Manganese potentiates in vitro production of proinflammatory cytokines and nitric oxide by microglia through a nuclear factor kappa B-dependent mechanism

Toxicological Sciences

Volumn 84, Issue 1, 2005, Pages 139-148

  Filipov, Nikolay M ^a,b   Seegal, Richard F ^a   Lawrence, David A ^a  

^a WADSWORTH CENTER   (United States)

^b Department of Basic Sciences   (United States)

Author keywords

Cytokines; Inflammation; Manganese; Microglia; Neurotoxicity; Nitric oxide

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; MANGANESE; N(G) NITROARGININE METHYL ESTER; NEUTRAL RED; NITRIC OXIDE; PENTOXIFYLLINE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME RELEASE; IN VITRO STUDY; INFLAMMATION; MICROGLIA; MOUSE; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION;

ACETYLCYSTEINE; ANIMALS; BUTHIONINE SULFOXIMINE; CELLS, CULTURED; CHROMANS; CYTOKINES; ENZYME INHIBITORS; INFLAMMATION; L-LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDES; MANGANESE POISONING; MICE; MICROGLIA; NF-KAPPA B; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; SERINE PROTEINASE INHIBITORS; TOSYLPHENYLALANYL CHLOROMETHYL KETONE;

EID: 14844321909     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi055     Document Type: Article

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