Development and biological evaluation of a novel aurora A kinase inhibitor

ChemBioChem

Volumn 10, Issue 3, 2009, Pages 464-478

  Sardon, Teresa ^a   Cottin, Thomas ^b   Xu, Jing ^b   Giannis, Athanassios ^b   Vernos, Isabelle ^a,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

Antitumor agents; Biological activity; Cell cycle; Inhibitors; Kinases

Indexed keywords

3 [2 (FURAN 2 YL) 4 (ISOPROPYLAMINO)QUINAZOLIN 6 YL]PROP 2 YN 1 OL; 3 [4 (3 FLUOROPHENYLAMINO)QUINAZOLIN 6 YL]PROP 2 YN 1 OL; 4 [2 (FURAN 2 YL) 4 (ISOPROPYLAMINO)QUINAZOLIN 6 YL] 2 METHYLBUT 3 EN 2 OL; AURORA A KINASE INHIBITOR; AURORA KINASE INHIBITOR; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; TC 107; TC 28; TC 34; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MITOSIS SPINDLE; PRIORITY JOURNAL; REACTION ANALYSIS;

CELL CYCLE; CILIA; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MITOTIC SPINDLE APPARATUS; MOLECULAR STRUCTURE; NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES;

MAMMALIA;

EID: 60349113216     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800600     Document Type: Article

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