메뉴 건너뛰기




Volumn 48, Issue 8, 2005, Pages 1503-1509

Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes

Author keywords

Exercise training; Gene environment interaction; Glucose; Peroxisome proliferator activated receptor ; Type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 23844479300     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1827-y     Document Type: Article
Times cited : (41)

References (60)
  • 1
  • 2
    • 0032945920 scopus 로고    scopus 로고
    • Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men
    • Rice B, Janssen I, Hudson R, Ross R (1999) Effects of aerobic or resistance exercise and/or diet on glucose tolerance and plasma insulin levels in obese men. Diabetes Care 22:684-691
    • (1999) Diabetes Care , vol.22 , pp. 684-691
    • Rice, B.1    Janssen, I.2    Hudson, R.3    Ross, R.4
  • 4
    • 0028088111 scopus 로고
    • Strength training increases insulin action in healthy 50- to 65-yr-old men
    • Miller JP, Pratley RE, Goldberg AP et al (1994) Strength training increases insulin action in healthy 50- to 65-yr-old men. J Appl Physiol 77:1122-1127
    • (1994) J Appl Physiol , vol.77 , pp. 1122-1127
    • Miller, J.P.1    Pratley, R.E.2    Goldberg, A.P.3
  • 5
    • 0033287298 scopus 로고    scopus 로고
    • Prevention and treatment of non-insulin-dependent diabetes mellitus
    • Ivy J, Zderic T, Fogt D (1999) Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 27:1-35
    • (1999) Exerc Sport Sci Rev , vol.27 , pp. 1-35
    • Ivy, J.1    Zderic, T.2    Fogt, D.3
  • 6
    • 0033851079 scopus 로고    scopus 로고
    • Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue
    • Stallknecht B, Larsen J, Mikines K et al (2000) Effect of training on insulin sensitivity of glucose uptake and lipolysis in human adipose tissue. Am J Physiol Endocrinol Metabol 279:376-385
    • (2000) Am J Physiol Endocrinol Metabol , vol.279 , pp. 376-385
    • Stallknecht, B.1    Larsen, J.2    Mikines, K.3
  • 7
    • 1542650920 scopus 로고    scopus 로고
    • Diabetes control with physical activity and exercise
    • Castaneda C (2003) Diabetes control with physical activity and exercise. Nutr Clin Care 6:89-96
    • (2003) Nutr Clin Care , vol.6 , pp. 89-96
    • Castaneda, C.1
  • 8
    • 0033034435 scopus 로고    scopus 로고
    • Nutrition and exercise in individuals with diabetes
    • Zinker BA (1999) Nutrition and exercise in individuals with diabetes. Clin Sports Med 18:585-606, vii-viii
    • (1999) Clin Sports Med , vol.18 , pp. 585-606
    • Zinker, B.A.1
  • 9
    • 0035248419 scopus 로고    scopus 로고
    • Insulin resistance and associated metabolic abnormalities in muscle: Effects of exercise
    • Perez-Martin A, Raynaud E, Mercier J (2001) Insulin resistance and associated metabolic abnormalities in muscle: effects of exercise. Obes Rev 2:47-59
    • (2001) Obes Rev , vol.2 , pp. 47-59
    • Perez-Martin, A.1    Raynaud, E.2    Mercier, J.3
  • 11
    • 1842526874 scopus 로고    scopus 로고
    • Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification
    • McCarthy M (2004) Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification. Hum Mol Genet 1-21
    • (2004) Hum Mol Genet , pp. 1-21
    • McCarthy, M.1
  • 12
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
    • Forman B, Tontonoz P, Chen J, Brun R, Speigelman B, Evans R (1995) 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.1    Tontonoz, P.2    Chen, J.3    Brun, R.4    Speigelman, B.5    Evans, R.6
  • 13
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma (PPARγ)
    • Lehmann J, Moore K, Smith-Oliver T, Wilkison W, Wilson T, Kliewer S (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator activated receptor gamma (PPARγ). J Biol Chem 270:12953-12956
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.1    Moore, K.2    Smith-Oliver, T.3    Wilkison, W.4    Wilson, T.5    Kliewer, S.6
  • 14
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • Kersten S, Besvergne B, Wahli W (2000) Roles of PPARs in health and disease. Nature 405:421-424
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Besvergne, B.2    Wahli, W.3
  • 15
    • 0033615353 scopus 로고    scopus 로고
    • PPARγ: An essential regulator of adipogenesis and modulator of fat cell function
    • Lowell B (1999) PPARγ: an essential regulator of adipogenesis and modulator of fat cell function. Cell 99:239-242
    • (1999) Cell , vol.99 , pp. 239-242
    • Lowell, B.1
  • 16
    • 0031898610 scopus 로고    scopus 로고
    • PPARγ: Adipogenic regulator and thiazolidinedione receptor
    • Speigelman B (1998) PPARγ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Speigelman, B.1
  • 17
    • 0031595923 scopus 로고    scopus 로고
    • 12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • 12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 18
    • 0031912333 scopus 로고    scopus 로고
    • A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans
    • Meirhaeghe A, Fajas L, Helbecque N et al (1998) A genetic polymorphism of the peroxisome proliferator-activated receptor γ gene influences plasma leptin levels in obese humans. Hum Mol Genet 7:435-440
    • (1998) Hum Mol Genet , vol.7 , pp. 435-440
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3
  • 20
    • 0033626426 scopus 로고    scopus 로고
    • 12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients
    • 12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients. Horm Metab Res 32:413-416
    • (2000) Horm Metab Res , vol.32 , pp. 413-416
    • Jacob, S.1    Stumvoll, M.2    Becker, R.3
  • 21
    • 0034745184 scopus 로고    scopus 로고
    • 12Ala variant: Association with type 2 diabetes and trait differences
    • 12Ala variant: association with type 2 diabetes and trait differences. Diabetes 50:886-890
    • (2001) Diabetes , vol.50 , pp. 886-890
    • Douglas, J.1    Erdos, M.2    Watanabe, R.3
  • 22
    • 0034728762 scopus 로고    scopus 로고
    • 12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes
    • 12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun 271:212-216
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 212-216
    • Hara, K.1    Okada, T.2    Tobe, K.3
  • 23
    • 0034745185 scopus 로고    scopus 로고
    • The Pro12→Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    • Mori H, Ikegami H, Kawaguchi Y et al (2001) The Pro12→Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 50:891-894
    • (2001) Diabetes , vol.50 , pp. 891-894
    • Mori, H.1    Ikegami, H.2    Kawaguchi, Y.3
  • 25
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K, Pearce C, Pike M, Lander E, Hirschlorn J (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182
    • (2003) Nat Genet , vol.33 , pp. 177-182
    • Lohmueller, K.1    Pearce, C.2    Pike, M.3    Lander, E.4    Hirschlorn, J.5
  • 26
    • 0035123646 scopus 로고    scopus 로고
    • Evidence for gene-nutrient interaction at the PPAR-γ locus
    • Luan J, Browne P, Harding AH et al (2001) Evidence for gene-nutrient interaction at the PPAR-γ locus. Diabetes 50:686-689
    • (2001) Diabetes , vol.50 , pp. 686-689
    • Luan, J.1    Browne, P.2    Harding, A.H.3
  • 27
    • 0345306138 scopus 로고    scopus 로고
    • Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass
    • Memisoglu A, Hu FB, Hankinson SE et al (2003) Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass. Hum Mol Genet 12:2923-2929
    • (2003) Hum Mol Genet , vol.12 , pp. 2923-2929
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3
  • 28
    • 0037073439 scopus 로고    scopus 로고
    • 12Ala and C1431T variants reveals opposing associations with body weight
    • 12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 3:21
    • (2002) BMC Genet , vol.3 , pp. 21
    • Doney, A.1    Fischer, B.2    Frew, D.3
  • 29
    • 0347316400 scopus 로고    scopus 로고
    • 12Ala) modify the association of physical activity and dietary fat with fasting insulin level?
    • 12Ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 53:11-16
    • (2004) Metabolism , vol.53 , pp. 11-16
    • Franks, P.W.1    Luan, J.2    Browne, P.O.3
  • 30
    • 0036329369 scopus 로고    scopus 로고
    • 12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study
    • 12Ala polymorphism in the PPAR-γ2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 51:2581-2586
    • (2002) Diabetes , vol.51 , pp. 2581-2586
    • Lindi, V.I.1    Uusitupa, M.I.2    Lindstrom, J.3
  • 32
    • 0001435659 scopus 로고    scopus 로고
    • Report of the expert committee on the diagnosis of diabetes mellitus
    • Gavin J, Alberti K, Davidson M et al (1997) Report of the expert committee on the diagnosis of diabetes mellitus. Diabetes Care 20:1183-1197
    • (1997) Diabetes Care , vol.20 , pp. 1183-1197
    • Gavin, J.1    Alberti, K.2    Davidson, M.3
  • 33
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.1    Hosker, J.2    Rudenski, A.3    Naylor, B.4    Treacher, D.5    Turner, R.6
  • 34
    • 0031710787 scopus 로고    scopus 로고
    • Prevalence of insulin resistance in metabolic disorders: The Bruneck Study
    • Bonora E, Kiechl S, Willeit J et al (1998) Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 47:1643-1649
    • (1998) Diabetes , vol.47 , pp. 1643-1649
    • Bonora, E.1    Kiechl, S.2    Willeit, J.3
  • 36
    • 0035093082 scopus 로고    scopus 로고
    • 12Ala variant on obesity, glucose homeostasis and blood pressure in members of familial type 2 diabetic kindreds
    • 12Ala variant on obesity, glucose homeostasis and blood pressure in members of familial type 2 diabetic kindreds. J Clin Endocrinol Metab 86:536-541
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 536-541
    • Hassetedt, S.1    Ren, Q.F.2    Teng, K.3    Elbein, S.4
  • 37
    • 0034994741 scopus 로고    scopus 로고
    • Effect of exercise on glucose homeostasis in type 2 diabetes mellitus
    • Kelley D, Goodpaster B (2001) Effect of exercise on glucose homeostasis in type 2 diabetes mellitus. Med Sci Sports Exerc 33:S495-S501
    • (2001) Med Sci Sports Exerc , vol.33
    • Kelley, D.1    Goodpaster, B.2
  • 38
    • 0036315611 scopus 로고    scopus 로고
    • Intense exercise has unique effects on both insulin release and its roles in glucoregulation: Implications for diabetes
    • Marliss EB, Vranic M (2002) Intense exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes. Diabetes 51(Suppl 1):S271-S283
    • (2002) Diabetes , vol.51 , Issue.1 SUPPL.
    • Marliss, E.B.1    Vranic, M.2
  • 40
    • 0034483827 scopus 로고    scopus 로고
    • The role of PPARgamma as a thrifty gene both in mice and humans
    • Hara K, Kubota N, Tobe K et al (2000) The role of PPARgamma as a thrifty gene both in mice and humans. Br J Nutr 84:235-239
    • (2000) Br J Nutr , vol.84 , pp. 235-239
    • Hara, K.1    Kubota, N.2    Tobe, K.3
  • 41
    • 0142209179 scopus 로고    scopus 로고
    • 12Ala variant on body mass index: A meta-analysis
    • 12Ala variant on body mass index: a meta-analysis. J Med Genet 40:773-780
    • (2003) J Med Genet , vol.40 , pp. 773-780
    • Masud, S.1    Ye, S.2
  • 42
    • 0037313934 scopus 로고    scopus 로고
    • PPARγ gene polymorphism is associated with exercise-mediated changes of insulin resistance in health men
    • Kahara T, Takamura T, Hayakawa T et al (2003) PPARγ gene polymorphism is associated with exercise-mediated changes of insulin resistance in health men. Metabolism 52:209-212
    • (2003) Metabolism , vol.52 , pp. 209-212
    • Kahara, T.1    Takamura, T.2    Hayakawa, T.3
  • 43
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor γ2 on thiazolidinedione-induced adipogenesis
    • Masugi J, Tamori Y, Mori Y, Koike T, Kasuga M (2000) Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor γ2 on thiazolidinedione-induced adipogenesis. Biochem Biophys Res Commun 268:178-182
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, Y.3    Koike, T.4    Kasuga, M.5
  • 44
    • 0036297755 scopus 로고    scopus 로고
    • Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists
    • Ciaraldi T, Cha B-S, Park K, Carter L, Mudaliar S, Henry R (2002) Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists. Ann N Y Acad Sci 967:66-70
    • (2002) Ann N Y Acad Sci , vol.967 , pp. 66-70
    • Ciaraldi, T.1    Cha, B.-S.2    Park, K.3    Carter, L.4    Mudaliar, S.5    Henry, R.6
  • 45
    • 0033548216 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene
    • Frohnert B, Hui T, Bernlohr DA (1999) Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. J Biol Chem 274:3970-3977
    • (1999) J Biol Chem , vol.274 , pp. 3970-3977
    • Frohnert, B.1    Hui, T.2    Bernlohr, D.A.3
  • 46
    • 0029796038 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation
    • Johnson E, Palmer CN, Griffin K, Hsu M (1996) Role of peroxisome proliferator-activated receptor in cytochrome P450 4A gene regulation. FASEB J 10:1241-1248
    • (1996) FASEB J , vol.10 , pp. 1241-1248
    • Johnson, E.1    Palmer, C.N.2    Griffin, K.3    Hsu, M.4
  • 47
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
    • Schoonjans K, Staels B, Auwerx J (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302:93-109
    • (1996) Biochim Biophys Acta , vol.1302 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 48
    • 0036189407 scopus 로고    scopus 로고
    • PPARadigms and PPARadoxes: Expanding roles for PPARγ in the control of lipid metabolism
    • Walczak R, Tontonoz P (2002) PPARadigms and PPARadoxes: expanding roles for PPARγ in the control of lipid metabolism. J Lipid Res 43:177-186
    • (2002) J Lipid Res , vol.43 , pp. 177-186
    • Walczak, R.1    Tontonoz, P.2
  • 49
    • 0034745183 scopus 로고    scopus 로고
    • 12Ala polymorphism in peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity
    • 12Ala polymorphism in peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity. Diabetes 50:876-881
    • (2001) Diabetes , vol.50 , pp. 876-881
    • Stumvoll, M.1    Wahl, H.2    Loblein, K.3
  • 51
    • 0036217533 scopus 로고    scopus 로고
    • Evidence for greater oxidative substrate flexibility in male carriers of the Pro 12 Ala polymorphism in PPARgamma2
    • Thamer C, Haap M, Volk A et al (2002) Evidence for greater oxidative substrate flexibility in male carriers of the Pro 12 Ala polymorphism in PPARgamma2. Horm Metab Res 34:132-136
    • (2002) Horm Metab Res , vol.34 , pp. 132-136
    • Thamer, C.1    Haap, M.2    Volk, A.3
  • 53
    • 0033967003 scopus 로고    scopus 로고
    • Exercise and insulin sensitivity: A review
    • Borghouts LB, Keiser HA (2000) Exercise and insulin sensitivity: a review. Int J Sports Med 21:1-12
    • (2000) Int J Sports Med , vol.21 , pp. 1-12
    • Borghouts, L.B.1    Keiser, H.A.2
  • 54
    • 0042266366 scopus 로고    scopus 로고
    • Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    • Short KR, Vittone JL, Bigelow ML et al (2003) Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52:1888-1896
    • (2003) Diabetes , vol.52 , pp. 1888-1896
    • Short, K.R.1    Vittone, J.L.2    Bigelow, M.L.3
  • 55
    • 0042093749 scopus 로고    scopus 로고
    • Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults
    • Duncan G, Perri M, Theriaque D, Hutson A, Eckel R, Stacpoole P (2003) Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 26:557-562
    • (2003) Diabetes Care , vol.26 , pp. 557-562
    • Duncan, G.1    Perri, M.2    Theriaque, D.3    Hutson, A.4    Eckel, R.5    Stacpoole, P.6
  • 56
    • 0026322241 scopus 로고
    • Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men
    • Segal KR, Edano A, Abalos A et al (1991) Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol 71:2402-2411
    • (1991) J Appl Physiol , vol.71 , pp. 2402-2411
    • Segal, K.R.1    Edano, A.2    Abalos, A.3
  • 57
    • 0037677523 scopus 로고    scopus 로고
    • A functional variant in the peroxisome proliferator-activated receptor γ2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians
    • Muller YL, Bogardus C, Beamer BA, Shuldiner AR, Baier LJ (2003) A functional variant in the peroxisome proliferator-activated receptor γ2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians. Diabetes 52:1864-1871
    • (2003) Diabetes , vol.52 , pp. 1864-1871
    • Muller, Y.L.1    Bogardus, C.2    Beamer, B.A.3    Shuldiner, A.R.4    Baier, L.J.5
  • 60
    • 0003169091 scopus 로고    scopus 로고
    • Guidelines for the nutritional management of diabetes mellitus in the new millennium
    • Wolever T, Barbeau MC, Charron S et al (2003) Guidelines for the nutritional management of diabetes mellitus in the new millennium. Can J Diabetes Care 23:56-69
    • (2003) Can J Diabetes Care , vol.23 , pp. 56-69
    • Wolever, T.1    Barbeau, M.C.2    Charron, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.