7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5130-5133

  Hughes, Terry V ^a   Emanuel, Stuart L ^a   O'Grady, Harold R ^a   Connolly, Peter J ^a   Rugg, Catherine ^a   Fuentes Pesquera, Angel R ^a   Karnachi, Prabha ^a   Alexander, Richard ^a   Middleton, Steven A ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

2,3 Dihydro isoindol 1 ones; Aurora A; Aurora B; Aurora C; Cancer; Isoindolinone; Kinase; Kinase inhibition; Vascular endothelial growth factor receptor 2; VEGF R2

Indexed keywords

7 [1H INDOLO 2 YL] 2,3 DIHYDRO ISOINDOL 1 ONE DERIVATIVE; AURORA A KINASE; AURORA KINASE INHIBITOR; SUNITINIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; X RAY ANALYSIS;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; INDOLES; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 51549112706     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.090     Document Type: Article

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