Hypoxia induces permeability in brain microvessel endothelial cells via VEGF and NO

American Journal of Physiology - Cell Physiology

Volumn 276, Issue 4 45-4, 1999, Pages

  Fischer, Silvia ^a,b   Clauss, Matthias ^a   Wiesnet, Marion ^a   Renz, Dieter ^a   Schafer, Wolfgang ^a   Karliczek, Gerhard F ^a  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b KERCKHOFF HEART CENTER   (Germany)

Author keywords

Blood brain barrier; Endothelial barrier function; Hyperpermeability; Nitric oxide; Vascular endothelial growth factor

Indexed keywords

ANTIOXIDANT; CYCLIC GMP; MESSENGER RNA; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN CAPILLARY; BRAIN MICROCIRCULATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER; SWINE; VASCULAR ENDOTHELIUM;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0032925332     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.276.4.c812     Document Type: Article

References (16)

1. Baethmann, A. Pathophysiological and pathochemical aspects of cerebral edema. Neurosurg. Rev. 1: 85-100, 1978.
2. Beckman, J. S., T. W. Beckman, J. Chen, P. A, Marshall, and B. A. Freeman. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624,1990.
3. Berse, B., L. F. Brown, L. Van de Water, H. F. Dvorak, and D. R. Senger. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 3: 211-220,1992.
4. Bierhaus, A., S. Chevion, M. Chevion, M. Hofmann, P. Quehenberger, T. Illmer, T. Luther, E. Berentshtein, H. Tritschler, M. Müller, P. Wahl, R. Ziegler, and P. P. Nawroth. Advanced glycation end product-induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells. Diabetes 46: 1481-1490, 1997.
5. Bradbury, M. W. B. The structure and function of the blood-brain barrier. Federation Proc. 43: 186-190, 1984.
6. Brightman, M. W., and T. S. Reese. Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40: 648-677, 1969.
7. Brogi, E., G. Schatteman, T. Wu, E. A. Kim, L. Varticovski, B. Key, and J. M. Isner. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J. Clin. Invest. 97: 469-476, 1996.
8. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. Collins, P. D., D. T. Connolly, and T. J. Williams. Characterization of the increase in vascular permeability induced by vascular permeability factor in vivo. Br. J. Pharmacol. 109: 195-199, 1993.
10. Connolly, D. T., D. M. Heuvelman, R. Nelson, J. V. Olander, B. L. Eppley, J. J. Delfino, N. R. Siegel, R. M. Leimgruber, and J. Feder. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J. Clin. Invest. 84: 1470-1478, 1989.
11. Criscuolo, G. R. Clinical neuroscience in the decade of the brain hypothesis in neuro-oncology. The genesis of peritumoral vasogenic brain edema and tumor cysts: a hypothetical role for tumor-derived vascular permeability factor. Yale J. Biol. Med. 66: 277-314, 1993.
12. Crone, C., and S. P. Olesen. Electrical resistance of brain microvascular endothelium. Brain Res. 241: 49-55, 1982.
13. Darley-Usmar, V., H. Wiseman, and B. Halliwell. Nitric oxide and oxygen radicals: a question of balance. FEBS Lett. 369: 131-135, 1995.
14. Detmar, M., L. F. Brown, B. Berse, R. W. Jackman, B. M. Elicker, H. F. Dvorak, and K. P. Claffey. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J. Invest. Dermatol. 108: 263-268, 1997.
15. Dvorak, H. F., L. F. Brown, M. Detmar, and A. M. Dvorak. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146: 1029-1039, 1995.
16. Erben, M., S. Decker, H. Franke, and H.-J. Galla. Electrical resistance of measurements of cerebral capillary endothelial cells: a new technique to study small surface areas. J. Biochem. Biophys. Methods 30: 227-238, 1995.