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Volumn , Issue SUPPL. 83, 2008, Pages

Using morpholinos to control gene expression

Author keywords

Antisense; Knockdown; Morpholino; Oligo; Splicing; Xenopus; Zebrafish

Indexed keywords

COMPLEMENTARY RNA; MESSENGER RNA; MICRORNA; MORPHOLINE DERIVATIVE; MORPHOLINO OLIGONUCLEOTIDE; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; AGAROSE;

EID: 58849118461     PISSN: 19343639     EISSN: 19343647     Source Type: Journal    
DOI: 10.1002/0471142727.mb2608s83     Document Type: Review
Times cited : (43)

References (78)
  • 1
    • 0022423486 scopus 로고
    • Base-basemismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,T)
    • Aboul-ela, F., Koh, D., Tinoco, I. Jr., and Martin, F.H. 1985. Base-basemismatches. Thermodynamics of double helix formation for dCA3XA3G + dCT3YT3G (X, Y = A,C,G,T). Nucleic Acids Res. 13:4811-4824.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 4811-4824
    • Aboul-ela, F.1    Koh, D.2    Tinoco Jr., I.3    Martin, F.H.4
  • 2
    • 27644550636 scopus 로고    scopus 로고
    • Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptideconjugated morpholino oligomers
    • Alonso, M., Stein, D.A., Thomann, E., Moulton, H.M., Leong, J.C., Iversen, P., and Mourich, D.V. 2005. Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptideconjugated morpholino oligomers. J. Fish Dis. 28:399-410.
    • (2005) J. Fish Dis. , vol.28 , pp. 399-410
    • Alonso, M.1    Stein, D.A.2    Thomann, E.3    Moulton, H.M.4    Leong, J.C.5    Iversen, P.6    Mourich, D.V.7
  • 3
    • 19544363571 scopus 로고    scopus 로고
    • Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements
    • Bruno, I.G., Jin, W., and Cote, G.J. 2004. Correction of aberrant FGFR1 alternative RNA splicing through targeting of intronic regulatory elements. Hum. Mol. Genet. 13:2409-2420.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 2409-2420
    • Bruno, I.G.1    Jin, W.2    Cote, G.J.3
  • 4
    • 33746907778 scopus 로고    scopus 로고
    • Electroporation of DNA, RNA, and morpholinos into zebrafish embryos
    • Cerda, G.A., Thomas, J.E., Allende, M.L., Karlstrom, R.O., and Palma, V. 2006. Electroporation of DNA, RNA, and morpholinos into zebrafish embryos. Methods 39:207-211.
    • (2006) Methods , vol.39 , pp. 207-211
    • Cerda, G.A.1    Thomas, J.E.2    Allende, M.L.3    Karlstrom, R.O.4    Palma, V.5
  • 5
    • 0026737313 scopus 로고
    • Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures
    • Cheong, C. and Moore, P.B. 1992. Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures. Biochemistry 31:8406-8414.
    • (1992) Biochemistry , vol.31 , pp. 8406-8414
    • Cheong, C.1    Moore, P.B.2
  • 6
    • 35348914716 scopus 로고    scopus 로고
    • Target protectors reveal dampening and balancing of nodal agonist and antagonist by miR-430
    • Choi, W.Y., Giraldez, A.J., and Schier, A.F. 2007. Target protectors reveal dampening and balancing of nodal agonist and antagonist by miR-430. Science 318:271-274.
    • (2007) Science , vol.318 , pp. 271-274
    • Choi, W.Y.1    Giraldez, A.J.2    Schier, A.F.3
  • 8
    • 0034904642 scopus 로고    scopus 로고
    • Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: A quantifiable method for gene knockdown
    • Draper, B.W., Morcos, P.A., and Kimmel, C.B. 2001. Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: A quantifiable method for gene knockdown. Genesis 30:154-156.
    • (2001) Genesis , vol.30 , pp. 154-156
    • Draper, B.W.1    Morcos, P.A.2    Kimmel, C.B.3
  • 9
    • 33749208029 scopus 로고    scopus 로고
    • Morphants: A new systematic vertebrate functional genomics approach
    • Ekker, S.C. 2000. Morphants: A new systematic vertebrate functional genomics approach. Yeast 17:302-306.
    • (2000) Yeast , vol.17 , pp. 302-306
    • Ekker, S.C.1
  • 10
    • 0034897373 scopus 로고    scopus 로고
    • Morphant technology in model developmental systems
    • Ekker, S.C. and Larson, J.D. 2001. Morphant technology in model developmental systems. Genesis 30:89-93.
    • (2001) Genesis , vol.30 , pp. 89-93
    • Ekker, S.C.1    Larson, J.D.2
  • 12
    • 21244503545 scopus 로고    scopus 로고
    • Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis
    • Geller, B.L., Deere, J., Tilley, L., and Iversen, P.L. 2005. Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis. J. Antimicrob. Chemother. 55:983-988.
    • (2005) J. Antimicrob. Chemother. , vol.55 , pp. 983-988
    • Geller, B.L.1    Deere, J.2    Tilley, L.3    Iversen, P.L.4
  • 14
    • 25444458618 scopus 로고    scopus 로고
    • A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates
    • Hayashi, Y., Horibata, Y., Sakaguchi, K., Okino, N., and Ito, M. 2005. A sensitive and reproducible assay to measure the activity of glucosylceramide synthase and lactosylceramide synthase using HPLC and fluorescent substrates. Anal. Biochem. 345:181-186.
    • (2005) Anal. Biochem. , vol.345 , pp. 181-186
    • Hayashi, Y.1    Horibata, Y.2    Sakaguchi, K.3    Okino, N.4    Ito, M.5
  • 15
    • 0347569577 scopus 로고    scopus 로고
    • Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting
    • He, J., Liu, G., Zhang, S., Rusckowski, M., and Hnatowich, D.J. 2003. Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting. Cancer Biother. Radiopharm. 18:941-947.
    • (2003) Cancer Biother. Radiopharm. , vol.18 , pp. 941-947
    • He, J.1    Liu, G.2    Zhang, S.3    Rusckowski, M.4    Hnatowich, D.J.5
  • 16
    • 3242734128 scopus 로고    scopus 로고
    • Amplification targeting: A modified pretargeting approach with potential for signal amplification-proof of a concept
    • He, J., Liu, G., Gupta, S., Zhang, Y., Rusckowski, M., and Hnatowich, D.J. 2004. Amplification targeting: A modified pretargeting approach with potential for signal amplification-proof of a concept. J. Nucl. Med. 45:1087-1095.
    • (2004) J. Nucl. Med. , vol.45 , pp. 1087-1095
    • He, J.1    Liu, G.2    Gupta, S.3    Zhang, Y.4    Rusckowski, M.5    Hnatowich, D.J.6
  • 17
    • 0034213262 scopus 로고    scopus 로고
    • Betacatenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
    • Heasman, J., Kofron, M., and Wylie, C. 2000. Betacatenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach. Dev. Biol. 222:124-134.
    • (2000) Dev. Biol. , vol.222 , pp. 124-134
    • Heasman, J.1    Kofron, M.2    Wylie, C.3
  • 18
    • 0015913815 scopus 로고
    • Reaction of diethylpyrocarbonate with nucleic acid components. Adenosinecontaining nucleotides and dinucleoside phosphates
    • Henderson, R.E., Kirkegaard, L.H., and Leonard, N.J. 1973. Reaction of diethylpyrocarbonate with nucleic acid components. Adenosinecontaining nucleotides and dinucleoside phosphates. Biochim. Biophys. Acta 294:356-364.
    • (1973) Biochim. Biophys. Acta , vol.294 , pp. 356-364
    • Henderson, R.E.1    Kirkegaard, L.H.2    Leonard, N.J.3
  • 19
    • 4644308292 scopus 로고    scopus 로고
    • Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotides
    • Howard, M.T., Gesteland, R.F., and Atkins, J.F. 2004. Efficient stimulation of site-specific ribosome frameshifting by antisense oligonucleotides. RNA 10:1653-1661.
    • (2004) RNA , vol.10 , pp. 1653-1661
    • Howard, M.T.1    Gesteland, R.F.2    Atkins, J.F.3
  • 21
    • 16544379812 scopus 로고    scopus 로고
    • Optimizing electroporation conditions for intracellular delivery of Morpholino antisense oligonucleotides directed against the hepatitis C virus internal ribosome entry site
    • Jubin, R. 2005. Optimizing electroporation conditions for intracellular delivery of Morpholino antisense oligonucleotides directed against the hepatitis C virus internal ribosome entry site. Methods Mol. Med. 106:309-322.
    • (2005) Methods Mol. Med. , vol.106 , pp. 309-322
    • Jubin, R.1
  • 22
    • 0033765890 scopus 로고    scopus 로고
    • Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding
    • Jubin, R., Vantuno, N.E., Kieft, J.S., Murray, M.G., Doudna, J.A., Lau, J.Y., and Baroudy, B.M. 2000. Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. J. Virol. 74:10430-10437.
    • (2000) J. Virol. , vol.74 , pp. 10430-10437
    • Jubin, R.1    Vantuno, N.E.2    Kieft, J.S.3    Murray, M.G.4    Doudna, J.A.5    Lau, J.Y.6    Baroudy, B.M.7
  • 23
    • 40949101777 scopus 로고    scopus 로고
    • Quantitative assessment of the knockdown efficiency of Morpholino antisense oligonucleotides in zebrafish embryos using a luciferase assay
    • Kamachi, Y., Okuda, Y., and Kondoh, H. 2008. Quantitative assessment of the knockdown efficiency of Morpholino antisense oligonucleotides in zebrafish embryos using a luciferase assay. Genesis 46:1-7.
    • (2008) Genesis , vol.46 , pp. 1-7
    • Kamachi, Y.1    Okuda, Y.2    Kondoh, H.3
  • 26
    • 0021969796 scopus 로고
    • Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer
    • Kimmel, C.B. and Law, R.D. 1985a. Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer. Dev. Biol. 108:86-93.
    • (1985) Dev. Biol. , vol.108 , pp. 86-93
    • Kimmel, C.B.1    Law, R.D.2
  • 27
    • 0021943613 scopus 로고
    • Cell lineage of zebrafish blastomeres. III. Clonal analyses of the blastula and gastrula stages
    • Kimmel, C.B. and Law, R.D. 1985b. Cell lineage of zebrafish blastomeres. III. Clonal analyses of the blastula and gastrula stages. Dev. Biol. 108:94-101.
    • (1985) Dev. Biol. , vol.108 , pp. 94-101
    • Kimmel, C.B.1    Law, R.D.2
  • 28
    • 16244366477 scopus 로고    scopus 로고
    • Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with Morpholino oligomers
    • Kinney, R.M., Huang, C.Y., Rose, B.C., Kroeker, A.D., Dreher, T.W., Iversen, P.L., and Stein, D.A. 2005. Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with Morpholino oligomers. J. Virol. 79:5116-5128.
    • (2005) J. Virol. , vol.79 , pp. 5116-5128
    • Kinney, R.M.1    Huang, C.Y.2    Rose, B.C.3    Kroeker, A.D.4    Dreher, T.W.5    Iversen, P.L.6    Stein, D.A.7
  • 29
    • 13444312098 scopus 로고    scopus 로고
    • Substrate requirements for let-7 function in the developing zebrafish embryo
    • Kloosterman, W.P., Wienholds, E., Ketting, R.F., and Plasterk, R.H. 2004. Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res. 32:6284-6291.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 6284-6291
    • Kloosterman, W.P.1    Wienholds, E.2    Ketting, R.F.3    Plasterk, R.H.4
  • 30
    • 34548284448 scopus 로고    scopus 로고
    • Targeted inhibition ofmiRNA maturation with Morpholinos reveals a role formiR-375 in pancreatic islet development
    • Kloosterman, W.P., Lagendijk, A.K., Ketting, R.F., Moulton, J.D., and Plasterk, R.H. 2007. Targeted inhibition ofmiRNA maturation with Morpholinos reveals a role formiR-375 in pancreatic islet development. PLoS Biol. 5:e203.
    • (2007) PLoS Biol. , vol.5
    • Kloosterman, W.P.1    Lagendijk, A.K.2    Ketting, R.F.3    Moulton, J.D.4    Plasterk, R.H.5
  • 31
    • 0037371654 scopus 로고    scopus 로고
    • Methods for introducing Morpholinos into the chicken embryo
    • Kos, R., Tucker, R.P., Hall, R., Duong, T.D., and Erickson, C.A. 2003. Methods for introducing Morpholinos into the chicken embryo. Dev. Dyn. 226:470-477.
    • (2003) Dev. Dyn. , vol.226 , pp. 470-477
    • Kos, R.1    Tucker, R.P.2    Hall, R.3    Duong, T.D.4    Erickson, C.A.5
  • 32
    • 0035028575 scopus 로고    scopus 로고
    • Antisense oligonucleotides: Promise and reality
    • Lebedeva, I. and Stein, C.A. 2001. Antisense oligonucleotides: Promise and reality. Annu. Rev. Pharmacol. Toxicol. 41:403-419.
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 403-419
    • Lebedeva, I.1    Stein, C.A.2
  • 33
    • 47749133787 scopus 로고    scopus 로고
    • Design and synthesis of dendritic molecular transporter that achieves efficient in vivo delivery of morpholino antisense oligo
    • In press
    • Li, Y.F. and Morcos, P.A. 2008. Design and synthesis of dendritic molecular transporter that achieves efficient in vivo delivery of morpholino antisense oligo. Bioconjug. Chem. In press.
    • (2008) Bioconjug. Chem.
    • Li, Y.F.1    Morcos, P.A.2
  • 35
    • 0036750551 scopus 로고    scopus 로고
    • The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc- Morpholinos in mice
    • Liu, G., Zhang, S., He, J., Liu, N., Gupta, S., Rusckowski, M., and Hnatowich, D.J. 2002b. The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc- Morpholinos in mice. Q. J. Nucl. Med. 46:233-243.
    • (2002) Q. J. Nucl. Med. , vol.46 , pp. 233-243
    • Liu, G.1    Zhang, S.2    He, J.3    Liu, N.4    Gupta, S.5    Rusckowski, M.6    Hnatowich, D.J.7
  • 38
    • 0042265573 scopus 로고    scopus 로고
    • Apotent and specific Morpholino antisense inhibitor of hepatitis C translation in mice
    • McCaffrey, A.P., Meuse, L., Karimi, M., Contag, C.H., and Kay, M.A. 2003.Apotent and specific Morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology 38:503-508.
    • (2003) Hepatology , vol.38 , pp. 503-508
    • McCaffrey, A.P.1    Meuse, L.2    Karimi, M.3    Contag, C.H.4    Kay, M.A.5
  • 39
    • 33745479703 scopus 로고    scopus 로고
    • Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD
    • McClorey, G., Moulton, H.M., Iversen, P.L., Fletcher, S., and Wilton, S.D. 2006. Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD. Gene Ther. 13:1373-1381.
    • (2006) Gene Ther. , vol.13 , pp. 1373-1381
    • McClorey, G.1    Moulton, H.M.2    Iversen, P.L.3    Fletcher, S.4    Wilton, S.D.5
  • 40
    • 0036806941 scopus 로고    scopus 로고
    • Spatial and temporal 'knock down' of gene expression by electroporation of doublestranded RNA and Morpholinos into early postimplantation mouse embryos
    • Mellitzer, G., Hallonet, M., Chen, L., and Ang, S.L. 2002. Spatial and temporal 'knock down' of gene expression by electroporation of doublestranded RNA and Morpholinos into early postimplantation mouse embryos. Mech. Dev. 118:57-63.
    • (2002) Mech. Dev. , vol.118 , pp. 57-63
    • Mellitzer, G.1    Hallonet, M.2    Chen, L.3    Ang, S.L.4
  • 41
    • 34748892292 scopus 로고    scopus 로고
    • Combinatorial control of signalinduced exon repression by hnRNP L and PSF
    • Melton, A.A., Jackson, J., Wang, J., and Lynch, K.W. 2007. Combinatorial control of signalinduced exon repression by hnRNP L and PSF. Mol. Cell Biol. 27:6972-6984.
    • (2007) Mol. Cell Biol. , vol.27 , pp. 6972-6984
    • Melton, A.A.1    Jackson, J.2    Wang, J.3    Lynch, K.W.4
  • 42
    • 0037220834 scopus 로고    scopus 로고
    • Beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification
    • Monga, S.P., Monga, H.K., Tan, X., Mule, K., Pediaditakis, P., and Michalopoulos, G.K. 2003. Beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and lineage specification. Gastroenterology 124:202-216.
    • (2003) Gastroenterology , vol.124 , pp. 202-216
    • Monga, S.P.1    Monga, H.K.2    Tan, X.3    Mule, K.4    Pediaditakis, P.5    Michalopoulos, G.K.6
  • 43
    • 0034910904 scopus 로고    scopus 로고
    • Achieving efficient delivery of Morpholino oligos in cultured cells
    • Morcos, P.A. 2001. Achieving efficient delivery of Morpholino oligos in cultured cells. Genesis 30:94-102.
    • (2001) Genesis , vol.30 , pp. 94-102
    • Morcos, P.A.1
  • 44
    • 34248562970 scopus 로고    scopus 로고
    • Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos
    • Morcos, P.A. 2007. Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos. Biochem. Biophys. Res. Commun. 358:521-527.
    • (2007) Biochem. Biophys. Res. Commun. , vol.358 , pp. 521-527
    • Morcos, P.A.1
  • 45
    • 0038814141 scopus 로고    scopus 로고
    • Peptideassisted delivery of steric-blocking antisense oligomers
    • Moulton, H.M. and Moulton, J.D. 2003. Peptideassisted delivery of steric-blocking antisense oligomers. Curr. Opin. Mol. Ther. 5:123-132.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 123-132
    • Moulton, H.M.1    Moulton, J.D.2
  • 46
    • 58849150615 scopus 로고    scopus 로고
    • Antisense morpholino oligomers and their peptide conjugates
    • In (J. Kurreck, ed.) Royal Society of Chemistry, London. In press
    • Moulton, H.M. and Moulton, J.D. 2008. Antisense morpholino oligomers and their peptide conjugates. In Therapeutic Oligonucleotides (J. Kurreck, ed.) pp. 43-79. Royal Society of Chemistry, London. In press.
    • (2008) Therapeutic Oligonucleotides , pp. 43-79
    • Moulton, H.M.1    Moulton, J.D.2
  • 47
    • 1642321105 scopus 로고    scopus 로고
    • Cellular uptake of antisense Morpholino oligomers conjugated to arginine-rich peptides
    • Moulton, H.M., Nelson, M.H., Hatlevig, S.A., Reddy, M.T., and Iversen, P.L. 2004. Cellular uptake of antisense Morpholino oligomers conjugated to arginine-rich peptides. Bioconjug. Chem. 15:290-299.
    • (2004) Bioconjug. Chem. , vol.15 , pp. 290-299
    • Moulton, H.M.1    Nelson, M.H.2    Hatlevig, S.A.3    Reddy, M.T.4    Iversen, P.L.5
  • 48
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius, A. and Ekker, S.C. 2000. Effective targeted gene 'knockdown' in zebrafish. Nat. Genet. 26:216-220.
    • (2000) Nat. Genet. , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 49
    • 22644440063 scopus 로고    scopus 로고
    • Arginine-rich peptide conjugation to Morpholino oligomers: Effects on antisense activity and specificity
    • Nelson, M.H., Stein, D.A., Kroeker, A.D., Hatlevig, S.A., Iversen, P.L., and Moulton, H.M. 2005. Arginine-rich peptide conjugation to Morpholino oligomers: Effects on antisense activity and specificity. Bioconjug. Chem. 16:959-966.
    • (2005) Bioconjug. Chem. , vol.16 , pp. 959-966
    • Nelson, M.H.1    Stein, D.A.2    Kroeker, A.D.3    Hatlevig, S.A.4    Iversen, P.L.5    Moulton, H.M.6
  • 50
    • 2442696477 scopus 로고    scopus 로고
    • Antisense Morpholinooligomers directed against the 5′ end of the genome inhibit coronavirus proliferation and growth
    • Neuman, B.W., Stein, D.A., Kroeker, A.D., Paulino, A.D., Moulton, H.M., Iversen, P.L., and Buchmeier, M.J. 2004. Antisense Morpholinooligomers directed against the 5′ end of the genome inhibit coronavirus proliferation and growth. J. Virol. 78:5891-5899.
    • (2004) J. Virol. , vol.78 , pp. 5891-5899
    • Neuman, B.W.1    Stein, D.A.2    Kroeker, A.D.3    Paulino, A.D.4    Moulton, H.M.5    Iversen, P.L.6    Buchmeier, M.J.7
  • 52
    • 0034908648 scopus 로고    scopus 로고
    • Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis
    • Nutt, S.L., Bronchain, O.J., Hartley, K.O., and Amaya, E. 2001. Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis. Genesis 30:110-113.
    • (2001) Genesis , vol.30 , pp. 110-113
    • Nutt, S.L.1    Bronchain, O.J.2    Hartley, K.O.3    Amaya, E.4
  • 55
    • 34848818078 scopus 로고    scopus 로고
    • Synchrony dynamics during initiation, failure, and rescue of the segmentation clock
    • Riedel-Kruse, I.H., Muller, C., and Oates, A.C. 2007. Synchrony dynamics during initiation, failure, and rescue of the segmentation clock. Science 317:1911-1915.
    • (2007) Science , vol.317 , pp. 1911-1915
    • Riedel-Kruse, I.H.1    Muller, C.2    Oates, A.C.3
  • 59
    • 0033618247 scopus 로고    scopus 로고
    • Antisense oligonucleotides with different backbones. Modification of splicing pathways and efficacy of uptake
    • Schmajuk, G., Sierakowska, H., and Kole, R. 1999. Antisense oligonucleotides with different backbones. Modification of splicing pathways and efficacy of uptake. J. Biol. Chem. 274:21783-21789.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21783-21789
    • Schmajuk, G.1    Sierakowska, H.2    Kole, R.3
  • 60
    • 0043178993 scopus 로고    scopus 로고
    • A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos
    • Stancheva, I., Collins, A.L., Van Den Veyver, I.B., Zoghbi, H., and Meehan, R.R. 2003. A mutant form of MeCP2 protein associated with human Rett syndrome cannot be displaced from methylated DNA by notch in Xenopus embryos. Mol. Cell. 12:425-435.
    • (2003) Mol. Cell. , vol.12 , pp. 425-435
    • Stancheva, I.1    Collins, A.L.2    Van Den Veyver, I.B.3    Zoghbi, H.4    Meehan, R.R.5
  • 61
    • 0030747101 scopus 로고    scopus 로고
    • A specificity comparison of four antisense types: Morpholino, 2′-Omethyl RNA, DNA, and phosphorothioate DNA
    • Stein, D., Foster, E., Huang, S.B., Weller, D., and Summerton, J. 1997. A specificity comparison of four antisense types: Morpholino, 2′-Omethyl RNA, DNA, and phosphorothioate DNA. Antisense Nucleic Acid Drug Dev. 7:151-157.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 151-157
    • Stein, D.1    Foster, E.2    Huang, S.B.3    Weller, D.4    Summerton, J.5
  • 62
    • 0035181386 scopus 로고    scopus 로고
    • Inhibition of Vesivirus infections in mammalian tissue culture with antisense Morpholino oligomers
    • Stein, D.A., Skilling, D.E., Iversen, P.L., and Smith, A.W. 2001. Inhibition of Vesivirus infections in mammalian tissue culture with antisense Morpholino oligomers. Antisense Nucleic Acid Drug Dev. 11:317-325.
    • (2001) Antisense Nucleic Acid Drug Dev. , vol.11 , pp. 317-325
    • Stein, D.A.1    Skilling, D.E.2    Iversen, P.L.3    Smith, A.W.4
  • 63
    • 0024382446 scopus 로고
    • Uncharged stereoregular nucleic acid analogs: 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages
    • Stirchak, E.P., Summerton, J.E., and Weller, D.D. 1989. Uncharged stereoregular nucleic acid analogs: 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages. Nucleic Acids Res. 17:6129-6141.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 6129-6141
    • Stirchak, E.P.1    Summerton, J.E.2    Weller, D.D.3
  • 64
    • 0032699477 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: The case for an RNase Hindependent structural type
    • Summerton, J. 1999. Morpholino antisense oligomers: The case for an RNase Hindependent structural type. Biochim. Biophys. Acta 1489:141-158.
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 141-158
    • Summerton, J.1
  • 65
    • 11144290145 scopus 로고    scopus 로고
    • Morpholinos and PNAs compared
    • Summerton, J. 2004. Morpholinos and PNAs compared. Lett. Pept. Sci. 10:215-236.
    • (2004) Lett. Pept. Sci. , vol.10 , pp. 215-236
    • Summerton, J.1
  • 66
    • 33745321945 scopus 로고    scopus 로고
    • Endo-Porter: A novel reagent for safe, effective delivery of substances into cells
    • Summerton, J. 2005. Endo-Porter: A novel reagent for safe, effective delivery of substances into cells. Ann. N.Y. Acad. Sci. 1058:1-14.
    • (2005) Ann. N.Y. Acad. Sci. , vol.1058 , pp. 1-14
    • Summerton, J.1
  • 67
    • 0030862707 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: Design, preparation, and properties
    • Summerton, J. and Weller, D. 1997. Morpholino antisense oligomers: Design, preparation, and properties. Antisense Nucleic Acid Drug Dev. 7:187-195.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 187-195
    • Summerton, J.1    Weller, D.2
  • 68
    • 0036942827 scopus 로고    scopus 로고
    • Repair of a splicing defect in erythroid cells from patients with betathalassemia/HbE disorder
    • Suwanmanee, T., Sierakowska, H., Fucharoen, S., and Kole, R. 2002. Repair of a splicing defect in erythroid cells from patients with betathalassemia/HbE disorder. Mol. Ther. 6:718-726.
    • (2002) Mol. Ther. , vol.6 , pp. 718-726
    • Suwanmanee, T.1    Sierakowska, H.2    Fucharoen, S.3    Kole, R.4
  • 69
    • 0036595981 scopus 로고    scopus 로고
    • Manipulating gene expressions by electroporation in the developing brain of mammalian embryos
    • Takahashi, M., Sato, K., Nomura, T., and Osumi, N. 2002. Manipulating gene expressions by electroporation in the developing brain of mammalian embryos. Differentiation 70:155-162.
    • (2002) Differentiation , vol.70 , pp. 155-162
    • Takahashi, M.1    Sato, K.2    Nomura, T.3    Osumi, N.4
  • 71
    • 0344427102 scopus 로고    scopus 로고
    • Expression of c-myc is not critical for cell proliferation in established human leukemia lines
    • Tidd, D.M., Giles, R.V., Broughton, C.M., and Clark, R.E. 2001. Expression of c-myc is not critical for cell proliferation in established human leukemia lines. BMC Mol. Biol. 2:13.
    • (2001) BMC Mol. Biol. , vol.2 , pp. 13
    • Tidd, D.M.1    Giles, R.V.2    Broughton, C.M.3    Clark, R.E.4
  • 72
    • 8444236068 scopus 로고    scopus 로고
    • Antisense knockdown of the beta1 integrin subunit in the chicken embryo results in abnormal neural crest cell development
    • Tucker, R.P. 2004. Antisense knockdown of the beta1 integrin subunit in the chicken embryo results in abnormal neural crest cell development. Int. J. Biochem. Cell Biol. 36:1135-1139.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 1135-1139
    • Tucker, R.P.1
  • 73
    • 33644843816 scopus 로고    scopus 로고
    • Novel targeting of cyclooxygenase-2 (COX-2) pre-mRNAusing antisense morpholino oligonucleotides directed to the 3′ acceptor and 5′ donor splice sites of exon 4: Suppression of COX-2 activity in human amnion-derivedWISH and myometrial cells
    • Tyson-Capper, A.J. and Europe-Finner, G.N. 2006. Novel targeting of cyclooxygenase-2 (COX-2) pre-mRNAusing antisense morpholino oligonucleotides directed to the 3′ acceptor and 5′ donor splice sites of exon 4: Suppression of COX-2 activity in human amnion-derivedWISH and myometrial cells. Mol. Pharmacol. 69:796-804.
    • (2006) Mol. Pharmacol. , vol.69 , pp. 796-804
    • Tyson-Capper, A.J.1    Europe-Finner, G.N.2
  • 74
    • 27644566456 scopus 로고    scopus 로고
    • Antiviral activity of Morpholino oligomers designed to block various aspects of equine arteritis virus amplification in cell culture
    • van den Born, E., Stein, D.A., Iversen, P.L., and Snijder, E.J. 2005. Antiviral activity of Morpholino oligomers designed to block various aspects of equine arteritis virus amplification in cell culture. J. Gen. Virol. 86:3081-3090.
    • (2005) J. Gen. Virol. , vol.86 , pp. 3081-3090
    • van den Born, E.1    Stein, D.A.2    Iversen, P.L.3    Snijder, E.J.4
  • 78
    • 33846434072 scopus 로고    scopus 로고
    • Stability of cell-penetrating peptide-Morpholino oligomer conjugates in human serum and in cells
    • Youngblood, D.S., Hatlevig, S.A., Hassinger, J.N., Iversen, P.L., and Moulton, H.M. 2007. Stability of cell-penetrating peptide-Morpholino oligomer conjugates in human serum and in cells. Bioconjug. Chem. 18:50-60.
    • (2007) Bioconjug. Chem. , vol.18 , pp. 50-60
    • Youngblood, D.S.1    Hatlevig, S.A.2    Hassinger, J.N.3    Iversen, P.L.4    Moulton, H.M.5


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