Use of a three-dimensional in vitro model of the rat blood-brain barrier to assay nucleoside efflux from brain

Brain Research

Volumn 980, Issue 2, 2003, Pages 233-241

  Parkinson, Fiona E ^a   Friesen, Jessica ^a   Krizanac Bengez, Ljiljana ^b   Janigro, Damir ^b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Adenosine; Blood brain barrier; Cell culture; Dipyridamole; Endothelial cell; Nucleoside transport

Indexed keywords

ADENOSINE; DIPYRIDAMOLE; INOSINE; NUCLEOSIDE; POLYPROPYLENE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN; CELL CULTURE; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; FOREBRAIN; HOLLOW FIBER; MEMBRANE MODEL; MICROVASCULATURE; NONHUMAN; NUCLEOSIDE TRANSPORT; PERFUSION; PRIORITY JOURNAL; RAT;

EID: 0038303407     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02980-9     Document Type: Article

References (27)

1. Geiger J.D., Parkinson F.E., Kowaluk E.A. Regulators of endogenous adenosine levels as therapeutic agents. Jacobson K.A., Jarvis M.F. Purinergic Approaches in Experimental Therapeutics. 1997;55-84 Wiley-Liss, New York.
2. von Lubitz D.K. Adenosine and cerebral ischemia: therapeutic future or death of a brave concept? Eur. J. Pharmacol. 371:1999;85-102.
3. Rudolphi K.A., Schubert P., Parkinson F.E., Fredholm B.B. Adenosine and brain ischemia. Cerebrovasc. Brain Metab. Rev. 4:1992;346-369.
4. Parkinson F.E., Zhang Y.W., Shepel P.N., Greenway S.C., Peeling J., Geiger J.D. Effects of nitrobenzylthioinosine on neuronal injury, adenosine levels, and adenosine receptor activity in rat forebrain ischemia. J. Neurochem. 75:2000;795-802.
5. Zhang Y.W., Shepel P.N., Peeling J., Geiger J.D., Parkinson F.E. Effects of nitrobenzylthioinosine on neuronal injury and adenosine levels in rat forebrain ischemia. Neurosci. Res. Commun. 30:2002;83-89.
6. Stanness K.A., Guatteo E., Janigro D. A dynamic model of the blood-brain barrier in vitro. Neurotoxicology. 17:1996;481-496.
7. Stanness K.A., Westrum L.E., Fornaciari E., Mascagni P., Nelson J.A., Stenglein S.G., Myers T., Janigro D. Morphological and functional characterization of an in vitro blood-brain barrier model. Brain Res. 84:1997;329-342.
8. Sollevi A., Link H., Fredholm B.B. Dipyridamole treatment doubles the plasma adenosine level in patients with minor stroke. Thromb. Haemost. 50:1983;20.
9. Sollevi A. Cardiovascular effects of adenosine in man: possible clinical implications. Prog. Neurobiol. 27:1986;319-349.
10. Sinclair C.J., Krizanac-Bengez L., Stanness K.A., Janigro D., Parkinson F.E. Adenosine permeation of a dynamic in vitro blood-brain barrier inhibited by dipyridamole. Brain Res. 898:2001;122-125.
11. Phillis J.W., O'Regan M.H., Walter G.A. Effects of two nucleoside transport inhibitors, dipyridamole and soluflazine, on purine release from the rat cerebral cortex. Brain Res. 481:1989;309-316.
12. Picano E., Abbracchio M.P. European Stroke Prevention Study-2 results: serendipitous demonstration of neuroprotection induced by endogenous adenosine accumulation? Trends Pharmacol. Sci. 19:1998;14-16.
13. L. Krizanac-Bengez, M. Kapural, F.E. Parkinson, L. Cucullo, M. Hossain, M.R. Mayberg, D. Janigro, Effects of transient loss of shear stress on blood-brain barrier endothelium: role of nitric oxide and IL-6, Brain Res., in press.
14. Sinclair C.J., Othman T., Haughey N.J., Geiger J.D., Parkinson F.E. Differences between rat primary cortical neurons and astrocytes in purine release evoked by ischemic conditions. Neuropharmacology. 43:2002;836-846.
15. Schrader J., Gerlach E. Compartmentation of cardiac adenine nucleotides and formation of adenosine. Pflugers Arch. 367:1976;129-135.
16. Stanness K.A., Neumaier J.F., Sexton T.J., Grant G.A., Emmi A., Maris D.O., Janigro D. A new model of the blood-brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions. Neuroreport. 10:1999;3725-3731.
17. Li J.Y., Boado R.J., Pardridge W.M. Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2. J. Cereb. Blood Flow Metab. 21:2001;929-936.
18. Yao S.Y.M., Ng A.M., Muzyka W.R., Griffiths M., Cass C.E., Baldwin S.A., Young J.D. Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues. J. Biol. Chem. 272:1997;28423-28430.
19. Sweeney M.I., White T.D., Sawynok J. Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine. Brain Res. 614:1993;301-307. [published erratum appears in Brain Res. 618(1) (1993) 179].
20. Sinclair C.J., LaRiviere C.G., Young J.D., Cass C.E., Baldwin S.A., Parkinson F.E. Purine uptake and release in rat C6 glioma cells: nucleoside transport and purine metabolism under ATP-depleting conditions. J. Neurochem. 75:2000;1528-1538.
21. Grant G.A., Meno J.R., Nguyen T.S., Stanness K.A., Janigro D., Winn R.H. Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles. J. Neurosurg. 98:2003;554-560.
22. Chen P., Goldberg D.E., Kolb B., Lanser M., Benowitz L.I. Inosine induces axonal rewiring and improves behavioral outcome after stroke. Proc. Natl. Acad. Sci. USA. 99:2002;9031-9036.
23. Weishaar R.E., Burrows S.D., Kobylarz D.C., Quade M.M., Evans D.B. Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. Biochem. Pharmacol. 35:1986;787-800.
24. Iuliano L., Pedersen J.Z., Rotilio G., Ferro D., Violi F. A potent chain-breaking antioxidant activity of the cardiovascular drug dipyridamole. Free Radic. Biol. Med. 18:1995;239-247.
25. Rubin L.L., Hall D.E., Porter S., Barbu K., Cannon C., Horner H.C., Janatpour M., Liaw C.W., Manning K., Morales J., et al. A cell culture model of the blood-brain barrier. J. Cell Biol. 115:1991;1725-1735.
26. Igarashi Y., Utsumi H., Chiba H., Yamada-Sasamori Y., Tobioka H., Kamimura Y., Furuuchi K., Kokai Y., Nakagawa T., Mori M., Sawada N. Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier. Biochem. Biophys. Res. Commun. 261:1999;108-112.
27. de Vries H.E., Blom-Roosemalen M.C., de Boer A.G., van Berkel T.J., Breimer D.D., Kuiper J. Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. J. Pharmacol. Exp. Ther. 277:1996;1418-1423.