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Volumn 9, Issue 3-4, 1998, Pages 259-275

Cytokine actions in the central nervous system

Author keywords

Cytokines; Glial Cells; Multiple Sclerosis; Neurons; Receptors

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA;

EID: 0345580623     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6101(98)00015-X     Document Type: Review
Times cited : (324)

References (199)
  • 1
    • 0017734968 scopus 로고
    • Immunologically privileged sites
    • Baker CF, Billingham RF. Immunologically privileged sites. Adv Immunol 1977, 25, 1-49.
    • (1977) Adv Immunol , vol.25 , pp. 1-49
    • Baker, C.F.1    Billingham, R.F.2
  • 2
    • 0024507995 scopus 로고
    • Immunological function of the blood-cerebrospinal fluid barrier
    • Nathanson JA, Chun LLY. Immunological function of the blood-cerebrospinal fluid barrier. Proc Natl Acad Sci USA 1989, 86, 1684-1688.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 1684-1688
    • Nathanson, J.A.1    Chun, L.L.Y.2
  • 3
    • 0030240326 scopus 로고    scopus 로고
    • The central nervous system as an immunocompetent organ: Role of glial cells in antigen presentation
    • Shrikant P, Benveniste EN. The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation. J Immunol 1996, 157, 1819-1822.
    • (1996) J Immunol , vol.157 , pp. 1819-1822
    • Shrikant, P.1    Benveniste, E.N.2
  • 4
    • 0025981021 scopus 로고
    • T-lymphocyte entry into the central nervous system
    • Hickey WF, Hsu BL, Kimura H. T-lymphocyte entry into the central nervous system. J Neurosci Res 1991, 28, 254-260.
    • (1991) J Neurosci Res , vol.28 , pp. 254-260
    • Hickey, W.F.1    Hsu, B.L.2    Kimura, H.3
  • 5
    • 0030663981 scopus 로고    scopus 로고
    • Cytokines: Influence on glial cell gene expression and function
    • Blalock JE, ed. Karger, Basel
    • Benveniste EN. Cytokines: Influence on glial cell gene expression and function. In Blalock JE, ed. Neuroimmunoendocrinology, Karger, Basel, 1997: 31-75.
    • (1997) Neuroimmunoendocrinology , pp. 31-75
    • Benveniste, E.N.1
  • 7
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988, 239, 290-292.
    • (1988) Science , vol.239 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 8
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19, 312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 9
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • Benveniste EN. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 1997, 75, 165-173.
    • (1997) J Mol Med , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 11
    • 0029994319 scopus 로고    scopus 로고
    • Interferon-γ: Biology and role in pathogenesis
    • Academic Press, Inc.
    • Billiau A. Interferon-γ: biology and role in pathogenesis. In Advances in Immunology. Academic Press, Inc., 1996: 61-130.
    • (1996) Advances in Immunology , pp. 61-130
    • Billiau, A.1
  • 13
    • 0027411525 scopus 로고
    • The molecular cell biology of interferon-γ and its receptor
    • Farrar MA, Schreiber RD. The molecular cell biology of interferon-γ and its receptor. Annu Rev Immunol 1993, 11, 571-611.
    • (1993) Annu Rev Immunol , vol.11 , pp. 571-611
    • Farrar, M.A.1    Schreiber, R.D.2
  • 14
    • 0030840464 scopus 로고    scopus 로고
    • STATs and gene regulation
    • Darnell JE, Jr. STATs and gene regulation. Science 1997, 277, 1630-1635.
    • (1997) Science , vol.277 , pp. 1630-1635
    • Darnell J.E., Jr.1
  • 15
    • 0022651246 scopus 로고
    • Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain
    • Hofman FM, VonHanwher R, Dinarello C, Mizel S, Hinton D, Merrill JE. Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain. J Immunol 1986, 136, 3239-3245.
    • (1986) J Immunol , vol.136 , pp. 3239-3245
    • Hofman, F.M.1    Vonhanwher, R.2    Dinarello, C.3    Mizel, S.4    Hinton, D.5    Merrill, J.E.6
  • 16
    • 0023858304 scopus 로고
    • Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions
    • Traugott U, Lebon P. Interferon-γ and Ia antigen are present on astrocytes in active chronic multiple sclerosis lesions. J Neurol Sci 1988, 84, 257-264.
    • (1988) J Neurol Sci , vol.84 , pp. 257-264
    • Traugott, U.1    Lebon, P.2
  • 17
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B, Raine CS. The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 1995, 37, 424-435.
    • (1995) Ann Neurol , vol.37 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 19
    • 0025033980 scopus 로고
    • Gamma interferon-like immunoreactivity in the rat nervous system
    • Kiefer R, Kreutzberg GW. Gamma interferon-like immunoreactivity in the rat nervous system. Neurosci 1990, 37, 725-734.
    • (1990) Neurosci , vol.37 , pp. 725-734
    • Kiefer, R.1    Kreutzberg, G.W.2
  • 20
    • 0031441350 scopus 로고    scopus 로고
    • Interferon γ gene expression in sensory neurons: Evidence for autocrine gene regulation
    • Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H. Interferon γ gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med 1997, 186, 2023-2031.
    • (1997) J Exp Med , vol.186 , pp. 2023-2031
    • Neumann, H.1    Schmidt, H.2    Wilharm, E.3    Behrens, L.4    Wekerle, H.5
  • 21
    • 0025330382 scopus 로고
    • Rat astrocytes express interferon-γ immunoreactivity in normal optic nerve and after nerve transaction
    • Schmidt B, Stoll G, Toyka KV, Hartung H-P. Rat astrocytes express interferon-γ immunoreactivity in normal optic nerve and after nerve transaction. Brain Res 1990, 515, 347-350.
    • (1990) Brain Res , vol.515 , pp. 347-350
    • Schmidt, B.1    Stoll, G.2    Toyka, K.V.3    Hartung, H.-P.4
  • 22
    • 0032101935 scopus 로고    scopus 로고
    • Interferon-γ gene expression in rat central nervous system glial cells
    • De Simone R, Levi G, Aloisi F. Interferon-γ gene expression in rat central nervous system glial cells. Cytokine 1998, 10, 418-422.
    • (1998) Cytokine , vol.10 , pp. 418-422
    • De Simone, R.1    Levi, G.2    Aloisi, F.3
  • 23
    • 0025734387 scopus 로고
    • γ-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo
    • Yong VW, Moumdjian R, Yong FP, Ruijs TCG, Freedman MS, Cashman N, Antel JP. γ-interferon promotes proliferation of adult human astrocytes in vitro and reactive gliosis in the adult mouse brain in vivo. Proc Natl Acad Sci USA 1991, 88, 7016-7020.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7016-7020
    • Yong, V.W.1    Moumdjian, R.2    Yong, F.P.3    Ruijs, T.C.G.4    Freedman, M.S.5    Cashman, N.6    Antel, J.P.7
  • 24
    • 0028012270 scopus 로고
    • Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines
    • Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 1994, 14, 846-856.
    • (1994) J Neurosci , vol.14 , pp. 846-856
    • Balasingam, V.1    Tejada-Berges, T.2    Wright, E.3    Bouckova, R.4    Yong, V.W.5
  • 25
    • 0030135421 scopus 로고    scopus 로고
    • Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development
    • Corbin JG, Kelly D, Rath EM, Baerwald KD, Suzuki K, Popko B. Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development. Mol Cell Neurosci 1996, 7, 354-370.
    • (1996) Mol Cell Neurosci , vol.7 , pp. 354-370
    • Corbin, J.G.1    Kelly, D.2    Rath, E.M.3    Baerwald, K.D.4    Suzuki, K.5    Popko, B.6
  • 26
    • 0030972777 scopus 로고    scopus 로고
    • Astrogliosis in the neonatal and adult murine brain post-trauma: Elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-γ
    • Rostworowski M, Balasingam V, Chabot S, Owens T, Yong VW. Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-γ. J Neurosci 1997, 17, 3664-3674.
    • (1997) J Neurosci , vol.17 , pp. 3664-3674
    • Rostworowski, M.1    Balasingam, V.2    Chabot, S.3    Owens, T.4    Yong, V.W.5
  • 28
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998, 16, 111-135.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111-135
    • Grewal, I.S.1    Flavell, R.A.2
  • 29
    • 0021191999 scopus 로고
    • Astrocytes present myelin basic protein to encephalitogenic T-cell lines
    • Fontana A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 1984, 307, 273-276.
    • (1984) Nature , vol.307 , pp. 273-276
    • Fontana, A.1    Fierz, W.2    Wekerle, H.3
  • 31
    • 0025152145 scopus 로고
    • Induction and regulation of class II MHC mRNA expression in astrocytes by IFN-γ and TNF-α
    • Vidovic M., Sparacio SM, Elovitz M, Benveniste EN. Induction and regulation of class II MHC mRNA expression in astrocytes by IFN-γ and TNF-α. J Neuroimmunol 1990, 30, 189-200.
    • (1990) J Neuroimmunol , vol.30 , pp. 189-200
    • Vidovic, M.1    Sparacio, S.M.2    Elovitz, M.3    Benveniste, E.N.4
  • 32
    • 0024409242 scopus 로고
    • The induction of intercellular adhesion molecule -1 (ICAM-1) expression on human fetal astrocytes by interferon-γ, tumor necrosis factor-α, lymphotoxin, and interleukin-1: Relevance to intracerebral antigen presentation
    • Frohman EM, Frohman TC, Dustin ML, Vayuvegula B, Choi B, Gupta A, van den Noort S, Gupta S. The induction of intercellular adhesion molecule -1 (ICAM-1) expression on human fetal astrocytes by interferon-γ, tumor necrosis factor-α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation. J Neuroimmunol 1989, 23, 117-124.
    • (1989) J Neuroimmunol , vol.23 , pp. 117-124
    • Frohman, E.M.1    Frohman, T.C.2    Dustin, M.L.3    Vayuvegula, B.4    Choi, B.5    Gupta, A.6    Van Den Noort, S.7    Gupta, S.8
  • 33
    • 0028796804 scopus 로고
    • Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines
    • Rosenman SJ, Shrikant P, Dubb L, Benveniste EN, Ransohoff RM. Cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines. J Immunol 1995, 154, 1888-1899.
    • (1995) J Immunol , vol.154 , pp. 1888-1899
    • Rosenman, S.J.1    Shrikant, P.2    Dubb, L.3    Benveniste, E.N.4    Ransohoff, R.M.5
  • 34
    • 0029166306 scopus 로고
    • ICAM-1 gene expression by glial cells: Differential mechanisms of inhibition by interleukin-10 and interleukin-6
    • Shrikant P, Weber E, Jilling T, Benveniste EN. ICAM-1 gene expression by glial cells: differential mechanisms of inhibition by interleukin-10 and interleukin-6. J Immunol 1995, 155, 1489-1501.
    • (1995) J Immunol , vol.155 , pp. 1489-1501
    • Shrikant, P.1    Weber, E.2    Jilling, T.3    Benveniste, E.N.4
  • 35
    • 0032006605 scopus 로고    scopus 로고
    • Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes
    • Winkler M, Benveniste EN. Transforming growth factor-beta inhibition of cytokine-induced vascular cell adhesion molecule-1 expression in human astrocytes. GLIA 1998, 22, 171-179.
    • (1998) GLIA , vol.22 , pp. 171-179
    • Winkler, M.1    Benveniste, E.N.2
  • 36
    • 0025104589 scopus 로고
    • Intrathecal application of interferon gamma
    • Vass K, Lassmann H. Intrathecal application of interferon gamma. Amer J Path 1990, 137, 789-800.
    • (1990) Amer J Path , vol.137 , pp. 789-800
    • Vass, K.1    Lassmann, H.2
  • 37
    • 0025278577 scopus 로고
    • Multiple sclerosis: A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study
    • Lee SC, Moore GRW, Golenwsky G, Raine CS. Multiple sclerosis: A role for astroglia in active demyelination suggested by class II MHC expression and ultrastructural study. J Neuropathol Exp Neurol 1990, 49, 122-136.
    • (1990) J Neuropathol Exp Neurol , vol.49 , pp. 122-136
    • Lee, S.C.1    Moore, G.R.W.2    Golenwsky, G.3    Raine, C.S.4
  • 38
    • 0021907881 scopus 로고
    • Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat
    • Hickey WF, Osborn JP, Kirby WM. Expression of Ia molecules by astrocytes during acute experimental allergic encephalomyelitis in the Lewis rat. Cell Immunol 1985, 91, 528-535.
    • (1985) Cell Immunol , vol.91 , pp. 528-535
    • Hickey, W.F.1    Osborn, J.P.2    Kirby, W.M.3
  • 39
    • 0024561679 scopus 로고
    • In situ Ia expression on brain cells in the rat: Autoimmune encephalomyelitis-resistant strain (BN) and susceptible strain (Lewis) compared
    • Matsumoto Y, Kawai K, Fujiwara M. In situ Ia expression on brain cells in the rat: Autoimmune encephalomyelitis-resistant strain (BN) and susceptible strain (Lewis) compared. Immunol 1989, 66, 621-627.
    • (1989) Immunol , vol.66 , pp. 621-627
    • Matsumoto, Y.1    Kawai, K.2    Fujiwara, M.3
  • 40
    • 0028876151 scopus 로고
    • T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture
    • Satoh J-I, Lee YB, Kim SU. T-cell costimulatory molecules B7-1 (CD80) and B7-2 (CD86) are expressed in human microglia but not in astrocytes in culture. Brain Res 1995, 704, 92-96.
    • (1995) Brain Res , vol.704 , pp. 92-96
    • Satoh, J.-I.1    Lee, Y.B.2    Kim, S.U.3
  • 41
    • 0032524997 scopus 로고    scopus 로고
    • Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
    • Aloisi F, Ria F, Penna G, Adorini L. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation. J Immunol 1998, 160, 4671-4680.
    • (1998) J Immunol , vol.160 , pp. 4671-4680
    • Aloisi, F.1    Ria, F.2    Penna, G.3    Adorini, L.4
  • 43
    • 0032080658 scopus 로고    scopus 로고
    • Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-γ-activated SJL/J astrocytes
    • Tan L, Gordon KB, Mueller JP, Matis LA, Miller SD. Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-γ-activated SJL/J astrocytes. J Immunol 1998, 160, 4271-4279.
    • (1998) J Immunol , vol.160 , pp. 4271-4279
    • Tan, L.1    Gordon, K.B.2    Mueller, J.P.3    Matis, L.A.4    Miller, S.D.5
  • 44
    • 0032145434 scopus 로고    scopus 로고
    • Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo
    • Issazadeh S, Navikas V, Schaub M, Sayegh M, Khoury S. Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in vivo. J Immunol 1998, 161, 1104-1112.
    • (1998) J Immunol , vol.161 , pp. 1104-1112
    • Issazadeh, S.1    Navikas, V.2    Schaub, M.3    Sayegh, M.4    Khoury, S.5
  • 45
    • 0021805991 scopus 로고
    • Astrocytes as antigen presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation
    • Fierz W, Endler B, Reske K., Wekerle H, Fontana A. Astrocytes as antigen presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation. J Immunol 1985, 134, 3785-3793.
    • (1985) J Immunol , vol.134 , pp. 3785-3793
    • Fierz, W.1    Endler, B.2    Reske, K.3    Wekerle, H.4    Fontana, A.5
  • 46
    • 0026628844 scopus 로고
    • Immune regulation by brain cells in the central nervous system: Microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions
    • Matsumoto Y, Ohmori K, Fujiwara M. Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions. Immunol 1992, 76, 209-216.
    • (1992) Immunol , vol.76 , pp. 209-216
    • Matsumoto, Y.1    Ohmori, K.2    Fujiwara, M.3
  • 49
    • 0028970282 scopus 로고
    • Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1
    • Williams KC, Dooley NP, Ulvestad E, Waage A, Blain M, Yong VW, Antel JP. Antigen presentation by human fetal astrocytes with the cooperative effect of microglia or the microglial-derived cytokine IL-1. J Neurosci 1995, 15, 1869-1878.
    • (1995) J Neurosci , vol.15 , pp. 1869-1878
    • Williams, K.C.1    Dooley, N.P.2    Ulvestad, E.3    Waage, A.4    Blain, M.5    Yong, V.W.6    Antel, J.P.7
  • 52
    • 0345626668 scopus 로고    scopus 로고
    • IL-1β inhibits IFN-γ induced class II MHC expression by suppressing transcription of the class II transactivator gene
    • In press
    • Rohn W, Tang LP, Dong Y, Benveniste EN. IL-1β inhibits IFN-γ induced class II MHC expression by suppressing transcription of the class II transactivator gene. J Immunol 1998, (In press).
    • (1998) J Immunol
    • Rohn, W.1    Tang, L.P.2    Dong, Y.3    Benveniste, E.N.4
  • 53
    • 0027414638 scopus 로고
    • Cortical neurons selectively inhibit MHC class II induction in astrocytes but not in microglial cells
    • Tontsch U, Rott O. Cortical neurons selectively inhibit MHC class II induction in astrocytes but not in microglial cells. Inter Immunol 1993, 5, 249-254.
    • (1993) Inter Immunol , vol.5 , pp. 249-254
    • Tontsch, U.1    Rott, O.2
  • 54
    • 0030480978 scopus 로고    scopus 로고
    • Neuronal control of MHC class II inducibility in rat astrocytes and microglia
    • Neumann H, Boucraut J, Hahnel C, Misgeld T, Wekerle H. Neuronal control of MHC class II inducibility in rat astrocytes and microglia. Eur J Neurosci 1996, 8, 2582-2590.
    • (1996) Eur J Neurosci , vol.8 , pp. 2582-2590
    • Neumann, H.1    Boucraut, J.2    Hahnel, C.3    Misgeld, T.4    Wekerle, H.5
  • 55
    • 0031984426 scopus 로고    scopus 로고
    • Neuronal control of the immune response in the central nervous system: Linking brain immunity to neurodegeneration
    • Neumann H, Wekerle H. Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration. J Neuropathol Exp Neurol 1998, 57, 1-9.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 1-9
    • Neumann, H.1    Wekerle, H.2
  • 56
    • 0028351424 scopus 로고
    • Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes
    • Shrikant P, Chung IY, Ballestas M, Benveniste EN. Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes. J Neuroimmunol 1994, 51, 209-220.
    • (1994) J Neuroimmunol , vol.51 , pp. 209-220
    • Shrikant, P.1    Chung, I.Y.2    Ballestas, M.3    Benveniste, E.N.4
  • 57
    • 0032890333 scopus 로고    scopus 로고
    • Transcriptional regulation of the intercellular adhesion molecule-1 gene by proinflammatory cytokines in human astrocytes
    • In press
    • Lee SJ, Park JY, Hou J, Benveniste EN. Transcriptional regulation of the intercellular adhesion molecule-1 gene by proinflammatory cytokines in human astrocytes. GLIA 1998, (In press).
    • (1998) GLIA
    • Lee, S.J.1    Park, J.Y.2    Hou, J.3    Benveniste, E.N.4
  • 58
    • 0028927545 scopus 로고
    • Adhesion to human neurons and astrocytes of monocytes: The role of interaction of CR3 and ICAM-1 and modulation by cytokines
    • Héry C, Sébire G, Peudenier S, Tardieu M. Adhesion to human neurons and astrocytes of monocytes: the role of interaction of CR3 and ICAM-1 and modulation by cytokines. J Neuroimmunol 1995, 57, 101-109.
    • (1995) J Neuroimmunol , vol.57 , pp. 101-109
    • Héry, C.1    Sébire, G.2    Peudenier, S.3    Tardieu, M.4
  • 59
    • 0023618311 scopus 로고
    • Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells
    • Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A. Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells. Eur J Immunol 1987, 17, 1271-1278.
    • (1987) Eur J Immunol , vol.17 , pp. 1271-1278
    • Frei, K.1    Siepl, C.2    Groscurth, P.3    Bodmer, S.4    Schwerdel, C.5    Fontana, A.6
  • 60
    • 0023252003 scopus 로고
    • MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by γ-interferon
    • Suzumura A, Mezitis SGE, Gonatas NK, Silberberg DH. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by γ-interferon. J Neuroimmunol 1987, 15, 263-278.
    • (1987) J Neuroimmunol , vol.15 , pp. 263-278
    • Suzumura, A.1    Mezitis, S.G.E.2    Gonatas, N.K.3    Silberberg, D.H.4
  • 61
    • 0028950550 scopus 로고
    • Class IIMHC gene expression in microglia: Regulation by the cytokines IFN-γ, TNF-α and TGF-β
    • Panek RB, Benveniste EN. Class IIMHC gene expression in microglia: regulation by the cytokines IFN-γ, TNF-α and TGF-β. J Immunol 1995, 154, 2846-2854.
    • (1995) J Immunol , vol.154 , pp. 2846-2854
    • Panek, R.B.1    Benveniste, E.N.2
  • 63
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • Dickson DW, Lee SC, Mattiace LA, Yen S-HC, Brosnan C. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. GLIA 1993, 7, 75-83.
    • (1993) GLIA , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.-H.C.4    Brosnan, C.5
  • 64
    • 0028578704 scopus 로고
    • B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ
    • Williams K, Ulvestad E, Antel JP. B7/BB-1 antigen expression on adult human microglia studied in vitro and in situ. Eur J Immunol 1994, 24, 3031-3037.
    • (1994) Eur J Immunol , vol.24 , pp. 3031-3037
    • Williams, K.1    Ulvestad, E.2    Antel, J.P.3
  • 65
    • 0028964455 scopus 로고
    • The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions
    • De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F. The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropath Exp Neurol 1995, 54, 175-187.
    • (1995) J Neuropath Exp Neurol , vol.54 , pp. 175-187
    • De Simone, R.1    Giampaolo, A.2    Giometto, B.3    Gallo, P.4    Levi, G.5    Peschle, C.6    Aloisi, F.7
  • 66
    • 0343990850 scopus 로고    scopus 로고
    • Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: Upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents
    • Iglesias BM, Cerase J, Ceracchini C, Levi G, Aloisi F. Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-γ and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E2 and cyclic AMP-elevating agents. J Neuroimmunol 1997, 72, 83-93.
    • (1997) J Neuroimmunol , vol.72 , pp. 83-93
    • Iglesias, B.M.1    Cerase, J.2    Ceracchini, C.3    Levi, G.4    Aloisi, F.5
  • 67
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
    • Winghagen A, Newcombe J, Dangond F, Strand C, Woodroofe MN, Cuzner ML, Hafler DA. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 1995, 182, 1985-1996.
    • (1995) J Exp Med , vol.182 , pp. 1985-1996
    • Winghagen, A.1    Newcombe, J.2    Dangond, F.3    Strand, C.4    Woodroofe, M.N.5    Cuzner, M.L.6    Hafler, D.A.7
  • 68
    • 0030964198 scopus 로고    scopus 로고
    • Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity
    • Dangond F, Windhagen A, Groves CJ, Hafler DA. Constitutive expression of costimulatory molecules by human microglia and its relevance to CNS autoimmunity. J Neuroimmunol 1997, 76, 132-138.
    • (1997) J Neuroimmunol , vol.76 , pp. 132-138
    • Dangond, F.1    Windhagen, A.2    Groves, C.J.3    Hafler, D.A.4
  • 69
    • 0030744132 scopus 로고    scopus 로고
    • Functions of CD40 on B cells, dendritic cells and other cells
    • van Kooten C, Banchereau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Cell Biol 1997, 9, 330-337.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 330-337
    • Kooten, C.1    Banchereau, J.2
  • 71
    • 0029744798 scopus 로고    scopus 로고
    • Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
    • Grewal I, Foellmer H, Grewal K, Xu J, Hardardottir F, Baron J, Janeway C, Flavell R. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 1996, 273, 1864-1867.
    • (1996) Science , vol.273 , pp. 1864-1867
    • Grewal, I.1    Foellmer, H.2    Grewal, K.3    Xu, J.4    Hardardottir, F.5    Baron, J.6    Janeway, C.7    Flavell, R.8
  • 72
    • 0031948066 scopus 로고    scopus 로고
    • Post-transcriptional inhibition of CD40 gene expression in microglia by TGF-β
    • Nguyen V, Walker WS, Benveniste EN. Post-transcriptional inhibition of CD40 gene expression in microglia by TGF-β. Eur J Immunol. 1998, 28, 2537-2548.
    • (1998) Eur J Immunol. , vol.28 , pp. 2537-2548
    • Nguyen, V.1    Walker, W.S.2    Benveniste, E.N.3
  • 73
    • 0029936653 scopus 로고    scopus 로고
    • Human microglia activate lymphoproliferative responses to recall viral antigens
    • Dhib-Jalbut S, Gogate N, Jiang H, Eisenberg H, Bergey G. Human microglia activate lymphoproliferative responses to recall viral antigens. J Neuroimmunol 1996, 65, 67-73.
    • (1996) J Neuroimmunol , vol.65 , pp. 67-73
    • Dhib-Jalbut, S.1    Gogate, N.2    Jiang, H.3    Eisenberg, H.4    Bergey, G.5
  • 74
    • 0027970495 scopus 로고
    • + T lymphocytes in the central nervous system
    • + T lymphocytes in the central nervous system. Clin Exp Immunol 1994, 98, 313-318.
    • (1994) Clin Exp Immunol , vol.98 , pp. 313-318
    • Cash, E.1    Rott, O.2
  • 75
    • 0029848128 scopus 로고    scopus 로고
    • Microglia induce CD4 T lymphocyte final effector function and death
    • Ford AL, Foulcher E, Lemckert FA, Sedgwick JD. Microglia induce CD4 T lymphocyte final effector function and death. J Exp Med. 1996, 184, 1737-1745.
    • (1996) J Exp Med. , vol.184 , pp. 1737-1745
    • Ford, A.L.1    Foulcher, E.2    Lemckert, F.A.3    Sedgwick, J.D.4
  • 76
    • 0028215961 scopus 로고
    • Antigen presentation in the central nervous system: The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed
    • Frei K, Lins H, Schwerdel C, Fontana A. Antigen presentation in the central nervous system: The inhibitory effect of IL-10 on MHC class II expression and production of cytokines depends on the inducing signals and the type of cell analyzed. J Immunol 1994, 152, 2720-2728.
    • (1994) J Immunol , vol.152 , pp. 2720-2728
    • Frei, K.1    Lins, H.2    Schwerdel, C.3    Fontana, A.4
  • 77
    • 0027422234 scopus 로고
    • Granulocyte-macrophage colony stimulating factor inhibits class II major histocompatibility complex expression and antigen presentation by microglia
    • Hayashi M, Dorf ME, Abromson-Leeman S. Granulocyte-macrophage colony stimulating factor inhibits class II major histocompatibility complex expression and antigen presentation by microglia. J Neuroimmunol 1993, 48, 23-32.
    • (1993) J Neuroimmunol , vol.48 , pp. 23-32
    • Hayashi, M.1    Dorf, M.E.2    Abromson-Leeman, S.3
  • 78
    • 0027238093 scopus 로고
    • Macrophage colony-stimulating factor in human fetal astrocytes and microglia: Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia
    • Lee SC, Liu W, Roth P, Dickson DW, Berman JW, Brosnan CF. Macrophage colony-stimulating factor in human fetal astrocytes and microglia: Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J Immunol 1993, 150, 594-604.
    • (1993) J Immunol , vol.150 , pp. 594-604
    • Lee, S.C.1    Liu, W.2    Roth, P.3    Dickson, D.W.4    Berman, J.W.5    Brosnan, C.F.6
  • 79
    • 0028026864 scopus 로고
    • Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
    • Suzumura A, Sawada M, Itoh Y, Marunouchi T. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J Neuroimmunol 1994, 53, 209-218.
    • (1994) J Neuroimmunol , vol.53 , pp. 209-218
    • Suzumura, A.1    Sawada, M.2    Itoh, Y.3    Marunouchi, T.4
  • 80
    • 0032510798 scopus 로고    scopus 로고
    • Neurotrophins inhibit major histocompatibility class II inducibility of microglia: Involvement of the p75 neurotrophin receptor
    • Neumann H, Misgeld T, Matsumuro K, Wekerle H. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Natl Acad Sci USA 1998, 95, 5779-5784.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5779-5784
    • Neumann, H.1    Misgeld, T.2    Matsumuro, K.3    Wekerle, H.4
  • 81
    • 0031913982 scopus 로고    scopus 로고
    • Inflammatory signals induce neurotrophin expression in human microglial cells
    • Heese K, Hock C, Otten W. Inflammatory signals induce neurotrophin expression in human microglial cells. J Neurochem 1998, 70, 699-707.
    • (1998) J Neurochem , vol.70 , pp. 699-707
    • Heese, K.1    Hock, C.2    Otten, W.3
  • 82
    • 0029972857 scopus 로고    scopus 로고
    • Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
    • Elkabes S, DiCicco-Bloom EM, Black IB. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 1996, 16, 2508-2521.
    • (1996) J Neurosci , vol.16 , pp. 2508-2521
    • Elkabes, S.1    Dicicco-Bloom, E.M.2    Black, I.B.3
  • 83
    • 0029166259 scopus 로고
    • Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells
    • Hayashi M, Luo Y, Laning J. Stricter RM, Dorf M.E. Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells. J Neuroimmunol 1995, 60, 143-150.
    • (1995) J Neuroimmunol , vol.60 , pp. 143-150
    • Hayashi, M.1    Luo, Y.2    Laning, J.3    Stricter, R.M.4    Dorf, M.E.5
  • 85
    • 0029078126 scopus 로고
    • Tumor necrosis factor-alpha production by human fetal microglial cells: Regulation by other cytokines
    • Chao CC, Hu S, Sheng WS, Peterson PK. Tumor necrosis factor-alpha production by human fetal microglial cells: regulation by other cytokines. Dev Neurosci 1995, 17, 97-105.
    • (1995) Dev Neurosci , vol.17 , pp. 97-105
    • Chao, C.C.1    Hu, S.2    Sheng, W.S.3    Peterson, P.K.4
  • 86
    • 0031571317 scopus 로고    scopus 로고
    • IL-12 production by central nervous system microglia is inhibited by astrocytes
    • Aloisi F, Penna G, Cerase J, Iglesias BM, Adorini L. IL-12 production by central nervous system microglia is inhibited by astrocytes. J Immunol 1997, 159, 1604-1612.
    • (1997) J Immunol , vol.159 , pp. 1604-1612
    • Aloisi, F.1    Penna, G.2    Cerase, J.3    Iglesias, B.M.4    Adorini, L.5
  • 88
    • 0027082393 scopus 로고
    • Interactions between oligodendrocytes and microglia
    • Zajicek JP, Wing M, Scolding NJ, Compston DAS. Interactions between oligodendrocytes and microglia. Brain 1992, 115, 1611-1631.
    • (1992) Brain , vol.115 , pp. 1611-1631
    • Zajicek, J.P.1    Wing, M.2    Scolding, N.J.3    Compston, D.A.S.4
  • 89
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri G. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 1995, 13, 251-276.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 91
    • 0028971386 scopus 로고
    • Expression of interferon-γ receptors on murine oligodendrocytes and its regulation by cytokines and mitogens
    • Torres C, Aránguez I, Rubio N. Expression of interferon-γ receptors on murine oligodendrocytes and its regulation by cytokines and mitogens. Immunology 1995, 86, 250-255.
    • (1995) Immunology , vol.86 , pp. 250-255
    • Torres, C.1    Aránguez, I.2    Rubio, N.3
  • 92
    • 0029882579 scopus 로고    scopus 로고
    • Reversible inhibitory effects of interferon-γ and tumour necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro
    • Agresti C, D'Urso D, Levi G. Reversible inhibitory effects of interferon-γ and tumour necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur J Neurosci 1996, 8, 1106-1116.
    • (1996) Eur J Neurosci , vol.8 , pp. 1106-1116
    • Agresti, C.1    D'Urso, D.2    Levi, G.3
  • 93
    • 0029410743 scopus 로고
    • Interferon-γ-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
    • Vartanian T, Li Y, Zhao M, Stefansson K. Interferon-γ-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1995, 1, 732-743.
    • (1995) Mol Med , vol.1 , pp. 732-743
    • Vartanian, T.1    Li, Y.2    Zhao, M.3    Stefansson, K.4
  • 94
    • 0026059873 scopus 로고
    • Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-γ and TNF-α
    • Turnley AM, Miller JFAP, Bartlett PF. Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-γ and TNF-α. Neurosci Letters 1991, 123, 45-48.
    • (1991) Neurosci Letters , vol.123 , pp. 45-48
    • Turnley, A.M.1    Miller, J.F.A.P.2    Bartlett, P.F.3
  • 96
    • 0029961665 scopus 로고    scopus 로고
    • Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice
    • Power C, Kong P-A, Trapp BD. Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice. J Neurosci Res 1996, 44, 165-173.
    • (1996) J Neurosci Res , vol.44 , pp. 165-173
    • Power, C.1    Kong, P.-A.2    Trapp, B.D.3
  • 98
    • 0031054508 scopus 로고    scopus 로고
    • Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: Differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α
    • Neumann H, Schmidt H, Cavalid A, Jenne D, Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-γ and tumor necrosis factor (TNF)-α. J Exp Med 1997, 185, 305-316.
    • (1997) J Exp Med , vol.185 , pp. 305-316
    • Neumann, H.1    Schmidt, H.2    Cavalid, A.3    Jenne, D.4    Wekerle, H.5
  • 99
    • 0029816768 scopus 로고    scopus 로고
    • Neurons induced to express major histocompatibility complex class I antigen are killed via the perform and not the Fas (APO- 1/CD95) pathway
    • Rensing-Ehl A, Malipiero U, Irmler M, Tschopp D, Fontana A. Neurons induced to express major histocompatibility complex class I antigen are killed via the perform and not the Fas (APO- 1/CD95) pathway. Eur J Immunol 1996, 26, 2271-2274.
    • (1996) Eur J Immunol , vol.26 , pp. 2271-2274
    • Rensing-Ehl, A.1    Malipiero, U.2    Irmler, M.3    Tschopp, D.4    Fontana, A.5
  • 100
    • 0030890718 scopus 로고    scopus 로고
    • gp130 and the interleukin-6 family of cytokines
    • Taga T, Kishimoto T. gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol 1997, 15, 797-819.
    • (1997) Annu Rev Immunol , vol.15 , pp. 797-819
    • Taga, T.1    Kishimoto, T.2
  • 101
    • 0031301027 scopus 로고    scopus 로고
    • Physiological and pathological roles of interleukin-6 in the central nervous system
    • Gruol DL, Nelson TE. Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol 1997, 15, 307-339.
    • (1997) Mol Neurobiol , vol.15 , pp. 307-339
    • Gruol, D.L.1    Nelson, T.E.2
  • 102
    • 0031471861 scopus 로고    scopus 로고
    • Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha
    • Modur V, Li Y, Zimmerman GA, Prescott SM, McIntyre TM. Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha. J Clin Invest 1997, 100, 2752-2756.
    • (1997) J Clin Invest , vol.100 , pp. 2752-2756
    • Modur, V.1    Li, Y.2    Zimmerman, G.A.3    Prescott, S.M.4    McIntyre, T.M.5
  • 104
    • 0028146329 scopus 로고
    • Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-γ involves binding of distinct factors to a palindromic response element
    • Caldenhoven E, Coffer P, Yuan J, Van De Stolpe A, Horn F, Kruijer W, Van Der Saag PT. Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-γ involves binding of distinct factors to a palindromic response element. J Biol Chem 1994, 269, 21146-21154.
    • (1994) J Biol Chem , vol.269 , pp. 21146-21154
    • Caldenhoven, E.1    Coffer, P.2    Yuan, J.3    Van De Stolpe, A.4    Horn, F.5    Kruijer, W.6    Van Der Saag, P.T.7
  • 105
    • 0029010133 scopus 로고
    • Differential regulation of astrocyte TNF-α expression by the cytokines TGF-β, IL-6 and IL-10
    • Benveniste EN, Tang LP, Law RM. Differential regulation of astrocyte TNF-α expression by the cytokines TGF-β, IL-6 and IL-10. Int J Dev Neurosci 1995, 13, 341-349.
    • (1995) Int J Dev Neurosci , vol.13 , pp. 341-349
    • Benveniste, E.N.1    Tang, L.P.2    Law, R.M.3
  • 106
    • 0024404853 scopus 로고
    • IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice
    • Aderka D, Le J, Vilcek J. IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice. J Immunol 1989, 143, 3517-3523.
    • (1989) J Immunol , vol.143 , pp. 3517-3523
    • Aderka, D.1    Le, J.2    Vilcek, J.3
  • 107
    • 0028031990 scopus 로고
    • Interleukin-6 (IL-6) as an anti-inflammatory cytokine: Induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55
    • Tilg H, Trehu E, Atkins MB, Dinarello CA, Mier JW. Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55. Blood 1994, 83, 113-118.
    • (1994) Blood , vol.83 , pp. 113-118
    • Tilg, H.1    Trehu, E.2    Atkins, M.B.3    Dinarello, C.A.4    Mier, J.W.5
  • 108
    • 0027939355 scopus 로고
    • Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis
    • Rodriguez M, Pavelko KD, McKinney CW, Leibowitz JL. Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J Immunol 1994, 153, 3811-3821.
    • (1994) J Immunol , vol.153 , pp. 3811-3821
    • Rodriguez, M.1    Pavelko, K.D.2    McKinney, C.W.3    Leibowitz, J.L.4
  • 109
    • 0028960035 scopus 로고
    • Cytokines and murine autoimmune encephalomyelitis: Inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system
    • Willenborg DO, Fordham SA, Cowden WB, Ramshaw IA. Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system. Scand J Immunol 1995, 41, 31-41.
    • (1995) Scand J Immunol , vol.41 , pp. 31-41
    • Willenborg, D.O.1    Fordham, S.A.2    Cowden, W.B.3    Ramshaw, I.A.4
  • 112
    • 0028226196 scopus 로고
    • Soluble receptors for cytokines and growth factors: Generation and biological function
    • Rose-John S, Heinrich PC. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J 1994, 300, 281-290.
    • (1994) Biochem J , vol.300 , pp. 281-290
    • Rose-John, S.1    Heinrich, P.C.2
  • 113
    • 0024358178 scopus 로고
    • Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis
    • Waage A, Halstensen A, Shalaby R, Brandtzaeg P, Kierulf P, Espevik T. Local production of tumor necrosis factor α, interleukin 1, and interleukin 6 in meningococcal meningitis. J Exp Med 1989, 170, 1859-1867.
    • (1989) J Exp Med , vol.170 , pp. 1859-1867
    • Waage, A.1    Halstensen, A.2    Shalaby, R.3    Brandtzaeg, P.4    Kierulf, P.5    Espevik, T.6
  • 115
    • 0027302864 scopus 로고
    • Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy
    • Maimone D, Annunziata P, Simone IL, Livrea P, Guazzi GC. Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Neuroimmunol 1993, 47, 55-62.
    • (1993) J Neuroimmunol , vol.47 , pp. 55-62
    • Maimone, D.1    Annunziata, P.2    Simone, I.L.3    Livrea, P.4    Guazzi, G.C.5
  • 116
    • 0029865078 scopus 로고    scopus 로고
    • Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes
    • Kossmann T, Hans V, Imhof H-G, Trentz O, Morganti-Kossmann MC. Interleukin-6 released in human cerebrospinal fluid following traumatic brain injury may trigger nerve growth factor production in astrocytes. Brain Res 1996, 713, 143-152.
    • (1996) Brain Res , vol.713 , pp. 143-152
    • Kossmann, T.1    Hans, V.2    Imhof, H.-G.3    Trentz, O.4    Morganti-Kossmann, M.C.5
  • 117
    • 0029417080 scopus 로고
    • Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P. Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci Lett 1995, 202, 17-20.
    • (1995) Neurosci Lett , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 118
    • 0344333426 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients
    • März P, Heese K, Hock C, Golombowski S, Müller-Spahn F, Rose-John S, Otten U. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients. Neurosci Lett 1997, 239, 29-32.
    • (1997) Neurosci Lett , vol.239 , pp. 29-32
    • März, P.1    Heese, K.2    Hock, C.3    Golombowski, S.4    Müller-Spahn, F.5    Rose-John, S.6    Otten, U.7
  • 119
    • 0031894808 scopus 로고    scopus 로고
    • Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat
    • Loddick SA, Turnbull AV, Rothwell NJ. Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 1998, 18, 176-179.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 176-179
    • Loddick, S.A.1    Turnbull, A.V.2    Rothwell, N.J.3
  • 122
    • 0029981358 scopus 로고    scopus 로고
    • Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor
    • Suzumura A, Sawada M, Marunouchi T. Selective induction of interleukin-6 in mouse microglia by granulocyte-macrophage colony-stimulating factor. Brain Res 1996, 713, 192-198.
    • (1996) Brain Res , vol.713 , pp. 192-198
    • Suzumura, A.1    Sawada, M.2    Marunouchi, T.3
  • 123
    • 0028293559 scopus 로고
    • Signal transduction pathways mediating astrocyte IL-6 induction by IL-1β and tumor necrosis factor-α
    • Norris JG, Tang L-P, Sparacio SM, Benveniste EN. Signal transduction pathways mediating astrocyte IL-6 induction by IL-1β and tumor necrosis factor-α. J Immunol 1994, 152, 841-850.
    • (1994) J Immunol , vol.152 , pp. 841-850
    • Norris, J.G.1    Tang, L.-P.2    Sparacio, S.M.3    Benveniste, E.N.4
  • 125
    • 0027669848 scopus 로고
    • Interleukin-6 production by brain tissue and cultured astrocytes infected with Theiler's murine encephalomyelitis virus
    • Rubio N, Sierra A. Interleukin-6 production by brain tissue and cultured astrocytes infected with Theiler's murine encephalomyelitis virus. GLIA 1993, 9, 41-47.
    • (1993) GLIA , vol.9 , pp. 41-47
    • Rubio, N.1    Sierra, A.2
  • 126
    • 0024339530 scopus 로고
    • On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases
    • Frei K, Malipiero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A. On the cellular source and function of interleukin-6 produced in the central nervous system in viral diseases. Eur J Immunol 1989, 19, 689-694.
    • (1989) Eur J Immunol , vol.19 , pp. 689-694
    • Frei, K.1    Malipiero, U.V.2    Leist, T.P.3    Zinkernagel, R.M.4    Schwab, M.E.5    Fontana, A.6
  • 127
    • 0032212261 scopus 로고    scopus 로고
    • Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression
    • In press
    • Oh J-W, Van Wagoner N, Rose-John S, Benveniste EN. Role of IL-6 and the soluble IL-6 receptor in inhibition of VCAM-1 gene expression. J Immunol 1998, (In press)
    • (1998) J Immunol
    • Oh, J.-W.1    Van Wagoner, N.2    Rose-John, S.3    Benveniste, E.N.4
  • 128
    • 0030823183 scopus 로고    scopus 로고
    • IL-6 and APPS: Anti- Inflammatory and immunosuppressive mediators
    • Tilg H, Dinarello CA, Mier JW. IL-6 and APPS: anti- inflammatory and immunosuppressive mediators. Immunol Today 1997, 18, 428-432.
    • (1997) Immunol Today , vol.18 , pp. 428-432
    • Tilg, H.1    Dinarello, C.A.2    Mier, J.W.3
  • 129
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) - A molecule with both beneficial and destructive potentials
    • Gadient RA, Otten UH. Interleukin-6 (IL-6) - a molecule with both beneficial and destructive potentials. Progress in Neurobiology 1997, 52, 379-390.
    • (1997) Progress in Neurobiology , vol.52 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 130
    • 0025092159 scopus 로고
    • Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor
    • Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF. Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor. J Immunol 1990, 144, 129-135.
    • (1990) J Immunol , vol.144 , pp. 129-135
    • Selmaj, K.W.1    Farooq, M.2    Norton, W.T.3    Raine, C.S.4    Brosnan, C.F.5
  • 132
    • 0028829231 scopus 로고
    • IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage
    • Fattori E, Lazzaro D, Musiani P, Modesti A, Alonzi T, Ciliberto G. IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage. Eur J Neurosci 1995, 7, 2441-2449.
    • (1995) Eur J Neurosci , vol.7 , pp. 2441-2449
    • Fattori, E.1    Lazzaro, D.2    Musiani, P.3    Modesti, A.4    Alonzi, T.5    Ciliberto, G.6
  • 133
    • 0028866623 scopus 로고
    • Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes
    • Brett FM, Mizisin AP, Powell HC, campbell IL. Evolution of neuropathologic abnormalities associated with blood-brain barrier breakdown in transgenic mice expressing interleukin-6 in astrocytes. J Neuropath Exp Nenrol 1995, 54, 766-775.
    • (1995) J Neuropath Exp Nenrol , vol.54 , pp. 766-775
    • Brett, F.M.1    Mizisin, A.P.2    Powell, H.C.3    Campbell, I.L.4
  • 134
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • Heyser CJ, Masliah E, Samimi A, Campbell IL, Gold LH. Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain. Proc Natl Acad Sci USA 1997, 94, 1500-1505.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 137
    • 0029757719 scopus 로고    scopus 로고
    • Characteristic localization of gp130 (the signal transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain
    • Watanabe D, Yoshimura R, Khalil M, Yoshida K, Kishimoto T, Taga T, Kiyama H. Characteristic localization of gp130 (the signal transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain. Eur J Neurosci 1996, 8, 1630-1640.
    • (1996) Eur J Neurosci , vol.8 , pp. 1630-1640
    • Watanabe, D.1    Yoshimura, R.2    Khalil, M.3    Yoshida, K.4    Kishimoto, T.5    Taga, T.6    Kiyama, H.7
  • 138
    • 0027299467 scopus 로고
    • Multiple extracellular signals are required for long-term oligodendrocyte survival
    • Barres BA, Schmid R, Sendnter M, Raff MC. Multiple extracellular signals are required for long-term oligodendrocyte survival. Development 1993, 118, 283-295.
    • (1993) Development , vol.118 , pp. 283-295
    • Barres, B.A.1    Schmid, R.2    Sendnter, M.3    Raff, M.C.4
  • 139
    • 0028088916 scopus 로고
    • Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro
    • Mayer M, Bhakoo K, Noble M. Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro. Development 1994, 120, 143-153.
    • (1994) Development , vol.120 , pp. 143-153
    • Mayer, M.1    Bhakoo, K.2    Noble, M.3
  • 140
    • 0027398906 scopus 로고
    • CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death
    • Louis J-C, Magal E, Takayama S, Varon S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 1993, 259, 689-692.
    • (1993) Science , vol.259 , pp. 689-692
    • Louis, J.-C.1    Magal, E.2    Takayama, S.3    Varon, S.4
  • 141
    • 0030062861 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury
    • D'Souza SD, Alinauskas KA, Antel JP. Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injury. J Neurosci Res 1996, 43, 289-298.
    • (1996) J Neurosci Res , vol.43 , pp. 289-298
    • D'Souza, S.D.1    Alinauskas, K.A.2    Antel, J.P.3
  • 142
    • 15844406056 scopus 로고    scopus 로고
    • Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell (E2) line
    • Wu YY, Bradshaw RA. Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell (E2) line. J Biol Chem 1996, 271, 13023-13032.
    • (1996) J Biol Chem , vol.271 , pp. 13023-13032
    • Wu, Y.Y.1    Bradshaw, R.A.2
  • 143
    • 0031240004 scopus 로고    scopus 로고
    • Molecule of the month. TGF-β: A critical modulator of immune cell function
    • Letterio JJ, Roberts AB. Molecule of the month. TGF-β: a critical modulator of immune cell function. Clin Immunol Inununopathol 1997, 84, 244-250.
    • (1997) Clin Immunol Inununopathol , vol.84 , pp. 244-250
    • Letterio, J.J.1    Roberts, A.B.2
  • 146
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 1997, 18, 335-343.
    • (1997) Immunol Today , vol.18 , pp. 335-343
    • Weiner, H.L.1
  • 148
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265, 1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 149
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin C-H, Miyazono K, ten Dijke P. TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 1997, 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.-H.1    Miyazono, K.2    Ten Dijke, P.3
  • 150
    • 0032451414 scopus 로고    scopus 로고
    • Molecular mechanisms of transforming growth factor signaling
    • Hu PP, Datto MB, Wang X-F. Molecular mechanisms of transforming growth factor signaling. Endocrine Rev 1998, 19, 349-363.
    • (1998) Endocrine Rev , vol.19 , pp. 349-363
    • Hu, P.P.1    Datto, M.B.2    Wang, X.-F.3
  • 151
    • 0026009129 scopus 로고
    • TGF-β-like activity produced during regression of exacerbations in multiple sclerosis
    • Beck J, Rondot P, Jullien P, Wietzerbin J, Lawrence DA. TGF-β-like activity produced during regression of exacerbations in multiple sclerosis. Acta Neurol Scand 1991, 84, 452-455.
    • (1991) Acta Neurol Scand , vol.84 , pp. 452-455
    • Beck, J.1    Rondot, P.2    Jullien, P.3    Wietzerbin, J.4    Lawrence, D.A.5
  • 152
    • 0028241924 scopus 로고
    • Defective production of anti-inflammatory cytokine, TGF-β by T cell lines of patients with active multiple sclerosis
    • Mokhtarian F, Shi Y, Shirazian D, Morgante L, Miller A, Grob D. Defective production of anti-inflammatory cytokine, TGF-β by T cell lines of patients with active multiple sclerosis. J Immunol 1994, 152, 6003-6010.
    • (1994) J Immunol , vol.152 , pp. 6003-6010
    • Mokhtarian, F.1    Shi, Y.2    Shirazian, D.3    Morgante, L.4    Miller, A.5    Grob, D.6
  • 153
    • 0028906889 scopus 로고
    • Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis
    • Correale J, Gilmore W, McMillan M, Li S, McCarthy K, Le T, Weiner LP. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J Immunol 1995, 154, 2959-2968.
    • (1995) J Immunol , vol.154 , pp. 2959-2968
    • Correale, J.1    Gilmore, W.2    McMillan, M.3    Li, S.4    McCarthy, K.5    Le, T.6    Weiner, L.P.7
  • 154
    • 0025775004 scopus 로고
    • Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome
    • Wahl SM, Allen JB, Francis NM. Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome. J Exp Med 1991, 173, 981-991.
    • (1991) J Exp Med , vol.173 , pp. 981-991
    • Wahl, S.M.1    Allen, J.B.2    Francis, N.M.3
  • 155
    • 0030035509 scopus 로고    scopus 로고
    • Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients
    • Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-β1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest 1996, 98, 70-77.
    • (1996) J Clin Invest , vol.98 , pp. 70-77
    • Fukaura, H.1    Kent, S.C.2    Pietrusewicz, M.J.3    Khoury, S.J.4    Weiner, H.L.5    Hafler, D.A.6
  • 157
    • 0029816909 scopus 로고    scopus 로고
    • Serial measurement of interleukin-6, transforming growth factor-β, and S-100 protein in patients with acute stroke
    • Kim JS, Yoon SS, Kim YH, Ryu JD. Serial measurement of interleukin-6, transforming growth factor-β, and S-100 protein in patients with acute stroke. Stroke 1996, 27, 1553-1557.
    • (1996) Stroke , vol.27 , pp. 1553-1557
    • Kim, J.S.1    Yoon, S.S.2    Kim, Y.H.3    Ryu, J.D.4
  • 159
    • 0031836723 scopus 로고    scopus 로고
    • Sequential expression of transforming growth factor-β1 by T cells, macrophages, and microglia in rat spinal cord during autoimmune inflammation
    • Kiefer R, Schweitzer T, Jung S, Toyka KV, Hartung H-P. Sequential expression of transforming growth factor-β1 by T cells, macrophages, and microglia in rat spinal cord during autoimmune inflammation. J Neuropathol Exp Neurol 1998, 57, 385-395.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 385-395
    • Kiefer, R.1    Schweitzer, T.2    Jung, S.3    Toyka, K.V.4    Hartung, H.-P.5
  • 160
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain
    • Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992, 176, 1355-1364.
    • (1992) J Exp Med , vol.176 , pp. 1355-1364
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 161
    • 0026583488 scopus 로고
    • Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis
    • Racke MK, Cannella B, Albert P, Sporn M, Raine CS, McFarlin DE. Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. Inter. Immunol 1992, 4, 615-620.
    • (1992) Inter. Immunol , vol.4 , pp. 615-620
    • Racke, M.K.1    Cannella, B.2    Albert, P.3    Sporn, M.4    Raine, C.S.5    McFarlin, D.E.6
  • 162
    • 0030248470 scopus 로고    scopus 로고
    • Cytokines in relapsing experimental autoimmune encephalomyelitis in da rats: Persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β
    • Issazadeh S, Lorentzen J, Mustafa M, Hojeberg B, Mussener A, Olsson T. Cytokines in relapsing experimental autoimmune encephalomyelitis in da rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β. J Neuroimmunol 1996, 69, 103-115.
    • (1996) J Neuroimmunol , vol.69 , pp. 103-115
    • Issazadeh, S.1    Lorentzen, J.2    Mustafa, M.3    Hojeberg, B.4    Mussener, A.5    Olsson, T.6
  • 164
    • 0026595740 scopus 로고
    • Transforming growth factor-beta (TGF-β1) expression and regulation in rat cortical astrocytes
    • da Cunha A, Vitkovic L. Transforming growth factor-beta (TGF-β1) expression and regulation in rat cortical astrocytes. J Neuroimmunol 1992, 36, 157-169.
    • (1992) J Neuroimmunol , vol.36 , pp. 157-169
    • Da Cunha, A.1    Vitkovic, L.2
  • 165
    • 0027389930 scopus 로고
    • Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex
    • da Cunha A, Jefferson JA, Jackson RW, Vitkovic L. Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex. J Neuroimmunol 1993, 42, 71-86.
    • (1993) J Neuroimmunol , vol.42 , pp. 71-86
    • Da Cunha, A.1    Jefferson, J.A.2    Jackson, R.W.3    Vitkovic, L.4
  • 166
    • 0028983551 scopus 로고
    • TGF-β suppression of IFN-γ induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2 or STATIα or modification of IFNEX expression
    • Panek RB, Lee Y-J, Benveniste EN. TGF-β suppression of IFN-γ induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2 or STATIα or modification of IFNEX expression. J Immunol 1995, 154, 610-619.
    • (1995) J Immunol , vol.154 , pp. 610-619
    • Panek, R.B.1    Lee, Y.-J.2    Benveniste, E.N.3
  • 167
    • 0028181360 scopus 로고
    • Transforming growth factor-β inhibits inflammatory cytokine-induced C3 gene expression in astrocytes
    • Barnum SR, Jones JL. Transforming growth factor-β inhibits inflammatory cytokine-induced C3 gene expression in astrocytes. J Immunol 1994, 152, 765-773.
    • (1994) J Immunol , vol.152 , pp. 765-773
    • Barnum, S.R.1    Jones, J.L.2
  • 169
  • 170
    • 0028967734 scopus 로고
    • Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1
    • Hurwitz AA, Lyman WD, Berman JW. Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1. J Neuroimmunol 1995, 57, 193-198.
    • (1995) J Neuroimmunol , vol.57 , pp. 193-198
    • Hurwitz, A.A.1    Lyman, W.D.2    Berman, J.W.3
  • 172
    • 0029925503 scopus 로고    scopus 로고
    • Cytokine-regulated expression of platelet-derived growth factor gene and protein in cultured human astrocytes
    • Silberstein FC, De Simone R, Levi G, Aloisi F. Cytokine-regulated expression of platelet-derived growth factor gene and protein in cultured human astrocytes. J Neurochem 1996, 66, 1409-1417.
    • (1996) J Neurochem , vol.66 , pp. 1409-1417
    • Silberstein, F.C.1    De Simone, R.2    Levi, G.3    Aloisi, F.4
  • 173
    • 0026510668 scopus 로고
    • Transforming growth factor-β1 in the rat brain: Increase after injury and inhibition of astrocyte proliferation
    • Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H. Transforming growth factor-β1 in the rat brain: increase after injury and inhibition of astrocyte proliferation. J Cell Biol 1992, 117, 395-400.
    • (1992) J Cell Biol , vol.117 , pp. 395-400
    • Lindholm, D.1    Castren, E.2    Kiefer, R.3    Zafra, F.4    Thoenen, H.5
  • 174
    • 0027563273 scopus 로고
    • Transforming growth factor-βs inhibit mitogen-stimulated proliferation of astrocytes
    • Hunter KE, Sporn MB, Davies AM. Transforming growth factor-βs inhibit mitogen-stimulated proliferation of astrocytes. GLIA 1993, 7, 203-211.
    • (1993) GLIA , vol.7 , pp. 203-211
    • Hunter, K.E.1    Sporn, M.B.2    Davies, A.M.3
  • 175
    • 0027569648 scopus 로고
    • Effects of transforming growth factor-β1 on the extracellular matrix and cytoskeleton of cultured astrocytes
    • Baghdassarian D, Toru-Delbauffe D, Gavaret JM, Pierre M. Effects of transforming growth factor-β1 on the extracellular matrix and cytoskeleton of cultured astrocytes. GLIA 1993, 7, 193-202.
    • (1993) GLIA , vol.7 , pp. 193-202
    • Baghdassarian, D.1    Toru-Delbauffe, D.2    Gavaret, J.M.3    Pierre, M.4
  • 178
    • 0028982243 scopus 로고
    • TGF-β2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo
    • Fabry Z, Topham DJ, Fee D, Herlein J, Carlino JA, Hart MN, Sriram S. TGF-β2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in vivo. J Immunol 1995, 155, 325-332.
    • (1995) J Immunol , vol.155 , pp. 325-332
    • Fabry, Z.1    Topham, D.J.2    Fee, D.3    Herlein, J.4    Carlino, J.A.5    Hart, M.N.6    Sriram, S.7
  • 179
    • 0025892475 scopus 로고
    • Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1
    • Racke MK, Jalbut SD, Cannella B, Albert PS, Raine CS, McFarlin DE. Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J Immunol 1991, 146, 3012-3017.
    • (1991) J Immunol , vol.146 , pp. 3012-3017
    • Racke, M.K.1    Jalbut, S.D.2    Cannella, B.3    Albert, P.S.4    Raine, C.S.5    McFarlin, D.E.6
  • 180
  • 181
    • 0028989549 scopus 로고
    • Overexpression of TGF-β1 in the central nervous system of transgenic mice results in hydocephalus
    • Galbreath E, Kim S-J, Park K, Brenner M, Messing A. Overexpression of TGF-β1 in the central nervous system of transgenic mice results in hydocephalus. J Neuropath Exp Neurol 1995, 54, 339-349.
    • (1995) J Neuropath Exp Neurol , vol.54 , pp. 339-349
    • Galbreath, E.1    Kim, S.-J.2    Park, K.3    Brenner, M.4    Messing, A.5
  • 182
    • 0029077755 scopus 로고
    • Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-β1
    • Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-β1. Amer J Pathol 1995, 147, 53-67.
    • (1995) Amer J Pathol , vol.147 , pp. 53-67
    • Wyss-Coray, T.1    Feng, L.2    Masliah, E.3    Ruppe, M.D.4    Lee, H.S.5    Toggas, S.M.6    Rockenstein, E.M.7    Mucke, L.8
  • 183
    • 0030793527 scopus 로고    scopus 로고
    • Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice
    • Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice. J Neuroimmunol 1997, 77, 45-50.
    • (1997) J Neuroimmunol , vol.77 , pp. 45-50
    • Wyss-Coray, T.1    Borrow, P.2    Brooker, M.J.3    Mucke, L.4
  • 184
    • 0030987180 scopus 로고    scopus 로고
    • Biology of TGF-β in knockout and transgenic mouse models
    • Böttinger EP, Letterio JJ, Roberts AB. Biology of TGF-β in knockout and transgenic mouse models. Kidney Int 1997, 51, 1355-1360.
    • (1997) Kidney int , vol.51 , pp. 1355-1360
    • Böttinger, E.P.1    Letterio, J.J.2    Roberts, A.B.3
  • 185
    • 0027200944 scopus 로고
    • Transforming growth factor suppresses activation and proliferation of microglia in vitro
    • Suzumura A, Sawada M, Yamamoto H, Marunouchi T. Transforming growth factor suppresses activation and proliferation of microglia in vitro. J Immunol 1993, 151, 2150-2158.
    • (1993) J Immunol , vol.151 , pp. 2150-2158
    • Suzumura, A.1    Sawada, M.2    Yamamoto, H.3    Marunouchi, T.4
  • 186
    • 0029956457 scopus 로고    scopus 로고
    • Regulation of microglial activation by TGF-β, IL-10, and CSF-1
    • Lodge PA, Sriram S. Regulation of microglial activation by TGF-β, IL-10, and CSF-1. J Leukoc Biol 1996, 60, 502-508.
    • (1996) J Leukoc Biol , vol.60 , pp. 502-508
    • Lodge, P.A.1    Sriram, S.2
  • 189
    • 0026636723 scopus 로고
    • Transforming growth factor β has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor
    • Chalazonitis A, Kalberg J, Twardzik DR, Morrison RS, Kessler JA. Transforming growth factor β has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor. Develop Biol 1992, 152, 121-132.
    • (1992) Develop Biol , vol.152 , pp. 121-132
    • Chalazonitis, A.1    Kalberg, J.2    Twardzik, D.R.3    Morrison, R.S.4    Kessler, J.A.5
  • 190
    • 0025058008 scopus 로고
    • Transforming growth factor β1 is a potent survival factor for rat embryo motoneurons in culture
    • Martinou J-C, Le Van Thai A, Valette A, Weber MJ. Transforming growth factor β1 is a potent survival factor for rat embryo motoneurons in culture. Dev Brain Res 1990, 52, 175-181.
    • (1990) Dev Brain Res , vol.52 , pp. 175-181
    • Martinou, J.-C.1    Van Le Thai, A.2    Valette, A.3    Weber, M.J.4
  • 191
    • 0028180666 scopus 로고
    • Transforming growth factor-β1 and -β2 promote neurite sprouting and elongation of cultured rat hippocampal neurons
    • Ishihara A, Saito H, Abe K. Transforming growth factor-β1 and -β2 promote neurite sprouting and elongation of cultured rat hippocampal neurons. Brain Res 1994, 639, 21-25.
    • (1994) Brain Res , vol.639 , pp. 21-25
    • Ishihara, A.1    Saito, H.2    Abe, K.3
  • 194
    • 0027196619 scopus 로고
    • Transforming growth factor-β1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse from ischemic injury in vivo
    • Prehn JHM, Backhaub C, Krieglstein J. Transforming growth factor-β1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse from ischemic injury in vivo. Cereb Blood Flow Metab 1993, 13, 521-525.
    • (1993) Cereb Blood Flow Metab , vol.13 , pp. 521-525
    • Prehn, J.H.M.1    Backhaub, C.2    Krieglstein, J.3
  • 195
    • 0029897649 scopus 로고    scopus 로고
    • TGF-β-induced apoptosis of cerebellar granule neurons is prevented by depolarization
    • de Luca A, Weller M, Fontana A. TGF-β-induced apoptosis of cerebellar granule neurons is prevented by depolarization. J Neurosci 1996, 16, 4174-4185.
    • (1996) J Neurosci , vol.16 , pp. 4174-4185
    • De Luca, A.1    Weller, M.2    Fontana, A.3
  • 196
    • 0031949488 scopus 로고    scopus 로고
    • Gene therapy in the treatment of autoimmune disease
    • Mathisen PM, Tuohy VK. Gene therapy in the treatment of autoimmune disease. Immunol Today 1998, 19, 103-105.
    • (1998) Immunol Today , vol.19 , pp. 103-105
    • Mathisen, P.M.1    Tuohy, V.K.2
  • 198
    • 0030738659 scopus 로고    scopus 로고
    • Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells
    • Mathisen PM., Yu M, Johnson JM, Drazba JA, Tuohy VK. Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J Exp Med 1997, 186, 159-164.
    • (1997) J Exp Med , vol.186 , pp. 159-164
    • Mathisen, P.M.1    Yu, M.2    Johnson, J.M.3    Drazba, J.A.4    Tuohy, V.K.5
  • 199
    • 0027181354 scopus 로고
    • Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine
    • Norris JG, Benveniste EN. Interleukin-6 production by astrocytes: Induction by the neurotransmitter norepinephrine. J Neuroimmunol 1993, 45, 137-146.
    • (1993) J Neuroimmunol , vol.45 , pp. 137-146
    • Norris, J.G.1    Benveniste, E.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.