메뉴 건너뛰기




Volumn 10, Issue 3-4, 2003, Pages 215-236

Morpholinos and PNAs compared

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DNA; MORPHOLINE DERIVATIVE; PEPTIDE NUCLEIC ACID; RNA;

EID: 11144290145     PISSN: 09295666     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02484560     Document Type: Review
Times cited : (43)

References (85)
  • 1
    • 0030808415 scopus 로고    scopus 로고
    • Progress in developing PNA as a gene-targeted drug
    • Liam, G. and Nielsen, P.E. Progress in developing PNA as a gene-targeted drug. Antisense Nucl. Acid Drug Dev., 7 (1997) 431-437.
    • (1997) Antisense Nucl. Acid Drug Dev. , vol.7 , pp. 431-437
    • Liam, G.1    Nielsen, P.E.2
  • 3
    • 0030862707 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: Design, preparation and properties
    • Summerton, J. and Weller, D. Morpholino antisense oligomers: design, preparation and properties. Antisense Nucleic Acid Drug Dev. 7 (1997) 187-195.
    • (1997) Antisense Nucleic Acid Drug Dev. , vol.7 , pp. 187-195
    • Summerton, J.1    Weller, D.2
  • 4
    • 0032699477 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: The case for an RNase H-independent structural type
    • Summerton, J. Morpholino antisense oligomers: the case for an RNase H-independent structural type. Biochim. Biophys. Acta, 1489 (1999) 141-158.
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 141-158
    • Summerton, J.1
  • 5
    • 84888925154 scopus 로고
    • Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404
    • Summerton, J. (1990) Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404. Summerton J, Weller D. (1993). Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444.
    • (1990)
    • Summerton, J.1
  • 6
    • 84888903415 scopus 로고
    • Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444
    • Summerton, J. (1990) Polynucleotide assay reagent and method. Canadian Patent; 1, 268, 404. Summerton J, Weller D. (1993). Uncharged Morpholino-based polymers having phosphorous containing chiral intersubunit linkages. US Patent; 5, 185, 444.
    • (1993)
    • Summerton, J.1    Weller, D.2
  • 7
    • 84888924498 scopus 로고    scopus 로고
    • Website
    • Website: www.gene-tools.com
  • 8
    • 0029980721 scopus 로고    scopus 로고
    • Antisense properties of duplex and triplex forming PNA
    • Knudsen, H. and Nielsen, P.E. Antisense properties of duplex and triplex forming PNA. Nucl. Acids Res., 24 (1996) 494-500.
    • (1996) Nucl. Acids Res. , vol.24 , pp. 494-500
    • Knudsen, H.1    Nielsen, P.E.2
  • 9
    • 0030902471 scopus 로고    scopus 로고
    • Selecting effective antisense reagents on combinatorial oligonucleotide arrays
    • Milner, N., Mir, K. and Southern, E. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat. Biotechnol., 15 (1997) 537-541.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 537-541
    • Milner, N.1    Mir, K.2    Southern, E.3
  • 10
    • 0003038882 scopus 로고    scopus 로고
    • Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries
    • Ho, S., Bao, Y., Lesher, T., Malhotra, R., Ma, L., Fluharty, S. and Sakai R. Mapping of RNA accessible sites for antisense experiments with oligonucleotide libraries. Nat. Biotechnol. 16(1998)59.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 59
    • Ho, S.1    Bao, Y.2    Lesher, T.3    Malhotra, R.4    Ma, L.5    Fluharty, S.6    Sakai, R.7
  • 11
    • 33749208029 scopus 로고    scopus 로고
    • Morphants: A new systematic vertebrate functional genomics approach
    • Ekker, S. Morphants: a new systematic vertebrate functional genomics approach. Yeast, 17 (2000) 302-306.
    • (2000) Yeast , vol.17 , pp. 302-306
    • Ekker, S.1
  • 12
    • 0002586862 scopus 로고    scopus 로고
    • PNA oligomer synthesis by BOC chemistry
    • P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
    • Koch, T. PNA oligomer synthesis by BOC chemistry. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 21-37.
    • (1999) Peptide Nucleic Acids , pp. 21-37
    • Koch, T.1
  • 13
    • 0002152559 scopus 로고    scopus 로고
    • Synthesis of PNA oligomers by Fmoc Chemistry
    • P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
    • Casale, R., Jensen, I.S. and Egholm, M. Synthesis of PNA oligomers by Fmoc Chemistry. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 39-50.
    • (1999) Peptide Nucleic Acids , pp. 39-50
    • Casale, R.1    Jensen, I.S.2    Egholm, M.3
  • 14
    • 0010912592 scopus 로고    scopus 로고
    • PNA/DNA chimeras
    • P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
    • Uhlmann, E., Greinerm B. and Breipohl, G. PNA/DNA chimeras. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 51-70.
    • (1999) Peptide Nucleic Acids , pp. 51-70
    • Uhlmann, E.1    Greinerm, B.2    Breipohl, G.3
  • 18
    • 0034908648 scopus 로고    scopus 로고
    • Comparison of Morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis
    • Nutt, S.L., Bronchain, O.J., Hartley, K.O. and Amaya, E. Comparison of Morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis. Genesis, 30 (2001) 110-113.
    • (2001) Genesis , vol.30 , pp. 110-113
    • Nutt, S.L.1    Bronchain, O.J.2    Hartley, K.O.3    Amaya, E.4
  • 19
    • 0001018934 scopus 로고    scopus 로고
    • Characterization of PNA-dsDNA strand displacement complexes
    • P. Neilsen and M. Egholm (Eds.), Norfolk: Horizon Scientific Press
    • Larsen, H.J. and Nielsen, P.E. Characterization of PNA-dsDNA strand displacement complexes. In: P. Neilsen and M. Egholm (Eds.), Peptide Nucleic Acids. Norfolk: Horizon Scientific Press (1999) 221-240.
    • (1999) Peptide Nucleic Acids , pp. 221-240
    • Larsen, H.J.1    Nielsen, P.E.2
  • 23
    • 0001823921 scopus 로고
    • Non-ionic antisense oligonucleotides: Oligonucleotide alkylphosphotriesters
    • J. Cohen (Ed.), Boca Raton: CRC Press
    • Miller, P. Non-ionic antisense oligonucleotides: Oligonucleotide alkylphosphotriesters. In: J. Cohen (Ed.), Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression. Boca Raton: CRC Press (1989) 82-85.
    • (1989) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression , pp. 82-85
    • Miller, P.1
  • 24
    • 0001823921 scopus 로고
    • Non-ionic antisense oligonucleotides: Oligonucleotide methylphosphonates
    • J. Cohen (Ed.) Boca Raton: CRC Press
    • Miller, P. Non-ionic antisense oligonucleotides: Oligonucleotide methylphosphonates. In: J. Cohen (Ed.) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression. Boca Raton: CRC Press (1989) 85-92.
    • (1989) Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression , pp. 85-92
    • Miller, P.1
  • 25
    • 0023638996 scopus 로고
    • Uncharged stereoregular nucleic acid analogues. 1. Synthesis of a cytosine-containing oligomer with carbamate internucleoside linkages
    • Stirchak, E., Summerton, J. and Weller, D. Uncharged stereoregular nucleic acid analogues. 1. Synthesis of a cytosine-containing oligomer with carbamate internucleoside linkages. J. Org. Chem., 52 (1987) 4202-4206.
    • (1987) J. Org. Chem. , vol.52 , pp. 4202-4206
    • Stirchak, E.1    Summerton, J.2    Weller, D.3
  • 26
    • 0024382446 scopus 로고
    • Uncharged stereoregular nucleic acid analogues. 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages
    • Stirchak, E., Summerton, J. and Weller, D. Uncharged stereoregular nucleic acid analogues. 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages. Nucl. Acids Res., 17 (1989) 6129-6141.
    • (1989) Nucl. Acids Res. , vol.17 , pp. 6129-6141
    • Stirchak, E.1    Summerton, J.2    Weller, D.3
  • 28
    • 0026942133 scopus 로고
    • Stacking interactions of ApA analogues with modified backbones
    • Kang, H., Chou, P., Johnson, C., Weller, D., Huang, S, and Summerton, J. Stacking interactions of ApA analogues with modified backbones. Biopolymers, 32 (1992) 1351-1363.
    • (1992) Biopolymers , vol.32 , pp. 1351-1363
    • Kang, H.1    Chou, P.2    Johnson, C.3    Weller, D.4    Huang, S.5    Summerton, J.6
  • 29
    • 84888885813 scopus 로고    scopus 로고
    • Entire issue
    • Genesis, 30 (2001) 3: Entire issue.
    • (2001) Genesis , vol.30 , pp. 3
  • 31
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter, J.C. et al. The sequence of the human genome. Science, 291 (2001) 1304-1351.
    • (2001) Science , vol.291 , pp. 1304-1351
    • Venter, J.C.1
  • 32
    • 0030747101 scopus 로고    scopus 로고
    • A specificity comparison of four antisense types: Morpholino, 2′-O-methyl RNA, DNA, and Phosphorothioate DNA
    • Stein, D., Foster, E., Huang, S.B., Weller, D. and Summerton, J. A specificity comparison of four antisense types: Morpholino, 2′-O-methyl RNA, DNA, and Phosphorothioate DNA. Antis. Nucl. Acids Drug Dev., 7 (1997) 151-157.
    • (1997) Antis. Nucl. Acids Drug Dev. , vol.7 , pp. 151-157
    • Stein, D.1    Foster, E.2    Huang, S.B.3    Weller, D.4    Summerton, J.5
  • 34
    • 0026009971 scopus 로고
    • Interaction of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes)
    • Akhtar, S., Basu, S., Wickstrom, E. and Juliano, R. Interaction of antisense DNA oligonucleotide analogs with phospholipid membranes (liposomes). Nucl. Acids Res., 19 (1991) 5551-5559.
    • (1991) Nucl. Acids Res. , vol.19 , pp. 5551-5559
    • Akhtar, S.1    Basu, S.2    Wickstrom, E.3    Juliano, R.4
  • 35
    • 0344596735 scopus 로고
    • Adsorption and efflux characteristics of modified oligodeoxynucleotides from liposomes
    • Akhtar, S. and Juliano, R. Adsorption and efflux characteristics of modified oligodeoxynucleotides from liposomes. Proc. Am. Assoc. Cancer Res. 32 (1991) 333.
    • (1991) Proc. Am. Assoc. Cancer Res. , vol.32 , pp. 333
    • Akhtar, S.1    Juliano, R.2
  • 36
    • 0001014648 scopus 로고
    • Cellular internalization of oligodeoxynucleotides
    • S. Crooke and B. Lebleu B. (Eds.), Boca Raton: CRC Press
    • Neckers, L. Cellular internalization of oligodeoxynucleotides. In: S. Crooke and B. Lebleu B. (Eds.), Antisense Research and Applications. Boca Raton: CRC Press (1993) 451-460.
    • (1993) Antisense Research and Applications , pp. 451-460
    • Neckers, L.1
  • 40
    • 0029079310 scopus 로고
    • Vector-mediated delivery of a polyamide ('peptide') nucleic acid analogue through the blood-brain barrier in vivo
    • Pardridge, W.M., Boado, R.J. and Kang, Y.S. Vector-mediated delivery of a polyamide ('peptide') nucleic acid analogue through the blood-brain barrier in vivo. Proc. Natl. Acad. Sci, 92 (1995) 5592-5596.
    • (1995) Proc. Natl. Acad. Sci , vol.92 , pp. 5592-5596
    • Pardridge, W.M.1    Boado, R.J.2    Kang, Y.S.3
  • 41
    • 0032211042 scopus 로고    scopus 로고
    • A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons
    • Aldrain-Herrada, G., Desarménien, M.G., Orcel, H., Boissin-Agasse, L., Méry, J., Brugidou, J. and Rabie, A. A peptide nucleic acid (PNA) is more rapidly internalized in cultured neurons when coupled to a retro-inverso delivery peptide. The antisense activity depresses the target mRNA and protein in magnocellular oxytocin neurons. Nucl. Acids Res., 26 (1998) 4910-4916.
    • (1998) Nucl. Acids Res. , vol.26 , pp. 4910-4916
    • Aldrain-Herrada, G.1    Desarménien, M.G.2    Orcel, H.3    Boissin-Agasse, L.4    Méry, J.5    Brugidou, J.6    Rabie, A.7
  • 42
    • 0031193331 scopus 로고    scopus 로고
    • Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake
    • Basu, S. and Wickstrom, E. Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake. Bioconj. Chem., 8 (1997) 481-188.
    • (1997) Bioconj. Chem. , vol.8 , pp. 481-1188
    • Basu, S.1    Wickstrom, E.2
  • 43
    • 0031979354 scopus 로고    scopus 로고
    • Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
    • Good, L. and Nielsen, P.E. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat. Biotechnol., 16 (1998) 355-358.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 355-358
    • Good, L.1    Nielsen, P.E.2
  • 44
    • 0032539707 scopus 로고    scopus 로고
    • Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells
    • Faruqi, A.F., Egholm, M. and Glazer, P.M. Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc. Natl. Acad. Sci. USA, 95 (1998) 1398-1403.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1398-1403
    • Faruqi, A.F.1    Egholm, M.2    Glazer, P.M.3
  • 46
    • 0033991403 scopus 로고    scopus 로고
    • Gene switching: Analyzing a broad range of mutations using steric block antisense oligonucleotides
    • Morcos, P.A. Gene switching: analyzing a broad range of mutations using steric block antisense oligonucleotides. Meth. Enzymol., 313 (1999) 174-189.
    • (1999) Meth. Enzymol. , vol.313 , pp. 174-189
    • Morcos, P.A.1
  • 47
    • 0034910904 scopus 로고    scopus 로고
    • Achieving efficient delivery of Morpholino oligos in cultured cells
    • Morcos, P.A. Achieving efficient delivery of Morpholino oligos in cultured cells. Genesis, 30 (2001) 94-102.
    • (2001) Genesis , vol.30 , pp. 94-102
    • Morcos, P.A.1
  • 48
    • 0029977448 scopus 로고    scopus 로고
    • Antitumor activity of a Phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
    • Monia, B., Johnston, J., Geiger, T., Muller, M. and Fabbro, D. Antitumor activity of a Phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nat. Med., 2 (1996) 668-675.
    • (1996) Nat. Med. , vol.2 , pp. 668-675
    • Monia, B.1    Johnston, J.2    Geiger, T.3    Muller, M.4    Fabbro, D.5
  • 49
    • 12644268252 scopus 로고    scopus 로고
    • Sequence-specific antitumor activity of a Phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
    • Monia, B., Sasmor, H., Johnston, J., Freier, S., Lesnik, E., Muller, M., Geiger, T., Altmann, K., Moser, H. and Fabbro, D. Sequence-specific antitumor activity of a Phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc. Natl. Acad. Sci. USA, 93 (1996) 15481-15484.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 15481-15484
    • Monia, B.1    Sasmor, H.2    Johnston, J.3    Freier, S.4    Lesnik, E.5    Muller, M.6    Geiger, T.7    Altmann, K.8    Moser, H.9    Fabbro, D.10
  • 50
    • 0032724911 scopus 로고    scopus 로고
    • Novel mechanisms for antisense-mediated regulation of gene expression
    • Baker, B.F. and Monia, B.P. Novel mechanisms for antisense-mediated regulation of gene expression. Biochem. Biophys. Acta, 1489 (1999) 3-18.
    • (1999) Biochem. Biophys. Acta , vol.1489 , pp. 3-18
    • Baker, B.F.1    Monia, B.P.2
  • 51
    • 0000965423 scopus 로고    scopus 로고
    • Non-antisense effects of oligodeoxynucleotides
    • C. Lichtenstein C. and Nellen, W. (Eds.) Oxford: IRL Press
    • Quote from Stein, C. and Krieg, A., Non-antisense effects of oligodeoxynucleotides. In: C. Lichtenstein C. and Nellen, W. (Eds.) Antisense Technology. Oxford: IRL Press, 1997: 260. '... non-antisense effects of PS oligos are also pointed out by a close examination of the oligo ISIS 2922, an 'antisense' oligo with remarkably potent antiviral effects against cytomegalovirus (CMV). ISIS 2922 is reported to have encouraging in vivo efficacy in early clinical trials against CMV retinitis. The sequence of this oligo is quite interesting because it has two atypical CpG motifs: there is a GCG at both the extreme 5′ and 3′ ends (79). Although not fully recognized at the time, published studies on ISIS 2922 demonstrate that its antiviral effect cannot be due to 'antisense' since internal mismatch control oligos lost very little antiviral activity despite a severe drop in the Tm. On the other hand, deletion of a single base from one of the CpG motifs caused a 40% drop in antiviral efficacy, and deletion of a single base from both of the CpG motifs abolished antiviral effect despite little change in the Tm for hybridization to the supposed mRNA target (79)'.
    • (1997) Antisense Technology , pp. 260
    • Stein, C.1    Krieg, A.2
  • 52
    • 0034937680 scopus 로고    scopus 로고
    • Perspectives on antisense therapy for the prevention of restenosis
    • Kipshidze, N., Moses, J., Shankar, L.R. and Leon, M. Perspectives on antisense therapy for the prevention of restenosis. Curr. Opin. Mol. Ther., 3 (2001) 265-277.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 265-277
    • Kipshidze, N.1    Moses, J.2    Shankar, L.R.3    Leon, M.4
  • 54
    • 0028857988 scopus 로고
    • The uptake and distribution of Phosphorothioate oligonucleotides into vascular smooth muscle cells in vitro and in rabbit arteries
    • Farrell, C., Bready, J., Saufman, S., Quian, Y. and Burgess, T. The uptake and distribution of Phosphorothioate oligonucleotides into vascular smooth muscle cells in vitro and in rabbit arteries. Antis. Res. Dev., 5 (1995) 175-183.
    • (1995) Antis. Res. Dev. , vol.5 , pp. 175-183
    • Farrell, C.1    Bready, J.2    Saufman, S.3    Quian, Y.4    Burgess, T.5
  • 55
    • 0021916816 scopus 로고
    • Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells
    • Kimmel, C.B. and Law, R.D. Cell lineage of zebrafish blastomeres. I. Cleavage pattern and cytoplasmic bridges between cells. Dev. Biol., 108 (1985) 78-85.
    • (1985) Dev. Biol. , vol.108 , pp. 78-85
    • Kimmel, C.B.1    Law, R.D.2
  • 56
    • 0021969796 scopus 로고
    • Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer
    • Kimmel, C.B. and Law, R.D. Cell lineage of zebrafish blastomeres. II. Formation of the yolk syncytial layer. Dev. Biol., 108 (1985) 86-93.
    • (1985) Dev. Biol. , vol.108 , pp. 86-93
    • Kimmel, C.B.1    Law, R.D.2
  • 57
    • 0000965423 scopus 로고    scopus 로고
    • Non-antisense effects of oligodeoxy-nucleotides
    • C. Lichtenstein and W. Nellen (Eds.) Oxford: IRL Press
    • Stein, C. and Krieg, A. Non-antisense effects of oligodeoxy-nucleotides. In: C. Lichtenstein and W. Nellen (Eds.) Antisense Technology. Oxford: IRL Press (1997) 241-264.
    • (1997) Antisense Technology , pp. 241-264
    • Stein, C.1    Krieg, A.2
  • 58
    • 0028806487 scopus 로고
    • Does antisense exist?
    • Stein, C. Does antisense exist? Nat. Med., 1 (1995) 1119-1121.
    • (1995) Nat. Med. , vol.1 , pp. 1119-1121
    • Stein, C.1
  • 63
    • 0031472380 scopus 로고    scopus 로고
    • Pretargeting using peptide nucleic acid
    • Rusckowski, M., Qu, T., Chang, F. and Hnatowich, D.J. Pretargeting using peptide nucleic acid. Cancer, 80 (1997) (12 suppl) 2699-2705.
    • (1997) Cancer , vol.80 , Issue.12 SUPPL. , pp. 2699-2705
    • Rusckowski, M.1    Qu, T.2    Chang, F.3    Hnatowich, D.J.4
  • 66
    • 0003116322 scopus 로고    scopus 로고
    • PNA blocker probes enhance specificity in probe assays
    • P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
    • Fiandaca, M.J., Hyldig-Nielsen, J.J. and Coull, J.M. PNA blocker probes enhance specificity in probe assays. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 129-142.
    • (1999) Peptide Nucleic Acids: Protocols and Applications , pp. 129-142
    • Fiandaca, M.J.1    Hyldig-Nielsen, J.J.2    Coull, J.M.3
  • 67
    • 84888889958 scopus 로고    scopus 로고
    • MALDI-TOF mass spectrometric detection of PNA hybrids for genetic analysis
    • P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
    • Griffin, T.J., Tang, W. and Smith, L.M. MALDI-TOF mass spectrometric detection of PNA hybrids for genetic analysis. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 143-154.
    • (1999) Peptide Nucleic Acids: Protocols and Applications , pp. 143-154
    • Griffin, T.J.1    Tang, W.2    Smith, L.M.3
  • 68
    • 0003936711 scopus 로고    scopus 로고
    • PNA biosensors for nucleic acid detection
    • P. Nielsen and M. Egholm (Eds.), Wymondham: Horizon Scientific Press
    • Wang, J. PNA biosensors for nucleic acid detection. In: P. Nielsen and M. Egholm (Eds.), Peptide Nucleic Acids: Protocols and Applications. Wymondham: Horizon Scientific Press (1999) 155-161.
    • (1999) Peptide Nucleic Acids: Protocols and Applications , pp. 155-161
    • Wang, J.1
  • 70
    • 0034456664 scopus 로고    scopus 로고
    • Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis
    • Deng, J., Hua, K., Lesser, S.S. and Harp, J.B. Activation of signal transducer and activator of transcription-3 during proliferative phases of 3T3-L1 adipogenesis. Endocrinology, 141 (2000) 2370-2376.
    • (2000) Endocrinology , vol.141 , pp. 2370-2376
    • Deng, J.1    Hua, K.2    Lesser, S.S.3    Harp, J.B.4
  • 72
    • 0033062736 scopus 로고    scopus 로고
    • Antisense morpholino oligonucleotide analog induces missplicing of c-myc mRNA
    • Apr
    • Giles, R.V., Spiller, D.G., Clark, R.E. and Tidd, D.M. Antisense morpholino oligonucleotide analog induces missplicing of c-myc mRNA. Antis. Nucl. Acids Drug Dev., (Apr)9(2) (1999) 213-20.
    • (1999) Antis. Nucl. Acids Drug Dev. , vol.9 , Issue.2 , pp. 213-220
    • Giles, R.V.1    Spiller, D.G.2    Clark, R.E.3    Tidd, D.M.4
  • 73
    • 0034213262 scopus 로고    scopus 로고
    • Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
    • Heasman, J., Kofron, M. and Wylie, C. Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. Devel. Biol., 222 (2000) 124-134.
    • (2000) Devel. Biol. , vol.222 , pp. 124-134
    • Heasman, J.1    Kofron, M.2    Wylie, C.3
  • 74
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius, A. and Ekker, S.C. Effective targeted gene 'knockdown' in zebrafish. Nat. Genetics, 26 (2000) 216-220.
    • (2000) Nat. Genetics , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 75
    • 0035122848 scopus 로고    scopus 로고
    • SpKr1: A direct target of (beta)-catenin regulation required for endoderm differentiation in sea urchin embryos
    • Howard, E.W., Newman, L.A., Oleksyn, D.W., Angerer, R.C. and Angerer, L.M. SpKr1: a direct target of (beta)-catenin regulation required for endoderm differentiation in sea urchin embryos. Development, 128 (2001) 365-375.
    • (2001) Development , vol.128 , pp. 365-375
    • Howard, E.W.1    Newman, L.A.2    Oleksyn, D.W.3    Angerer, R.C.4    Angerer, L.M.5
  • 76
    • 0035042293 scopus 로고    scopus 로고
    • The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos
    • Kos, R., Reedy, M.V., Johnson, R.L. and Erickson, C.A. The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos. Development, 128 (2001) 1467-1479.
    • (2001) Development , vol.128 , pp. 1467-1479
    • Kos, R.1    Reedy, M.V.2    Johnson, R.L.3    Erickson, C.A.4
  • 77
    • 0034904642 scopus 로고    scopus 로고
    • Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: A quantifiable method for gene knockdown
    • Draper, B.W., Morcos, P.A. and Kimmel, C.B. Inhibition of zebrafish fgf8 pre-mRNA splicing with Morpholino oligos: a quantifiable method for gene knockdown. Genesis, 30 (2001) 154-156.
    • (2001) Genesis , vol.30 , pp. 154-156
    • Draper, B.W.1    Morcos, P.A.2    Kimmel, C.B.3
  • 78
    • 0034049471 scopus 로고    scopus 로고
    • Quantitative and cost comparison of ultra-sensitive human immunodeficiency virus type 1 RNA viral load assays
    • Elbeik, T. et al. Quantitative and cost comparison of ultra-sensitive human immunodeficiency virus type 1 RNA viral load assays. J. Clin. Micro., 39 (2000) 1113-1120
    • (2000) J. Clin. Micro. , vol.39 , pp. 1113-1120
    • Elbeik, T.1
  • 79
    • 84888903072 scopus 로고    scopus 로고
    • Reagent and method for isolation and detection of selected nucleic acid sequences. US Patent; (2000), 6,060,246
    • Summerton, J.E., Weller, D.D. and Wages, J.M. Reagent and method for isolation and detection of selected nucleic acid sequences. US Patent; (2000), 6,060,246.
    • Summerton, J.E.1    Weller, D.D.2    Wages, J.M.3
  • 81
    • 0034933539 scopus 로고    scopus 로고
    • Redirection of drug metabolism using antisense technology
    • Arora, V. and Iversen, P. Redirection of drug metabolism using antisense technology. Curr. Opin. Mol. Ther., 3 (2001) 249-257.
    • (2001) Curr. Opin. Mol. Ther. , vol.3 , pp. 249-257
    • Arora, V.1    Iversen, P.2
  • 82
    • 0034739603 scopus 로고    scopus 로고
    • Transdermal delivery of antisense compounds
    • Brand, R.M. and Iversen, PL. Transdermal delivery of antisense compounds. Adv. Drug Develop. Rev., 44 (2000) 51-58.
    • (2000) Adv. Drug Develop. Rev. , vol.44 , pp. 51-58
    • Brand, R.M.1    Iversen, P.L.2
  • 83
    • 0033967806 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeted to the p53 gene modulate rat liver regeneration
    • Aurora, V. and Iversen, P.L. Antisense oligonucleotides targeted to the p53 gene modulate rat liver regeneration. Drug. Metab. Disp., 28 (2000) 131-138.
    • (2000) Drug. Metab. Disp. , vol.28 , pp. 131-138
    • Aurora, V.1    Iversen, P.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.