Crystal structure of Aurora-2, an oncogenic serine/threonine kinase

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 42419-42422

  Cheetham, Graham M T ^a   Knegtel, Ronald M A ^a   Coll, Joyce T ^a   Renwick, Suzanne B ^a   Swenson, Lora ^a   Weber, Peter ^a   Lippke, Judith A ^a   Austen, Douglas A ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYMES; TUMORS;

MITOTIC EVENTS;

BIOCHEMISTRY;

ADENOSINE; ADENOSINE TRIPHOSPHATE; AURORA 2 KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; COMPETITIVE INHIBITION; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME BINDING; GENE ACTIVATION; GENE AMPLIFICATION; GENE FUNCTION; GENE STRUCTURE; GENE TARGETING; MITOSIS; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN CONFORMATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SEQUENCE DELETION;

EID: 0037044846     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200426200     Document Type: Article

References (39)

1. Nigg, E. A., Blangy, A., and Lane, H. A. (1996) Exp. Cell Res. 229, 174-180
2. Giet, R., and Prigent, C. (1999) J. Cell Sci. 112, 3591-3601
3. Bischoff, J. R., and Plowman, G. D. (1999) Trends Cell Biol. 9, 454-459
4. Walter, A. O., Seghezzi, W., Korver, W., Sheung, J., and Lees, E. (2000) Oncogene 19, 4906-4916
5. Schumacher, J. M., Golden, A., and Donovan, P. J. (1998) J. Cell Biol. 143, 1635-1646
6. Kimura, M., Kotani, S., Hattori, T., Sumi, N., Yoshioka, T., Todokoro, K., and Okano, Y. (1997) J. Biol. Chem. 272, 13766-13771
7. Bischoff, J. R., Anderson, L., Zhu, Y., Mossie, K., Ng, L., Souza, B., Schryver, B., Flanagan, P., Clairvoyant, F., Ginther, C., Chan, C. S. M., Novotny, M., Slamon, D. J., and Plowman, G. D. (1998) EMBO J. 17, 3052-3065
8. Goepfert, T. M., and Brinkley, B. R. (2000) Curr. Top. Dev. Biol. 49, 331-342
9. Sakakura, C., Hagiwara, A., Yasuoka, R., Fujita, Y., Nakanishi, M., Masuda, K., Shimomura, K., Nakamura, Y., Inazawa, J., Abe, T., and Yamagishi, H. (2001) Br. J. Cancer 84, 824-831
10. Bicher, A., Ault, K., Kimmelman, A., Gershenson, D., Reed, E., and Liang, B. (1997) Gynecol. Oncol. 66, 36-40
11. Hoglund, M., Gorunova, L., Andren-Sandberg, A., Dawiskiba, S., Mitelman, F., and Johansson, B. (1998) Genes Chromosomes Cancer 21, 8-16
12. Miyoshi, Y., Iwao, K., Egawa, C., and Noguchi, S. (2001) Int. J. Cancer 92, 370-373
13. Terada, Y., Tatsuka, M., Suzuki, F., Yasuda, Y., Fujita, S., and Otsu, M. (1998) EMBO J. 17, 667-676
14. Adams, R. R., Carmena, M., and Earnshaw, W. C. (2001) Trends Cell Biol. 11, 49-54
15. Wheatley, S. P., Carvalho, A., Vagnarelli, P., and Earnshaw, W. C. (2001) Curr. Biol. 11, 886-890
16. Glotzer, M., Murray, A. W., and Kirschner, M. W. (1991) Nature 349, 100-101
17. Garcia-Echeverria, C., Traxler, P., and Evans, D. B. (2000) Med. Res. Rev. 20, 28-57
18. Fox, T., Coll, J. T., Xie, X., Ford, P. J., Germann, U. A., Porter, M. D., Pazhanisamy, S., Fleming, M. A., Galullo, V., Su, M. S., and Wilson, K. P. (1998) Protein Sci. 7, 2249-2255
19. Leslie, A. G. W. (1992) Joint CCP4 and ESF-EACMB Newsletter on Protein Crystallography, Daresbury Laboratory, Warrington, UK
20. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
21. Brünger, A. T. (1991) Acta Crystallogr. Sect. A 47, 195-204
22. Hanks, S. K., Quinn, A. M., and Hunter, T. (1988) Science 241, 42-52
23. Brünger, A. T., Adams, P. D., and Rice, L. M. (1998) Curr. Opin. Struct. Biol. 8, 606-611
24. Bossemeyer, D., Engh, R. A., Kinzel, V., Ponstingl, H., and Huber, R. (1993) EMBO J. 12, 849-859
25. Sicheri, F., Moarefi, I., and Kuriyan, J. (1997) Nature 385, 602-609
26. Xu, W., Harrison, S. C., and Eck, M. J. (1997) Nature 385, 595-602
27. Lamers, M. B. A. C., Antson, A. A., Hubbard, R. E., Scott, R. K., and Williams, D. H. (1999) J. Mol. Biol. 285, 713-725
28. Tereshko, V., Teplova, M., Brunzelle, J., Watterson, D. M., and Egli, M. (2001) Nat. Struct. Biol. 8, 899-907
29. Sondhi, D., and Cole, P. A. (1999) Biochemistry 38, 11147-11155
30. Kaitner, S., Mendoza, M., Jantsch-Plunger, V., and Glotzer, M. (2000) Curr. Biol. 10, 1172-1181
31. Narayana, N., Cox, S., Shaltiel, S., Taylor, S. S., and Xuong, N. (1997) Biochemistry 36, 4438-4448
32. Wang, Z., Canagarajah, B. J., Boehm, J. C., Kassisa, S., Cobb, M. H., Young, P. R., Abdel-Meguid, S., Adams, J. L., and Goldsmith, E. J. (1998) Structure 6, 1117-1128
33. Russo, A. A., Jeffrey, P. D., and Pavletich, N. P. (1996) Nat. Struct. Biol. 3, 696-700
34. Brown, N. R., Noble, M. E., Endicott, J. A., and Johnson, L. N. (1999) Nat. Cell Biol. 1, 438-443
35. ter Haar, E., Coll, J. T., Austen, D. A., Hsiao, H.-M., Swenson, L., and Jain, J. (2001) Nat. Struct. Biol. 8, 593-596
36. Zhang, J., Zhang, F., Ebert, D., Cobb, M. H., and Goldsmith, E. J. (1995) Structure 3, 299-307
37. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-4302
38. Brünger, A. T. (1992) Nature 355, 472-474
39. Carson, M. (1991) J. Appl. Crystallogr. 24, 958-961