A specificity comparison of four antisense types: Morpholino, 2'-O-methyl RNA, DNA, and phosphorothioate DNA

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 3, 1997, Pages 151-157

  Stein, David ^a   Foster, Ernest ^a   Huang, Sung Ben ^a   Weller, Dwight ^a   Summerton, James ^a  

^a Antivirals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; ANTISENSE OLIGONUCLEOTIDE; DNA; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; RNA DERIVATIVE;

ARTICLE; DNA RNA HYBRIDIZATION; DRUG EFFICACY; DRUG STRUCTURE; NONHUMAN; PRIORITY JOURNAL; RNA RNA HYBRIDIZATION; RNA SEQUENCE; RNA TRANSLATION;

ORYCTOLAGUS CUNICULUS;

EID: 0030747101     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.151     Document Type: Article

References (5)

1. BLAKE, K., MURAKAMI, A., and MILLER, P. (1985). Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides. Biochemistry 24, 6132-6138.
2. CAZENAVE, C., STEIN, C., LOREAU, N., THUONG, N., NECKERS, L., SUBASINGHE, C., HELENE, C., COHEN, J., and TOULME, J. (1989). Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides. Nucleic Acids Res. 17, 4255-4274.
3. CROUCH, R., and DIRKSEN, M. (1982). Ribonuclease H. In: Nucleases. S. Linn and R. Roberts, eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY), pp. 211-241.
4. HUDZIAK, R., BAROFSKY, L., BAROFSKY, D., WELLER, C.L., HUANG S., and WELLER, D.D. (1996). Resistance of Morpholino phosphorodiamidate oligomers to enzymatic degradation. Antisense Nucleic Acid Drug Dev. 6, 267-272.
5. WALDER, R., and WALDER, J. (1988). Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 85, 5011-5015.