Morphants: A new systematic vertebrate functional genomics approach

Yeast

Volumn 17, Issue 4, 2000, Pages 302-306

  Ekker, Stephen C ^a  

^a Minnesota Medical School Minneapolis   (United States)

Author keywords

Functional genomics; Morphant; Morpholino; Vertebrate; Zebrafish

Indexed keywords

EID: 33749208029     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0061(200012)17:4<302::aid-yea53>3.0.co;2-%23     Document Type: Article

References (26)

1. Amsterdam A, Burgess S, Golling G, et al. 1999. A largescale insertional mutagencsis screen in zebrafish. Genes Dev 13: 2713-2724.
2. Arora V, Knapp DC, Smith BL, et al. 2000. c-Myc antisense limits rat liver regeneration and indicates role for c- Myc in regulating cytochrome P-450 3A activity. J Pharmacol Exp Ther 292: 921-928.
3. Barabino SM, Spada F, Cotelli F, Boncinelli E. 1997. Inactivation of the zebrafish homologue of ChxIO by antisense oligonucleotides causes eye malformations similar to the ocular retardation phenotype. Mech Dev 63: 133-143.
4. Driever W, Solnica-Krezel L, Schier AF, et al. 1996. A genetic screen for mutations affecting embryogenesis jn zebrafish. Development 123: 37-46.
5. Gates MA, Kirn L, Egan ES, et al. 1999. A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences. Genome Res 9: 334-347.
6. Haffter P, Granato M, Brand M, et al. 1996. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123: 1-36.
7. Heasman J, Kofron M, Wylie C. 2000. -catenin signalling activity dissected in the early Xenopus embryo: a novel antisense approach. Dev Biol 222: 124-134.
8. Hunter CP. 2000. Shrinking the black box of RNAi. Cttrr Biol 10: R137-R140.
9. Ivies Z, Hackett PB, Plasterk RH, Izsvak Z. 1997. Molecular reconstruction of Sleeping Beauty, a Tel-like transposon from fish, and its transposition in human cells. Cell 91: 501-510.
10. Kennerdell JR, Carthew RW. 1998. Use of dsRNA-mcdiated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95: 1017-1026.
11. Li YX, Farrell MJ, Liu R, Mohanty N, Kirby ML. 2000. Double-stranded RNA injection produces null phenotypes in zebrafish. Dev Biol 217: 394-405.
12. Nasevicius A, Ekker SC. 2000. Effective targeted gene knock-down in zebrafish. Nature Genet 26: 216-220.
13. Gates AC, Bruce AE, Ho RK. 2000. Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo. Dev Biol 224: 20-28.
14. Gates AC, Wollberg P, Pratt SJ, et al. 1999. Zebrafish stat3 is expressed in restricted tissues during embryogenesis and stall rescues cytokine signalling in a ST ATI-deficient human cell line. Dev Dyn 215: 352-370.
15. Postlethwait J, Amores A, Force A, Van YL. 1999. The zebrafish genome. Methods Cell Biol 60: 149-163.
16. Qin G, Taylor M, Ning YY, Iversen P, Kobzik L. 2000. In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha. Antisense Nucleic Acid Drug Dev 10: 11-16.
17. Raz E, van Luenen HG, Schaerringer B, Plasterk RHA, Driever W. 1998. Transposition of the nematode Caenorhabdilis elegans Tc3 element in the zebrafish Danio rerio. Curr Biol 8: 82-88.
18. Summerton J. 1999. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim Biophys Acta 1489: 141-158.
19. Summerton J, Weller D. 1997. Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Der 7: 187-195.
20. Svoboda P, Stein P, Hayashi H, Schultz RM. 2000. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development 127: 4147-156.
21. Talbot WS, Hopkins N. 2000. Zebrafish mutations and functional analysis of the vertebrate genome. Genes Der 14: 755-762.
22. Tavernarakis N, Wang SL, Dorovkov M, Ryazanov A, Driscoll M. 2000. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nature Genet 2-4: 180-183.
23. Wallis DE, Muenke M. 1999. Molecular mechanisms of holoprosencephaly. Mol Genet Metabol 68: 126-138.
24. Wargelius A, Ellingsen S, Fjose A. 1999. Double-stranded RNA induces specific developmental defects in zebrafish embryos. Biochem Biophys Res Commun 263: 156-161.
25. Wianny F, Zernicka-Goetz M. 2000. Specific interference with gene function by double-stranded RNA in early mouse development. Nature Cell Biol 2: 70-75.
26. Zernicka-Goetz M. 2000. Jumping the gun on mouse gene expression. Nature 405: 733.