The role of cytokines in the regulation of neurotransmission

NeuroImmunoModulation

Volumn 16, Issue 1, 2009, Pages 1-12

  Camacho Arroyo, I ^a   Lopez Griego L ^a   Morales Montor, J ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Central nervous system; Cytokines; Immune system; Neuroimmune network; Neuroimmunoendocrine function; Neurotransmission

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 3; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ASTROCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROENDOCRINE SYSTEM; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEIZURE;

ANIMALS; BRAIN DISEASES; CENTRAL NERVOUS SYSTEM; CYTOKINES; ENCEPHALITIS; HUMANS; INTERLEUKINS; NEURODEGENERATIVE DISEASES; NEUROIMMUNOMODULATION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 57449084966     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000179661     Document Type: Review

References (117)

1. Besedovsky HO, del Rey A: Immune-neuroendocrine interactions: facts and hypotheses. Endocr Rev 1996;17:64-102.
2. Stella MC, Vercelli A, Repici M, Follenzi A, Comoglio PM: Macrophage stimulating protein in a novel neurotrophic factor. Mol Biol Cell 2001;12:1341-1352.
3. Yoshida K, Kakihana M, Chen LS, Ong M, Baird A, Gage FH: Cytokine regulation of nerve growth factor-mediated cholinergic neurotrophic activity synthesized by astrocytes and fibroblasts. J Neurochem 1992;59:919-931.
4. Besedovsky HO, del Rey A: The cytokine-HPA axis feed-back circuit. Z Rheumatol 2000;59:26-30.
5. Rivier C: Neuroendocrine effects of cytokines in the rat. Rev Neurosci 1993;4:223-237.
6. Chikanza IC, Grossman AB: Reciprocal interactions between the neuroendocrine and immune systems during inflammation. Rheum Dis Clin North Am 2000;26:693-711.
7. Morales-Montor J, Chavarria A, De Leon MA, Del Castillo LI, Escobedo EG, Sánchez EN, Vargas JA, Hernandez-Flores M, Romo-Gonzalez T, Larralde C: Host gender in parasitic infections of mammals: an evaluation of the female host supremacy paradigm. J Parasitol 2004;90:531-546.
8. Haddad JJ, Saade NE, Safieh-Garabedian B: Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary- adrenal revolving axis. J Neuroimmunol 2002;133:1-19.
9. Ferone D, Boschetti M, Resmini E, Giusti M, Albanese V, Goglia U, Albertelli M, Vera L, Bianchi F, Minuto F: Neuroendocrine-immune interactions: the role of cortistatin/somatostatin system. Ann NY Acad Sci 2006;1069:129-144.
10. Morales-Montor J, Larralde C: The role of sex steroids in the complex physiology of the host-parasite relationship: the case of the larval cestode of Taenia crassiceps. Parasitology 2005;131:287-294.
11. Besedovsky HO, del Rey A: Introduction: immune-neuroendocrine network. Front Horm Res 2002;29:1-14.
12. Vinogradova OS: Neuroscience at the end of the 2nd millennium: a shift in paradigms. Zh Vyssh Nerv Deiat Im I P Pavlova 2000;50:743-774.
13. Benveniste EN, Kwon J, Chung WJ, Sampson J, Pandya K, Tang LP: Differential modulation of astrocyte cytokine gene expression by TGF-beta. J Immunol 1994;153:5210-5221.
14. Hu S, Martella A, Anderson WR, Chao CC: Role of cytokines in lipopolysaccharide-induced functional and structural abnormalities of astrocytes. Glia 1994;10:227-234.
15. Feldhaus B, Dietzel ID, Heumann R, Berger B: Corticoids protect oligodendrocyte precursor cells against cytokine induced damage (in German). Zentralbl Gynakol 2004;126:282-285.
16. Croitoru-Lamoury J, Gullemin GJ, Boussin FD, Magnetti B, Gigout LI, Cheret A, Vaslin B, Le Grand R, Brew BJ, Dormont D: Expression of chemokines and their receptors in human and simian astrocytes. Glia 2003;41:354-370.
17. De Simone R, Levi G, Aloisi F: Interferon-γ gene expression on rat central nervous system glial cells. Cytokine 1998;10:418-422.
18. Benveniste E: Cytokine actions in the central nervous system. Cytokine Growth Factor Rev 1998;9:259-275.
19. Aronica E, Gorter JA, Rozemuller AJ, Yankaya B, Troost D: Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1β-stimulated release of IL-6 in cultured human astrocytes. Neuroscience 2005;130:927-933.
20. Fontana A, Grob PJ: Astrocyte-derived interleukin-1-like factors. Lymphokine Res 1984;3:11-16.
21. Fontana A, Hengartner H, De Tribolet N, Weber E: Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects. J Immunol 1984;132:1837-1844.
22. Da Cunha A, Vitkovic L: Transforming growth factor-beta 1 (TGF-beta 1) expression and regulation in rat cortical astrocytes. J Neuroimmunol 1992;36:157-169.
23. Bianchi M, Ferrario P, Zonta N, Panerai AE: Effects of interleukin-1 beta and interleukin-2 on amino acids levels in mouse cortex and hippocampus. Neuroreport 1995;6:1689-1692.
24. Ponomarev ED, Maresz K, Tan Y, Dittel BN: CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci 2007;27:10714-10721.
25. Xu J, Racke MK, Drew PD: Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis. J Neurochem 2007;103:1801-1810.
26. Tsakiri N, Kimber I, Rothwell NJ, Pinteaux E: Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/ Src kinase pathway in neurones. Br J Pharmacol 2008;3:775-783.
27. Neumann H: Interferon-γ gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med 1997;186:2023-2031.
28. Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage FH, Young MJ, Berman MA: Expression of cytokines by multipotent neural progenitor cells. Cytokine 2003;22:101-106.
29. Miljkovic D, Momcilovic M, Stojanovic I, Stosic-Grujicic S, Ramic Z, Mostarica-Stojkovic M: Astrocytes stimulate interleukin-17 and interferon-gamma production in vitro. J Neurosci Res 2007;85:3598-3606.
30. Schobitz B, de Kloet ER, Zutanito W, Holsboer F: Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur J Neuroci 1993;5:1426-1435.
31. Gadient R, Otten U: Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats. Neurosci Lett 1994;182:243-246.
32. Sallmann S, Juttler E, Prinz S, Petersen N, Knopf U, Weiser T, Schwaninger M: Induction of interleukin-6 by depolarization of neurons. J Neurosci 2000;20:8637-8642.
33. Breder CD, Dinarello CA, Saper CB: Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 1988;240:321-324.
34. Gadient RA, Otten U: Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci Lett 1993;153:13-16.
35. Gadient RA, Otten U: Postnatal expression of interleukin 6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia. Brain Res 1996;724:41-46.
36. Pfeffer K: Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev 2003;14:185-191.
37. Pejovic V, Soskic V, Pan W, Kastin AJ: Brain proteome of mice lacking the receptors for tumour necrosis factor alpha. Proteomics 2004;4:1461-1464.
38. Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann M, Kollias G, Probert L: Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signalling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendropathy. Am J Pathol 1998;153:801-813.
39. Gu C, Casaccia-Bonnefil P, Srinivasan A, Chao MV: Oligodendrocyte apoptosis mediated by caspase activation. J Neurosci 1999;19:3043-3049.
40. Samland H, Huitron-Resendiz S, Masliah E, Criado J, Henriksen SJ, Campbell IL: Profound increase in sensitivity to glutamatergic - but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J Neurosci Res 2003;73:176-187.
41. Kubera M, Maes M, Kenis G, Kim YK, Lasoń W: Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry Res 2005;134:251-258.
42. Casamenti F, Prosperi C, Scali C, Giovannelli L, Colivicchi MA, Faussone-Pellegrini MS, Pepeu G: Interleukin-1β activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience 1999;91:831-842.
43. Hu S, Sheng WS, Ehrlich LC, Peterson PK, Chao CC: Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation 2000;7:153-159.
44. Miller LG, Galpern WR, Dunlap K, Dinarello CA, Turner TJ: Interleukin-1 augments gamma-aminobutyric acidA receptor function n brain. Mol Pharmacol 1991;39:105-108.
45. Yu B, Shinnick-Gallager P: Interleukin-1 beta inhibits synaptic transmission and induces membrane hyperpolarisation in amygdala neurons. J Pharmacol Exp Ther 1994;271:590-600.
46. Miller LG, Fahey JM: Interleukin-1 modulates GABAergic and glutamatergic function in brain. Ann NY Acad Sci 1994;739:292-298.
47. Mazzoni IE, Kenigsberg RL: Microglia from the developing rat medial septal area can affect cholinergic and GABAergic neuronal differentiation in vitro . Neuroscience 1997;76:147-157.
48. Feleder C, Refojo D, Natch S, Moguilevsky JA: Interleukin-1 stimulates hypothalamic inhibitory amino acid neurotransmitter release. Neuroimmunomodulation 1998;5:1-4.
49. Feleder C, Arias P, Refojo D, Nacht S, Moguilevsky J: Interleukin-1 inhibits NMDA-stimulated GnRH secretion: associated effects on the release of hypothalamic inhibitory amino acid neurotransmitters. Neuroimmunomodulation 2000;7:46-50.
50. Wang S, Cheng Q, Malik S, Yang J: Interleukin-1 beta inhibits gamma-aminobutyric acid type A (GABA-A) receptor current in cultured hippocampal neurons. J Pharmacol Exp Ther 2000;292:497-504.
51. Parnet P, Amindari S, Wu C, Brunke-Reese D, Goujon E, Weyhenmeyer JA, Dantzer R, Kelley KW: Expression of type I and type II interleukin-1 receptors in mouse brain. Brain Res Mol Brain Res 1994;27:63-70.
52. Bianchi M, Clavenna A, Bondiolotti GP, Ferrario P, Panerai AE: GM-CSF affects hypothalamic neurotransmitter levels in mice: involvement of interleukin-1. Neuroreport 1997;8:3587-3590.
53. McCann SM, Kimura M, Karanth S, Yu WH, Rettori V: Role of nitric oxide in the neuroendocrine responses to cytokines. Ann NY Acad Sci 1998;840:174-184.
54. Spangelo BL, Horrell S, Goodwin AL, Shroff S, Jarvis WD: Somatostatin and gama-aminobutyric acid inhibit interleukin-1 beta-stimulated release of interleukin-6 from rat C6 glioma cells. Neuroimmunomodulation 2004;11:332-340.
55. Borsody MK, Weiss JM: Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotrophin-relasing hormone. Neuroimmunomodulation 2002-2003;10:101-121.
56. Ho A, Blum M: Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease. J Neurosci 1998;18:5614-5629.
57. Parish CL, Finkelstein DI, Tripanichkul W, Satoskar AR, Drago J, Horne MK: The role of interleukin-1, interleukin-6, and glia in inducing growth of neuronal terminal arbors in mice. J Neurosci 2002;22:8034-8041.
58. Newman-Tancredi A, Caussac D, Brocco M, Rivet JM, Chaput C, Touzard M, Pasteau V, Millan MJ: Dopamine D2 receptor-mediated G-protein activation in rat striatum: functional autoradiography and influence of the unilateral G-hydroxydopamine lesions of the substantia nigra. Brain Res 2001;920:41-54.
59. Parati EA, Bez A, Ponti D, Sala S, Pozzi S, Pagano SF: Neural stem cells. Biological features and therapeutic potential in Parkison's disease. J Neurosurg Sci 2003;47:8-17.
60. - current in identified Aplysia neurons. J Neurosci Res 1992;33:461-465.
61. Seto D, Kar S, Quirion R: Evidence for direct and indirect mechanisms in the potent modulatory action of interleukin-2 on the release of acetylcholine in rat hippocampal slices. Br J Pharmacol 1997;120:1151-1157.
62. 3H] dopamine in rat cultured mesencephalic cells. J Neurochem 1993;61:1284-1290.
63. McCann SM, Kimura M, Karanth S, Yu WH, Mastronardi CA, Rettori V: The mechanism of action of cytokines to control the release of hypothalamic and pituitary hormones in infection. Ann NY Acad Sci 2000;917:4-18.
64. Petitto JM, Huang Z: Molecular cloning of a partial cDNA of the interleukin-2 receptor-beta in normal mouse brain: in situ localization in the hippocampus and expression by neuroblastoma cells. Brain Res 1994;650:140-145.
65. Tabira T, Chui DH, Fan JP, Shirabe T, Konishi Y: Interleukin-3 and interleukin-3 receptors in the brain. Ann NY Acad Sci 1998;840:107-116.
66. Wen TC, Tanaka J, Peng H, Desaki J, Matsuda S, Maeda N, Fujita H, Sato K, Sakanaka M: Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. J Exp Med 1998;188:635-649.
67. De Laurentiis A, Pisera D, Lasaga M, Díaz M, Theas S, Duvilanski B, Seilicovich A: Effect of interleukin-6 and tumor necrosis factor-alpha on GABA release from mediobasal hypothalamus and posterior pituitary. Neuroimmunomodulation 2000;7:77-83.
68. Flatters SJ, Fox AJ, Dickenson AH: Nerve injury alters the effects of interleukin-6 on nociceptive transmission in peripheral afferents. Eur J Pharmacol 2004;484:183-191.
69. Brenn D, Richter F, Schaible HG: Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain. Arthritis Rheum 2007;56:351-359.
70. Valliers L, Campbell IL, Gage FH, Sawchenko PE: Reduced hippocampal neurogenesis in adult transgenic mice in chronic astrocytic production of interleukin-6. J Neurosci 2002;22:486-492.
71. Nelson TE, Campbell IL, Gruol DL: Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6. Neuroscience 1999;89:127-136.
72. Nelson TE, Ur CL, Gruol DL: Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar Purkinje neurons in culture. J Neurophysiol 2002;88:475-486.
73. Nelson TE, Netzeband JG, Gruol DL: Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons. Eur J Neurosci 2004;20:2387-2400.
74. Tancredi V, D'Antuono M, Café C, Giovedi S, Bue MC, D'Arcangelo G, Onofri F, Benfenati F: The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK. J Neurochem 2000;75:634-643.
75. Brask J, Kistensson K, Hill RH: Exposure to interferon-gamma during synaptogenesis increases inhibitory activity after a latent period in cultured rat hippocampal neurons. Eur J Neurosci 2004;19:3193-3201.
76. Vikman KS, Owe-Larsson B, Brask J, Kristensson KS, Hill RH: Interferon-gamma-induced changes in synaptic activity and AMPA receptor clustering in hippocampal cultures. Brain Res 2001;896:18-29.
77. Mendoza-Fernandez V, Andrew RD, Barajas-Lopez C: Interferon-alpha inhibits long-term potentiation and unmasks a long-term depression in the rat hippocampus. Brain Res 2000;885:14-24.
78. Okada K, Kuroda E, Yoshida Y, Yamashita U, Suzumura A, Tsuji S: Effects of interferon-beta on the cytokine production of astrocytes. J Neuroimmunol 2005;159:48-54.
79. Sato T, Suzuki E, Yokoyama M, Semba J, Watanabe S, Miyaoka H: Chronic intraperitoneal injection of interferon-α reduces serotonin levels in various regions of rat brain, but does not change levels of serotonin transporter mRNA, nitrite or nitrate. Psychiatry Clin Neurosci 2006;60:499-506.
80. Furukawa K, Mattson MP: The transcription factor NF-κB mediates increases in calcium currents and decreases in NMDA- and AMPKA/kainate-induced currents by tumor necrosis factor alpha in hippocampal neurons. J Neurochem 1998;70:1876-1886.
81. Liu B, Li H, Brull SJ, Zhang JM: Increased sensitivity of sensory neurons to tumor necrosis factor alpha in rats with chronic compression of the lumbar ganglia. J Neurophysiol 2002;88:1393-1399.
82. Wang JY, Wang JY: Hypoxia/reoxygenation induces nitric oxide and TNF-alpha release from cultured microglia but not astrocytes of the rat. Chin J Physiol 2007;50:127-134.
83. Di Santo E, Foddi MC, Ricciardi-Castagnoli P, Mennini T, Ghezzi P: DHEAS inhibits TNF production in monocytes, astrocytes and microglial cells. Neuroimmunomodulation 1996;3:285-288.
84. Golan H, Levav, T, Mendelsohn A, Huleihel M: Involvement of tumor necrosis factor alpha in hippocampal development and function. Cereb Cortex 2004;14:97-105.
85. Rehn M, Hubschle T, Diener M: TNF-alpha hyperpolarizes membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurons. Acta Physiol Scand 2004;181:13-22.
86. Reeve AJ, Patel S, Fox A, Walker K, Urban L: Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat. Eur J Pain 2000;4:247-257.
87. Conti B, Tabarean I, Andrei C, Bartfai T: Cytokines and fever. Front Biosci 2004;9:1433-1449.
88. Yang L, Blumbergs PC, Jones NR, Manavis J, Sarvestani GT, Ghabriel MN: Early expression and cellular localization of proinflammatory cytokines interleukin-1β, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injury. Spine 2004;29:966-971.
89. Lindholm D, Heumann R, Meyer M, Thoenen H: Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 1987;330:658-659.
90. Maimone D, Cioni C, Rosa S, Macchia G, Aloisi F, Annunziata P: Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1β and TNF-α. J Neuroimmunol 1993;47:73-81.
91. Giulian D, Young DG, Woodward J, Brown DC, Lachman LB: Interleukin-1 is an astroglial growth factor in the developing brain. J Neurosci 1988;8:709-714.
92. Horton AR, Barlett PF, Pennica D, Davies AM: Cytokines promote the survival of mouse cranial sensory neurons at different developmental stages. Eur J Neurosci 1998;10:673-679.
93. Liberto CM, Albrecht PJ, Herx LM, Yong VW, Levison SW: Pro-regenerative properties of cytokine-activated astrocytes. J Neurochem 2004;89:1092-1100.
94. Alam MN, McGinty D, Bashir T, Kumar S, Imeri L, Opp MR, Szymusiak R: Interleukin-1β modulates state-dependent discharge activity of preoptic area and basal forebrain neurons: role in sleep regulation. Eur J Neurosci 2004;20:207-216.
95. Scarborough DE, Lee SL, Dinarello CA, Reichlin S: Interleukin-1 beta stimulates somatostatin biosynthesis in primary cultures of fetal rat brain. Endocrinology 1989;124:549-551.
96. Schneider H, Pitossi F, Balschun D, Wagner A, del Rey A, Besedovsky HO: A neuromodulatory role of interleukin-1β in the hippocampus. Proc Natl Acad Sci USA 1998;95:7778-7783.
97. Ikegaya Y, Delcroix I, Iwakura Y, Matsuki N, Nishiyama N: Interleukin-1β abrogates long-term depression of hippocampal CA1 synaptic transmission. Synapse 2003;47:54-57.
98. Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK: Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci 2007;27:9301-9309.
99. Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN: Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 1999;19:5236-5244.
100. Gruol DL, Nelson TE: Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol 1997;15:307-339.
101. Kushima Y, Ham T, Hatanaka H: Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains. Neurosci Res 1992;134:267-280.
102. Ye JH, Tao L, Zalcman SS: Interleukin-2 modulates N-methyl-D-aspartate receptors of native mesolimbic neurons. Brain Res 2001;894:241-248.
103. Campbell IL, Krucker T, Steffensen S, Akwa Y, Powell HC, Lane T, Carr DJ, Gold LH, Heinriksen SJ, Siggins GR: Structural and functional neuropathology in transgenic mice with CNS expression of IFN-alpha. Brain Res 1999;835:46-61.
104. Diemel LT, Copelman CA, Cuzner ML: Macrophages in CNS remyelination: friend or foe? Neurochem Res 1998;23:341-347.
105. Filipov NM, Seegal RF, Lawrence DA: Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism. Toxicol Sci 2005;84:139-148.
106. Friedman WJ: Cytokines regulate expression of the type 1 interleukin-1 receptor in rat hippocampal neurons and glia. Exp Neurol 2001;168:23-31.
107. Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA: Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by rho-dependent mechanism. J Neurosci 2002;22:854-862.
108. Ye SM, Johnson RW: An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice. Neuroimmunomodulation 2001;9:183-192.
109. Mao X, Moerman-Herzog AM, Wang W, Barger SW: Differential transcriptional control of the superoxide dismutase-2 κB element in neurons and astrocytes. J Biol Chem 2006;281:35863-35872.
110. Syed MM, Phulwani NK, Kielian T: Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia. J Neurochem 2007;103:1461-1471. s
111. Rothwell NJ, Luheshi GN: Brain TNF: damage limitation or damaged reputation? Nat Med 1996;2:746-747.
112. Tabakman R, Lecht S, Sephanova S, Arien-Zakay H, Lazarovici P: Interactions between the cells of the immune and nervous system: neurotrophins as neuroprotection mediators in CNS injury. Prog Brain Res 2004;146:387-401.
113. Wieseler-Frank J, Jekich BM, Mahoney JH, Bland ST, Maier SF, Watkins LR: A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus. Brain Behav Immun 2007;2:711-718.
114. Masihi KN: Novel concepts for anti-infective activity of cytokines, chemokines and diverse agents. Recent Patents Anti-Infect Drug Disc 2006;1:147-156.
115. Jee Y, Liu R, Bai XF, Campagnolo DI, Shi FD, Vollmer T: Do Th2 cells mediate the effects of glatiramer acetate in experimental autoimmune encephalomyelitis? Int Immunol 2006;18:537-544.
116. Capuron L, Hauser P, Hinze-Selch D, Miller AH, Neveu PJ: Treatment of cytokine-induced depression. Brain Behav Immun 2002;16:575-580.
117. Adachi Y, Yoshio-Hoshino N, Nishimoto N: The blockade of IL-6 signaling in rational drug design. Curr Pharm Des 2008;14:1217-1224.