Heterocyclic Quinones. 17. A New in Vivo Active Antineoplastic Drug: 6,7-Bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8-quinazolinedione

Journal of Medicinal Chemistry

Volumn 34, Issue 1, 1991, Pages 38-46

  Giorgi Renault, Sylviane ^a   Renault, Jean ^a   Gebel Servolles, Patricia ^a   Baron, Michel ^a   Paoletti, Claude ^b   Cros, Suzanne ^c   Bissery, Marie Christine ^d   Lavelle, François ^d   Atassi, Ghanem ^e  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c CNRS   (France)

^d Centre de Recherches de Vitry ^*  (Belgium)

^e UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 BIS(1 AZIRIDINYL) 4 [[3 (DIMETHYLAMINO)PROPYL]AMINO] 5,8 QUINAZOLINEDIONE; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; CANCER; CELL CYCLE; CELL GROWTH; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LEUKEMIA L 1210; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; TUMOR CELL;

ANIMAL; ANTINEOPLASTIC AGENTS; AZIRIDINES; BREAST NEOPLASMS; CELL DIVISION; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMAN; LEUKEMIA L1210; LEUKEMIA, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; QUINAZOLINES; SARCOMA, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T;

EID: 0026013262     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00105a007     Document Type: Article

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