Discovery of a potent and selective Aurora kinase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 17, 2008, Pages 4880-4884

  Oslob, Johan D ^a   Romanowski, Michael J ^a   Allen, Darin A ^a   Baskaran, Subramanian ^a   Bui, Minna ^a   Elling, Robert A ^a   Flanagan, William M ^a   Fung, Amy D ^a   Hanan, Emily J ^a   Harris, Shannon ^a   Heumann, Stacey A ^a   Hoch, Ute ^a   Jacobs, Jeffrey W ^a   Lam, Joni ^a   Lawrence, Chris E ^a   McDowell, Robert S ^a   Nannini, Michelle A ^a   Shen, Wang ^a   Silverman, Jeffrey A ^a   Sopko, Michelle M ^a   Tangonan, Bradley T ^a   Teague, Juli ^a   Yoburn, Josh C ^a   Yu, Chul H ^a   Zhong, Min ^a   Zimmerman, Kristin M ^a   O'Brien, Tom ^a   Lew, Willard ^a   more..

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

Aurora; Inhibitor; Kinases; SNS 314

Indexed keywords

AURORA KINASE INHIBITOR; SNS 314; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PHENOTYPE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HCT116 CELLS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PHENYLUREA COMPOUNDS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 49849102479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.073     Document Type: Article

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