Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: An inflammatory mechanism of joint pain

Arthritis and Rheumatism

Volumn 56, Issue 1, 2007, Pages 351-359

  Brenn, Daniel ^a   Richter, Frank ^a   Schaible, Hans Georg ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6 RECEPTOR; RECOMBINANT INTERLEUKIN 6;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRALGIA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; JOINT; KNEE; KNEE PAIN; MALE; NONHUMAN; NONMYELINATED NERVE; PAIN; PRIORITY JOURNAL; RAT; RECEPTIVE FIELD; SENSORY NERVE;

ACTION POTENTIALS; ANIMALS; CYTOKINE RECEPTOR GP130; DRUG COMBINATIONS; HUMANS; INTERLEUKIN-6; JOINTS; MALE; NERVE FIBERS, UNMYELINATED; NEURONS, AFFERENT; PAIN THRESHOLD; PHYSICAL STIMULATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; STRESS, MECHANICAL;

EID: 33846218186     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22282     Document Type: Article

References (33)

1. Arvidson NG, Gudbjornsson B, Elfrnan L, Ryden AC, Totterman TH, Hallgren R. Circadian rhythm of serum interleukin-6 in rheumatoid arthritis. Ann Rheum Dis 1994;521-4.
2. Desgeorges A, Gabay C, Silacci P, Novick D, Roux-Lombard P, Grau G, et al. Concentrations and origins of soluble interleukin 6 receptor-α in serum and synovial fluid. J Rheumatol 1997;24:1510-6.
3. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 1988;18:1797-1801.
4. Swaak AJ, van Rooyen A, Nieuwenhuis E, Aarden LA. Interleukin-6 (IL-6) in synovial fluid and serum of patient with rheumatic diseases. Scand J Rheumatol 1988;17:469-74.
5. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer [review]. Eur J Cancer 2005;41:2502-12.
6. Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model [review]. Rev Physiol Biochem Pharmacol 2003;149:1-38.
7. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/JAK/STAT pathway [review]. Biochem J 1998;334:297-314.
8. Ihle JN. Cytokine receptor signalling [review]. Nature 1995;377:591-4.
9. Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med 1989;170:1409-14.
10. De Benedetti F, Massa M, Pignatti P, Albani S, Novick D, Martini A. Serum soluble interleukin-6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. J Clin Invest 1994;93:2114-9.
11. Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 1996;11:88-95.
12. Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 1993;82:1120-6.
13. Muller-Newen G, Kuster A, Hemmann U, Keul R, Horsten U, Martens A, et al. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses. J Immunol 1998;161:6347-55.
14. Schaible HG, Grubb BD. Afferent and spinal mechanisms of joint pain [review]. Pain 1993;55:5-54.
15. Schaible HG. Basic mechanisms of deep somatic pain. In: McMahon SB, Koltzenburg M, editors. Wall and Melzack's textbook of pain. 5th ed. London: Churchill Livingstone; 2005. p. 621-33.
16. Chichorro JG, Lorenzetti BB, Zampronio AR. Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats. Br J Pharmacol 2004;141:1175-84.
17. Cunha TM, Verri WA Jr, Silva JS, Poole S, Cunha FQ, Ferreira SH. A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A 2005;102:1755-60.
18. Obreja O, Biasio W, Andratsch M, Lips KS, Rathee PK, Ludwig A, et al. Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons. Brain 2005;128:1634-41.
19. Obreja O, Schmelz M, Poole S, Kress M. Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo. Pain 2002;96:57-62.
20. Von Banchet GS, Kiehl M, Schaible HG. Acute and long-term effects of IL-6 on cultured dorsal root ganglion neurones from adult rat. J Neurochem 2005;94:238-48.
21. Brenn D, Richter F, Schaible HG. Interleukin-6 (IL-6) enhances responses to mechanical stimulation of C-fibres innervating the rat knee joint [abstract]. Acta Physiologica 2006;186 Suppl 1:76.
22. Schaible HG, Schmidt RF. Effects of an experimental arthritis on the sensory properties of fine articular afferent units. J Neurophysiol 1985;54:1109-22.
23. Just S, Pawlak M, Heppelmann B. Responses of fine primary afferent nerve fibres innervating the rat knee joint to defined torque. J Neurosci Methods 2000;103:157-62.
24. Forster C, Handwerker HO. Automatic classification and analysis of microneurographic spike data using a PC/AT. J Neurosci Methods 1990;31:109-18.
25. Harper AA, Lawson SN. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J Physiol 1985;359:31-46.
26. Fitzcharles MA, Almahrezi A, Shir Y. Pain: understanding and challenges for the rheumatologist [review]. Arthritis Rheum 2005;52:3685-92.
27. Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Scholmerich J, et al. Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 2005;64:13-20.
28. Gomis A, Pawlak M, Balazs EA, Schmidt RF, Belmonte C. Effects of different molecular weight elastoviscous hyaluronan solutions on articular nociceptive afferents. Arthritis Rheum 2004;50:314-26.
29. Li Z, Proud D, Zhang C, Wiehler S, McDougall JJ. Chronic arthritis down-regulates peripheral μ-opioid receptor expression with concomitant loss of endomorphin 1 antinociception [review]. Arthritis Rheum 2005;52:3210-9.
30. Heppelmann B, McDougall JJ. Inhibitory effect of amiloride and gadolinium on fine afferent nerves in the rat knee: evidence of mechanogated ion channels in joints. Exp Brain Res 2005;167:114-8.
31. Gardiner NJ, Cafferty WB, Slack SE, Thompson SW. Expression of gp130 and leukaemia inhibitory factor receptor subunits in adult rat sensory neurones: regulation by nerve injury. J Neurochem 2002;83:100-9.
32. D'Arcangelo G, Tancredi V, Onofri F, D'Antuono M, Giovedi S, Benfenati F. Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex. Eur J Neurosci 2000;12:1241-52.
33. Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum 2006;54:1662-72.