Physiology and pathology of the blood-brain barrier: Implications for microbial pathogenesis, drug delivery and neurodegenerative disorders

Journal of NeuroVirology

Volumn 5, Issue 6, 1999, Pages 538-555

  Banks, William A ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Adsorptive endocytosis; Aging; gp120; HIV; Neuroaids; Peptides; Transmembrane diffusion

Indexed keywords

ANTIVIRUS AGENT; NEUROTOXIN; SAQUINAVIR; ZIDOVUDINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGING; ALCOHOLISM; BLOOD BRAIN BARRIER; BLOOD LEVEL; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; DRUG ABUSE; DRUG TRANSPORT; ENDOCYTOSIS; HUMAN IMMUNODEFICIENCY VIRUS 1; MENTAL DEFICIENCY; MULTIPLE SCLEROSIS; NERVE DEGENERATION; OBESITY; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

EID: 0033377523     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550289909021284     Document Type: Review

References (195)

1. Adler WH, Baskar PV, Chrest FJ, Dorsey-Cooper B, Winchurch RA, Nagel JE (1997). HIV infection and aging: mechanisms to explain the accelerated rate of progression in the older patient. Mechanisms of Ageing and Development 96: 137 - 155 (Abstract).
2. Adler WH, Nagel JE (1994). Acquired immunodeficiency syndrome in the elderly. Drugs and Aging 4: 410 - 416 (Abstract).
3. Advokat C, Gulati A (1991). Spinal transection reduces both spinal antinociception and CNS concentration of systemically administered morphine in rats. Brain Res 555: 251 - 258.
4. Arimura A (1992). Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research. Regul Pept 37: 287 - 303.
5. Audus KL, Chikhale PJ, Miller DW, Thompson SE, Borchardt RT (1992). Brain uptake of drugs: the influence of chemical and biological factors. In: Advances in Drug Research. Testa B (ed) Academic Press: London, pp 1 - 64.
6. Baba M, Oishi R, Saeki K (1988). Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation of μ opioid receptors in mice. Naunyn-Schmied Arch Pharmacol 37: 423 - 428.
7. Balin BJ, Broadwell RD, Salcman M, el-Kalliny M (1986). Avenues for entry of peripherally administered protein to the central nervous system in mouse, rat, and squirrel monkey. J Comp Neurol 251: 260 - 280.
8. Banks WA (1999a). Internalization and fusion of HIV-1 gp120 with brain endothelial cells is cAMP dependent. In press.
9. Banks WA (1999b). Characterization of IL 1α binding to mouse brain endothelial cells. J Pharmacol Exp Ther In press.
10. Banks WA, Akerstrom V, Kastin AJ (1998). Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor. J Cell Sci 111: 533 - 540.
11. Banks WA, Broadwell RD (1994). Blood to brain and brain to blood passage of native horseradish peroxidase, wheat germ agglutinin and albumin: pharmacokinetic and morphological assessments. J Neurochem 62: 2404 - 2419.
12. Banks WA, DiPalma CR, Farrell CL (1999b). Impaired transport of leptin across the blood-brain barrier in obesity. Peptides, in press.
13. Banks WA, Ibrahimi F, Farr SA, Flood JF, Morley JE (1999c). Effects of wheatgerm agglutinin and aging on the regional brain uptake of HIV-1 gp120. Life Sci 65: 81 - 89.
14. Banks WA, Kastin AJ (1984). A brain-to-blood carriermediated transport system for small, N-tyrosinated peptides. Pharmacol Biochem Behav 21: 943 - 946.
15. Banks WA, Kastin AJ (1985). Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability. Brain Res Bull 15: 287 - 292.
16. Banks WA, Kastin AJ (1986a). Aging, peptides, and the blood-brain barrier: implications and speculations. In: Treatment Development Strategies for Alzheimer's Disease. Crook T, Bartus R, Ferris S, Gershon S (eds). Mark Powley Associates: Madison, CT, pp 245 - 265.
17. Banks WA, Kastin AJ (1986b). Modulation of the carriermediated transport of the Tyr-MIF-1 across the blood-brain barrier by essential amino acids. J Pharmacol Exp Ther 239: 668-672.
18. Banks WA, Kastin AJ (1993a). The potential for alcohol to affect the passage of peptide and protein hormones across the blood-brain barrier: a hypothesis for a disturbance in brain-body communication. In: NIAAA Research Monograph 23, Alcohol and the Endocrine System. Zakhari S (ed). National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism: Bethesda, MD, pp 401 - 411.
19. Banks WA, Kastin AJ (1993b). Peptide binding in blood and passage across the blood-brain barrier. In: Proceedings of the International Symposium on Blood Binding and Drug Transfer. Tillement JP, Eckert H, Albengres E, Barre J, Baumann P, Belpare F, Lemaire M (eds). Fort and Clair: Paris, pp 223 - 242.
20. Banks WA, Kastin AJ (1994a). Opposite direction of transport across the blood-brain barrier for Tyr-MIF-1 and MIF-1: comparison with morphine. Peptides 15: 23 - 29.
21. Banks WA, Kastin AJ (1994b). Brain-to-blood transport of peptides and the alcohol withdrawal syndrome. In: Models of Neuropeptide Action. Strand FL, Beckwith B. Chronwall B, Sandman CA (eds). New York Academy of Sciences: New York, New York, pp 108 - 118.
22. Banks WA, Kastin AJ (1997). The role of the blood-brain barrier transporter PTS-1 in regulating concentrations of methionine enkephalin in blood and brain. Alcohol 14: 237 - 245.
23. Banks WA, Kastin AJ (1998a). Characterization of lectinmediated brain uptake of HIV1 gp120. J Neurosci Res 54: 522 - 529.
24. Banks WA, Kastin AJ (1998b). Differential permeability of the blood-brain barrier to two pancreatic peptides: Insulin and amylin. Peptides 19: 883 - 889.
25. Banks WA, Kastin AJ, Akerstrom V (1997b). HIV-1 protein gp120 crosses the blood-brain barrier: role of adsorptive endocytosis. Life Sci 61: PL119 - PL125.
26. Banks WA, Kastin AJ, Arimura A (1998). Effect of spinal cord injury on the permeability of the blood-brain and blood-spinal cord barriers to the neurotropin PACAP. Exp Neurol 151: 116 - 123.
27. Banks WA, Kastin AJ, Brennan JM, Vallance KL (1999a). Adsorptive endocytosis of HIV-1 gp120 by blood-brain barrier is enhanced by lipopolysaccharide. Exp Neurol 156: 165 - 171.
28. Banks WA, Kastin AJ, Fasold MB (1988). Differential effect of aluminum on the blood-brain barrier transport of peptides, technetium and albumin. J Pharmacol Exp Ther 244: 579 - 585.
29. Banks WA, Kastin AJ, Fischman AJ, Coy DH, Strauss SL (1986). Carrier-mediated transport of enkephalins and N-Tyr-MIF-1 across blood-brain barrier. Am J Physiol 251: E477 - E482.
30. Banks WA, Kastin AJ, Harrison LM, Zadina JE (1996b). Perinatal treatment of rats with opiates affects the development of the blood-brain barrier transport system PTS-1. Neurotoxicol Teratol 18: 711 - 715.
31. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM (1996a). Leptin enters the brain by a saturable system independent of insulin. Peptides 17: 305 - 311.
32. Banks WA, Kastin AJ, Jaspan JB (1995). Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice. Pharmacol Biochem Behav 51: 139 - 147.
33. 1-38 across the blood-brain barrier. J Pharmacol Exp Ther 267: 690 - 696.
34. Banks WA, Kastin AJ, Rapoport SI (1997a). Permeability of the blood-brain barrier to circulating free fatty acids. In: Handbook of Essential Fatty Acid Biology: Biochemistry, Physiology, and Behavioral Neurobiology. Yehuda S, Mostofsky DI (eds). Human Press: Totowa, NJ, pp 3 - 14.
35. Banks WA, Ortiz L, Plotkin SR, Kastin AJ (1991). Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther 259: 988 - 996.
36. Barrera CM, Kastin AJ, Fasold MB, Banks WA (1991). Bidirectional saturable transport of LHRH across the blood-brain barrier. Am J Physiol 261: E312 - E318.
37. Baura GD, Foster DM, Porte Jr D, Kahn SE, Bergman RN, Cobelli C, Schwartz MW (1993). Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: a mechanism for regulated insulin delivery to the brain. J Clin Invest 92: 1824 - 1830.
38. Begley DJ (1992). The interaction of some centrally active drugs with the blood-brain barrier and circumventricular organs. Prog Brain Res 91: 163 - 169.
39. Begley DJ (1994). Strategies for delivery of peptide drugs to the central nervous system: exploiting molecular structure. J Control Release 29: 293 - 306.
40. Betz AL, Goldstein GW (1978). Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science 202: 225 - 227.
41. Blasberg RG, Fenstermacher JD, Patlak CS (1983). Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab 3: 8 - 32.
42. Bodnar RJ, Pasternak GW, Mann PE, Paul D, Warren R, Donner DB (1989). Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat. Cancer Res 15: 6280 - 6284.
43. Bourinbaiar AS, Phillips DM (1991). Transmission of human immunodeficiency virus from monocytes to epithelia. J Acquir Immune Defic Syndr 4: 56 - 63.
44. Bradbury M (1979). The Concept of a Blood-Brain Barrier, John Wiley and Sons Ltd, New York.
45. Broadwell RD (1989). Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal. Acta Neuropathol. (Berl) 79: 117 - 128.
46. Broadwell RD (1993). Endothelial cell biology and the enigma of transcytosis through the blood-brain barrier. Adv Exp Med Biol 331: 137 - 141.
47. Broadwell RD, Balin BJ, Salcman M (1988). Transcytotic pathway for blood-borne protein through the blood-brain barrier. Proc Natl. Acad. Sci USA 85: 632 - 636.
48. Broadwell RD, Banks WA (1993). Cell biological perspective for the transcytosis of peptides and proteins through the mammalian blood-brain fluid barriers. In: The Blood-Brain Barrier. Pardridge WM (ed). Raven Press Ltd: New York, pp 165 - 199.
49. Broadwell RD, Salcman M (1981). Expanding the definition of the blood-brain barrier to protein. Proc Natl. Acad Sci. USA 78: 7820 - 7824.
50. Broadwell RD, Sofroniew MV (1993). Serum proteins bypass the blood-brain barrier for extracellular entry to the central nervous system. Exp Neurol 120: 245-263.
51. Bulat M, Zivkovic B (1978). Neurochemical study of the cerebrospinal fluid. In: Research Methods in Neurochemistry. Marks N, Rodnight R (eds). Volume 4. Plenum Press: New York, pp 57 - 89.
52. Büttner A, Mehraein P, Weis S (1996). Vascular changes in the cerebral cortex in HIV-1 infection. Acta Neuropathol 92: 35 - 41.
53. Caro JF, Kolaczynski JW, Nyce MR, Ohannesian JP, Opentanova I, Goldman WH, Lynn RB, Zhang P-L, Sinha MD, Considine RV (1996). Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348: 159 - 161.
54. Cashion MF, Banks WA, Bost KL, Kastin AJ (1999). Transmission routes of HIV-1 gp120 from brain to lymphoid tissues. Brain Res 822: 26 - 33.
55. 125I-labelled interleukin-6 from brain into blood following intracerebroventricular injection in rats. Endocrinology 138: 4830 - 4836.
56. Chikale EG, Burton PS, Borchardt RT (1995). The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism. J Pharmacol Exp Ther 273: 298 - 303.
57. Chikhale EG, Ng KY, Burton PS, Borchardt RT (1994). Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm Res 11: 412 - 419.
58. Chin Y-H, Sackstein R, Cai J-P (1991). Lymphocytehoming receptors and preferential migration pathways. Proc Soc Exp Biol Med 196: 374 - 380.
59. Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR (1989). Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 86: 695 - 698.
60. Cornford EM, Braun LD, Oldendorf WH, Hill MA (1982). Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults. Am J Physiol 243: C161 - C168.
61. Cserr HF, Knopf PM (1992). Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view. Immunol Today 13: 507 - 512.
62. Daniel PM, Love ER, Pratt OE (1978). The effect of age upon the influx of glucose into the brain. J Physiol (London) 274: 141 - 148.
63. Davson H (1967). The blood-brain barrier. In: AnonymousPhysiology of the Cerebrospinal Fluid. J and A Churchill Ltd: London, pp 82 - 103.
64. Davson H, Hollingsworth JG, Carey MB, Fenstermacher JD (1982). Ventriculo-cisternal perfusion of twelve amino acids in the rabbit. J Neurobiol 13: 293 - 318.
65. Davson H, Segal MB (1996a). The return of the cerebrospinal fluid to the blood: The drainage mechanism. In: Anonymous Physiology of the CSF and Blood-Brain Barriers. CRC Press: Boca Raton, pp 489 - 523.
66. Davson H, Segal MB (1996b). Morphological aspects of the barriers. In: AnonymousPhysiology of the CSF and Blood-Brain Barriers. CRC Press: Boca Raton, 93 - 192.
67. Davson H, Segal MB (1996c). The proteins and other macromolecules of the CSF. In: Anonymous Physiology of the CSF and the Blood-Brain Barriers. CRC Press: Boca Raton, pp 573 - 606.
68. Davson H, Segal MB (1996d). Special aspects of the blood-brain barrier. In: Anonymous Physiology of the CSF and Blood-Brain Barriers. CRC Press: Boca Raton, pp 303 - 485.
69. de la Torre JC, Mussivant T (1993). Can disturbed brain microcirculation cause Alzheimer's disease? Neurological Research 15: 146 - 153.
70. de Lange EC, Bouw MR, Mandema JW, Danhof M, De Boer AG, Breimer DD (1995). Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain. Br J Pharmacol 2538 - 2544.
71. De Vivo DC, Trifiletti RR, Jacobson RI, Rouen GM, Behmand RA, Harik SI (1991). Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N Engl J Med 325: 703 - 709.
72. Defazio G, Trojano M, Ribatti D, Nico B, Giorelli M, De Salvia R, Russo G, Roncali L, Livrea P (1998) ICAM 1 expression and fluid phase endocytosis of cultured brain microvascular endothelial cells following exposure to interferon beta-1a and TNFalpha. J Neuroimmunol 88: 13 - 20.
73. Donaldson YK, Bell JE, Ironside JW, Brettle RP, Robertson JR, Busuttil A, Simmonds P (1994). Redistribution of HIV outside the lymphoid system with onset of AIDS. Lancet 343: 383 - 385.
74. Dorheim M-A, Tracey WR, Pollock JS, Grammas P (1994). Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease. Biochem Biophys Res Commun 205: 659 - 665.
75. Drewes LR, Conway WP, Gilboe DD (1977). Net amino acid transport between plasma and erythrocytes and perfused dog brain. Am J Physiol 2: E320 - E325.
76. Drion N, Lemaire M, Lefauconnier JM, Scherrmann J-M (1996). Role of p-glycoprotein in the blood-brain transport of colchicine and vinblastine. J Neurochem 67: 1688 - 1693.
77. Duffy KR, Pardridge WM (1987). Blood-brain barrier transcytosis of insulin in developing rabbirs. Brain Bes 420: 32 - 38.
78. Dux E, Doczi T, Joo F, Szerdahelyi P, Siklos L (1988). Reverse pinocytosis induced in cerebral endothelial cells by injection of histamine into the cerebral ventricle. Acta Neuropathol (Berl) 76: 484 - 488.
79. Feng Y, Broder CC, Kennedy PE, Berger EA (1996). HIV-1 entry cofactor: function cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872 - 877.
80. Ferro S, Salit IE (1992). HIV infection in patients over 55 years of age. J Acquir Immune Defic Syndr 5: 348 - 353 (Abstract).
81. Fiala AM, Gan XH, Newton T, Chiappelli F, Shapshak P, Kermaini V, Kung MA, Diagne A, Martinez O, Way D, Weinand M, Witte M, Graves M (1996). Divergent effects of cocaine on cytokine production by lymphocytes and monocyte/macrophages: HIV-1 enhancement by cocaine within the blood-brain barrier. Adv Exp Med Biol 402: 145 - 156.
82. Fiala M, Looney DJ, Stins M, Way DD, Zhang L, Gan X, Chiappelli F, Schweitzer ES, Shapshak P, Weinand M, Graves MC, Witte M, Kim KS (1997). TNF-α opens a paracellular route for HIV-1 invasion across the blood-brain barrier. Molecular Medicine 3: 553 - 564.
83. Friedman JM, Halaas JL (1998). Leptin and the regulation of body weight in mammals. Nature 395: 763 - 770.
84. Frigerio S, Gelati M, Ciusani E, Corsini E, Dufour A, Massa G, Salmaggi A (1998). Immunocompetence of human microvascular brain endothelial cells: cytokine regulation of IL-1beta, MCP-1, IL-10, sICAM-1 and sVCAM-1. J Neurol 245: 727 - 730.
85. Gilat D, Hershkoviz R, Mekori YA, Vlodavsky I, Lider O (1994). Regulation of adhesion of CD4+ T lymphocytes to intact or heparinase-treated subendothelial extracellular matrix by diffusible or anchored RANTES and MIP-1 beta. J Immunol 153: 4899 - 4906.
86. Glynn SL, Yazdanian M (1998). In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J Pharm Sci 87: 306 - 310.
87. Gonindard C, Goigoux C, Hollande E, D'Hinterland LD (1996). The administration of an alpha-MSH analogue reduces the serum release of IL-1 alpha and TNF alpha induced by the injection of a sublethal dose of lipopolysaccharides in the BALB/c mouse. Pigment Cell Res 9: 148 - 153.
88. Grammas P, Moore P, Botchlet T, Hanson-Painton O, Cooper DR, Ball MJ, Roher A (1995). Cerebral microvessels in Alzheimer's have reduced protein kinase C activity. Neurobiol Aging 16: 563 - 569.
89. Grammas P, Moore P, Weigel PH (1999). Microvessels from Alzheimer's disease brains kill neurons in vitro. Am J Pathol 154: 337 - 342.
90. Grammas P, Toya R, Botchlet TR, Moore P, Weigel PH (1997). Production of neurotoxic factors by brain endothelium in Alzheimer's disease. In: Cerebrovascular Pathology in Alzheimer's Disease, de la Torre JC and Hachinski V. (eds). New York, Annals of the New York Academy of Sciences (GENERIC), 826, pp 47 - 55. Ref type: Serial (Book, Monograph).
91. Greenwood J, Pratt OE (1983). The effect of ethanol upon thiamine transport across the blood-brain barrier in the rat. J Physiol (London) 348: 61P.
92. Hansson HA, Johansson B, Blomstrand C (1975). Ultrastructural studies on cerebrovascular permeability in acute hypertension. Acta Neuropathol 32: 187 - 198.
93. Hardebo JE, Kahrstrom J (1985). Endothelial negative surface charge areas and blood-brain barrier function. Acta Physiol Scand 125: 495 - 499.
94. Harik SI, Kalaria RN (1991). Blood-brain barrier abnormalities in Alzherimer's disease. Ann NY Acad Sci 640: 47 - 52.
95. Harrison LM, Zadina JE, Banks WA, Kastin AJ (1993). Effects of neonatal treatment with Tyr-MIF-1, morphiceptin, and morphine on development, tail flick, and blood-brain barrier transport. Dev Brain Res 75: 207-212.
96. Haworth SJ, Christofalo B, Anderson RD, Dunkle LM (1998). A single-dose study to assess the penetration of stavudine into human cerebrospinal fluid in adults. J Acquir Immune Defic Syndr Human Retrovir 17: 235 - 238.
97. Hernandez LD, Hoffman LR, Wolfsber TG, White JM (1996). Virus-cell and cell-cell fusion. Annual Review of Cell and Developmental Biology 12: 627 - 661.
98. Johanson CE (1988). The choroid plexus-arachnoid membrane-cerebrospinal fluid system. In: Neuronal Microenvironment. Boulton AA, Baker GB, Walz W (eds). The Humana Press: Clifton, New Jersey, pp 33 - 104.
99. Johansson BB (1989). Hypertension and the blood-brain barrier. In: Implications of the Blood-Brain Barrier and its Manipulation. Vol 2. Clinical Aspects. Neuwelt EA (ed). Plenum Publishing Co; New York, pp 389 - 410.
100. Johnson AK, Gross PM (1993). Sensory circumventricular organs and brain homeostatic pathways. FASEB J 7: 678 - 686.
101. Kakee A, Terasaki T, Sugiyama Y (1996). Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J Pharmacol Exp Ther 277: 1550 - 1559.
102. Kalomiris EL, Bourguignon LY (1988). Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin. J Cell Biol 106: 319 - 327.
103. Kety SS (1987). Cerebral circulation and its measurement by inert diffusible tracers. In: Encyclopedia of Neuroscience, Volume 1. Adelman G (ed). Birkhäuser, Boston, pp 206 - 208.
104. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJJ, Roden DM, Wilkinson GR (1999). The drug transporter p-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest 101: 289 - 294.
105. Kimura C, Ohkubo S, Ogi K, Hosoya M, Itoh Y, Onda H, Miyata A, Jiang L, Dahl RR, Stibbs HH, Arimura A, Fujino M (1990). A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun 166: 81 - 89.
106. Knopf PM, Cserr HF, Nolan SC, Wu T-Y, Harling-Berg CJ (1995). Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain. Neuropathology and Applied Neurobiology 21: 175 - 180.
107. Komura J, Tamai I, Senmaru M, Terasaki T, Sai Y, Tsuji A (1997). Brain-to-blood active transport of β-alanine across the blood-brain barrier. FEBS Lett 400: 131 - 135.
108. Krisch B, Leonhardt H (1989). Relations between leptomeningeal compartments and the neurohemal regions of circumventricular organs. Biomed Res 10 (Suppl 3): 155 - 168.
109. Laye S, Parnet P, Goujon E, Dantzer R (1994). Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Brain Res 27: 157 - 162.
110. Lee CGL, Gottesman MM, Cardarelli CO, Ramachandra M, Jeang K-T, Ambudkar SV, Pastan I, Dey S (1998). HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 37: 3594 - 3601.
111. Lehto VP, Virtanen I (1983). Immunolocalization of a novel, cytoskeleton-associated polypeptide of Mr 230,000 daltons (p230). J Cell Biol 96: 703 - 716.
112. Levin VA (1999). Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. Journal of Medicinal Chemistry 23: 683 - 685.
113. Lossinsky AS, Pluta R, Song MJ, Badmajew V, Moretz RC, Wisniewski HM (1991). Mechanisms of inflammatory cell attachment in chronic relapsing experimental allergic encephalomyelitis: a scanning and high-voltage electron microscopy study of the injured mouse blood-brain barrier. Microvasc Res 41: 299 - 310.
114. Lossinsky AS, Vorbrodt AW, Wisniewski HM (1983). Ultracytochemical studies of vesicular and canalicular transport structures in the injured mammalian blood-brain barrier. Acta Neuropathol (Berl) 61: 239 - 245.
115. Male D (1995). The blood-brain barrier - No barrier to a determined lymphocyte. In: New Concepts of a Blood-Brain Barrier. Greenwood J, Begley DJ, Segal MB (eds). Plenum Press: New York, pp 311 - 314.
116. Mandi Y, Ocsovszki I, Szabo D, Nagy Z, Nelson J, Molnar J (1998). Nitric oxide production and MDR expression by human brain endothelial cells. Anticancer Research 18: 3049 - 3052.
117. Maness LM, Banks WA, Zadina JE, Kastin AJ (1995). Selective transport of blood-borne interleukin-lα into the posterior division of the septum of the mouse brain. Brain Res 700: 83 - 88.
118. Maness LM, Kastin AJ, Banks WA (1998). Relative contributions of a CVO and the microvascular bed to delivery of blood-borne IL-1α to the brain. Am J Physiol 275: E207 - E212.
119. Marsh M (1984). The entry of enveloped viruses into cells by endocytosis. Biochem J 218: 1 - 10.
120. Martins JM, Banks WA, Kastin AJ (1997a). Acute modulation of the active carrier-mediated brain to blood transport of corticotropin-releasing hormone. Am J Physiol 272: E312 - E319.
121. Martins JM, Banks WA, Kastin AJ (1997b). Transport of CRH from mouse brain directly affects peripheral production of β-endorphin by the spleen. Am J Physiol 273: E1083 - E1089.
122. Masereeuw R, Jaehde U, Langemeijer MWE, De Boer AG, Breimer DD (1994). In vivo and in vitro transport of zidovudine (AZT) across the blood-brain barrier and the effects of transport inhibitors. Pharm Res 11: 324 - 330.
123. Mayhan WG, Heistad DD (1985). Permeability of the blood-brain barrier to various sized molecules. Am J Physiology 248: H712 - H718.
124. McQuay HJ, Sullivan AF, Smallman K, Dickenson AH (1989). Intrathecal opioids, potency and lipophilicity. Pain 36: 111 - 115.
125. Mehta R, Zingde S, Advani S, Desai H, Gothoskar B (1999). Protein la: a major wheat germ agglutinin binding protein on the surface of human granulocytes associated with the cytoskeleton. Mol Cell Biochem 144: 153 - 165.
126. Mooradian AD, Morin AM, Cipp LJ, Haspel HC (1991). Glucose transport is reduced in the blood-brain barrier of aged rats. Brain Res 551: 145 - 149.
127. Moses AV, Bloom FE, Pauza CD, Nelson JA (1993). Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/ galactosylceramide-independent mechanism. Proc Natl Acad Sci USA 90: 10474 - 10478.
128. Murray CL, Quaglia M, Arnason JT, Morris CE (1994). A putative nicotine pump at the metabolic blood-brain barrier of the tobacco hornworm. J Neurobiol 25: 23 - 34.
129. Murray JE, Cutler RWP (1970). Transport of glycine from the cerebrospinal fluid: Factors regulating amino acid concentration in feline cerebrospinal fluid. Arch Neurol 23: 23 - 31.
130. Nelson PK, Masters LT, Zagzag D, Kelly PJ (1999). Angiographic abnormalities in progressive multifocal leukoencephalopathy: an explanation based on neuropathologic findings. American Journal of Neuroradiology 20: 487 - 494.
131. Nottet HS, Persidsky Y, Sasseville VG, Nukuna AN, Bock P, Zhai QH, Sharer ER, McComb RD, Swindells S, Soderland C, Gendelman HE (1996). Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J Immunol 156: 1284-1295.
132. Ogle CK, Ogle JD, Hartmann S, Szczur K, Guo X (1994). Production of tumor necrosis factor, interleukin-6 and prostaglandin E2 by LPS-stimulated rat bone marrow macrophages after thermal injury: effect of indomethacin. Inflammation 18: 175 - 185.
133. Oldendorf WH (1971). Brain uptake of radio-labelled amino acids, amines and hexoses after arterial injection. Am J Physiol 221: 1629 - 1639.
134. Oldendorf WH (1974). Lipid solubility and drug penetration of the blood-brain barrier. Proc Soc Exp Biol Med 147: 813 - 816.
135. Pan W, Banks WA, Kastin AJ (1997). BBB permeability to ebiratide and TNF in cute spinal cord injury. Exp Neurol 146: 367 - 373.
136. Pan W, Banks WA, Kennedy MK, Gutierrez EG, Kastin AJ (1996). Differential permeability of the BBB in acute EAE: enhanced transport of TNF-α. Am J Physiol 271: E636 - E642.
137. Passaro Jr E, Debas H, Oldendorf W, Yamada T (1982). Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation. Brain Res 241: 338 - 340.
138. Patlak CS, Blasberg RG, Fenstermacher JD (1983). Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3: 1 - 7.
139. Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, Bock P, Gendelman HE, Fiala M (1997). A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. J Immunol 158: 3499 - 3510.
140. Pettipher ER, Wimberly DJ (1994). Cyclooxygenase inhibitors enhance tumor necrosis factor production and mortality in murine endotoxic shock. Cytokine 6: 500 - 503.
141. Phillips AN, Lee CA, Elford J, Webster A, Janossy G, Timms A, Bofill M, Kernoff PB (1991). More rapid progression to AIDS in older HIV-infected people: role of CD4+ T-cell counts. J Acquir Immune Defic Syndr 4: 970 - 975 (Abstract).
142. Pleskoff O, Treboute C, Brelot A, Heveker N, Seman M, Alizon M (1997). Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry. Science 276: 1874 - 1878.
143. Plotkin SR, Banks WA, Waguespack PJ, Kastin AJ (1997). Ethanol alters the concentration of met-enkephalin in brain by affecting peptide transport system-1 independent of preproenkephalin mRNA. J Neurosci Res 48: 273 - 280.
144. Qin Y, Sato TN (1995). Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development. Dev Dynamics 202: 172 - 180.
145. Raeissi S, Audus KL (1989). In-vitro characterization of blood-brain barrier permeability to delta sleep-inducing peptide. Ann NY Acad Sci 41: 848 - 852.
146. Rapoport SI (1976). Blood Brain Barrier in Physiology and Medicine, Raven Press, New York.
147. Reed DJ, Woodbury DM, Jacobs L, Squires R (1965). Factors affecting distribution of iodide in brain and cerebrospinal fluid. Am J Physiol 209: 757 - 764.
148. Reese TS, Brightman MW (1968). Similarity in structure and permeability to peroxidase of epithelia overlying fenestrated cerebral capillaries. Anat Record 160: 414 (Abstract).
149. Romero LI, Lldiko K, Lechan RM, Reichlin S (1996). Interluekin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1β in rats. Am J Physiol 270: R518 - R524.
150. Rottenberg DA, Sidtis JJ, Strother SC, Schaper KA, Andersen JR, Nelson MJ, Price RW (1996). Abnormal cerebral glucose metabolism in HIV-1 seropositive subjects with and without dementia. J Nucl Med 37: 1133 - 1141.
151. Sakata A, Tamai I, Kawazu K, Deguchi Y, Ohnishi T, Saheki A, Tsuji A (1994). In vivo evidence for ATP-dependent and p-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier. Biochem Pharmacol 48: 1989 - 1992.
152. Saland LC, Van Epps DE, Ortiz E, Samora A (1983). Acute injections of opiate peptides into the rat cerebral ventricle: a macrophage-like cellular response. Brain Res Bull 10: 523 - 528.
153. Salmivirta M, Lidholt K, Lindahl U (1996). Heparan sulfate: a piece of information. FASEB J 10: 1270 - 1279.
154. Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CAAM, van der Valk MA, Robanus-Maandag EC, te Riele HPJ, Berns AJM, Borst P (1994). Disruption of the mouse mdr1a p-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77: 491 - 502.
155. Schinkel AH, Wagenaar E, Mol CAAM, van Deemter L (1996). P-Glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97: 2517 - 2524.
156. Schwartz MW, Peskind E, Raskind M, Boyko EJ, Porte Jr D (1996). Cerebrospinal fluid leptin levels: relationship to plasma levels and adiposity in humans. Nature Medicine 2: 589 - 593.
157. Sharief MK, Noori MA, Ciardi M, Cirelli A, Thompson EJ (1993). Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage. J Neuroimmunol 43: 15 - 22.
158. Shaw KT, Greig NH (1999). Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection. Neuroreport 10: 53 - 56.
159. Shimura T, Tabata S, Ohnishi T, Terasaki T, Tsuji A (1991). Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier. J Pharmacol Exp Ther 258: 459 - 465.
160. Sjölander A, Magnusson K-E (1988). Effects of wheat germ agglutinin on the cellular content of filamentous actin in Intestine 407 cells. Eur J Cell Biol 47: 32 - 35.
161. Snodgrass SR, Cutler RWP, Kang ES, Lorenzo AV (1969). Transport of neutral amino acids from feline cerebrospinal fluid. Am J Physiol 217: 974 - 980.
162. Spector R (1987). Ceftriaxone transport through the blood-brain barrier. J Infect Dis 156: 209 - 211.
163. Spector R, Lorenzo AV (1974). The effects of salicylate and probenecid on the cerebrospinal fluid transport of penicillin, aminosalicylic acid and iodide. J Pharmacol Exp Ther 188: 55 - 65.
164. Spiegelman BM, Flier JS (1996), Adipogenesis and obesity: rounding out the big picture. Cell 87: 377 - 389.
165. Suchard SJ, Boxer LA (1989). Characterization and cytoskeletal association of a major cell surface glycoprotein, GP 140, in human neutrophils. J Clin Invest 84: 484 - 492.
166. Takasato Y, Rapoport SI, Smith QR (1984). An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 247: H484 - H493.
167. Takasawa M, Terasaki T, Suzuki H, Ooie T, Sugiyama Y (1997a). Distributed model analysis of 3′-azido-3′deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J Pharmacol Exp Ther 282: 1509 - 1517.
168. Takasawa M, Terasaki T, Suzuki H, Sugiyama Y (1997b). In vivo evidence for carrier-mediated efflux transport of 3′azido-3′deoxythymidine and 2′,3′-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. J Pharmacol Exp Ther 281: 369 - 375.
169. Tamaru M, Tomura K, Sakamoto S, Tezuka K, Tamatani T, Narumi S (1998). Interleukin-1beta induces tissue-and cell type-specific expression of adhesion molecules in vivo. Artarioscl Throm Vasc Biol 18: 1292-1303.
170. Tavassoli M, Minguell JJ (1991). Homing of hemopoietic progenitor cells to the marrow. Proc Soc Exp Biol Med 196: 367 - 373.
171. Tenner-Racz K, Stellbrink HJ, van Lunzen J, Schneider C, Jacobs JP, Raschdorff B, Grosschupff G, Steinman RM, Racz P (1998). The unenlarged lymph nodes of HIV-1-infected, asymptomatic patients with high CD4 T cell counts are sites for virus replication and CD4 T cell proliferation. The impact of highly active antiretroviral therapy. J Exp Med 187: 949 - 959.
172. Teraski T, Pardridge WM (1988). Restricted transport of 3′-azido-3′-deoxythymidine and 2′-3′-dideoxynucleosides through the blood-brain barrier. Journal of Infectious Diseases 158: 630 - 632.
173. Terasaki T, Takakuwa S, Saheki A, Moritani S, Shimura T, Tabata S, Tsuji A (1992). Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells. Pharm Res 9: 529 - 534.
174. Terracina L, De Medio GE, Trovarelli G, Gaiti A (1994). Phospholipid
175. Thompson SE, Audus KL (1994). Leucine enkephalin effects on brain microvessel endothelial cell monolayer permeability. Pharm Res 11: 1366 - 1369.
176. Thompson SE, Cavitt J, Audus KL (1994). Leucine enkephalin effects on paracellular and transcellular permeation pathways across brain microvessel endothelial cell monolayers. J Cardiovasc Pharmacol 24: 818 - 825.
177. Ting P, Xu S, Krumins S (1994). Endogenous opioid system activity following temporary focal cerebral ischemia. Acta Neurochir Suppl (Wien) 60: 253 - 256.
178. Tsuji A, Tamai I (1997). Blood-brain barrier function of P-glycoprotein. Advanced Drug Delivery Reviews 25: 287 - 298.
179. Tsuji A, Tamai I, Sakata A, Tenda Y, Terasaki T (1993). Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein. Biochem Pharmacol 46: 1096 - 1099.
180. Tsuji A, Terasaki T, Takabatake Y, Tenda Y, Tamai I, Yamashima T, Moritani S, Tsuruo T, Yamashita J (1992). P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci 51: 1427 - 1437.
181. Uchida D, Arimura A, Somogyvari-Vigh A, Shioda S, Banks WA (1996). Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide. Brain Res 736: 280 - 286.
182. Uchida D, Shloda S, Takaki A, Arimura A (1994). Cytoprotective action of pituitary adenylate cyclase activating polypeptide (PACAP) in ischemia-induced neuronal cell death in rat hippocampus. Soc Neurosci Abstr 193.10: 442 (Abstract).
183. Vann JM, Goldman AJ, Szurek PF, Brooks BR (1999). Deoxyglucose uptake by mouse astrocytes: Effects of temperature and retrovirus infection. Neurochem Res 20: 1013 - 1020.
184. Villegas JC, Broadwell RD (1993). Transcytosis of protein through the mammalian cerebral epithelium and endothelium: II. Adsorptive transcytosis of WGA-HRP and the blood-brain and brain-blood barriers. J Neurocytol 22: 67 - 80.
185. Vorbrodt AW (1994). Glycoconjugates and anionic sites in the blood-brain barrier. In: Glycobiologv and the Brain. Nicolini M, Zatta PF (eds). Pergamon Press, Oxford, pp 37 - 62.
186. Wang Y, Sawchuck RJ (1995). Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion. J Pharm Sci 4: 871 - 876.
187. 5]enkephalin opioid analogs. J Pharmacol Exp Ther 266: 1649 - 1655.
188. Weindl A (1973). Neuroendocrine aspects of circumventricular organs. In: Frontiers in Neuroendocrinology. Ganong WF, Martini L (eds). Oxford Univers ty Press, New York, pp 3 - 32.
189. Westergren I, Johansson BB (1993). Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: a comparison between protamine, poly-L-lysine and poly-L-arginine. Acta Physiol Scand 149: 99 - 104.
190. Wiley CA, Schrier RD, Nelson JA, Lamport PW, Oldstone MBA (1986). Cellular localization of human Immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci USA 83: 7089 - 7093.
191. Yamada S, DePasquale M, Patlak CS, Cserr HF (1991). Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol 261: H1197 - H1204.
192. Yu YG, King DS, Shin Y-K (1994). Insertion of a coiledcoil peptide from influenza virus hemagglutinin into membranes. Science 266: 274 - 276.
193. Zhang L, Looney D, Taub D, Chang SL, Way D, Witte MH, Graves MC, Fiala M (1998). Cocaine opens the blood-brain barrier to HIV-1 invasion. Journal of Neurovirology 4: 619 - 626.
194. Zidovetzki R, Wang JL, Chen P, Jeyasseelan R. Hofman F (1998). Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. AIDS Res Hum Retroviruses 14: 825 - 833.
195. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM (1986). Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-α-amincisobutyric acid. J Neurochem 46: 1444 - 1451.