhara H, Suzuki H, Naito M, Tsuruo T, Sugiyama Y. 1998. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. J Pharmacol Exp Ther 285:1260-1265.
110. Lee S-W, Kim WJ, Choi YK, Song HS, Son M. J., et al. 2003. SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med 9:900-906.
111. Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, et al. 2002. Human immunodeficiency virus type 1 enters brain micro-vascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 76:6689-6700.
112. Lundquist S, Renftel M, Brillault J, Fenart L, Cecchelli R, et al. 2002. Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro cell models. Pharm Res 19:976-981.
113. Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, et al. 1999. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res 16:1360-1365.
114. Mark KS, Burroughs AR, Brown RC, Huber JD, Davis TP. 2004. Nitric oxide mediates hypoxia-induced changes in paracellular permeability of cerebral microvasculature. Am J Physiol Heart Circ Physiol 286:H174-H180.
115. Mathieu C, Fouchet P, Gauthier LR, Lassalle B, Boussin FD, et al. 2006. Coculture with endothelial cells reduces the population of cycling LeX neural precursors but increases that of quiescent cells with a side population phenotype. Exp Cell Res 312:707-718.
116. Miller F, Fenart L, Landry V, Coisne C, Cecchelli R, et al. 2005. The MAP kinase pathway mediates transcytosis induced by TNF-alpha in an in vitro blood-brain barrier model. Eur J Neurosci 22:835-844.
117. Muruganandam A, Tanha J, Narang S, Stanimirovic D. 2002. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood-brain barrier endothelium. FASEB J 16:240-242.
118. Nakaoke R, Ryerse JS, Niwa M, Banks WA. 2005. Human immunodeficiency virus type 1 transport across the in vitro mouse brain endothelial cell monolayer. Exp Neurol 193:101-109.
119. Neuwelt EA, Rapoport SI. 1984. Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors. Fed Proc 43:214-219.
120. Nitz T, Eisenblatter T, Psathaki K, Galla H-J. 2003. Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro. Brain Res 981:30-40.
121. Omidi Y, Campbell L, Barar J, Connell D, Akhtar S, et al. 2003. Evaluation of the immortalised mouse brain capillary en-dothelial cell line, b. End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res 990:95-122.
122. Panula P, Joó F, Rechardt L. 1978. Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brain. Experientia 34:95-97.
123. Pardridge WM. 2002. Drug and gene targeting to brain with molecular Trojan horses. Nat Rev Drug Discov 1:131-139.
124. Parkinson FE, Friesen J, Krizanac-Bengez L, Janigro D. 2003. Use of three-dimensional in vitro model of the rat blood-brain barrier to assay nucleoside efflux from brain. Brain Res 980:233-241.
125. Parkinson FE, Hacking C. 2005. Pericyte abundance affects sucrose permeability in cultures of rat brain microvascular endothelial cells. Brain Res 1049:8-14.
126. Perrière N, Demeuse P, Garcia E, Regina A, Debray M, et al. 2005. Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties. J Neurochem 93:279-289.
127. Plateel M, Dehouck M-P, Torpier G, Cecchelli R, Teissier E. 1995. Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer. J Neurochem 65:2138-2145.
128. Plateel M, Teissier E, Cecchelli R. 1997. Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain. J Neurochem 68:874-877.
129. Preston JE, Hipkiss AR, Himsworth DT, Romero IA, Abbott JN. 1998. Toxic effects of beta-amyloid (25-35) onimmortalised rat brain endothelial cell: Protection by car-nine, homocarnosine and beta-alanine. Neurosci Lett 242:105-108.
130. Raub TJ. 1996. Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions. Am J Physiol Cell Physiol 271:C495-C503.
131. Raub TJ, Kuentzel SL, Sawada GA. 1992. Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells. Exp Cell Res 199:330-340.
132. Ramsohoye PV, Fritz IB. 1998. Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model. Neurochem Res 23:1545-1551.
133. Reese TS, Karnovsky MJ. 1967. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 34:207-217.
134. Reichel A, Begley DJ, Abbott NJ. 2003. An overview of in vitro techniques for blood-brain barrier studies. The Blood-Brain Barrier: Biology and Research Protocols. Nag S, editor. Methods in Molecular Medicine, Vol. 89. Totowa, NJ: Humana Press.
135. Romero IA, Prevost M-C, Perret E, Adamson P, Greenwood J, et al. 2000. Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: Mechanisms of viral entry into the central nervous system. J Virol 74:6021-6030.
136. Romero IA, Radewicz K, Jubin E, Michel CC, Greenwood J, et al. 2003. Changes in cytoskeletal and tight junctional proteins correlate with decreased permeability induced by dexamethasone in cultured rat brain endothelial cells. Neurosci Lett 344:112-116.
137. Roux F, Couraud P-O. 2005. Rat brain endothelial cell lines for the study of blood-brain barrier permeability and transport functions. Cell Mol Neurobiol 25:41-58.
138. Rubin LL, Hall DE, Porter S, Barbu K, Cannon C, et al. 1991. A cell culture model of the blood-brain barrier. J Cell Biol 115:1725-1735.
139. Rubin LL, Staddon JM. 1999. The cell biology of the blood-brain barrier. Annu Rev Neurosci 22:11-28.
140. Rutten MJ, Hoover RL, Karnovsky MJ. 1987. Electrical resistance and macromolecular permeability of brain endothe-lial monolayer cultures. Brain Res 425:301-310.
141. Sahagun G, Moore SA, Hart MN. 1990. Permeability of neutral vs. anionic dextrans in cultured brain microvascular endothelium. Am J Physiol 259:H162-H166.
142. Sakaeda T, Siahaan TJ, Audus KL, Stella VJ. 2000. Enhancement of transport of D-melphalan analogue by conjugation with L-glutamate across bovine brain microvessel endothe-lial cell monolayers. J Drug Target 8:195-204.
143. Schiera G, Bono E, Raffa MP, Gallo A, Pitarresi GL, et al. 2003. Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture. J Cell Mol Med 7:165-170.
144. Schiera G, Sala S, Gallo A, Raffa MP, Pitarresi GL, et al. 2005. Permeability properties of a three-cell type in vitro model of blood-brain barrier. J Cell Mol Med 9:373-379.
145. Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, et al. 2004. Endothelial cells stimulate self-renewal and expand neuro-genesis of neural stem cells. Science 304:1338-1340.
146. Smith KR, Borchardt RT. 1989. Permeability and mechanism of albumin, cationized albumin, and glycosylated albumin transcellular transport across monolayers of cultured bovine brain capillary endothelial cells. Pharm Res 6:466-473.
147. Sobue K, Yamamoto N, Yoneda K, Hodgson ME, Yamashiro K, et al. 1999. Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors. Neurosci Res 35:155-164.
148. Song HS, Son MJ, Lee YM, Kim WJ, Stanness KA, Neumaier JF, Sexton TJ, Grant GA, Emmi A, et al. 1999. A new model of the blood-brain barrier: Co-culture of neuronal, endothelial, and glial cells under dynamic conditions. Neuroreport 10:3725-3731.
149. Stins MF, Badger J, Kim KS. 2001. Bacterial invasion and transcytosis in transfected human brain microvascular en-dothelial cells. Microb Pathog 30:19-28.
150. Strazielle N, Ghersi-Egea JF, Ghiso J, Dehouck M-P, Frangione B, et al. 2000. In vitro evidence that beta-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability. J Neuropathol Exp Neurol 59:29-38.
151. Suda K, Rothen-Rutishauser B, Gunthert M, Wunderli-Allenspach H. 2001. Phenotypic characterization of human umbilical vein endothelial (ECV304) and urinary carcinoma (T24) cells: Endothelial versus epithelial features. In Vitro Cell Dev Biol Anim 37:505-514.
152. Tan KH, Dobbie MS, Felix RA, Barrand MA, Hurst RD. 2001. A comparison of the induction of immortalized endothelial cell impermeability by astrocytes. Neuroreport 12:1329-1334.
153. Tao-Cheng JH, Nagy Z, Brightman MW. 1987. Tight junctions of brain endothelium in vitro are enhanced by astro-glia. J Neurosci 7:3293-3299.
154. Terasaki T, Ohtsuki S, Hori S, Takanaga H, Nakashima E, et al. 2003. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov Today 8:944-954.
155. Tilling T, Korte D, Hoheisel D, Galla H-J. 1998. Basement membrane proteins influence brain capillary endothelial barrier function in vitro. J Neurochem 71:1151-1157.
156. Tilloy S, Monnaert V, Fenart L, Bricout H, Cecchelli R, et al. 2006. Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier. Bioorg Med Chem Lett 16:2154-2157.
157. Trottein F, Descamps L, Nutten S, Dehouck M-P, Angeli V, et al. 1999. Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype. Infect Immun 67:3403-3409.
158. Tsuji A, Tamai I. 1999. Carrier-mediated or specialized transport of drugs across the blood-brain barrier. Adv Drug Deliv Rev 36:277-290.
159. Tunkel AR, Rosser SW, Hansen EJ, Scheld WM. 1991. Blood-brain barrier alterations in bacterial meningitis: Development of an in vitro model and observations on the effects of lipopolysaccharide. In Vitro Cell Dev Biol 27A:113-120.
160. Ueda Y, Nakagawa T, Kubota T, Ido K, Sato K. 2005. Glioma cells under hypoxic conditions block the brain microvascu-lar endothelial cell death induced by serum starvation. J Neurochem 95:99-110.
161. Utepbergenov DI, Mertsch K, Sporbert A, Tenz K, Paul M, et al. 1998. Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation- mediated injury. FEBS Lett 424:197-201.
162. Valable S, Montaner J, Bellail A, Berezowski V, Brillault J, et al. 2005. VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: Both effects decreased by Ang-1. J Cereb Blood Flow Metab 25:1491-1504.
163. van der Sandt IC, Gaillard PJ, Voorwinden HH, de Boer AG, Breimer DD. 2001. P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cyto-statics at the in vitro blood-brain barrier. Pharm Res 18:587-592.
164. Walshe TE, Ferguson G, Connell P, O'Brien C, Cahill PA. 2005. Pulsatile flow increases the expression of eNOS, ET-1, and prostacyclin in a novel in vitro coculture model of the retinal vasculature. Invest Ophthalmol Vis Sci 46:375-382.
165. Wang W, Merrill MJ, Borchardt RT. 1996. Vascular endothelial growth factor affects permeability of brain microvesselendothelial cells in vitro. Am J Physiol Cell Physiol 271:C1973-C1980.
166. Weidenfeller C, Schrot S, Zozulya A, Galla H-J. 2005. Murine brain capillary endothelial cells exhibit improved barrier properties under the influence of hydrocortisone. Brain Res 1053:162-174.
167. Weksler BB, Subileau EA, Perriére N, Charneau P, Holloway K, et al. 2005. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J 19:1872-1874.
168. Wolburg H, Lippoldt A. 2002. Tight junctions of the blood-brain barrier: Development, composition and regulation. Vascul Pharmacol 38:323-337.
169. Yamagata K, Tagami M, Nara Y, Fujino H, Kubota A, et al. 1997. Faulty induction of blood-brain barrier functions by astrocytes isolated from stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol 24:686-691.
170. Yamagata K, Tagami M, Takenaga F, Yamori Y, Nara Y, et al. 2003. Polyunsaturated fatty acids induce tight junctions to form in brain capillary endothelial cells. Neuroscience 116:649-656.
171. Youdim KA, Avdeef A, Abbott NJ. 2003. In vitro trans-mono-layer permeability calculations: Often forgotten assumptions. Drug Discov Today 8:997-1003.
172. Zenker D, Begley D, Bratzke H, Rübsamen-Waigmann H, von Briesen H. 2003. Human blood-derived macrophages enhance barrier function of cultured brain capillary endo-thelial cells. J Physiol 551:1023-1032.
173. Zhang C, Harder DR. 2002. Cerebral capillary endothelial cell mitogenesis and morphogenesis induced by astrocytic epoxyeicosatrienoic acid. Stroke 33:2957-2964.
174. Zysk G, Schneider-Wald BK, Hwang JH, Bejo L, Kim KS, et al. 2001. Pneumolysin in the main inducer of cytotoxicity to brain microvascular endothelial cells caused by Streptococcus pneumoniae. Infect Immun 69:845-852.