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Volumn 280, Issue 4 43-4, 2001, Pages

Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training

Author keywords

Glycogen; Lipid metabolism; Obesity; Oil red O; Triglyceride; Weight reduction

Indexed keywords

GLYCOGEN; LIPID; MITOCHONDRIAL ENZYME;

EID: 0035020816     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2001.280.4.e632     Document Type: Article
Times cited : (66)

References (46)
  • 1
    • 0023149218 scopus 로고
    • Reduction in resting energy expenditure in relation to lean tissue loss in obese subjects during prolonged dieting
    • Abraham RR and Wynn V. Reduction in resting energy expenditure in relation to lean tissue loss in obese subjects during prolonged dieting. Ann Nutr Metab 31: 99-108, 1987.
    • (1987) Ann Nutr Metab , vol.31 , pp. 99-108
    • Abraham, R.R.1    Wynn, V.2
  • 2
    • 0023821632 scopus 로고
    • Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man
    • Acheson KJ, Schutz Y, Bessard T, Anantharaman K, Flatt JP, and Jequier E. Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr 48: 240-247, 1988.
    • (1988) Am J Clin Nutr , vol.48 , pp. 240-247
    • Acheson, K.J.1    Schutz, Y.2    Bessard, T.3    Anantharaman, K.4    Flatt, J.P.5    Jequier, E.6
  • 3
    • 0016685789 scopus 로고
    • Capillary density in skeletal muscle of man
    • Andersen P. Capillary density in skeletal muscle of man. Acta Physiol Scand 95: 203-205, 1975.
    • (1975) Acta Physiol Scand , vol.95 , pp. 203-205
    • Andersen, P.1
  • 4
    • 0028297976 scopus 로고
    • Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women
    • Astrup A, Buemann B, Christensen NJ, and Toubro S. Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. Am J Physiol Endocrinol Metab 266: E592-E599, 1994.
    • (1994) Am J Physiol Endocrinol Metab , vol.266
    • Astrup, A.1    Buemann, B.2    Christensen, N.J.3    Toubro, S.4
  • 6
    • 0029873010 scopus 로고    scopus 로고
    • Changes in glucose and lipid metabolism following weight loss produced by a very low calorie diet in obese subjects
    • Bryson JM, King SE, Burns CM, Baur LA, Swaraj S, and Caterson ID. Changes in glucose and lipid metabolism following weight loss produced by a very low calorie diet in obese subjects. Int J Obes Relat Metab Disord 20: 338-345, 1996.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 338-345
    • Bryson, J.M.1    King, S.E.2    Burns, C.M.3    Baur, L.A.4    Swaraj, S.5    Caterson, I.D.6
  • 7
    • 0030021709 scopus 로고    scopus 로고
    • Resting metabolic rate and postabsorptive substrate oxidation in morbidly obese subjects before and after massive weight loss
    • Buscemi S, Caimi G, and Verga S. Resting metabolic rate and postabsorptive substrate oxidation in morbidly obese subjects before and after massive weight loss. Int J Obes Relat Metab Disord 20: 41-46, 1996.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 41-46
    • Buscemi, S.1    Caimi, G.2    Verga, S.3
  • 8
    • 0033160545 scopus 로고    scopus 로고
    • Physical activity and low-fat diet: Is this enough to maintain weight stability in the reduced obese individuals following weight loss by drug therapy and energy restriction?
    • Doucet E, Imbeault P, Alméras N, and Tremblay A. Physical activity and low-fat diet: is this enough to maintain weight stability in the reduced obese individuals following weight loss by drug therapy and energy restriction? Obes Res 7: 323-333, 1999.
    • (1999) Obes Res , vol.7 , pp. 323-333
    • Doucet, E.1    Imbeault, P.2    Alméras, N.3    Tremblay, A.4
  • 10
    • 0029037798 scopus 로고
    • Sustained weight reduction in moderately obese women results in decreased activity of skeletal muscle lipoprotein lipase
    • Eckel RH, Yost TJ, and Jensen DR. Sustained weight reduction in moderately obese women results in decreased activity of skeletal muscle lipoprotein lipase. Eur J Clin Invest 25: 396-402, 1995.
    • (1995) Eur J Clin Invest , vol.25 , pp. 396-402
    • Eckel, R.H.1    Yost, T.J.2    Jensen, D.R.3
  • 12
    • 0020024468 scopus 로고
    • Suction applied to a muscle biopsy maximizes sample size
    • Evans WJ, Phinney SD, and Young VR. Suction applied to a muscle biopsy maximizes sample size. Med Sci Sports Exerc 14: 101-102, 1982.
    • (1982) Med Sci Sports Exerc , vol.14 , pp. 101-102
    • Evans, W.J.1    Phinney, S.D.2    Young, V.R.3
  • 13
    • 0029868034 scopus 로고    scopus 로고
    • Glycogen levels and obesity
    • Flatt JP. Glycogen levels and obesity. Int J Obes Relat Metab Disord 20, Suppl 2: S1-S11, 1996.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , Issue.SUPPL. 2
    • Flatt, J.P.1
  • 14
    • 0026503055 scopus 로고
    • Effects of weight loss on substrate oxidation, energy expenditure, and insulin sensitivity in obese individuals
    • Franssila-Kallunki A, Rissanen A, Ekstrand A, Ollus A, and Groop L. Effects of weight loss on substrate oxidation, energy expenditure, and insulin sensitivity in obese individuals. Am J Clin Nutr 55: 356-361, 1992.
    • (1992) Am J Clin Nutr , vol.55 , pp. 356-361
    • Franssila-Kallunki, A.1    Rissanen, A.2    Ekstrand, A.3    Ollus, A.4    Groop, L.5
  • 16
    • 0033054725 scopus 로고    scopus 로고
    • Effects of weight loss on regional fat distribution and insulin sensitivity in obesity
    • Goodpaster BH, Kelley DE, Wing RR, Meier A, and Thaete FL. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes 48: 839-847, 1999.
    • (1999) Diabetes , vol.48 , pp. 839-847
    • Goodpaster, B.H.1    Kelley, D.E.2    Wing, R.R.3    Meier, A.4    Thaete, F.L.5
  • 17
    • 0034112806 scopus 로고    scopus 로고
    • Intramuscular lipid content is increased in obesity and decreased by weight loss
    • Goodpaster BH, Theriault R, Watkins SC, and Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 49: 467-472, 2000.
    • (2000) Metabolism , vol.49 , pp. 467-472
    • Goodpaster, B.H.1    Theriault, R.2    Watkins, S.C.3    Kelley, D.E.4
  • 19
    • 0015865749 scopus 로고
    • The ultrastructure of the normal human skeletal muscle. A morphometric analysis on untrained men, women and well-trained orienteers
    • Hoppeler H, Luthi P, Claassen H, Weibel ER, and Howald H. The ultrastructure of the normal human skeletal muscle. A morphometric analysis on untrained men, women and well-trained orienteers. Pflügers Arch 344: 217-232, 1973.
    • (1973) Pflügers Arch , vol.344 , pp. 217-232
    • Hoppeler, H.1    Luthi, P.2    Claassen, H.3    Weibel, E.R.4    Howald, H.5
  • 20
    • 0021906677 scopus 로고
    • Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans
    • Howald H, Hoppeler H, Claassen H, Mathieu O, and Straub R. Influences of endurance training on the ultrastructural composition of the different muscle fiber types in humans. Pflügers Arch 403: 369-376, 1985.
    • (1985) Pflügers Arch , vol.403 , pp. 369-376
    • Howald, H.1    Hoppeler, H.2    Claassen, H.3    Mathieu, O.4    Straub, R.5
  • 21
    • 0031827488 scopus 로고    scopus 로고
    • Fat metabolism during exercise: A review - Part II: Regulation of metabolism and the effects of training
    • Jeukendrup AE, Saris WH, and Wagenmakers AJ. Fat metabolism during exercise: a review - part II: regulation of metabolism and the effects of training. Int J Sports Med 19: 293-302, 1998.
    • (1998) Int J Sports Med , vol.19 , pp. 293-302
    • Jeukendrup, A.E.1    Saris, W.H.2    Wagenmakers, A.J.3
  • 22
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss
    • Kelley DE, Goodpaster B, Wing RR, and Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. Am J Physiol Endocrinol Metab 277: E1130-E1141, 1999.
    • (1999) Am J Physiol Endocrinol Metab , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 23
    • 0025998981 scopus 로고
    • Skeletal muscle density: Effects of obesity and non-insulin-dependent diabetes mellitus
    • Kelley DE, Slasky BS, and Janosky J. Skeletal muscle density: effects of obesity and non-insulin-dependent diabetes mellitus. Am J Clin Nutr 54: 509-515, 1991.
    • (1991) Am J Clin Nutr , vol.54 , pp. 509-515
    • Kelley, D.E.1    Slasky, B.S.2    Janosky, J.3
  • 24
    • 0032457848 scopus 로고    scopus 로고
    • Skeletal muscle metabolic characteristics before and after energy restriction in human obesity: Fibre type, enzymatic beta-oxidative capacity and fatty acid-binding protein content
    • Kempen KP, Saris WH, Kuipers H, Glatz JF, and Van Der Vusse GJ. Skeletal muscle metabolic characteristics before and after energy restriction in human obesity: fibre type, enzymatic beta-oxidative capacity and fatty acid-binding protein content. Eur J Clin Invest 28: 1030-1037, 1998.
    • (1998) Eur J Clin Invest , vol.28 , pp. 1030-1037
    • Kempen, K.P.1    Saris, W.H.2    Kuipers, H.3    Glatz, J.F.4    Van Der Vusse, G.J.5
  • 26
    • 0019978312 scopus 로고
    • Coupling between dietary changes, reduced body weight, muscle fibre size and improved glucose tolerance in middle-aged men with impaired glucose tolerance
    • Lindgarde F, Eriksson KF, Lithell H, and Saltin B. Coupling between dietary changes, reduced body weight, muscle fibre size and improved glucose tolerance in middle-aged men with impaired glucose tolerance. Acta Med Scand 212: 99-106, 1982.
    • (1982) Acta Med Scand , vol.212 , pp. 99-106
    • Lindgarde, F.1    Eriksson, K.F.2    Lithell, H.3    Saltin, B.4
  • 27
    • 0018871033 scopus 로고
    • Actomyosin ATPase. II. Fiber typing by histochemical ATPase reaction
    • Mabuchi K and Sreter FA. Actomyosin ATPase. II. Fiber typing by histochemical ATPase reaction. Muscle Nerve 3: 233-239, 1980.
    • (1980) Muscle Nerve , vol.3 , pp. 233-239
    • Mabuchi, K.1    Sreter, F.A.2
  • 29
    • 0030052636 scopus 로고    scopus 로고
    • The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects
    • Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Paljarvi L, and Laakso M. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects. Int J Obes Relat Metab Disord 20: 154-60, 1996.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 154-160
    • Niskanen, L.1    Uusitupa, M.2    Sarlund, H.3    Siitonen, O.4    Paljarvi, L.5    Laakso, M.6
  • 31
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglycerides and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects
    • Phillips DIW, Caddy S, Llic V, Frayn KN, Borthwick AC, and Taylor R. Intramuscular triglycerides and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950, 1996.
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.W.1    Caddy, S.2    Llic, V.3    Frayn, K.N.4    Borthwick, A.C.5    Taylor, R.6
  • 33
    • 0030482757 scopus 로고    scopus 로고
    • Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men
    • Ross R, Rissanen J, Pedwell H, Clifford J, and Shragge P. Influence of diet and exercise on skeletal muscle and visceral adipose tissue in men. J Appl Physiol 81: 2445-2455, 1996.
    • (1996) J Appl Physiol , vol.81 , pp. 2445-2455
    • Ross, R.1    Rissanen, J.2    Pedwell, H.3    Clifford, J.4    Shragge, P.5
  • 35
    • 0024423218 scopus 로고
    • Human variation in skeletal muscle fiber-type proportion and enzyme activities
    • Simoneau JA and Bouchard C. Human variation in skeletal muscle fiber-type proportion and enzyme activities. Am J Physiol Endocrinol Metab 257: E567-E572, 1989.
    • (1989) Am J Physiol Endocrinol Metab , vol.257
    • Simoneau, J.A.1    Bouchard, C.2
  • 36
    • 0028987309 scopus 로고
    • Skeletal muscle glycolytic and oxydative enzyme capacities are determinants of insulin sensititvity and muscle composition in obese women
    • Simoneau JA, Colberg SR, Leland Thaete F, and Kelley DE. Skeletal muscle glycolytic and oxydative enzyme capacities are determinants of insulin sensititvity and muscle composition in obese women. FASEB J 9: 273-278, 1995.
    • (1995) FASEB J , vol.9 , pp. 273-278
    • Simoneau, J.A.1    Colberg, S.R.2    Leland Thaete, F.3    Kelley, D.E.4
  • 37
    • 0006500187 scopus 로고    scopus 로고
    • Metabolic aspects of skeletal muscle in obesity
    • edited by B Guy-Grand and G Ailhaud. London, UK: John Libbey
    • Simoneau JA and Kelley DE. Metabolic aspects of skeletal muscle in obesity. In: Progress in Obesity Research: 8, edited by B Guy-Grand and G Ailhaud. London, UK: John Libbey, 1999, p. 411-414.
    • (1999) Progress in Obesity Research , vol.8 , pp. 411-414
    • Simoneau, J.A.1    Kelley, D.E.2
  • 38
    • 0022502755 scopus 로고
    • Repeatability of fibre type and enzyme activity measurements in human skeletal muscle
    • Simoneau JA, Lortie G, Boulay MR, Thibault MC, and Bouchard C. Repeatability of fibre type and enzyme activity measurements in human skeletal muscle. Clin Physiol 6: 347-356, 1986.
    • (1986) Clin Physiol , vol.6 , pp. 347-356
    • Simoneau, J.A.1    Lortie, G.2    Boulay, M.R.3    Thibault, M.C.4    Bouchard, C.5
  • 39
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
    • Simoneau JA, Veerkamp JH, Turcotte LP, and Kelley DE. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J 13: 2051-2060, 1999.
    • (1999) FASEB J , vol.13 , pp. 2051-2060
    • Simoneau, J.A.1    Veerkamp, J.H.2    Turcotte, L.P.3    Kelley, D.E.4
  • 40
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, and Kraegen EW. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40: 280-289, 1991.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3    Pascoe, W.S.4    Khouri, S.5    Kraegen, E.W.6
  • 41
    • 0027518759 scopus 로고
    • Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex
    • Storlien LH, Oakes ND, Pan DA, Kusunoki M, and Jenkins AB. Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex. Diabetes 42: 457-462, 1993.
    • (1993) Diabetes , vol.42 , pp. 457-462
    • Storlien, L.H.1    Oakes, N.D.2    Pan, D.A.3    Kusunoki, M.4    Jenkins, A.B.5
  • 42
    • 0027093576 scopus 로고
    • Human obesity: A defect in lipid oxidation or in thermogenesis?
    • Tremblay A. Human obesity: a defect in lipid oxidation or in thermogenesis? Int J Obes Relat Metab Disord 16: 953-957, 1992.
    • (1992) Int J Obes Relat Metab Disord , vol.16 , pp. 953-957
    • Tremblay, A.1
  • 44
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44: 863-870, 1995.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 45
    • 0028947175 scopus 로고
    • Changes in body composition and resting energy expenditure after rapid weight loss: Is there an energy-metabolism adaptation in obese patients?
    • Valtuena S, Blanch S, Barenys M, Sola R, and Salas-Salvado J. Changes in body composition and resting energy expenditure after rapid weight loss: is there an energy-metabolism adaptation in obese patients? Int J Obes Relat Metab Disord 19: 119-125, 1995.
    • (1995) Int J Obes Relat Metab Disord , vol.19 , pp. 119-125
    • Valtuena, S.1    Blanch, S.2    Barenys, M.3    Sola, R.4    Salas-Salvado, J.5


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