Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity

Diabetes

Volumn 52, Issue 9, 2003, Pages 2191-2197

  Goodpaster, Bret H ^b   Katsiaras, Andreas ^b   Kelley, David E ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN;

ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; CALORIC INTAKE; CALORIMETRY; CLAMP; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY EXPENDITURE; EXERCISE; FATTY ACID METABOLISM; FEMALE; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID ABSORPTION; MALE; MEASUREMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SKELETAL MUSCLE; TASK PERFORMANCE; WEIGHT REDUCTION;

ABDOMEN; ADIPOSE TISSUE; ADULT; BODY COMPOSITION; DIET, REDUCING; ENERGY INTAKE; FASTING; FATS; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; PHYSICAL FITNESS; WEIGHT LOSS;

EID: 0042321037     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.9.2191     Document Type: Article

References (35)

1. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS: Physical activity and reduced occurence of non-insulin-dependent diabetes mellitus. N Engl J Med 325:147-152, 1991
2. Brown MD, Moore GE, Korytkowski MT, McCole SD, Hagberg JM: Improvement of insulin sensitivity by short-term exercise training in hypertensive African American women. Hypertension 30:1549-1553, 1997
3. Holloszy JO, Schultz J, Kusnierkiewicz J, Hagberg JM, Ehsani AA: Effects of exercise on glucose tolerance and insulin resistance. Acta Medica Scandinavica 711 (Suppl.):55-65, 1980
4. Kopelman PG: Obesity as a medical problem (Review). Nature 404:635-643, 2000
5. Mayer-Davis EJ, D'Agostino R Jr, Karter AJ, Haffner SM, Rewers MJ, Saad M, Bergman RN: Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA 279:669-674, 1998
6. Gordon NF: The Health Professional's Guide to Diabetes and Exercise. Alexandria, VA, American Diabetes Association, 1995
7. National Institutes of Health: Clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults: the evidence report. Obes Res 6 (Suppl. 2):461-462, 1998
8. Eriksson KF, Lindgärde F: Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. Diabetologica 34:891-898, 1991
9. Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang YY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV: Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20:537-544, 1997
10. Group DPPR: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403, 2002
11. Pi-Sunyer FX: Short-term medical benefits and adverse effects of weight loss (Review). Ann Intern Med 119:722-726, 1993
12. Dela F, LArsen JJ, Mikines KJ, Ploug T, Petersen LN, Galbo H: Insulin-stimulated muscle glucose clearance in patients with NIDDM. Diabetes 44:1010-1020, 1995
13. Devlin JT, Hirshman M, Horton ED, Horton ES: Enhanced peripheral and splanchnic insulin sensitivity in NIDDM men after single bout of exercise. Diabetes 36:434-439, 1987
14. Devlin JT, Horton ES: Effects of prior high-intensity exercise on glucose metabolism in normal and insulin-resistant men. Diabetes 34:973-979, 1985
15. King DS, Baldus PJ, Sharp RL, Kesl LD, Feltmeyer TL, Riddle MS: Time course for exercise-induced alterations in insulin action and glucose tolerance in middle-aged people. J Appl Physiol 78:17-22, 1995
16. Segal KR, Edano A, Abalos A, Albu J, Blando L, Tomas MB, Pi-Sunyer FX: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71:2402-2411, 1991
17. Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R, Janssen I: Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men: a randomized, controlled trial. Ann Intern Med 133:92-103, 2000
18. Kelley DE, Goodpaster B, Wing RR, Simoneau JA: Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. Am J Physiol 277:E1130-E1141, 1999
19. Kelley DE, Simoneau JA: Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest 94:2349-2356, 1994
20. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA: Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279:E1039-E1044, 2000
21. Zurlo F, Lillioja S, Esposito-DelPuente A, Nyomba BL, Raz I, Saad MF, Swiunburn WC, Knowler WC, Bogardus C, Ravussin E: Low ratio of fat to carbohydrate oxidation as a predictor of weight gain: a study of 24-h RQ. Am J Physiol 259:E650-E657, 1990
22. Ranneries C, Bulow J, Buemann B, Christensen NJ, Madsen J, Astrup A: Fat metabolism in formerly obese women. Am J Physiol 274:E155-E161, 1998
23. Goodpaster BH, He J, Watkins S, Kelley DE: Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761, 2001
24. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR: Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol 265:E380-E391, 1993
25. Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE: Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46:1579-1585, 1997
26. Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R: Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol 89:104-110, 2000
27. Goodpaster BH, Thaete FL, Kelley DE: Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Am J Clin Nutr 71:885-892, 2000
28. Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634, 1983
29. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL: Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48:839-847, 1999
30. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EA: Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33:311-318, 1984
31. Kelley DE, Reilly J, Veneman T, Mandarino LJ: The influence of physiologic hyperinsulinemia on skeletal muscle glucose storage, oxidation and glycolysis in man. Am J Physiol 258:E923-E929, 1990
32. Andres R, Cadar G, Zierler K: The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state. J Clin Invest 35:671-682, 1956
33. Kelley DE, Mandarino LJ: Fuel selection in human skeletal muscle in insulin resistance. Diabetes 49:677-683, 2000
34. Bergman BC, Butterfield GE, Wolfel EE, Casazza GA, Lopaschuk GD, Brooks GA: Evaluation of exercise and training on muscle lipid metabolism. Am J Physiol 276:E106-E117, 1999
35. Goodpaster B, Wolfe R, Kelley D: Effects of obesity on substrate utilization during exercise. Obes Res 10:575-584, 2002