Resistance of Morpholino phosphorodiamidate oligomers to enzymatic degradation

Antisense and Nucleic Acid Drug Development

Volumn 6, Issue 4, 1996, Pages 267-272

  Hudziak, Robert M ^a   Barofsky, Elisabeth ^b   Barofsky, Douglas F ^b   Weller, Doreen L ^a   Huang, Sung Ben ^a   Weller, Dwight D ^a  

^a Antivirals Inc   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; ESTERASE; MORPHOLINE DERIVATIVE; NUCLEASE; OLIGOMER; PHOSPHORAMIDIC ACID DERIVATIVE; PROTEINASE;

ARTICLE; CONTROLLED STUDY; DEGRADATION; MASS SPECTROMETRY; MOLECULAR STABILITY; PRIORITY JOURNAL; SERUM;

EID: 0030475053     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1996.6.267     Document Type: Article

References (5)

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2. BRUIN, G.J.M., BORNSEN, K.O., HUSKEN, D., GASSMANN, E., WIDMER, H.M., and PAULUS, A. (1995). Stability measurements of antisense oligonucleotides by capillary gel electrophoresis. J. Chromatography A 709, 181-195.
3. KEAN, J.M., CUSHMAN, C.D., KANG, Y., LEONARD, T.E., and MILLER, P.S. (1994). Interactions of oligonucleotide analogs containing methylphosphonate internucleoside linkages and 2′-O-methylribonucleosides. Nucleic Acids. Res. 22, 4497-4503.
4. KOMINATO, Y., NISHAMURA, N., and TAKEYAMA, K. (1976a). 1. Isolation and bacteriostatic effect of scordinin A1 and its decomposition product. Oyo Yakuri 11, 941-944.
5. TAYLOR, M.F., PAULAUSKIS, J.D., WELLER, D.D., and KOBZIK, L. (1996). In vitro efficacy of morpholino-modified antisense oligomers directed against TNF-α mRNA. J. Biol. Chem. 271, 17445-17452.