-
1
-
-
0030808415
-
Progress in developing PNA as a gene-targeted drug
-
Liam, G. and Nielsen, P.E. Progress in developing PNA as a gene-targeted drug. Antisense Nucl. Acid Drug Dev., 7 (1997) 431-437.
-
(1997)
Antisense Nucl. Acid Drug Dev.
, vol.7
, pp. 431-437
-
-
Liam, G.1
Nielsen, P.E.2
-
3
-
-
0030862707
-
Morpholino antisense oligomers: Design, preparation and properties
-
Summerton, J. and Weller, D. Morpholino antisense oligomers: design, preparation and properties. Antisense Nucleic Acid Drug Dev. 7 (1997) 187-195.
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 187-195
-
-
Summerton, J.1
Weller, D.2
-
4
-
-
0032699477
-
Morpholino antisense oligomers: The case for an RNase H-independent structural type
-
Summerton, J. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim. Biophys. Acta, 1489 (1999) 141-158.
-
(1999)
Biochim. Biophys. Acta
, vol.1489
, pp. 141-158
-
-
Summerton, J.1
-
5
-
-
84888925154
-
-
Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404
-
Summerton, J. (1990) Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404. Summerton J, Weller D. (1993). Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444.
-
(1990)
-
-
Summerton, J.1
-
6
-
-
84888903415
-
-
Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444
-
Summerton, J. (1990) Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404. Summerton J, Weller D. (1993). Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444.
-
(1993)
-
-
Summerton, J.1
Weller, D.2
-
7
-
-
84888924498
-
-
Website
-
Website: www.gene-tools.com
-
-
-
-
8
-
-
0029980721
-
Antisense properties of duplex and triplex forming PNA
-
Knudsen, H. and Nielsen, P.E. Antisense properties of duplex and triplex forming PNA. Nucl. Acids Res., 24 (1996) 494-500.
-
(1996)
Nucl. Acids Res.
, vol.24
, pp. 494-500
-
-
Knudsen, H.1
Nielsen, P.E.2
-
9
-
-
0030902471
-
Selecting effective antisense reagents on combinatorial oligonucleotide arrays
-
Milner, N., Mir, K. and Southern, E. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat. Biotechnol., 15 (1997) 537-541.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 537-541
-
-
Milner, N.1
Mir, K.2
Southern, E.3
-
10
-
-
0003038882
-
Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries
-
Ho, S., Bao, Y., Lesher, T., Malhotra, R., Ma, L., Fluharty, S. and Sakai R. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nat. Biotechnol. 16(1998)59.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 59
-
-
Ho, S.1
Bao, Y.2
Lesher, T.3
Malhotra, R.4
Ma, L.5
Fluharty, S.6
Sakai, R.7
-
11
-
-
33749208029
-
Morphants: A new systematic vertebrate functional genomics approach
-
Ekker, S. Morphants: a new systematic vertebrate functional genomics approach. Yeast, 17 (2000) 302-306.
-
(2000)
Yeast
, vol.17
, pp. 302-306
-
-
Ekker, S.1
-
12
-
-
0002586862
-
PNA oligomer synthesis by BOC chemistry
-
P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
-
Koch, T. PNA oligomer synthesis by BOC chemistry. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 21-37.
-
(1999)
Peptide Nucleic Acids
, pp. 21-37
-
-
Koch, T.1
-
13
-
-
0002152559
-
Synthesis of PNA oligomers by Fmoc Chemistry
-
P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
-
Casale, R., Jensen, I.S. and Egholm, M. Synthesis of PNA oligomers by Fmoc Chemistry. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 39-50.
-
(1999)
Peptide Nucleic Acids
, pp. 39-50
-
-
Casale, R.1
Jensen, I.S.2
Egholm, M.3
-
14
-
-
0010912592
-
PNA/DNA chimeras
-
P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
-
Uhlmann, E., Greinerm B. and Breipohl, G. PNA/DNA chimeras. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 51-70.
-
(1999)
Peptide Nucleic Acids
, pp. 51-70
-
-
Uhlmann, E.1
Greinerm, B.2
Breipohl, G.3
-
16
-
-
0028129843
-
Stability of peptide nucleic acids in human serum and cellular extracts
-
Demidov, V., Potaman, V.N., Frank-Kamenetskii, M.D., Buchardt, O., Egholm, M. and Nielsen, P.E. Stability of peptide nucleic acids in human serum and cellular extracts. Biochem. Pharmacol., 48 (1994) 1309-1313.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1309-1313
-
-
Demidov, V.1
Potaman, V.N.2
Frank-Kamenetskii, M.D.3
Buchardt, O.4
Egholm, M.5
Nielsen, P.E.6
-
17
-
-
0030475053
-
Resistance of Morpholino phosphorodiamidate oligomers to enzymatic degradation
-
Hudziak, R.M., Barofsky, E., Barofsky, D.E., Weller, D.L., Huang, S.B. and Weller, D.D. Resistance of Morpholino phosphorodiamidate oligomers to enzymatic degradation. Antisense Nucl. Acid Drug Dev., 6 (1996) 267-272.
-
(1996)
Antisense Nucl. Acid Drug Dev.
, vol.6
, pp. 267-272
-
-
Hudziak, R.M.1
Barofsky, E.2
Barofsky, D.E.3
Weller, D.L.4
Huang, S.B.5
Weller, D.D.6
-
18
-
-
0034908648
-
Comparison of Morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis
-
Nutt, S.L., Bronchain, O.J., Hartley, K.O. and Amaya, E. Comparison of Morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis. Genesis, 30 (2001) 110-113.
-
(2001)
Genesis
, vol.30
, pp. 110-113
-
-
Nutt, S.L.1
Bronchain, O.J.2
Hartley, K.O.3
Amaya, E.4
-
19
-
-
0001018934
-
Characterization of PNA-dsDNA strand displacement complexes
-
P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
-
Larsen, H.J. and Nielsen, P.E. Characterization of PNA-dsDNA strand displacement complexes. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 221-240.
-
(1999)
Peptide Nucleic Acids
, pp. 221-240
-
-
Larsen, H.J.1
Nielsen, P.E.2
-
20
-
-
0027104702
-
Antisense and antigene properties of peptide nucleic acids
-
Hanvey, J.C., Peffer, N.J., Bisi, J.E., Thomson, S.A., Cadilla, R., Josey, J.A., Ricca, D.J., Hassman, C.F., Bonham, M.A. and Au, K.G. et al. Antisense and antigene properties of peptide nucleic acids. Science, 258 (1992) 1481-1485.
-
(1992)
Science
, vol.258
, pp. 1481-1485
-
-
Hanvey, J.C.1
Peffer, N.J.2
Bisi, J.E.3
Thomson, S.A.4
Cadilla, R.5
Josey, J.A.6
Ricca, D.J.7
Hassman, C.F.8
Bonham, M.A.9
Au, K.G.10
-
23
-
-
0001823921
-
Non-ionic antisense oligonucleotides: Oligonucleotide alkylphosphotriesters
-
J. Cohen (Ed.), Boca Raton: CRC Press
-
Miller, P. Non-ionic antisense oligonucleotides: Oligonucleotide alkylphosphotriesters. In: J. Cohen (Ed.), Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression. Boca Raton: CRC Press (1989) 82-85.
-
(1989)
Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression
, pp. 82-85
-
-
Miller, P.1
-
24
-
-
0001823921
-
Non-ionic antisense oligonucleotides: Oligonucleotide methylphosphonates
-
J. Cohen (Ed.) Boca Raton: CRC Press
-
Miller, P. Non-ionic antisense oligonucleotides: Oligonucleotide methylphosphonates. In: J. Cohen (Ed.) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression. Boca Raton: CRC Press (1989) 85-92.
-
(1989)
Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression
, pp. 85-92
-
-
Miller, P.1
-
25
-
-
0023638996
-
Uncharged stereoregular nucleic acid analogues. 1. Synthesis of a cytosine-containing oligomer with carbamate internucleoside linkages
-
Stirchak, E., Summerton, J. and Weller, D. Uncharged stereoregular nucleic acid analogues. 1. Synthesis of a cytosine-containing oligomer with carbamate internucleoside linkages. J. Org. Chem., 52 (1987) 4202-4206.
-
(1987)
J. Org. Chem.
, vol.52
, pp. 4202-4206
-
-
Stirchak, E.1
Summerton, J.2
Weller, D.3
-
26
-
-
0024382446
-
Uncharged stereoregular nucleic acid analogues. 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages
-
Stirchak, E., Summerton, J. and Weller, D. Uncharged stereoregular nucleic acid analogues. 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages. Nucl. Acids Res., 17 (1989) 6129-6141.
-
(1989)
Nucl. Acids Res.
, vol.17
, pp. 6129-6141
-
-
Stirchak, E.1
Summerton, J.2
Weller, D.3
-
27
-
-
0032191513
-
-
Gildea, B.D., Casey, S., MacNeill, J., Perry-O'Keefe, H., Sørensen, D and Coull, J.M. Tetrah. Lett., 39 (1998) 7255.
-
(1998)
Tetrah. Lett.
, vol.39
, pp. 7255
-
-
Gildea, B.D.1
Casey, S.2
MacNeill, J.3
Perry-O'Keefe, H.4
Sørensen, D.5
Coull, J.M.6
-
28
-
-
0026942133
-
Stacking interactions of ApA analogues with modified backbones
-
Kang, H., Chou, P., Johnson, C., Weller, D., Huang, S, and Summerton, J. Stacking interactions of ApA analogues with modified backbones. Biopolymers, 32 (1992) 1351-1363.
-
(1992)
Biopolymers
, vol.32
, pp. 1351-1363
-
-
Kang, H.1
Chou, P.2
Johnson, C.3
Weller, D.4
Huang, S.5
Summerton, J.6
-
29
-
-
84888885813
-
-
Entire issue
-
Genesis, 30 (2001) 3: Entire issue.
-
(2001)
Genesis
, vol.30
, pp. 3
-
-
-
30
-
-
0030969949
-
Morpholino and Phosphorothioate antisense oligomers compared in cell-free and in-cell systems
-
Summerton, J., Stein, D., Huang, S., Matthews, P., Weller, D. and Partridge, M. Morpholino and Phosphorothioate antisense oligomers compared in cell-free and in-cell systems. Antis. Nucl. Acids Drug Dev., 7 (1997) 63-70.
-
(1997)
Antis. Nucl. Acids Drug Dev.
, vol.7
, pp. 63-70
-
-
Summerton, J.1
Stein, D.2
Huang, S.3
Matthews, P.4
Weller, D.5
Partridge, M.6
-
31
-
-
0035895505
-
The sequence of the human genome
-
Venter, J.C. et al. The sequence of the human genome. Science, 291 (2001) 1304-1351.
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
-
32
-
-
0030747101
-
A specificity comparison of four antisense types: Morpholino, 2′-O-methyl RNA, DNA, and Phosphorothioate DNA
-
Stein, D., Foster, E., Huang, S.B., Weller, D. and Summerton, J. A specificity comparison of four antisense types: Morpholino, 2′-O-methyl RNA, DNA, and Phosphorothioate DNA. Antis. Nucl. Acids Drug Dev., 7 (1997) 151-157.
-
(1997)
Antis. Nucl. Acids Drug Dev.
, vol.7
, pp. 151-157
-
-
Stein, D.1
Foster, E.2
Huang, S.B.3
Weller, D.4
Summerton, J.5
-
33
-
-
0030969949
-
Morpholino and Phosphorothioate antisense oligomers compared in cell-free and in-cell systems
-
Summerton, J., Stein, D., Huang, S.B., Matthews, P., Weller, D. and Partridge, M. Morpholino and Phosphorothioate antisense oligomers compared in cell-free and in-cell systems. Antis. Nucl. Acids Drug Dev., 7 (1997) 63-70.
-
(1997)
Antis. Nucl. Acids Drug Dev.
, vol.7
, pp. 63-70
-
-
Summerton, J.1
Stein, D.2
Huang, S.B.3
Matthews, P.4
Weller, D.5
Partridge, M.6
-
34
-
-
0026009971
-
Interaction of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes)
-
Akhtar, S., Basu, S., Wickstrom, E. and Juliano, R. Interaction of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes). Nucl. Acids Res., 19 (1991) 5551-5559.
-
(1991)
Nucl. Acids Res.
, vol.19
, pp. 5551-5559
-
-
Akhtar, S.1
Basu, S.2
Wickstrom, E.3
Juliano, R.4
-
35
-
-
0344596735
-
Adsorption and efflux characteristics of modified oligodeoxynucleotides from liposomes
-
Akhtar, S. and Juliano, R. Adsorption and efflux characteristics of modified oligodeoxynucleotides from liposomes. Proc. Am. Assoc. Cancer Res. 32 (1991) 333.
-
(1991)
Proc. Am. Assoc. Cancer Res.
, vol.32
, pp. 333
-
-
Akhtar, S.1
Juliano, R.2
-
36
-
-
0001014648
-
Cellular internalization of oligodeoxynucleotides
-
S. Crooke and B. Lebleu B. (Eds.), Boca Raton: CRC Press
-
Neckers, L. Cellular internalization of oligodeoxynucleotides. In: S. Crooke and B. Lebleu B. (Eds.), Antisense Research and Applications. Boca Raton: CRC Press (1993) 451-460.
-
(1993)
Antisense Research and Applications
, pp. 451-460
-
-
Neckers, L.1
-
37
-
-
0030723924
-
Synthesis and membrane permeability of PNA-peptide conjugates
-
Simmons, C.G., Pitts, A.E., Mayfield, L.D., Shay, J.W. and Corey, D.R. Synthesis and membrane permeability of PNA-peptide conjugates. Bioorg. Med. Chem. Lett. 7 (1997) 3001.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 3001
-
-
Simmons, C.G.1
Pitts, A.E.2
Mayfield, L.D.3
Shay, J.W.4
Corey, D.R.5
-
38
-
-
0031754150
-
Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
-
Pooga, M., Soomets, U., Hällbrink, M., Valkna, A., Saar, K., Rezaei, K., Kahl, U., Hao, J.X., Xu, X.J., Weisenfeld-Hallin, Z., Hökfelt, T., Bartfai, T. and Langel, Ü. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol., 16 (1998) 857-861.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 857-861
-
-
Pooga, M.1
Soomets, U.2
Hällbrink, M.3
Valkna, A.4
Saar, K.5
Rezaei, K.6
Kahl, U.7
Hao, J.X.8
Xu, X.J.9
Weisenfeld-Hallin, Z.10
Hökfelt, T.11
Bartfai, T.12
Langel, Ü.13
-
39
-
-
0032536102
-
Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
-
Tyler, B.M., McCormick, D.J., Hoshall, C.V., Douglas, C.L., Jansen, K, Lacy, B.W., Cusack, B. and Richelson, E. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo. FEBS Lett., 421 (1998) 280-284.
-
(1998)
FEBS Lett.
, vol.421
, pp. 280-284
-
-
Tyler, B.M.1
McCormick, D.J.2
Hoshall, C.V.3
Douglas, C.L.4
Jansen, K.5
Lacy, B.W.6
Cusack, B.7
Richelson, E.8
-
40
-
-
0029079310
-
Vector-mediated delivery of a polyamide ('peptide') nucleic acid analogue through the blood-brain barrier in vivo
-
Pardridge, W.M., Boado, R.J. and Kang, Y.S. Vector-mediated delivery of a polyamide ('peptide') nucleic acid analogue through the blood-brain barrier in vivo. Proc. Natl. Acad. Sci, 92 (1995) 5592-5596.
-
(1995)
Proc. Natl. Acad. Sci
, vol.92
, pp. 5592-5596
-
-
Pardridge, W.M.1
Boado, R.J.2
Kang, Y.S.3
-
41
-
-
0032211042
-
A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons
-
Aldrain-Herrada, G., Desarménien, M.G., Orcel, H., Boissin-Agasse, L., Méry, J., Brugidou, J. and Rabie, A. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons. Nucl. Acids Res., 26 (1998) 4910-4916.
-
(1998)
Nucl. Acids Res.
, vol.26
, pp. 4910-4916
-
-
Aldrain-Herrada, G.1
Desarménien, M.G.2
Orcel, H.3
Boissin-Agasse, L.4
Méry, J.5
Brugidou, J.6
Rabie, A.7
-
42
-
-
0031193331
-
Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake
-
Basu, S. and Wickstrom, E. Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake. Bioconj. Chem., 8 (1997) 481-188.
-
(1997)
Bioconj. Chem.
, vol.8
, pp. 481-1188
-
-
Basu, S.1
Wickstrom, E.2
-
43
-
-
0031979354
-
Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
-
Good, L. and Nielsen, P.E. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat. Biotechnol., 16 (1998) 355-358.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 355-358
-
-
Good, L.1
Nielsen, P.E.2
-
44
-
-
0032539707
-
Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells
-
Faruqi, A.F., Egholm, M. and Glazer, P.M. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc. Natl. Acad. Sci. USA, 95 (1998) 1398-1403.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1398-1403
-
-
Faruqi, A.F.1
Egholm, M.2
Glazer, P.M.3
-
45
-
-
0029833815
-
A simple method for delivering Morpholino antisense oligos in to the cytoplasm of cells
-
Partridge, M., Vincent, A., Matthews, P., Puma, J., Stein, D. and Summerton, J. A simple method for delivering Morpholino antisense oligos in to the cytoplasm of cells. Antis. Nucl. Acids Drug Dev., 6 (1996) 169-175.
-
(1996)
Antis. Nucl. Acids Drug Dev.
, vol.6
, pp. 169-175
-
-
Partridge, M.1
Vincent, A.2
Matthews, P.3
Puma, J.4
Stein, D.5
Summerton, J.6
-
46
-
-
0033991403
-
Gene switching: Analyzing a broad range of mutations using steric block antisense oligonucleotides
-
Morcos, P.A. Gene switching: analyzing a broad range of mutations using steric block antisense oligonucleotides. Meth. Enzymol., 313 (1999) 174-189.
-
(1999)
Meth. Enzymol.
, vol.313
, pp. 174-189
-
-
Morcos, P.A.1
-
47
-
-
0034910904
-
Achieving efficient delivery of Morpholino oligos in cultured cells
-
Morcos, P.A. Achieving efficient delivery of Morpholino oligos in cultured cells. Genesis, 30 (2001) 94-102.
-
(2001)
Genesis
, vol.30
, pp. 94-102
-
-
Morcos, P.A.1
-
48
-
-
0029977448
-
Antitumor activity of a Phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
-
Monia, B., Johnston, J., Geiger, T., Muller, M. and Fabbro, D. Antitumor activity of a Phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nat. Med., 2 (1996) 668-675.
-
(1996)
Nat. Med.
, vol.2
, pp. 668-675
-
-
Monia, B.1
Johnston, J.2
Geiger, T.3
Muller, M.4
Fabbro, D.5
-
49
-
-
12644268252
-
Sequence-specific antitumor activity of a Phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
-
Monia, B., Sasmor, H., Johnston, J., Freier, S., Lesnik, E., Muller, M., Geiger, T., Altmann, K., Moser, H. and Fabbro, D. Sequence-specific antitumor activity of a Phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc. Natl. Acad. Sci. USA, 93 (1996) 15481-15484.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 15481-15484
-
-
Monia, B.1
Sasmor, H.2
Johnston, J.3
Freier, S.4
Lesnik, E.5
Muller, M.6
Geiger, T.7
Altmann, K.8
Moser, H.9
Fabbro, D.10
-
50
-
-
0032724911
-
Novel mechanisms for antisense-mediated regulation of gene expression
-
Baker, B.F. and Monia, B.P. Novel mechanisms for antisense-mediated regulation of gene expression. Biochem. Biophys. Acta, 1489 (1999) 3-18.
-
(1999)
Biochem. Biophys. Acta
, vol.1489
, pp. 3-18
-
-
Baker, B.F.1
Monia, B.P.2
-
51
-
-
0000965423
-
Non-antisense effects of oligodeoxynucleotides
-
C. Lichtenstein C. and Nellen, W. (Eds.) Oxford: IRL Press
-
Quote from Stein, C. and Krieg, A., Non-antisense effects of oligodeoxynucleotides. In: C. Lichtenstein C. and Nellen, W. (Eds.) Antisense Technology. Oxford: IRL Press, 1997: 260. '... non-antisense effects of PS oligos are also pointed out by a close examination of the oligo ISIS 2922, an 'antisense' oligo with remarkably potent antiviral effects against cytomegalovirus (CMV). ISIS 2922 is reported to have encouraging in vivo efficacy in early clinical trials against CMV retinitis. The sequence of this oligo is quite interesting because it has two atypical CpG motifs: there is a GCG at both the extreme 5′ and 3′ ends (79). Although not fully recognized at the time, published studies on ISIS 2922 demonstrate that its antiviral effect cannot be due to 'antisense' since internal mismatch control oligos lost very little antiviral activity despite a severe drop in the Tm. On the other hand, deletion of a single base from one of the CpG motifs caused a 40% drop in antiviral efficacy, and deletion of a single base from both of the CpG motifs abolished antiviral effect despite little change in the Tm for hybridization to the supposed mRNA target (79)'.
-
(1997)
Antisense Technology
, pp. 260
-
-
Stein, C.1
Krieg, A.2
-
52
-
-
0034937680
-
Perspectives on antisense therapy for the prevention of restenosis
-
Kipshidze, N., Moses, J., Shankar, L.R. and Leon, M. Perspectives on antisense therapy for the prevention of restenosis. Curr. Opin. Mol. Ther., 3 (2001) 265-277.
-
(2001)
Curr. Opin. Mol. Ther.
, vol.3
, pp. 265-277
-
-
Kipshidze, N.1
Moses, J.2
Shankar, L.R.3
Leon, M.4
-
53
-
-
0004568191
-
Local delivery of antisense phosphorodiamidate morpholino oligomer: Resten-NG inhibits myointimal hyperplasia following balloon angioplasty
-
F. Navarro-Lopez (Ed.), Italy: Monduzzi Editore
-
Kipshidze, N., Keane, E., Stein, D., Chawla, P., Skrinska, V., Shandar, L.R., Komorowski, R., Haudenschild, C., Leon, M., Keelan, M.H., Moses, J. and Iversen, P. Local delivery of antisense phosphorodiamidate morpholino oligomer: Resten-NG inhibits myointimal hyperplasia following balloon angioplasty. In: F. Navarro-Lopez (Ed.), XXIst Congress of the European Society of Cardiology. Italy: Monduzzi Editore (1999) 463-167.
-
(1999)
XXIst Congress of the European Society of Cardiology
, pp. 463-1167
-
-
Kipshidze, N.1
Keane, E.2
Stein, D.3
Chawla, P.4
Skrinska, V.5
Shandar, L.R.6
Komorowski, R.7
Haudenschild, C.8
Leon, M.9
Keelan, M.H.10
Moses, J.11
Iversen, P.12
-
54
-
-
0028857988
-
The uptake and distribution of Phosphorothioate oligonucleotides into vascular smooth muscle cells in vitro and in rabbit arteries
-
Farrell, C., Bready, J., Saufman, S., Quian, Y. and Burgess, T. The uptake and distribution of Phosphorothioate oligonucleotides into vascular smooth muscle cells in vitro and in rabbit arteries. Antis. Res. Dev., 5 (1995) 175-183.
-
(1995)
Antis. Res. Dev.
, vol.5
, pp. 175-183
-
-
Farrell, C.1
Bready, J.2
Saufman, S.3
Quian, Y.4
Burgess, T.5
-
55
-
-
0021916816
-
Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells
-
Kimmel, C.B. and Law, R.D. Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells. Dev. Biol., 108 (1985) 78-85.
-
(1985)
Dev. Biol.
, vol.108
, pp. 78-85
-
-
Kimmel, C.B.1
Law, R.D.2
-
56
-
-
0021969796
-
Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer
-
Kimmel, C.B. and Law, R.D. Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer. Dev. Biol., 108 (1985) 86-93.
-
(1985)
Dev. Biol.
, vol.108
, pp. 86-93
-
-
Kimmel, C.B.1
Law, R.D.2
-
57
-
-
0000965423
-
Non-antisense effects of oligodeoxy-nucleotides
-
C. Lichtenstein and W. Nellen (Eds.) Oxford: IRL Press
-
Stein, C. and Krieg, A. Non-antisense effects of oligodeoxy-nucleotides. In: C. Lichtenstein and W. Nellen (Eds.) Antisense Technology. Oxford: IRL Press (1997) 241-264.
-
(1997)
Antisense Technology
, pp. 241-264
-
-
Stein, C.1
Krieg, A.2
-
58
-
-
0028806487
-
Does antisense exist?
-
Stein, C. Does antisense exist? Nat. Med., 1 (1995) 1119-1121.
-
(1995)
Nat. Med.
, vol.1
, pp. 1119-1121
-
-
Stein, C.1
-
59
-
-
0029867408
-
Inhibition of human telomerase activity by peptide nucleic acids
-
Norton, J.C., Piatyszek, M.A., Wright, W.E., Shay, J.W. and Corey, D.R. Inhibition of human telomerase activity by peptide nucleic acids. Nat. Biotechnol., 14 (1996) 615-619.
-
(1996)
Nat. Biotechnol.
, vol.14
, pp. 615-619
-
-
Norton, J.C.1
Piatyszek, M.A.2
Wright, W.E.3
Shay, J.W.4
Corey, D.R.5
-
60
-
-
0030866069
-
Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning
-
Hamilton, S.E., Pitts, A.E., Katipally, R.R., Jia, X., Rutter, J.P., Davies, B.A., Shay, J.W., Wright, W.E. and Corey, D.R. Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning. Biochemistry, 36 (1997) 11873-11880.
-
(1997)
Biochemistry
, vol.36
, pp. 11873-11880
-
-
Hamilton, S.E.1
Pitts, A.E.2
Katipally, R.R.3
Jia, X.4
Rutter, J.P.5
Davies, B.A.6
Shay, J.W.7
Wright, W.E.8
Corey, D.R.9
-
61
-
-
0035075441
-
Bactericidal antisense effects of peptide-PNA conjugates
-
Good, L., Awasthi, S.K., Dryselius, R., Larsson, O. and Nielson, P.E. Bactericidal antisense effects of peptide-PNA conjugates. Nat. Biotechnol., 19 (2001) 360-364.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 360-364
-
-
Good, L.1
Awasthi, S.K.2
Dryselius, R.3
Larsson, O.4
Nielson, P.E.5
-
62
-
-
0032536102
-
Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
-
Tyler, B.M., McCormick, D.J., Hoshall, C.V., Douglas, C.L., Jansen, K., Lacy, B.W., Cusack, B. and Richelson, E. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo. FEBS Lett., 421 (1998) 280-284.
-
(1998)
FEBS Lett.
, vol.421
, pp. 280-284
-
-
Tyler, B.M.1
McCormick, D.J.2
Hoshall, C.V.3
Douglas, C.L.4
Jansen, K.5
Lacy, B.W.6
Cusack, B.7
Richelson, E.8
-
63
-
-
0031472380
-
Pretargeting using peptide nucleic acid
-
Rusckowski, M., Qu, T., Chang, F. and Hnatowich, D.J. Pretargeting using peptide nucleic acid. Cancer, 80 (1997) (12 suppl) 2699-2705.
-
(1997)
Cancer
, vol.80
, Issue.12 SUPPL.
, pp. 2699-2705
-
-
Rusckowski, M.1
Qu, T.2
Chang, F.3
Hnatowich, D.J.4
-
64
-
-
0002772137
-
Application of peptide nucleic acid probes for in situ hybridization
-
P. Nielsen and M. Egholm (Eds.) Wymondham: Horizon Scientific Press
-
Thisted, M., Just, T., Pluzek, K.I., Hyldig-Nielsen, J.J., Nielsen, K.V., Mollerup, T.A., Stender, H., Rasmussen, O.F., Adelhorst, K. and Godtfredsen, S.E. Application of peptide nucleic acid probes for in situ hybridization. In: P. Nielsen and M. Egholm (Eds.) Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 99-118.
-
(1999)
Peptide Nucleic Acids: Protocols and Applications
, pp. 99-118
-
-
Thisted, M.1
Just, T.2
Pluzek, K.I.3
Hyldig-Nielsen, J.J.4
Nielsen, K.V.5
Mollerup, T.A.6
Stender, H.7
Rasmussen, O.F.8
Adelhorst, K.9
Godtfredsen, S.E.10
-
65
-
-
0003268553
-
PNA-arrays for nucleic acid detection
-
P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
-
Matysiak, S., Würtz, S., Hauser, N.C., Gausepohl, H. and Hoheisel, J.D. PNA-arrays for nucleic acid detection. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 119-128.
-
(1999)
Peptide Nucleic Acids: Protocols and Applications
, pp. 119-128
-
-
Matysiak, S.1
Würtz, S.2
Hauser, N.C.3
Gausepohl, H.4
Hoheisel, J.D.5
-
66
-
-
0003116322
-
PNA blocker probes enhance specificity in probe assays
-
P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
-
Fiandaca, M.J., Hyldig-Nielsen, J.J. and Coull, J.M. PNA blocker probes enhance specificity in probe assays. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 129-142.
-
(1999)
Peptide Nucleic Acids: Protocols and Applications
, pp. 129-142
-
-
Fiandaca, M.J.1
Hyldig-Nielsen, J.J.2
Coull, J.M.3
-
67
-
-
84888889958
-
MALDI-TOF mass spectrometric detection of PNA hybrids for genetic analysis
-
P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
-
Griffin, T.J., Tang, W. and Smith, L.M. MALDI-TOF mass spectrometric detection of PNA hybrids for genetic analysis. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 143-154.
-
(1999)
Peptide Nucleic Acids: Protocols and Applications
, pp. 143-154
-
-
Griffin, T.J.1
Tang, W.2
Smith, L.M.3
-
68
-
-
0003936711
-
PNA biosensors for nucleic acid detection
-
P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
-
Wang, J. PNA biosensors for nucleic acid detection. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 155-161.
-
(1999)
Peptide Nucleic Acids: Protocols and Applications
, pp. 155-161
-
-
Wang, J.1
-
69
-
-
0034662881
-
Restoration of hemoglobin a synthesis in erythroid cells from peripheral blood of thalassemic patients
-
Lacerra, G., Sierakowska, H., Carestia, C., Fucharoen, S., Summerton, J., Weller, D. and Kole, R. Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients. Proc. Natl. Acad. Sci. USA, 97 (2000) 9591-9596.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9591-9596
-
-
Lacerra, G.1
Sierakowska, H.2
Carestia, C.3
Fucharoen, S.4
Summerton, J.5
Weller, D.6
Kole, R.7
-
70
-
-
0034456664
-
Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis
-
Deng, J., Hua, K., Lesser, S.S. and Harp, J.B. Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis. Endocrinology, 141 (2000) 2370-2376.
-
(2000)
Endocrinology
, vol.141
, pp. 2370-2376
-
-
Deng, J.1
Hua, K.2
Lesser, S.S.3
Harp, J.B.4
-
71
-
-
0032725185
-
The Tangier disease gene product ABC 1 controls the cellular apolipoprotein-mediated lipid removal pathway
-
Lawn, R.M., Wade, D.P., Garvin, M.R., Wang, X., Schwartz, K., Porter, J.G., Seilhamer, J.J., Vaughan, A.M. and Oram, J.F. The Tangier disease gene product ABC 1 controls the cellular apolipoprotein-mediated lipid removal pathway. J. Clin. Invest., 104 (1999) R25-R31.
-
(1999)
J. Clin. Invest.
, vol.104
-
-
Lawn, R.M.1
Wade, D.P.2
Garvin, M.R.3
Wang, X.4
Schwartz, K.5
Porter, J.G.6
Seilhamer, J.J.7
Vaughan, A.M.8
Oram, J.F.9
-
72
-
-
0033062736
-
Antisense morpholino oligonucleotide analog induces missplicing of c-myc mRNA
-
Apr
-
Giles, R.V., Spiller, D.G., Clark, R.E. and Tidd, D.M. Antisense morpholino oligonucleotide analog induces missplicing of c-myc mRNA. Antis. Nucl. Acids Drug Dev., (Apr)9(2) (1999) 213-20.
-
(1999)
Antis. Nucl. Acids Drug Dev.
, vol.9
, Issue.2
, pp. 213-220
-
-
Giles, R.V.1
Spiller, D.G.2
Clark, R.E.3
Tidd, D.M.4
-
73
-
-
0034213262
-
Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
-
Heasman, J., Kofron, M. and Wylie, C. Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. Devel. Biol., 222 (2000) 124-134.
-
(2000)
Devel. Biol.
, vol.222
, pp. 124-134
-
-
Heasman, J.1
Kofron, M.2
Wylie, C.3
-
74
-
-
0033780376
-
Effective targeted gene 'knockdown' in zebrafish
-
Nasevicius, A. and Ekker, S.C. Effective targeted gene 'knockdown' in zebrafish. Nat. Genetics, 26 (2000) 216-220.
-
(2000)
Nat. Genetics
, vol.26
, pp. 216-220
-
-
Nasevicius, A.1
Ekker, S.C.2
-
75
-
-
0035122848
-
SpKr1: A direct target of (beta)-catenin regulation required for endoderm differentiation in sea urchin embryos
-
Howard, E.W., Newman, L.A., Oleksyn, D.W., Angerer, R.C. and Angerer, L.M. SpKr1: a direct target of (beta)-catenin regulation required for endoderm differentiation in sea urchin embryos. Development, 128 (2001) 365-375.
-
(2001)
Development
, vol.128
, pp. 365-375
-
-
Howard, E.W.1
Newman, L.A.2
Oleksyn, D.W.3
Angerer, R.C.4
Angerer, L.M.5
-
76
-
-
0035042293
-
The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos
-
Kos, R., Reedy, M.V., Johnson, R.L. and Erickson, C.A. The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development, 128 (2001) 1467-1479.
-
(2001)
Development
, vol.128
, pp. 1467-1479
-
-
Kos, R.1
Reedy, M.V.2
Johnson, R.L.3
Erickson, C.A.4
-
77
-
-
0034904642
-
Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: A quantifiable method for gene knockdown
-
Draper, B.W., Morcos, P.A. and Kimmel, C.B. Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: a quantifiable method for gene knockdown. Genesis, 30 (2001) 154-156.
-
(2001)
Genesis
, vol.30
, pp. 154-156
-
-
Draper, B.W.1
Morcos, P.A.2
Kimmel, C.B.3
-
78
-
-
0034049471
-
Quantitative and cost comparison of ultra-sensitive human immunodeficiency virus type 1 RNA viral load assays
-
Elbeik, T. et al. Quantitative and cost comparison of ultra-sensitive human immunodeficiency virus type 1 RNA viral load assays. J. Clin. Micro., 39 (2000) 1113-1120
-
(2000)
J. Clin. Micro.
, vol.39
, pp. 1113-1120
-
-
Elbeik, T.1
-
79
-
-
84888903072
-
-
Reagent and method for isolation and detection of selected nucleic acid sequences. US Patent; (2000), 6,060,246
-
Summerton, J.E., Weller, D.D. and Wages, J.M. Reagent and method for isolation and detection of selected nucleic acid sequences. US Patent; (2000), 6,060,246.
-
-
-
Summerton, J.E.1
Weller, D.D.2
Wages, J.M.3
-
80
-
-
0032536102
-
Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo
-
Tyler, B.M., McCormick, D.J., Hoshall, C.V., Douglas, C.L., Jansen, K., Lacy, B.W., Cusack, B. and Richelson, E. Specific gene blockade shows that peptide nucleic acids readily enter neuronal cells in vivo. FEBS Lett. 421 (1998) 280-284.
-
(1998)
FEBS Lett.
, vol.421
, pp. 280-284
-
-
Tyler, B.M.1
McCormick, D.J.2
Hoshall, C.V.3
Douglas, C.L.4
Jansen, K.5
Lacy, B.W.6
Cusack, B.7
Richelson, E.8
-
81
-
-
0034933539
-
Redirection of drug metabolism using antisense technology
-
Arora, V. and Iversen, P. Redirection of drug metabolism using antisense technology. Curr. Opin. Mol. Ther., 3 (2001) 249-257.
-
(2001)
Curr. Opin. Mol. Ther.
, vol.3
, pp. 249-257
-
-
Arora, V.1
Iversen, P.2
-
82
-
-
0034739603
-
Transdermal delivery of antisense compounds
-
Brand, R.M. and Iversen, PL. Transdermal delivery of antisense compounds. Adv. Drug Develop. Rev., 44 (2000) 51-58.
-
(2000)
Adv. Drug Develop. Rev.
, vol.44
, pp. 51-58
-
-
Brand, R.M.1
Iversen, P.L.2
-
83
-
-
0033967806
-
Antisense oligonucleotides targeted to the p53 gene modulate rat liver regeneration
-
Aurora, V. and Iversen, P.L. Antisense oligonucleotides targeted to the p53 gene modulate rat liver regeneration. Drug. Metab. Disp., 28 (2000) 131-138.
-
(2000)
Drug. Metab. Disp.
, vol.28
, pp. 131-138
-
-
Aurora, V.1
Iversen, P.L.2
-
84
-
-
0034099359
-
In vivo evaluation of a morpholino antisense oligomer directed against TNF
-
Qin, G., Taylor, M., Ning, Y.Y., Iversen, P. and Kobzik, L. In vivo evaluation of a morpholino antisense oligomer directed against TNF. Antis. Nucl. Acids Drug Develop., 10 (2000) 11-16.
-
(2000)
Antis. Nucl. Acids Drug Develop.
, vol.10
, pp. 11-16
-
-
Qin, G.1
Taylor, M.2
Ning, Y.Y.3
Iversen, P.4
Kobzik, L.5
|