Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6

Neuroscience

Volumn 89, Issue 1, 1999, Pages 127-136

  Nelson, T E ^a   Campbell, I L ^a   Gruol, D L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cerebellum; Electrophysiology; Immunohistochemistry; Interleukin 6; Purkinje neuron; Transgenic

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; HISTOPATHOLOGY; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PURKINJE CELL; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ANTIGENS, CD; BRAIN CHEMISTRY; CYTOKINE RECEPTOR GP130; ELECTROPHYSIOLOGY; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; PURKINJE CELLS; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 0033105025     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00316-9     Document Type: Article

References (48)

1. Aikawa H., Suzuki K., Iwasaki Y. and Iizuka R. (1985) Atypical Alzheimer's disease with spastic paresis and ataxia. Ann. Neurol. 17, 297-300.
2. Akira S., Hirano T., Taga T. and Kishimoto T. (1990) Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). Fedn Am. Socs Exp. Biol. J. 4, 2860-2867.
3. Bauer J., Strauss S., Schreiter-Gasser U., Ganter U., Schlegel P., Witt I., Yolk B. and Berger M. (1991) Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. Fedn Eur. Biochem. Socs Lett. 285, 111-114.
4. Bellinger F. P., Madamba S. G., Campbell I. L. and Siggins G. R. (1995) Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neurosci. Lett. 198, 95-98.
5. Benveniste E. N. (1992) Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action. Am. J. Physiol. 263, C1-C16.
6. Benveniste E. N., Sparacio S. M., Norris J. G., Grenett H. E. and Fuller G. M. (1990) Induction and regulation of interleukin-6 gene expression in rat astrocytes. J. Neuroimmunol. 30, 212-301.
7. Brett F. M., Mizisin A. P., Powell H. C. and Campbell I. L. (1996) Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J. Neuropath, Exp. Neurol. 546, 766-775.
8. Campbell I. L., Abraham C. R., Masliah E., Kemper P., Inglis J. D., Oldstone M. B. and Mucke L. (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natn. Acad. Sci. U.S.A. 90, 10,061-10,065.
9. Chiang C.-S., Stalder A., Samimi A. and Campbell I. L. (1994) Reactive gliosis as a consequence of interleukin-6 expression in the brain: Studies in transgenic mice. Devl Neurosci. 16, 212-221.
10. Chiu F. C. and Goldman J. E. (1985) Regulation of glial fibrillary acidic protein (GFAP) expression in CNS development and in pathological states. J. Neuroimmunol. 8, 283-292.
11. Davie C. A., Barker G. J., Webb S., Tofts P. S., Thompson A. J., Harding A. E. and Miller D. H. (1995) Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 118, 1583-1592.
12. De Schutter E. (1995) Cerebellar long-term depression might normalize excitation of Purkinje cells: A hypothesis. Trends Neurosci. 18, 291-295.
13. Eccles J. C., Ito M. and Szentagothai J. (1967) The Cerebellum as a Neuronal Machine, Pp. 306. Springer-Verlag, New York, Heidelberg.
14. Frei K., Malipiero U. V., Leist T. P., Zinkernagel R. M., Schwab M. E. and Fontana A. (1989) On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19, 689-694.
15. Freund R. K., Wang Y. and Palmer M. R. (1993) Differential effects of ethanol on the firing rates of Golgi-like neurons and Purkinje neurons in cerebellar slices in vitro. Neurosci. Lett. 164, 9-12.
16. Gahwiler B. H., Mamoon A. M. and Tobias C. A. (1973) Spontaneous bioelectric activity of cultured cerebellar Purkinje cells during exposure to agents which prevent synaptic transmission. Brain Res. 53, 71-79.
17. Gallo P., Frei K., Rordorf C., Lazdins J., Tavolato B. and Fontana A. (1989) Human immunodeficiency type 1 (HIV-1) infection of the central nervous system: An evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23, 109-116.
18. Graus F., Ribalta T., Abos J., Alom J., Cruz-Sanchez F., Mallolas J., Miro J. M., Cardesa A. and Tolosa E. (1990) Subacute cerebellar syndrome as the first manifestation of AIDS dementia complex. Acta Neurol. Scand. 81, 118- 120.
19. Heinrich P. C., Castell J. V. and Andus T. (1990) Interleukin-6 and the acute phase response. Biochem. J. 265, 621-636.
20. Heyser C. J., Masliah E., Samimi A., Campbell I. L. and Gold L. H. (1997) Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc. Natn. Acad. Sci. U.S.A. 94, 1500-1505.
21. Hirano T. (1992) The biology of interleukin-6. Chem. Immunol. 51, 153-180.
22. Hirohata S. and Miyamoto T. (1990) Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthr. Rheum. 33, 644-649.
23. Hopkins S. J. and Rothwell N. J. (1993) Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci. 18, 83-88.
24. Hounsgaard H. and Midtgaard J. (1988) Intrinsic determinants of firing pattern in Purkinje cells of the turtle cerebellum in vitro. J. Physiol. 402, 731-749.
25. Hounsgaard H. and Midtgaard J. (1989) Synaptic control of excitability in turtle cerebellar Purkinje cells. J. Physiol. 409, 157-170.
26. Houssiau F. A., Bukasa K., Sindic C. J. M., Van Damme J. and Van Snick J. (1988) Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin. Exp. Immunol. 71, 320-323.
27. Ito M. (1984) The Cerebellum and Neural Control, Pp. 580. Raven, New York.
28. Ito M. (1989) Long-term depression. A. Rev. Neurosci. 12, 85-102.
29. Kishimoto T., Akira S., Narazaki M. and Taga T. (1995) Interleukin-6 family of cytokines and gp130. Blood 86, 1243-1254.
30. Latham A. and Paul D. H. (1971) Spontaneous activity of cerebellar Purkinje cells and their responses to impulses in climbing fibers. J. Physiol. 213, 135-156.
31. Llinas R. and Sugimori M. (1980) Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices. J. Physiol. 305, 171-195.
32. Llinas R. and Sugimori M. (1980) Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices. J. Physiol. 305, 197-213.
33. Maimone D., Gregory S., Arnason B. G. W. and Reder A. T. (1991) Cytokine levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. J. Neuroimmunol. 32, 67-74.
34. Merrill J. E. (1992) Tumor necrosis alpha, interleukin 1, and related cytokines in brain development: Normal and pathological. Devl Neurosci. 14, 1-10.
35. Poser S., Luer W., Eichenlaub D., Pohle H. D., Weber T. and Jurgens S. (1988) Chronic HIV encephalitis - II. Clinical aspects. Klin. Wschr. 66, 26-31.
36. Qiu Z., Parsons K. L. and Gruol D. L. (1995) Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. J. Neurosci. 15, 6688-6699.
37. Rothwell N. J. (1991) Functions and mechanisms of interleukin 1 in the brain. Trends Pharmac. Sci. 12, 430-436.
38. Sato Y., Miura A., Fushiki H. and Kawasaki T. (1992) Short-term modulation of cerebellar Purkinje cell activity after spontaneous climbing fiber input. J. Neurophysiol. 68, 2051-2062.
39. Schobitz B., De Kloet E. R., Sutanto W. and Holsboer F. (1993) Cellular localization of interleukin-6 mRna and interleukin-6 receptor mRna in rat brain. Eur. J. Neurosci. 5, 1426-1435.
40. Schobitz B., Voorhuis D. A. M. and De Kloet E. R. (1992) Localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Neurosci. Lett. 136, 189-192.
41. Singh R. R., Prasad K., Kumar A., Misra A., Padmakumar K. and Malaviya A. N. (1988) Cerebellar ataxia in systemic lupus erythematosus: Three case reports. Ann. Rheum. Dis. 47, 954-956.
42. Steffensen S. C., Campbell I. L. and Henriksen S. J. (1994) Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice. Brain Res. 652, 149-153.
43. Tuchman A. J., Daras M. and David S. (1983) Cerebellar ataxia in systemic lupus erythematosus. N. Y. State J. Med. 83, 983-984.
44. Tyor W. R., Glass J. D., Griffin J. W., Becker P. S., McArthur J. C., Bezman L. and Griffin D. E. (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31, 349-360.
45. Vakili S. T. and Muller J. (1987) Juvenile Alzheimer's disease with cerebellar involvement. Archs Path. Lab. Med. 111, 480-482.
46. Vergani M. I., Reimao R., Silva A. M., Muskat M., Esposito S. and Diament A. (1988) Multiple sclerosis with early childhood onset. A case report. Arq. Neuropsiquiatr. 46, 195-197.
47. Woodroofe M. N., Sarna G. S., Wadhwa M., Hayes G. M., Loughlin A. J., Tinker A. and Cuzner M. L. (1991) Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role of microglia in cytokine production. J. Neuroimmunol. 33, 227-236.
48. Xin L. and Blatteis C. M. (1992) Hypothalamic neuronal responses to interleukin-6 in tissue slices: Effects of indomethacin and naloxone. Brain Res. Bull. 29, 27-35.