Interferon γ gene expression in rat central nervous system glial cells

Cytokine

Volumn 10, Issue 6, 1998, Pages 418-422

  De Simone, Roberta ^a   Levi, Giulio ^a   Aloisi, Francesca ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Astrocytes; Cytokines; Messenger RNA; Microglia

Indexed keywords

CYCLOHEXIMIDE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; MESSENGER RNA;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; ASTROCYTE; CELL CULTURE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FIBROBLAST; GENE EXPRESSION; GLIA CELL; IMMUNOREGULATION; LEPTOMENINX; MICROGLIA; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION;

EID: 0032101935     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1997.0314     Document Type: Article

References (30)

1. 1. Young HG, Hardy KJ (1995) Role of interferon-γ in immune cell regulation. J Leukoc Biol 58:373-381.
2. 2. Pang Y, Norihisa Y, Benjamin D, Kantor RRS, Young HA (1992) Interferon-γ gene expression in human B-cell lines: induction by interleukin-2, protein kinase C activators, and possible effect of hypomethylation on gene regulation. Blood 80:724-732.
3. 3. Fultz MJ, Barber SA, Dieffenbach CW, Vogel SN (1993) Induction of IFN-γ in macrophages by lipopolysaccharide. Int Immunol 5:1383-1392.
4. 4. Di Marzio P, Puddu P, Conti L, Belardelli F, Gessani S (1994) Interferon-γ upregulates its own gene expression in mouse peritoneal macrophages. J Exp Med 179:1731-1736.
5. 5. Nitta T, Ebato M, Sato K, Okumura K. (1994) Expression of tumour necrosis factor-α, β, and interferon-γ genes within human neuroglial tumour cells and brain specimens. Cytokine 6:171-180.
6. 6. Rady PL, Cadet P, Bui TK, Tyring SK, Baron S, Stanton GJ, Hughes TK (1995) Production of interferon-γ messenger RNA by cells of non-immune origin. Cytokine 7:793-798.
7. 7. Gupta AA, Leal-Berumen I, Croitoru K, Marshall JS (1996) Rat peritoneal mast cells produce IFN-γ following IL-12 treatment but not in response to IgE-mediated activation. J Immunol 157:2123-2128.
8. 8. Merrill JE, Benveniste EN (1996) Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci 19:331-338.
9. 9. Rothwell NJ, Hopkins SJ (1995) Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci 18:130-136.
10. 10. Owens T, Renno T, Taupin V, Krakowski M (1994) Inflammatory cytpkines in the brain: does the CNS shape immune response? Immunol Today 15:566-571.
11. 11. Traugott U, Lebon P (1988) Multiple sclerosis: involvement of interferons in lesion pathogenesis. Ann Neurol 24:243-251.
12. 12. Umehara F, Izumo S, Ronquillo AT, Matsumuro K, Sato E, Osame M (1994) Cytokine expression in the spinal cord lesions in HTLV-1 associated myelopathy. J Neuropathol Exp Neurol 53:72-77.
13. 13. Stoll G, Muller S, Schmidt B, van der Meide P, Jung S, Toyka KV, Hartung HP (1993) Localization of interferon-γ and Ia-antigen in T cell line-mediated experimental autoimmune encephalomyelitis. Am J Pathol 142:1866-1875.
14. 14. Kiefer R, Kreutzberg GW (1990) Gamma interferon-like immunoreactivity in the rat nervous system. Neuroscience 37:725-734.
15. 15. Olsson T, Kelic S, Bakhiet M, Hojeberg B, van der Meide PH, Ljungdahl A, Kristensson K (1994) Neuronal interferon-γ immunoreactivity molecule: bioactivities and purification. Eur J Immunol 24:308-314.
16. 16. Bentivoglio M, Florenzano F, Peng ZC, and Kristensson K (1994) Neuronal IFN-γ in tuberomammillary neurones. Neuroreport 5:2413-2416.
17. 17. Hardy KJ, Sawada T (1989) Human γ-interferon strongly upregulates its own gene expression in peripheral blood lymphocytes. J Exp Med 170:1021-1026.
18. 18. Hendrzak JA, Brunda MJ (1995) Biology of disease. Interleukin-12. Biologic activity, therapeutic utility, and role in disease. Lab Invest 72:619-637.
19. 19. Benveniste EN, Benos DJ (1995) TNF-α and IFN-γ-mediated signal transduction pathways: effects on glial cell gene expression and function. FASEB J 9:1577-1584.
20. 20. Kohanawa M, Nakane A, Minagawa T (1993) Endogenous gamma Interferon produced in central nervous system by systemic infection with Theiler's virus in mice. J Neuroimmunol 48:205-212.
21. 21. Fierz W, Endler B, Reske K, Wekerle H, Fontana A (1985) Astrocytes as antigen presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune Interferon and its effect on antigen presentation. J Immunol 134:3785-3793.
22. 22. Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A (1987) Antigen presentation and tumor cytotoxicity by IFN-γ-treated microglial cells. Eur J Immunol 17:1271-1278.
23. 23. Aloisi F, Borsellino G, Samoggia P, Testa U, Chelucci C, Russo G, Peschle C, Levi, G (1992) Astrocyte cultures from human embryonic brain: Characterization and modulation of surface molecules by inflammatory cytokines. J Neurosci Res 32:494-506.
24. 24. Fabry Z, Raine CS, Hart N (1994) Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol Today 15:218-224.
25. 25. De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropathol Exp Neurol 54:175-187.
26. 26. Agresti C, D'Urso D, Levi G (1996) Reversible inhibitory effects of interferon-γ and tumor necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur J Neurosci 8:1106-1116.
27. 27. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK (1992) Activated microglia mediate neuronal cell death injury via a nitric oxide mechanism. J Immunol 149:2736-2741.
28. 28. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE (1993) Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151:2132-2141.
29. 29. Agresti C, Aloisi F, Levi G (1991) Heterotypic and homotypic cellular interactions influencing the growth and differentiation of bipotential oligodendrocyte-type-2 astrocyte progenitors in culture. Dev Biol 144:16-29.
30. 30. Chirgwin JM, Pryzbyla AE, MacDonald RJ, Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.